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The map label for this gene is uppS1 [H]

Identifier: 116625349

GI number: 116625349

Start: 7912757

End: 7913467

Strand: Direct

Name: uppS1 [H]

Synonym: Acid_6294

Alternate gene names: 116625349

Gene position: 7912757-7913467 (Clockwise)

Preceding gene: 116625348

Following gene: 116625350

Centisome position: 79.4

GC content: 67.93

Gene sequence:

>711_bases
ATGTCATATAACTTTATGTCGCAAAGTACTCTTCATTGCGGGATCATCATGGATGGCAATGGCCGCTGGGCGGCGGCGCG
GGGGTTGCCGCGGATCCTGGGGCATCGCGCCGGAGTGGAAGCGGCGCGGCGCGTGGTGGAGGCGGCGCCCGATGCCGGGG
TCGGGATCCTCACGCTCTTCGCTTTTTCGAGTGACAACTGGCAGCGTCCGGCGGCCGAGGTGGATGCGCTGATGCGGCTG
ATGGCGACGTATCTGGAGAACGAGACGGCGCGGTGCGTGCAGCAGGGCGTGCGGCTGGAGGTGATCGGGCGGCGCGACCG
TTTGGGCGCGGGGTTGTGCGCGGCGATCGGCCGCGCCGAGGAGGCGACTGCCGGCGGACGCAGGCTGCGGCTGCGAATGG
CGGTGGACTATTCGGGCCGCGACGCGATTCTGACCGCGGCACGCGGAGTGCGGGAGCTTTCGCGGGATGCGTTTGAGGTG
GCGATGGGTCCGGCGGTGGACCTGTTGATCCGCACGGGAGGCGAGCGGCGGTTGAGCGATTTCCTGCTGTGGGAATCGGC
CTACGCGGAGCTTGTTTTCACGCGCACGATGTGGCCGGATTTCGGGGCGGTGGATCTGGCCGCCGCGGTCCAGGAATTCC
AGGGCCGTGAAAGGCGATTCGGTACGGTGCCGCAGGCTCCGGTCAGGCGGCATGAGGCGTGGCTGGACTGA

Upstream 100 bases:

>100_bases
GCTGACCTCGGCCGGCCGCCGCGCGCTGGATCGCTATTTGAATCACATGGAAGCTCTCATCCAGGCAATGAGGGAGAAAT
AGGGCGGAGGCCCTTTTTTT

Downstream 100 bases:

>100_bases
TGGGGCGCACGGTCGCAACGGAATACTCCTAGCTGACGCGCAATTTGGAAAGCGCGCGCGGTCTCGGTGGAAGACGCCTA
AAAGGCGGCTGCACGGTCGA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSYNFMSQSTLHCGIIMDGNGRWAAARGLPRILGHRAGVEAARRVVEAAPDAGVGILTLFAFSSDNWQRPAAEVDALMRL
MATYLENETARCVQQGVRLEVIGRRDRLGAGLCAAIGRAEEATAGGRRLRLRMAVDYSGRDAILTAARGVRELSRDAFEV
AMGPAVDLLIRTGGERRLSDFLLWESAYAELVFTRTMWPDFGAVDLAAAVQEFQGRERRFGTVPQAPVRRHEAWLD

Sequences:

>Translated_236_residues
MSYNFMSQSTLHCGIIMDGNGRWAAARGLPRILGHRAGVEAARRVVEAAPDAGVGILTLFAFSSDNWQRPAAEVDALMRL
MATYLENETARCVQQGVRLEVIGRRDRLGAGLCAAIGRAEEATAGGRRLRLRMAVDYSGRDAILTAARGVRELSRDAFEV
AMGPAVDLLIRTGGERRLSDFLLWESAYAELVFTRTMWPDFGAVDLAAAVQEFQGRERRFGTVPQAPVRRHEAWLD
>Mature_235_residues
SYNFMSQSTLHCGIIMDGNGRWAAARGLPRILGHRAGVEAARRVVEAAPDAGVGILTLFAFSSDNWQRPAAEVDALMRLM
ATYLENETARCVQQGVRLEVIGRRDRLGAGLCAAIGRAEEATAGGRRLRLRMAVDYSGRDAILTAARGVRELSRDAFEVA
MGPAVDLLIRTGGERRLSDFLLWESAYAELVFTRTMWPDFGAVDLAAAVQEFQGRERRFGTVPQAPVRRHEAWLD

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=32.1266968325792, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=32.1266968325792, Blast_Score=111, Evalue=6e-25,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=44.2982456140351, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=223, Percent_Identity=28.2511210762332, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=33.4862385321101, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=243, Percent_Identity=27.5720164609054, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18857969, Length=221, Percent_Identity=32.1266968325792, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25993; Mature: 25862

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNFMSQSTLHCGIIMDGNGRWAAARGLPRILGHRAGVEAARRVVEAAPDAGVGILTLF
CCCCCCCCCCEEEEEEECCCCCEEHHCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
AFSSDNWQRPAAEVDALMRLMATYLENETARCVQQGVRLEVIGRRDRLGAGLCAAIGRAE
EECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCH
EATAGGRRLRLRMAVDYSGRDAILTAARGVRELSRDAFEVAMGPAVDLLIRTGGERRLSD
HCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEECCCCHHHHH
FLLWESAYAELVFTRTMWPDFGAVDLAAAVQEFQGRERRFGTVPQAPVRRHEAWLD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SYNFMSQSTLHCGIIMDGNGRWAAARGLPRILGHRAGVEAARRVVEAAPDAGVGILTLF
CCCCCCCCCEEEEEEECCCCCEEHHCCCHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEE
AFSSDNWQRPAAEVDALMRLMATYLENETARCVQQGVRLEVIGRRDRLGAGLCAAIGRAE
EECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCH
EATAGGRRLRLRMAVDYSGRDAILTAARGVRELSRDAFEVAMGPAVDLLIRTGGERRLSD
HCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEECCCCHHHHH
FLLWESAYAELVFTRTMWPDFGAVDLAAAVQEFQGRERRFGTVPQAPVRRHEAWLD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]