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The map label for this gene is pleC [H]

Identifier: 116624972

GI number: 116624972

Start: 7399575

End: 7401419

Strand: Direct

Name: pleC [H]

Synonym: Acid_5902

Alternate gene names: 116624972

Gene position: 7399575-7401419 (Clockwise)

Preceding gene: 116624970

Following gene: 116624973

Centisome position: 74.25

GC content: 65.69

Gene sequence:

>1845_bases
ATGGACCTGCCCTCCCCGGGAGAATCGTCGAAATGGTGGCGGGTATCGCTGCGCGCCAAGGGCGTCGCGGTGCTTGCGGC
TCCCATTGCGGCGCTCTTCGGAGCCTTGTTCTCCGTCTACTGGGTGGAGGCCGACGTTCGCGGCGCCGACCAGGATGTCG
CCCGCTTGTACGGCATCCGGGGTCAGCTCGTCGAACTCCGCGGCTCGCTGCTCGACGGCCAAACCAAATCCGCCGAAGCC
GCCCTCGATCGCATCGGCGCGCAAACCGCGACCGACCCCGTGGCCGCCGCCGCGCTAGCCGAAATCAGGCGCGCAGCCCT
CGCGGAGCGCGGGCGAGTCGCGATGGCAGACCTTCAGGCGCGCATCTCACTGCTCGATAAATACGAGGAGCAGCGCTTCG
ACCAGGCTCGCTTGCAGCGCGACCTGGCGCGGCGCCGCCTTTTCCGAACCGTCATTCTCTGCGGCACCCTCGGACCGCTC
GCCGCCCTATTCATTCACCTGGTCCTGGCCGGCCGCATGGTTCGACGCCTGCAAGCCGTGCAGGAGAACGCGCGTCGCCT
GGCCCACGGCCTGCCGCTCGAAACACTGCCCGAAGGCACCGATGAGATCGCGTCGCTCGGCAGCCAACTGGAGACCGCCG
CCTTTCTGCTGGAAGGCCGCGAGCGCGAGCTCCGCGATAGCGAACGCCGCTACCGCGACCTGTTCGATCGCGCCCCCATC
CCTTACGAGGAGATGGACCGTAACGGCGCGCTCCACCGCTTCAACCAGGCTGTCTGCACGCTGCTCAAGAGTACGCCGGA
GCAGATGATCGGCAGGCTCGCCTGGGATTTCGTCGCGCCCGATCGCCAGGCCGAATTTCGCGCCGCCATGAAACGCCGCG
TCCTCACCGGCGAGGAAAGCGGACCCTTTGAATGCCCCTATGTGCTCGAAGATGGCACCCATCTGACCGTCGAGATCCGC
GAAAACCTGATCCGCAACGACCGCGGCGAAGTCACTGGCATCGTGCGATCCCTGCTCGATGTCACGGAGCGCAACCTGGC
CGCTGTGGCCGCGCGCAAAGTCGAACAGTACGCGCTCGAGCTGCGCAGCAAGAATGAGCAGCTGGCGCGCGCGCTCGAAG
GCGCGAGGGCCGCCACCGTCGCCAAGAGCCGCTTCCTGGCCAGCGTCTCCCACGAACTGCGCACCCCGCTCAATGGCATC
ATCGGCTTCAGCGAGCTGCTTTACGACGCCAAGCTGGGCCACCTCTCCGGCGAACAAATCGAAGTCATGGGCGACATCCT
GACCAGCGCACGCCACCTGCTGCAGCTGATCAACGATATCCTCGACCTCTCTAAAGTCGAGGCCGGGCGCATGGAGTTCC
GCCCGGAGCGCAGCCGCCTTCAGCCCCTGGTCTTTGAGGTGCGCGACGTGATTCGCCCGCTCGCCGAAAGAAAGAACCTC
GTCCTGGCCACGGAGGTGCCGGAGGATCTCGTCGCCCACCTCGACCCGGGGCGCTTTAGGCAGGTGCTGTACAACTACCT
TTCGAATGCCGTAAAGTTCACTCCGGCCGGGGGGAGCGTCACCGTGCGCATCGCGCGCGAGCGCCAGTTGTGGTTCCAGC
TGGAAGTGGAAGACACCGGAATCGGGATTGCGGCGGAAGAGATTCCACGCCTCTTCCAGGAATTCTCCCAGTTGCCGAAC
AGCCGTAAGGCCGACCAGGGAACCGGTCTCGGCCTGGCACTGACGCGCCATATCGTGGAGGCCCAGGGCGGCTCGGTCAC
GGTACGCAGCGAACTGGGGCGCGGCAGCGTCTTCTCCGCATTGCTACCTTTGGATAGCGCACTTCGGATAACTTCGACCC
AATAA

Upstream 100 bases:

>100_bases
CGGTGCTTCAGAGTTGATTCGTAGGGACATGCTTGAAATTGTACGCGAAATCCGGCGTCCCGACTTTCTCGATCGCCGTC
AATTAGAATGAGTTTTCACT

Downstream 100 bases:

>100_bases
CTTTTCATGTTCGAAGGTACACTACGATACACTGACTTTGCATGGCCGGAGAGCCGATATTAATCGTCGACGACACGCCT
GTGAACCTCAAATTGACCAG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MDLPSPGESSKWWRVSLRAKGVAVLAAPIAALFGALFSVYWVEADVRGADQDVARLYGIRGQLVELRGSLLDGQTKSAEA
ALDRIGAQTATDPVAAAALAEIRRAALAERGRVAMADLQARISLLDKYEEQRFDQARLQRDLARRRLFRTVILCGTLGPL
AALFIHLVLAGRMVRRLQAVQENARRLAHGLPLETLPEGTDEIASLGSQLETAAFLLEGRERELRDSERRYRDLFDRAPI
PYEEMDRNGALHRFNQAVCTLLKSTPEQMIGRLAWDFVAPDRQAEFRAAMKRRVLTGEESGPFECPYVLEDGTHLTVEIR
ENLIRNDRGEVTGIVRSLLDVTERNLAAVAARKVEQYALELRSKNEQLARALEGARAATVAKSRFLASVSHELRTPLNGI
IGFSELLYDAKLGHLSGEQIEVMGDILTSARHLLQLINDILDLSKVEAGRMEFRPERSRLQPLVFEVRDVIRPLAERKNL
VLATEVPEDLVAHLDPGRFRQVLYNYLSNAVKFTPAGGSVTVRIARERQLWFQLEVEDTGIGIAAEEIPRLFQEFSQLPN
SRKADQGTGLGLALTRHIVEAQGGSVTVRSELGRGSVFSALLPLDSALRITSTQ

Sequences:

>Translated_614_residues
MDLPSPGESSKWWRVSLRAKGVAVLAAPIAALFGALFSVYWVEADVRGADQDVARLYGIRGQLVELRGSLLDGQTKSAEA
ALDRIGAQTATDPVAAAALAEIRRAALAERGRVAMADLQARISLLDKYEEQRFDQARLQRDLARRRLFRTVILCGTLGPL
AALFIHLVLAGRMVRRLQAVQENARRLAHGLPLETLPEGTDEIASLGSQLETAAFLLEGRERELRDSERRYRDLFDRAPI
PYEEMDRNGALHRFNQAVCTLLKSTPEQMIGRLAWDFVAPDRQAEFRAAMKRRVLTGEESGPFECPYVLEDGTHLTVEIR
ENLIRNDRGEVTGIVRSLLDVTERNLAAVAARKVEQYALELRSKNEQLARALEGARAATVAKSRFLASVSHELRTPLNGI
IGFSELLYDAKLGHLSGEQIEVMGDILTSARHLLQLINDILDLSKVEAGRMEFRPERSRLQPLVFEVRDVIRPLAERKNL
VLATEVPEDLVAHLDPGRFRQVLYNYLSNAVKFTPAGGSVTVRIARERQLWFQLEVEDTGIGIAAEEIPRLFQEFSQLPN
SRKADQGTGLGLALTRHIVEAQGGSVTVRSELGRGSVFSALLPLDSALRITSTQ
>Mature_614_residues
MDLPSPGESSKWWRVSLRAKGVAVLAAPIAALFGALFSVYWVEADVRGADQDVARLYGIRGQLVELRGSLLDGQTKSAEA
ALDRIGAQTATDPVAAAALAEIRRAALAERGRVAMADLQARISLLDKYEEQRFDQARLQRDLARRRLFRTVILCGTLGPL
AALFIHLVLAGRMVRRLQAVQENARRLAHGLPLETLPEGTDEIASLGSQLETAAFLLEGRERELRDSERRYRDLFDRAPI
PYEEMDRNGALHRFNQAVCTLLKSTPEQMIGRLAWDFVAPDRQAEFRAAMKRRVLTGEESGPFECPYVLEDGTHLTVEIR
ENLIRNDRGEVTGIVRSLLDVTERNLAAVAARKVEQYALELRSKNEQLARALEGARAATVAKSRFLASVSHELRTPLNGI
IGFSELLYDAKLGHLSGEQIEVMGDILTSARHLLQLINDILDLSKVEAGRMEFRPERSRLQPLVFEVRDVIRPLAERKNL
VLATEVPEDLVAHLDPGRFRQVLYNYLSNAVKFTPAGGSVTVRIARERQLWFQLEVEDTGIGIAAEEIPRLFQEFSQLPN
SRKADQGTGLGLALTRHIVEAQGGSVTVRSELGRGSVFSALLPLDSALRITSTQ

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=487, Percent_Identity=28.5420944558522, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=38.3673469387755, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=36.2204724409449, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=33.4630350194552, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081816, Length=278, Percent_Identity=34.5323741007194, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786600, Length=316, Percent_Identity=28.4810126582279, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=32.034632034632, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=31.8385650224215, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=27.5, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082128, Length=246, Percent_Identity=31.7073170731707, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=29.5154185022026, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788549, Length=462, Percent_Identity=23.3766233766234, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=249, Percent_Identity=30.9236947791165, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=240, Percent_Identity=25.4166666666667, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68208; Mature: 68208

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLPSPGESSKWWRVSLRAKGVAVLAAPIAALFGALFSVYWVEADVRGADQDVARLYGIR
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCH
GQLVELRGSLLDGQTKSAEAALDRIGAQTATDPVAAAALAEIRRAALAERGRVAMADLQA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RISLLDKYEEQRFDQARLQRDLARRRLFRTVILCGTLGPLAALFIHLVLAGRMVRRLQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
QENARRLAHGLPLETLPEGTDEIASLGSQLETAAFLLEGRERELRDSERRYRDLFDRAPI
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
PYEEMDRNGALHRFNQAVCTLLKSTPEQMIGRLAWDFVAPDRQAEFRAAMKRRVLTGEES
CHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
GPFECPYVLEDGTHLTVEIRENLIRNDRGEVTGIVRSLLDVTERNLAAVAARKVEQYALE
CCCCCCEEEECCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSKNEQLARALEGARAATVAKSRFLASVSHELRTPLNGIIGFSELLYDAKLGHLSGEQI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHH
EVMGDILTSARHLLQLINDILDLSKVEAGRMEFRPERSRLQPLVFEVRDVIRPLAERKNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
VLATEVPEDLVAHLDPGRFRQVLYNYLSNAVKFTPAGGSVTVRIARERQLWFQLEVEDTG
EEEECCCHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCEEEEEEEECCC
IGIAAEEIPRLFQEFSQLPNSRKADQGTGLGLALTRHIVEAQGGSVTVRSELGRGSVFSA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHCCCCHHHHH
LLPLDSALRITSTQ
HHCCCCCCCCCCCC
>Mature Secondary Structure
MDLPSPGESSKWWRVSLRAKGVAVLAAPIAALFGALFSVYWVEADVRGADQDVARLYGIR
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCH
GQLVELRGSLLDGQTKSAEAALDRIGAQTATDPVAAAALAEIRRAALAERGRVAMADLQA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RISLLDKYEEQRFDQARLQRDLARRRLFRTVILCGTLGPLAALFIHLVLAGRMVRRLQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
QENARRLAHGLPLETLPEGTDEIASLGSQLETAAFLLEGRERELRDSERRYRDLFDRAPI
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
PYEEMDRNGALHRFNQAVCTLLKSTPEQMIGRLAWDFVAPDRQAEFRAAMKRRVLTGEES
CHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
GPFECPYVLEDGTHLTVEIRENLIRNDRGEVTGIVRSLLDVTERNLAAVAARKVEQYALE
CCCCCCEEEECCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSKNEQLARALEGARAATVAKSRFLASVSHELRTPLNGIIGFSELLYDAKLGHLSGEQI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHH
EVMGDILTSARHLLQLINDILDLSKVEAGRMEFRPERSRLQPLVFEVRDVIRPLAERKNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
VLATEVPEDLVAHLDPGRFRQVLYNYLSNAVKFTPAGGSVTVRIARERQLWFQLEVEDTG
EEEECCCHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCEEEEEEEECCC
IGIAAEEIPRLFQEFSQLPNSRKADQGTGLGLALTRHIVEAQGGSVTVRSELGRGSVFSA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHHHCCCCHHHHH
LLPLDSALRITSTQ
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]