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The map label for this gene is moaE [H]

Identifier: 116624981

GI number: 116624981

Start: 7409411

End: 7410100

Strand: Reverse

Name: moaE [H]

Synonym: Acid_5911

Alternate gene names: 116624981

Gene position: 7410100-7409411 (Counterclockwise)

Preceding gene: 116624983

Following gene: 116624980

Centisome position: 74.36

GC content: 61.74

Gene sequence:

>690_bases
ATGTTGAGAGATATCGTAGGAAAATCGGCGGAGGATGCCGAGTTTCCGCCGGGAACCGACCTGCAGTCGGTTTTCGAGTG
CTACCGGACCCGCTATCCGCGGCTCGGCGACTTGGCGCGCTCCATCGTAATTGCCCGGAATCAAGAGTTTGCCGAGCGGA
CCACACCCCTGCTGGATGGCGACGAAGTAGCCTTCCTGCCCCCGGTTTCGGGCGGCCGCCACGTGGACCCGATCGAAATC
GTCGAATCCGGCCACTACTTCGCCCTGACCCGCCACGCTATCGACACCCGCGGTGTGGTCGCCCGCCTCATGACGGGTGC
CGAGGGCGCGGTCGTGAACTTCGAAGGCACCGTCCGGAACAACACCAAGGGCCGTCCCACACTTTGCCTCGATTATGAAT
GCTATGAATCCATGGCATTGAAGATGATGGCGCAGATCGGTTGCGACATTGCCGCTACCCATCAGGTCGGCCGCGTGGCC
TTGGTGCACCGCCTCGGCCGTATGCTGGTGGGTGAAACCAGTGTGGCCGTGATTGTCACCGCACCGCACCGCCGCCCGGC
CTTTGAGGCCGCTCTCGAGGGCATCAACCGCCTCAAGAAAGTCGTGCCCATCTGGAAGAAGGAACACTTCGTGGATGGCG
AAGTCTGGGTGGAGGGAGAGTGGGATGAAAACCTTCCGGTTGTCGGCTAA

Upstream 100 bases:

>100_bases
GATTGATTGTAACTCAGCGCAACCCGGAGGCCGTCTGGAACCGTCTGTTAGACTGAGAGTTATCGTTCTGCCCATGCGCG
CGCGAGTTCTTTTTTTCGGG

Downstream 100 bases:

>100_bases
GGCCACCGGCCTCGCTCCGCTCGCCTTGGCACTCCTCGCCGGAGTGCTCTTTGCGCAGCAGCCTACCACCTTCCGCACCA
ACGTCAGTCTGGTGCGCGTG

Product: molybdopterin synthase subunit MoaD/molybdopterin synthase subunit MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLRDIVGKSAEDAEFPPGTDLQSVFECYRTRYPRLGDLARSIVIARNQEFAERTTPLLDGDEVAFLPPVSGGRHVDPIEI
VESGHYFALTRHAIDTRGVVARLMTGAEGAVVNFEGTVRNNTKGRPTLCLDYECYESMALKMMAQIGCDIAATHQVGRVA
LVHRLGRMLVGETSVAVIVTAPHRRPAFEAALEGINRLKKVVPIWKKEHFVDGEVWVEGEWDENLPVVG

Sequences:

>Translated_229_residues
MLRDIVGKSAEDAEFPPGTDLQSVFECYRTRYPRLGDLARSIVIARNQEFAERTTPLLDGDEVAFLPPVSGGRHVDPIEI
VESGHYFALTRHAIDTRGVVARLMTGAEGAVVNFEGTVRNNTKGRPTLCLDYECYESMALKMMAQIGCDIAATHQVGRVA
LVHRLGRMLVGETSVAVIVTAPHRRPAFEAALEGINRLKKVVPIWKKEHFVDGEVWVEGEWDENLPVVG
>Mature_229_residues
MLRDIVGKSAEDAEFPPGTDLQSVFECYRTRYPRLGDLARSIVIARNQEFAERTTPLLDGDEVAFLPPVSGGRHVDPIEI
VESGHYFALTRHAIDTRGVVARLMTGAEGAVVNFEGTVRNNTKGRPTLCLDYECYESMALKMMAQIGCDIAATHQVGRVA
LVHRLGRMLVGETSVAVIVTAPHRRPAFEAALEGINRLKKVVPIWKKEHFVDGEVWVEGEWDENLPVVG

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=108, Percent_Identity=39.8148148148148, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787003, Length=111, Percent_Identity=39.6396396396396, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509279, Length=141, Percent_Identity=35.4609929078014, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356259, Length=140, Percent_Identity=38.5714285714286, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 25337; Mature: 25337

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRDIVGKSAEDAEFPPGTDLQSVFECYRTRYPRLGDLARSIVIARNQEFAERTTPLLDG
CCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCC
DEVAFLPPVSGGRHVDPIEIVESGHYFALTRHAIDTRGVVARLMTGAEGAVVNFEGTVRN
CCEEEECCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCC
NTKGRPTLCLDYECYESMALKMMAQIGCDIAATHQVGRVALVHRLGRMLVGETSVAVIVT
CCCCCCEEEECHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
APHRRPAFEAALEGINRLKKVVPIWKKEHFVDGEVWVEGEWDENLPVVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCEECCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLRDIVGKSAEDAEFPPGTDLQSVFECYRTRYPRLGDLARSIVIARNQEFAERTTPLLDG
CCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCC
DEVAFLPPVSGGRHVDPIEIVESGHYFALTRHAIDTRGVVARLMTGAEGAVVNFEGTVRN
CCEEEECCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCC
NTKGRPTLCLDYECYESMALKMMAQIGCDIAATHQVGRVALVHRLGRMLVGETSVAVIVT
CCCCCCEEEECHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
APHRRPAFEAALEGINRLKKVVPIWKKEHFVDGEVWVEGEWDENLPVVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCEECCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]