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The map label for this gene is pip [H]

Identifier: 116625074

GI number: 116625074

Start: 7534447

End: 7535445

Strand: Reverse

Name: pip [H]

Synonym: Acid_6005

Alternate gene names: 116625074

Gene position: 7535445-7534447 (Counterclockwise)

Preceding gene: 116625075

Following gene: 116625073

Centisome position: 75.61

GC content: 60.76

Gene sequence:

>999_bases
ATGAGGACTCGTCTCATCGTCGCCAGTTTTGCAGCGGCGTTCGTGGTGGGGCTGCCTTCGGATTCGGCGAGGGCGTTTCA
GGCCATGCGCACGGCAGCCCCACGCGAGGGCCGTATTTCGGTTGGCAAGACATCGCTCTATTATCGGGAAATCGGGCAGG
GGCAGCCCATCATCGTCCTCCACGGCGGGCCGGACTTTGATCACAGCTATCTCCTCCCCGACTTGGATCGATTGGCGGAT
GTCTTCCGGCTCATCTACTACGACCAGAGGGGACGTGGCAGATCCGCAGATCAAGTGCTGCCAGAGGAAGTCACGCTCGC
ATCCGAAATCGACGATCTCGATATGGTGAGGCGGCACTTCCGCCTGGAATTGCCAGCCTTGCTCGGTCACTCCTGGAGCA
CGGTTCTTGCTCTGGAGTACGCCCTTCGACACCCGGAGCGCGTGTCTCATATGATCCTGCTGAATCCCGCACCGGCTTCT
ACAAGCGACCTCGCGATGTTTCGAAAGGTCTACGTGCAGAAGCTAGGCGCCGATATGGATCGACAGAGAGAAATCCTGGC
CAGCCCCGCCTATCAAGAGGGTGACCCCGAGGCCGTCGCCGCGCGCTATCGTCTCCACTTCAAGCCTGCGCTGAAGCGCC
CCGAGGATTACGAGAAGCTGATGGCGACGATGAAAGCGGCATTCGTCAGGCAGGGGAAGGAAGGCATCGTGAAGGCACGA
GCGGTCGAGGACCGGCTGATGCGCGAGAGCTGGCAGGTGGAAAGCTACGATCTGCTGCCCAAGCTGCAGACCCTGAACAT
CCCGACCTTAGTTATCTGGGGCGATCACGACTTCATCCCCGCCGAGATCGCCGCGCATATCGCGCGGGCAATTCCGAACG
CCCAACTGGTCACTCTCAACGACTGCGGGCACTTCGCCTATATGGAGTGTCCAGGCGAAGTTCGCAACGCGGTAGACGAC
TTCTTCCGGCGCACGCGGGCGACCGGGCATCCACATTGA

Upstream 100 bases:

>100_bases
CTGGCACCGATTTGTCCAGATTGCCGACGATCTGCTCGGAAGCCAACCACCCGCGAACCGGCACTTGCGCTGACCGCAGT
GGAACGGTAGGGTGTGTTCC

Downstream 100 bases:

>100_bases
TCGCTCCCCCAATTTGGAAGGGTGCTGGGACGACTCATGCTGATGCCGTAGCGTTCATGAATCCAGACGGCATGTCAATT
TCGTACATTTGATCCTGCTG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRTRLIVASFAAAFVVGLPSDSARAFQAMRTAAPREGRISVGKTSLYYREIGQGQPIIVLHGGPDFDHSYLLPDLDRLAD
VFRLIYYDQRGRGRSADQVLPEEVTLASEIDDLDMVRRHFRLELPALLGHSWSTVLALEYALRHPERVSHMILLNPAPAS
TSDLAMFRKVYVQKLGADMDRQREILASPAYQEGDPEAVAARYRLHFKPALKRPEDYEKLMATMKAAFVRQGKEGIVKAR
AVEDRLMRESWQVESYDLLPKLQTLNIPTLVIWGDHDFIPAEIAAHIARAIPNAQLVTLNDCGHFAYMECPGEVRNAVDD
FFRRTRATGHPH

Sequences:

>Translated_332_residues
MRTRLIVASFAAAFVVGLPSDSARAFQAMRTAAPREGRISVGKTSLYYREIGQGQPIIVLHGGPDFDHSYLLPDLDRLAD
VFRLIYYDQRGRGRSADQVLPEEVTLASEIDDLDMVRRHFRLELPALLGHSWSTVLALEYALRHPERVSHMILLNPAPAS
TSDLAMFRKVYVQKLGADMDRQREILASPAYQEGDPEAVAARYRLHFKPALKRPEDYEKLMATMKAAFVRQGKEGIVKAR
AVEDRLMRESWQVESYDLLPKLQTLNIPTLVIWGDHDFIPAEIAAHIARAIPNAQLVTLNDCGHFAYMECPGEVRNAVDD
FFRRTRATGHPH
>Mature_332_residues
MRTRLIVASFAAAFVVGLPSDSARAFQAMRTAAPREGRISVGKTSLYYREIGQGQPIIVLHGGPDFDHSYLLPDLDRLAD
VFRLIYYDQRGRGRSADQVLPEEVTLASEIDDLDMVRRHFRLELPALLGHSWSTVLALEYALRHPERVSHMILLNPAPAS
TSDLAMFRKVYVQKLGADMDRQREILASPAYQEGDPEAVAARYRLHFKPALKRPEDYEKLMATMKAAFVRQGKEGIVKAR
AVEDRLMRESWQVESYDLLPKLQTLNIPTLVIWGDHDFIPAEIAAHIARAIPNAQLVTLNDCGHFAYMECPGEVRNAVDD
FFRRTRATGHPH

Specific function: Releases the N-terminal proline from the dipeptides, Pro-Pro, Pro-Gln, Pro-Trp and Pro-Tyr. Also from amides (Pro-beta NA) and oligopeptides, Pro-Leu-GlyNH2, Pro-Leu-Gly and Pro-Phe- Gly-Lys. Higher activity toward small peptides (up to three residues), b

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 37530; Mature: 37530

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRLIVASFAAAFVVGLPSDSARAFQAMRTAAPREGRISVGKTSLYYREIGQGQPIIVL
CCCEEHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCEEEE
HGGPDFDHSYLLPDLDRLADVFRLIYYDQRGRGRSADQVLPEEVTLASEIDDLDMVRRHF
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHH
RLELPALLGHSWSTVLALEYALRHPERVSHMILLNPAPASTSDLAMFRKVYVQKLGADMD
HCCCHHHHCCCHHHHHHHHHHHCCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
RQREILASPAYQEGDPEAVAARYRLHFKPALKRPEDYEKLMATMKAAFVRQGKEGIVKAR
HHHHHHCCCCCCCCCHHHHHHHHHEEECHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
AVEDRLMRESWQVESYDLLPKLQTLNIPTLVIWGDHDFIPAEIAAHIARAIPNAQLVTLN
HHHHHHHHHHCCCCCHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
DCGHFAYMECPGEVRNAVDDFFRRTRATGHPH
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRTRLIVASFAAAFVVGLPSDSARAFQAMRTAAPREGRISVGKTSLYYREIGQGQPIIVL
CCCEEHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCEEEE
HGGPDFDHSYLLPDLDRLADVFRLIYYDQRGRGRSADQVLPEEVTLASEIDDLDMVRRHF
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCHHHHHHHHH
RLELPALLGHSWSTVLALEYALRHPERVSHMILLNPAPASTSDLAMFRKVYVQKLGADMD
HCCCHHHHCCCHHHHHHHHHHHCCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
RQREILASPAYQEGDPEAVAARYRLHFKPALKRPEDYEKLMATMKAAFVRQGKEGIVKAR
HHHHHHCCCCCCCCCHHHHHHHHHEEECHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
AVEDRLMRESWQVESYDLLPKLQTLNIPTLVIWGDHDFIPAEIAAHIARAIPNAQLVTLN
HHHHHHHHHHCCCCCHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
DCGHFAYMECPGEVRNAVDDFFRRTRATGHPH
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459939 [H]