Click here to switch to the map view.

The map label for this gene is yhdN [H]

Identifier: 116624947

GI number: 116624947

Start: 7366632

End: 7367582

Strand: Direct

Name: yhdN [H]

Synonym: Acid_5876

Alternate gene names: 116624947

Gene position: 7366632-7367582 (Clockwise)

Preceding gene: 116624945

Following gene: 116624949

Centisome position: 73.92

GC content: 63.41

Gene sequence:

>951_bases
ATGAAGATGAAACGGCTTGGCAACAGCGATTTGGAATTGACGCCGATCGGGGTCGGTGCCTGGGCGATGGGAGGCGGCGG
CTGGGCATTTGCCTGGGGACCGCAGGATGACGACGAATCCATCGCCGCCATCCAGGCCGCGCTCGATCGCGGCGTGAACT
GGATCGATACCGCGGCCGTCTACGGTCTTGGCCATTCCGAAGAAGTGGTGGCGCGCGCCATCGCCGGGCGGCCCAACCGG
CCCTACGTTTTCACCAAGTGCGAACGCGTGTGGAATGAAAAGGGCGAGATCAGCAAATCGCTAAAGCGCGATTCGGTTCG
CAAGGAGTGCGAGGCCAGTCTGCGACGCCTCAAGGTGGATACCATCGATCTCTATCAGATTCACTGGCCGGAGCCCGACG
AAGATGTCGAGGAAGGCTGGGAAACGCTGTCGCGCCTGAAAGAGGAAGGCAAGGTGCGCTGGATCGGCGTCTCCAATTTC
AACGTCGCCCAACTGGAGCGTGCCCGCAAGATCGCTCCCATCACGTCGCTGCAGCCTCCGTATTCCGCCGTCTCCCCGGA
AATCGAGGACGCCATTCTCCCTTACTGCCAGCAACACGGCATTGGCGTGCTGGCGTACTCGCCCATGAAATCCGGCCTGC
TCACCGGTAAAATGACCCGCGAACGCATCGCGGCATTCCCCGCTGACGATTTCCGAAAACGCGCGCTCGCCTTCCAGGAG
CCGAACCTCACCCGCAACCTGGCGCTCGCCGAGCATATGAAGAAAATCGGCGCGCGCCACGGCCGCACCGCCGGTGAAGT
CGCCCTGGCCTGGGTGCTTCGCCACCCCGCGATCACCGCCGCCATCGTCGGCATGCGCTCCGCCCAACAGGTCGAAGGCG
TGATCGGCGCCCTCGAATTCCGCCTGACCTTCGACGAAATCGCCGAGATCGACCGCGCCCGCCGCGAGTAA

Upstream 100 bases:

>100_bases
CGCGCCAGCACGATCGCGGCCGACAAGCCATTGGGCCCGGAACCGACGACCACAGCTCGTGTTTTCGCTGAGTCGGCCAA
CCTCCGTTATTGTAGAAGAG

Downstream 100 bases:

>100_bases
GATCTGACGAGCCGCCTACTTCTCCGATTCCTTAAGCAACTCCGCCAGATAGTTGCCCCAGATCGCCGGCAGCGAGTGCG
TCCCATGCCCCCGGGTCTGG

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKMKRLGNSDLELTPIGVGAWAMGGGGWAFAWGPQDDDESIAAIQAALDRGVNWIDTAAVYGLGHSEEVVARAIAGRPNR
PYVFTKCERVWNEKGEISKSLKRDSVRKECEASLRRLKVDTIDLYQIHWPEPDEDVEEGWETLSRLKEEGKVRWIGVSNF
NVAQLERARKIAPITSLQPPYSAVSPEIEDAILPYCQQHGIGVLAYSPMKSGLLTGKMTRERIAAFPADDFRKRALAFQE
PNLTRNLALAEHMKKIGARHGRTAGEVALAWVLRHPAITAAIVGMRSAQQVEGVIGALEFRLTFDEIAEIDRARRE

Sequences:

>Translated_316_residues
MKMKRLGNSDLELTPIGVGAWAMGGGGWAFAWGPQDDDESIAAIQAALDRGVNWIDTAAVYGLGHSEEVVARAIAGRPNR
PYVFTKCERVWNEKGEISKSLKRDSVRKECEASLRRLKVDTIDLYQIHWPEPDEDVEEGWETLSRLKEEGKVRWIGVSNF
NVAQLERARKIAPITSLQPPYSAVSPEIEDAILPYCQQHGIGVLAYSPMKSGLLTGKMTRERIAAFPADDFRKRALAFQE
PNLTRNLALAEHMKKIGARHGRTAGEVALAWVLRHPAITAAIVGMRSAQQVEGVIGALEFRLTFDEIAEIDRARRE
>Mature_316_residues
MKMKRLGNSDLELTPIGVGAWAMGGGGWAFAWGPQDDDESIAAIQAALDRGVNWIDTAAVYGLGHSEEVVARAIAGRPNR
PYVFTKCERVWNEKGEISKSLKRDSVRKECEASLRRLKVDTIDLYQIHWPEPDEDVEEGWETLSRLKEEGKVRWIGVSNF
NVAQLERARKIAPITSLQPPYSAVSPEIEDAILPYCQQHGIGVLAYSPMKSGLLTGKMTRERIAAFPADDFRKRALAFQE
PNLTRNLALAEHMKKIGARHGRTAGEVALAWVLRHPAITAAIVGMRSAQQVEGVIGALEFRLTFDEIAEIDRARRE

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=326, Percent_Identity=26.3803680981595, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4504825, Length=323, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI223718702, Length=290, Percent_Identity=30.6896551724138, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI27436964, Length=330, Percent_Identity=24.2424242424242, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI41327764, Length=279, Percent_Identity=31.1827956989247, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI27436962, Length=330, Percent_Identity=23.9393939393939, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI41152114, Length=289, Percent_Identity=28.719723183391, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI27436966, Length=330, Percent_Identity=23.9393939393939, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI27436971, Length=332, Percent_Identity=24.6987951807229, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI291291012, Length=301, Percent_Identity=27.2425249169435, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI223468663, Length=312, Percent_Identity=27.2435897435897, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI45446745, Length=326, Percent_Identity=27.3006134969325, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503285, Length=326, Percent_Identity=27.3006134969325, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5453543, Length=326, Percent_Identity=26.9938650306748, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310109920, Length=326, Percent_Identity=26.9938650306748, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI223718708, Length=128, Percent_Identity=35.9375, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310109922, Length=307, Percent_Identity=26.3843648208469, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788070, Length=317, Percent_Identity=34.0694006309148, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87081735, Length=322, Percent_Identity=30.1242236024845, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1789199, Length=347, Percent_Identity=26.8011527377522, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788081, Length=310, Percent_Identity=28.0645161290323, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789375, Length=338, Percent_Identity=25.4437869822485, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786400, Length=243, Percent_Identity=28.3950617283951, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI48994888, Length=272, Percent_Identity=29.0441176470588, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787674, Length=309, Percent_Identity=24.9190938511327, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082198, Length=310, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645785, Length=339, Percent_Identity=24.188790560472, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=326, Percent_Identity=23.6196319018405, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17537077, Length=334, Percent_Identity=25.748502994012, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17552492, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17566692, Length=270, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538386, Length=291, Percent_Identity=24.7422680412371, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17550248, Length=337, Percent_Identity=24.9258160237389, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=341, Percent_Identity=26.3929618768328, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323998, Length=316, Percent_Identity=23.1012658227848, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320079, Length=217, Percent_Identity=25.3456221198157, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320576, Length=230, Percent_Identity=28.695652173913, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319958, Length=300, Percent_Identity=22.6666666666667, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646155, Length=327, Percent_Identity=27.82874617737, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24644950, Length=335, Percent_Identity=27.4626865671642, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640980, Length=343, Percent_Identity=23.0320699708455, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549126, Length=343, Percent_Identity=23.0320699708455, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646159, Length=228, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24662789, Length=306, Percent_Identity=28.1045751633987, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35169; Mature: 35169

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKRLGNSDLELTPIGVGAWAMGGGGWAFAWGPQDDDESIAAIQAALDRGVNWIDTAAV
CCCCCCCCCCCEEEEECCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHH
YGLGHSEEVVARAIAGRPNRPYVFTKCERVWNEKGEISKSLKRDSVRKECEASLRRLKVD
HCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TIDLYQIHWPEPDEDVEEGWETLSRLKEEGKVRWIGVSNFNVAQLERARKIAPITSLQPP
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
YSAVSPEIEDAILPYCQQHGIGVLAYSPMKSGLLTGKMTRERIAAFPADDFRKRALAFQE
HHHCCCCHHHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCC
PNLTRNLALAEHMKKIGARHGRTAGEVALAWVLRHPAITAAIVGMRSAQQVEGVIGALEF
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHE
RLTFDEIAEIDRARRE
EECHHHHHHHHHHHCC
>Mature Secondary Structure
MKMKRLGNSDLELTPIGVGAWAMGGGGWAFAWGPQDDDESIAAIQAALDRGVNWIDTAAV
CCCCCCCCCCCEEEEECCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHH
YGLGHSEEVVARAIAGRPNRPYVFTKCERVWNEKGEISKSLKRDSVRKECEASLRRLKVD
HCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TIDLYQIHWPEPDEDVEEGWETLSRLKEEGKVRWIGVSNFNVAQLERARKIAPITSLQPP
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
YSAVSPEIEDAILPYCQQHGIGVLAYSPMKSGLLTGKMTRERIAAFPADDFRKRALAFQE
HHHCCCCHHHHHHHHHHHCCCEEEEECCHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCC
PNLTRNLALAEHMKKIGARHGRTAGEVALAWVLRHPAITAAIVGMRSAQQVEGVIGALEF
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHE
RLTFDEIAEIDRARRE
EECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]