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The map label for this gene is betC [H]

Identifier: 116625360

GI number: 116625360

Start: 7922995

End: 7924149

Strand: Direct

Name: betC [H]

Synonym: Acid_6305

Alternate gene names: 116625360

Gene position: 7922995-7924149 (Clockwise)

Preceding gene: 116625358

Following gene: 116625363

Centisome position: 79.5

GC content: 64.24

Gene sequence:

>1155_bases
ATGAACTTCACCCGCCGTCATTTTTTCCTCGGGAGTCTCGCGCTGCCGGCGCTCGCCGCCAAGAAGGCCGTTGGAGAACA
GCCCAACATCCTGCTGATCCTGGTGGACGGGCTGCCTTCATGGCTGCTCGGCTGCTACGGAAACAAGGAAATCCGTACGC
CCAAAATCGATCAGCTGGCGCAGACCGGAACCCGCTTCCTGAATCACTACGCCGCTGCTCCCCTGGCCGATCCGGCGCGG
GCCGCGCTGCTCAGCGGGCGCACCCCGATGCAATCGAAGGCGGCCGGCGAGGGGACGCTCGAAAAACTCCTCGGCGGCGT
CGGATACGCCTGCGGCAATACCACTGGCAGCGCAGCGGCCCTCCAGTTCATCGACGGGCAAAACGCCGGAAAGCCGTTTT
TCCTGACCGCGAGCTTCGCGCCCTTCGCCAGTCTGCCGGCCGATCCGGGCCCCTACGCGCAGGCCAAATTCGACACTTTC
GAGCAGGAAGCGCCAGCGAAGAATGCGGCGCGCGGCAAGGAAATGCTGGGCGCCAATCTGCTCCCCAACCTGCGTAGAGT
TGCGGCAGCCACTACCGCGCTCGATGCCGAAATCGGGGAGCTGGTCTCGCGGCTGACCCAGAAGAAGCTGCTCGGCGATA
CCCTTATCGCGTTCACATCCCCGGTCGGTTCCCTCTTCGGCCGGCACGGACTTTGGTCTGCGGGCGACGCCTCGGATCCC
GTTAATTTCTTCGAGGAGGTAGTGGCTACGCCCATGATCTGGAGCTGGTCGGGTCACGTTCCGCCGCTCGCGGCGCGGCC
CGAAGTGGTCAGCGCCTGCGATCTGCTGCCCACCATCTGCGACATCACGCCCGCCGAGCTGCCCGCCGCCAATCTCTGGG
GGCGCAGCTATCTGGCGATCGTCACCGGCAAGCCGCTTCCCAGGAAACAGCCGTGGCGCACCACCGTATTTGCCCAATCG
GGCGATGCCGGCATGGCGCGCAGCGATCGCTACAAGGTGATCGTTCGCAACGACGGGAAGGGACCAGGGGAGTTGTACGA
CGACAAAGTGGATGCGCGGGAGAGAGTCAACCAGCACGACAATCCGCAGTTTCTAACCGTGAAGACCTCCCACTCCGCCG
AACTGGCGAAGTGGAAACGAACCTATTCGGCGTAG

Upstream 100 bases:

>100_bases
GTCAGCGCATTCGGAAGGTTCATCGTCCAACCCAACTATAACAAGAGTCCGCCGGCTCGGGCTCGAATCCAGGACCGGGC
TTATACTGGAAATTCAAGCC

Downstream 100 bases:

>100_bases
GTGGGCCGGCAGGCGACCCAGCCGGTCCCCTGCCATGAGCCCCACCTGCCCGTATTACTTCTTGGGAACGTAGCCGTCCA
GCTTGTGATCGTGGTCCTTG

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNFTRRHFFLGSLALPALAAKKAVGEQPNILLILVDGLPSWLLGCYGNKEIRTPKIDQLAQTGTRFLNHYAAAPLADPAR
AALLSGRTPMQSKAAGEGTLEKLLGGVGYACGNTTGSAAALQFIDGQNAGKPFFLTASFAPFASLPADPGPYAQAKFDTF
EQEAPAKNAARGKEMLGANLLPNLRRVAAATTALDAEIGELVSRLTQKKLLGDTLIAFTSPVGSLFGRHGLWSAGDASDP
VNFFEEVVATPMIWSWSGHVPPLAARPEVVSACDLLPTICDITPAELPAANLWGRSYLAIVTGKPLPRKQPWRTTVFAQS
GDAGMARSDRYKVIVRNDGKGPGELYDDKVDARERVNQHDNPQFLTVKTSHSAELAKWKRTYSA

Sequences:

>Translated_384_residues
MNFTRRHFFLGSLALPALAAKKAVGEQPNILLILVDGLPSWLLGCYGNKEIRTPKIDQLAQTGTRFLNHYAAAPLADPAR
AALLSGRTPMQSKAAGEGTLEKLLGGVGYACGNTTGSAAALQFIDGQNAGKPFFLTASFAPFASLPADPGPYAQAKFDTF
EQEAPAKNAARGKEMLGANLLPNLRRVAAATTALDAEIGELVSRLTQKKLLGDTLIAFTSPVGSLFGRHGLWSAGDASDP
VNFFEEVVATPMIWSWSGHVPPLAARPEVVSACDLLPTICDITPAELPAANLWGRSYLAIVTGKPLPRKQPWRTTVFAQS
GDAGMARSDRYKVIVRNDGKGPGELYDDKVDARERVNQHDNPQFLTVKTSHSAELAKWKRTYSA
>Mature_384_residues
MNFTRRHFFLGSLALPALAAKKAVGEQPNILLILVDGLPSWLLGCYGNKEIRTPKIDQLAQTGTRFLNHYAAAPLADPAR
AALLSGRTPMQSKAAGEGTLEKLLGGVGYACGNTTGSAAALQFIDGQNAGKPFFLTASFAPFASLPADPGPYAQAKFDTF
EQEAPAKNAARGKEMLGANLLPNLRRVAAATTALDAEIGELVSRLTQKKLLGDTLIAFTSPVGSLFGRHGLWSAGDASDP
VNFFEEVVATPMIWSWSGHVPPLAARPEVVSACDLLPTICDITPAELPAANLWGRSYLAIVTGKPLPRKQPWRTTVFAQS
GDAGMARSDRYKVIVRNDGKGPGELYDDKVDARERVNQHDNPQFLTVKTSHSAELAKWKRTYSA

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI71852586, Length=72, Percent_Identity=55.5555555555556, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI71852584, Length=72, Percent_Identity=55.5555555555556, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI31742482, Length=98, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI157266309, Length=109, Percent_Identity=37.6146788990826, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI53831991, Length=76, Percent_Identity=47.3684210526316, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI58743319, Length=99, Percent_Identity=42.4242424242424, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI146229331, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI146229329, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI6005990, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI146229324, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 41182; Mature: 41182

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFTRRHFFLGSLALPALAAKKAVGEQPNILLILVDGLPSWLLGCYGNKEIRTPKIDQLA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCHHHHH
QTGTRFLNHYAAAPLADPARAALLSGRTPMQSKAAGEGTLEKLLGGVGYACGNTTGSAAA
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHE
LQFIDGQNAGKPFFLTASFAPFASLPADPGPYAQAKFDTFEQEAPAKNAARGKEMLGANL
EEEECCCCCCCCEEEEECCCCHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHH
LPNLRRVAAATTALDAEIGELVSRLTQKKLLGDTLIAFTSPVGSLFGRHGLWSAGDASDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCH
VNFFEEVVATPMIWSWSGHVPPLAARPEVVSACDLLPTICDITPAELPAANLWGRSYLAI
HHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEE
VTGKPLPRKQPWRTTVFAQSGDAGMARSDRYKVIVRNDGKGPGELYDDKVDARERVNQHD
EECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCC
NPQFLTVKTSHSAELAKWKRTYSA
CCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNFTRRHFFLGSLALPALAAKKAVGEQPNILLILVDGLPSWLLGCYGNKEIRTPKIDQLA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCHHHHH
QTGTRFLNHYAAAPLADPARAALLSGRTPMQSKAAGEGTLEKLLGGVGYACGNTTGSAAA
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHE
LQFIDGQNAGKPFFLTASFAPFASLPADPGPYAQAKFDTFEQEAPAKNAARGKEMLGANL
EEEECCCCCCCCEEEEECCCCHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHH
LPNLRRVAAATTALDAEIGELVSRLTQKKLLGDTLIAFTSPVGSLFGRHGLWSAGDASDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCH
VNFFEEVVATPMIWSWSGHVPPLAARPEVVSACDLLPTICDITPAELPAANLWGRSYLAI
HHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEE
VTGKPLPRKQPWRTTVFAQSGDAGMARSDRYKVIVRNDGKGPGELYDDKVDARERVNQHD
EECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCC
NPQFLTVKTSHSAELAKWKRTYSA
CCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]