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The map label for this gene is ppiA [C]

Identifier: 116624949

GI number: 116624949

Start: 7368696

End: 7369331

Strand: Direct

Name: ppiA [C]

Synonym: Acid_5878

Alternate gene names: 116624949

Gene position: 7368696-7369331 (Clockwise)

Preceding gene: 116624947

Following gene: 116624950

Centisome position: 73.94

GC content: 63.84

Gene sequence:

>636_bases
ATGCGATTTCTGCTCGGATTCTTAACTCTTTTGACCCTACCGCTGGCCGCCGCCGATGCCTATGCCCTGCGCCATCCGGA
CGCACGCATCTGGCGCAAACATGCACCCGCCGTCTATCGCGTGCGCGTCGAGAGCACCCAGGGGGCATTCGTGCTCGAGG
TCCACCGTGACTGGGCTCCCATCGGCGCCGACCGCTTCTACAACCTCGTGCGCTCCCGCTTCTACGATGACTCGCGGTTC
TACCGCGTGACCCCGCGCTTCGCCCAGTTCGGCATCGCCGGCAATCCGTCCATCGCCGCCGTGTGGCGTTCCGTCTCGAT
CGACGACGACCCCGTGCGCCAATCCAATACTCGCGGACGGTTCGCCTTCGCCATGACCGGTCCGAACACGCGCACCACCC
AAATCTATATCTGCAAGACCGACATGCAGGCGCAGGATAAAGACGGTTTCGCACCGCTCGGGCAGGTAGTCGCGGGCATG
GAAGTCGTGGACCGCCTTTACGCGGGATACGGCGAAACCGCCGGCGGCGGAATGCGTGGCGGCAAGCAGGCCCGCATCTT
CGAAGAGGGGAACACCCACCTCGATCGCGACTTCCCCAAACTTGAGAAGCTGCTGCGCGCCCACATCGTTCGATAG

Upstream 100 bases:

>100_bases
CGGGAAAATCGGCGGCGGCAAGCGGTACGGCGAGCAACGCAAGGAGCGCGGCAAAGCGGGTATGAGACATGGGTACGATC
CTATCGCATACTGAAAAACA

Downstream 100 bases:

>100_bases
CCCTTTGGAGCCGTATCCTTAATGACAGCGTAACCACTTCACGACACACTGCGCCTTCTGACCAGTGATTTCCAGAGTCC
CCGTTGCGACCCTGCTGGCG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: Peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase A; Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin Type

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRFLLGFLTLLTLPLAAADAYALRHPDARIWRKHAPAVYRVRVESTQGAFVLEVHRDWAPIGADRFYNLVRSRFYDDSRF
YRVTPRFAQFGIAGNPSIAAVWRSVSIDDDPVRQSNTRGRFAFAMTGPNTRTTQIYICKTDMQAQDKDGFAPLGQVVAGM
EVVDRLYAGYGETAGGGMRGGKQARIFEEGNTHLDRDFPKLEKLLRAHIVR

Sequences:

>Translated_211_residues
MRFLLGFLTLLTLPLAAADAYALRHPDARIWRKHAPAVYRVRVESTQGAFVLEVHRDWAPIGADRFYNLVRSRFYDDSRF
YRVTPRFAQFGIAGNPSIAAVWRSVSIDDDPVRQSNTRGRFAFAMTGPNTRTTQIYICKTDMQAQDKDGFAPLGQVVAGM
EVVDRLYAGYGETAGGGMRGGKQARIFEEGNTHLDRDFPKLEKLLRAHIVR
>Mature_211_residues
MRFLLGFLTLLTLPLAAADAYALRHPDARIWRKHAPAVYRVRVESTQGAFVLEVHRDWAPIGADRFYNLVRSRFYDDSRF
YRVTPRFAQFGIAGNPSIAAVWRSVSIDDDPVRQSNTRGRFAFAMTGPNTRTTQIYICKTDMQAQDKDGFAPLGQVVAGM
EVVDRLYAGYGETAGGGMRGGKQARIFEEGNTHLDRDFPKLEKLLRAHIVR

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 23826; Mature: 23826

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLLGFLTLLTLPLAAADAYALRHPDARIWRKHAPAVYRVRVESTQGAFVLEVHRDWAP
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCC
IGADRFYNLVRSRFYDDSRFYRVTPRFAQFGIAGNPSIAAVWRSVSIDDDPVRQSNTRGR
CCHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
FAFAMTGPNTRTTQIYICKTDMQAQDKDGFAPLGQVVAGMEVVDRLYAGYGETAGGGMRG
EEEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GKQARIFEEGNTHLDRDFPKLEKLLRAHIVR
CCEEEEEECCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRFLLGFLTLLTLPLAAADAYALRHPDARIWRKHAPAVYRVRVESTQGAFVLEVHRDWAP
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCC
IGADRFYNLVRSRFYDDSRFYRVTPRFAQFGIAGNPSIAAVWRSVSIDDDPVRQSNTRGR
CCHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCE
FAFAMTGPNTRTTQIYICKTDMQAQDKDGFAPLGQVVAGMEVVDRLYAGYGETAGGGMRG
EEEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GKQARIFEEGNTHLDRDFPKLEKLLRAHIVR
CCEEEEEECCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA