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The map label for this gene is vipB [H]

Identifier: 116624976

GI number: 116624976

Start: 7403531

End: 7404484

Strand: Direct

Name: vipB [H]

Synonym: Acid_5906

Alternate gene names: 116624976

Gene position: 7403531-7404484 (Clockwise)

Preceding gene: 116624975

Following gene: 116624977

Centisome position: 74.29

GC content: 62.89

Gene sequence:

>954_bases
ATGAGCCACTATGTAGTTACCGGAGGAGCGGGCTTCATCGGGTCCGCCATTACACGCAGACTGCTTGCCGAAGGCGCCGG
CCGCGTGGTTGTCATCGACAACCTGTTAAGCGGGCGCGAGAGCAACCTGGAGGAGATCCGCGCGCGCATCGATTTTCAAC
GCGCGGATATCCGCAACTACGAGGAGATCGCGCCTTTGATTCGCGGCGCCGCGGTGGTCTTCCACGAGGCGGCGATTCCC
TCCGTGCCGCGCTCGATCGAAGACCCGGTGCCCTCGCACGACGTAAATGCCAATGGGACCTTCAACGTCCTGCGCGCCGC
CAAAGAGGGGCAGGCCGGACGCGTGGTGTACGCCGCGTCGAGTTCGGCCTACGGCGATACGGAAGTGCTCCCCAAGGTCG
AGGATATGACGCCGCGGCCGAAGTCGCCGTACGCGCTCCAAAAGCTGCTTGGCGAGTACTACTGCAATGTCTTCACCGGC
GTATATGGATTGGAGACAGTGGCGCTGCGATACTTCAACGTTTATGGTCCGCGCCAGGATCCAGGCAGTCCGTACTCCGG
TGTGCTTTCCCTGTTCATGAAGGCCGCGCTGAACCGGACCGCGCCCACGATTTTCGGCGACGGCGAGCAATCGCGAGACT
TCACCTATGTGGAAGACGTGGCCGAGCTCAACCTGAAGGCCGCGCGCGCTAAAGGGGTCGCAGGCAAAGTGTACAACGGC
GGTAACGGCGGACGTATCACGCTCAATCAGGCCTGGGCGCTTTTACAGAAGCTGGAAGGGATCGAGATTCCGTCGGTGTA
CGGACCGCCGCGCGCCGGCGACGTCCGCGATTCGCAGGCCGATACGACGCTCGCCGTACGGGAGTTGGGCCACGCGCCGC
GCTATTCGTTCGAGGAAGGCATGCGGCTCACGCTGGAGTGGTATCGCAGCCAGCACGTGCTTCAGGCGAGATGA

Upstream 100 bases:

>100_bases
GTTGGATCTCGCTCGAAGCCTTCGACTTCACGCCCGGCGCCGAAGTGCTGGCCAACCAGTCCCTCAGATTTCTCGAAAGC
CAGATTCACCAACTGACATC

Downstream 100 bases:

>100_bases
TCGAATTCGGACTCGGCACCATCGGGATCGGCAAGCCCTGGGGCTTCGCCAATCCCGAAGTGCCCGATGAGAGCCTGGCG
CTGGCGCTTCTGGAAAAGGC

Product: NAD-dependent epimerase/dehydratase

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSHYVVTGGAGFIGSAITRRLLAEGAGRVVVIDNLLSGRESNLEEIRARIDFQRADIRNYEEIAPLIRGAAVVFHEAAIP
SVPRSIEDPVPSHDVNANGTFNVLRAAKEGQAGRVVYAASSSAYGDTEVLPKVEDMTPRPKSPYALQKLLGEYYCNVFTG
VYGLETVALRYFNVYGPRQDPGSPYSGVLSLFMKAALNRTAPTIFGDGEQSRDFTYVEDVAELNLKAARAKGVAGKVYNG
GNGGRITLNQAWALLQKLEGIEIPSVYGPPRAGDVRDSQADTTLAVRELGHAPRYSFEEGMRLTLEWYRSQHVLQAR

Sequences:

>Translated_317_residues
MSHYVVTGGAGFIGSAITRRLLAEGAGRVVVIDNLLSGRESNLEEIRARIDFQRADIRNYEEIAPLIRGAAVVFHEAAIP
SVPRSIEDPVPSHDVNANGTFNVLRAAKEGQAGRVVYAASSSAYGDTEVLPKVEDMTPRPKSPYALQKLLGEYYCNVFTG
VYGLETVALRYFNVYGPRQDPGSPYSGVLSLFMKAALNRTAPTIFGDGEQSRDFTYVEDVAELNLKAARAKGVAGKVYNG
GNGGRITLNQAWALLQKLEGIEIPSVYGPPRAGDVRDSQADTTLAVRELGHAPRYSFEEGMRLTLEWYRSQHVLQAR
>Mature_316_residues
SHYVVTGGAGFIGSAITRRLLAEGAGRVVVIDNLLSGRESNLEEIRARIDFQRADIRNYEEIAPLIRGAAVVFHEAAIPS
VPRSIEDPVPSHDVNANGTFNVLRAAKEGQAGRVVYAASSSAYGDTEVLPKVEDMTPRPKSPYALQKLLGEYYCNVFTGV
YGLETVALRYFNVYGPRQDPGSPYSGVLSLFMKAALNRTAPTIFGDGEQSRDFTYVEDVAELNLKAARAKGVAGKVYNGG
NGGRITLNQAWALLQKLEGIEIPSVYGPPRAGDVRDSQADTTLAVRELGHAPRYSFEEGMRLTLEWYRSQHVLQAR

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=317, Percent_Identity=30.9148264984227, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI7657641, Length=321, Percent_Identity=28.9719626168224, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI56237023, Length=336, Percent_Identity=27.6785714285714, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI56118217, Length=336, Percent_Identity=27.6785714285714, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI189083684, Length=336, Percent_Identity=27.6785714285714, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI193211614, Length=269, Percent_Identity=26.0223048327138, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI8393516, Length=269, Percent_Identity=26.0223048327138, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=30.9734513274336, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=31.1764705882353, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786974, Length=333, Percent_Identity=30.03003003003, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790049, Length=249, Percent_Identity=30.9236947791165, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=313, Percent_Identity=27.4760383386581, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71982035, Length=341, Percent_Identity=26.3929618768328, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=27.82874617737, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71982038, Length=343, Percent_Identity=26.2390670553936, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17568069, Length=337, Percent_Identity=26.7062314540059, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17570557, Length=281, Percent_Identity=24.1992882562278, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=30.2547770700637, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI19923002, Length=334, Percent_Identity=26.9461077844311, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 34610; Mature: 34479

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYVVTGGAGFIGSAITRRLLAEGAGRVVVIDNLLSGRESNLEEIRARIDFQRADIRNY
CCCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCH
EEIAPLIRGAAVVFHEAAIPSVPRSIEDPVPSHDVNANGTFNVLRAAKEGQAGRVVYAAS
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEC
SSAYGDTEVLPKVEDMTPRPKSPYALQKLLGEYYCNVFTGVYGLETVALRYFNVYGPRQD
CCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PGSPYSGVLSLFMKAALNRTAPTIFGDGEQSRDFTYVEDVAELNLKAARAKGVAGKVYNG
CCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEC
GNGGRITLNQAWALLQKLEGIEIPSVYGPPRAGDVRDSQADTTLAVRELGHAPRYSFEEG
CCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHC
MRLTLEWYRSQHVLQAR
CEEHHHHHHCCCHHCCC
>Mature Secondary Structure 
SHYVVTGGAGFIGSAITRRLLAEGAGRVVVIDNLLSGRESNLEEIRARIDFQRADIRNY
CCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCH
EEIAPLIRGAAVVFHEAAIPSVPRSIEDPVPSHDVNANGTFNVLRAAKEGQAGRVVYAAS
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEC
SSAYGDTEVLPKVEDMTPRPKSPYALQKLLGEYYCNVFTGVYGLETVALRYFNVYGPRQD
CCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PGSPYSGVLSLFMKAALNRTAPTIFGDGEQSRDFTYVEDVAELNLKAARAKGVAGKVYNG
CCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEC
GNGGRITLNQAWALLQKLEGIEIPSVYGPPRAGDVRDSQADTTLAVRELGHAPRYSFEEG
CCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHC
MRLTLEWYRSQHVLQAR
CEEHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]