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The map label for this gene is ilvD [H]

Identifier: 116624939

GI number: 116624939

Start: 7347120

End: 7348817

Strand: Reverse

Name: ilvD [H]

Synonym: Acid_5866

Alternate gene names: 116624939

Gene position: 7348817-7347120 (Counterclockwise)

Preceding gene: 116624942

Following gene: 116624938

Centisome position: 73.74

GC content: 64.25

Gene sequence:

>1698_bases
ATGGCTATCGACGATCCGACCAAACTGCGCAGCTATTCCTGGTTCAACGGCAAGGAGTACTACAACTTCTCCCGGCGGGC
GAACATTCGCGCGCTGGGGATCTCGCGCGAAGCCTTTCACGGCAAGCCCGTGATCGGCATCTGCAATTCCTTCAGTGAAC
TGAACAATTGCAATGCGCACCTGCGCCAGGTGGCCGATGCCGTGAAGCGCGGCGTATGGGCGGCCGGCGGACTGCCGCTC
GAATTCCCCGTGATCTCGCTCGGCGAGCAGTACATGAAGCCGACCACCATGCTCTTCCGCAACCTGATGGCGATGGATGT
GGAAGAGTGCATACGCGCGAATCCGGTGGATGGCGTGGTGCTGCTCGCAGGCTGCGACAAGACCACGCCCGCGATGCTGA
TGGGCGCCGCGTCGGCCGATATTCCAGCCATGATCGTCACCGGCGGTCCCACGCTTTCCGGAAATTATCAGGGCACGCCA
ATAGGACAGGGCACCGACGGACGCAAGATCTTCGACCTGTACCGCATGGGGCGCGTCTCGTCCGAAGAATTGCAGGAAAT
CGAGGGCTGCATGGTGCGCAGCGCGGGGCATTGCACCGTGATGGGAACGGCGTCGACGATGGCGATTGTGGCGGAGGCGC
TCGGCATGTCGCTGCCCGGATCGGCGGCGGTGCCGGCGCCCGATTCGCGCCGCCTCGCGATGGCTGAAATGAGCGGACGG
CGCATGGTGGAGATGGTGCGCGAAGACCTGCGGCCTTCCCGTGTGCTGACGCGCCAGGCCTTCGAAAATGCGATCACGGT
GGATATGGCGGTGGGCGGCTCGACCAATGCGGTGGTGCACCTGCTGGCGATCGCCGGGCGTACGCCGAATAAACTCGTGC
TCGACGATTTCGACGCGATCTCGCGCCGGACGCCGTTCCTGGTCAATGTCCGGCCCAGCGGGAAGCACATGATGGAGGAT
TTCTTCTTCGCCGGCGGCGTGCCCGCCGTGATGCGCGAACTGCTGCCCCTGCTGCACCGCGAGTGCCTGACGGTCAACGG
GAAAACCGTCGGCGAAAATGTCGGCGAAGCGCCCTGCTACAACCGCGACGTGATTCGCACGCCCGACCAGGCGCTGTTCG
CCGAAGGCGGTACGGTGGTGCTGCGCGGCAACCTGTGTCCCGATGGAGCGGTGCTCAAACAGACCGCGGCCTCGGCGGAG
CTTTGCGAACACACCGGCCCCGCCTATGTCTTCGAAAGCTACCAGGCCATGCACGACAGCATCGACCGCATGGATCTGCC
GATCGACCGCGATACCGTGCTGGTGATGAAGGGCTGCGGGCCAAAGGGCGCTCCCGGGATGCCGGAATGGGGACACATTC
CGATGCCCAAGGTGCTGCTGGAGCGCGGCGTCAGCGATTGCGTACGCATCTCGGACGCGCGTATGAGCGGGACCAGTTTC
GGCACGGTGGTGCTGCACGTGTCGCCGGAATCGGGCGTCGGCGGCCCGCTGGCGGTGGTGGAGACCGGTGACCGGATCAC
ACTTAGTGTGGCGGCCCGTAAGCTGCACCTTCATATTACGGAGGAAGAGTTGCGGCGGCGCACCGCGCTGCTTCAGCCGG
CCGCGCCCCACTATTCACGCGGATACGGGAAGCTCTTTCTCGACCACGTCACACAGGCTCACTTGGGTTGCGATTTCGAT
TTCCTGCAGGCCGAATAG

Upstream 100 bases:

>100_bases
TCTCATGGAAGTGGCCCGAGCGCCCGTTCCAGGGGATCGCTCTATTTACGTATCGGCACGAAGCAGGAATTTTTGAGGAA
GGGAGAGACAATGGTCTCTC

Downstream 100 bases:

>100_bases
GAACTGCAGGACTAATGGATTTCCGGGAACTGCCGATCATACGGTCATCGTATGAATACACGGACAGTTATCCTGTCGAT
GGCGCTCTGGTGCGGCGCTG

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MAIDDPTKLRSYSWFNGKEYYNFSRRANIRALGISREAFHGKPVIGICNSFSELNNCNAHLRQVADAVKRGVWAAGGLPL
EFPVISLGEQYMKPTTMLFRNLMAMDVEECIRANPVDGVVLLAGCDKTTPAMLMGAASADIPAMIVTGGPTLSGNYQGTP
IGQGTDGRKIFDLYRMGRVSSEELQEIEGCMVRSAGHCTVMGTASTMAIVAEALGMSLPGSAAVPAPDSRRLAMAEMSGR
RMVEMVREDLRPSRVLTRQAFENAITVDMAVGGSTNAVVHLLAIAGRTPNKLVLDDFDAISRRTPFLVNVRPSGKHMMED
FFFAGGVPAVMRELLPLLHRECLTVNGKTVGENVGEAPCYNRDVIRTPDQALFAEGGTVVLRGNLCPDGAVLKQTAASAE
LCEHTGPAYVFESYQAMHDSIDRMDLPIDRDTVLVMKGCGPKGAPGMPEWGHIPMPKVLLERGVSDCVRISDARMSGTSF
GTVVLHVSPESGVGGPLAVVETGDRITLSVAARKLHLHITEEELRRRTALLQPAAPHYSRGYGKLFLDHVTQAHLGCDFD
FLQAE

Sequences:

>Translated_565_residues
MAIDDPTKLRSYSWFNGKEYYNFSRRANIRALGISREAFHGKPVIGICNSFSELNNCNAHLRQVADAVKRGVWAAGGLPL
EFPVISLGEQYMKPTTMLFRNLMAMDVEECIRANPVDGVVLLAGCDKTTPAMLMGAASADIPAMIVTGGPTLSGNYQGTP
IGQGTDGRKIFDLYRMGRVSSEELQEIEGCMVRSAGHCTVMGTASTMAIVAEALGMSLPGSAAVPAPDSRRLAMAEMSGR
RMVEMVREDLRPSRVLTRQAFENAITVDMAVGGSTNAVVHLLAIAGRTPNKLVLDDFDAISRRTPFLVNVRPSGKHMMED
FFFAGGVPAVMRELLPLLHRECLTVNGKTVGENVGEAPCYNRDVIRTPDQALFAEGGTVVLRGNLCPDGAVLKQTAASAE
LCEHTGPAYVFESYQAMHDSIDRMDLPIDRDTVLVMKGCGPKGAPGMPEWGHIPMPKVLLERGVSDCVRISDARMSGTSF
GTVVLHVSPESGVGGPLAVVETGDRITLSVAARKLHLHITEEELRRRTALLQPAAPHYSRGYGKLFLDHVTQAHLGCDFD
FLQAE
>Mature_564_residues
AIDDPTKLRSYSWFNGKEYYNFSRRANIRALGISREAFHGKPVIGICNSFSELNNCNAHLRQVADAVKRGVWAAGGLPLE
FPVISLGEQYMKPTTMLFRNLMAMDVEECIRANPVDGVVLLAGCDKTTPAMLMGAASADIPAMIVTGGPTLSGNYQGTPI
GQGTDGRKIFDLYRMGRVSSEELQEIEGCMVRSAGHCTVMGTASTMAIVAEALGMSLPGSAAVPAPDSRRLAMAEMSGRR
MVEMVREDLRPSRVLTRQAFENAITVDMAVGGSTNAVVHLLAIAGRTPNKLVLDDFDAISRRTPFLVNVRPSGKHMMEDF
FFAGGVPAVMRELLPLLHRECLTVNGKTVGENVGEAPCYNRDVIRTPDQALFAEGGTVVLRGNLCPDGAVLKQTAASAEL
CEHTGPAYVFESYQAMHDSIDRMDLPIDRDTVLVMKGCGPKGAPGMPEWGHIPMPKVLLERGVSDCVRISDARMSGTSFG
TVVLHVSPESGVGGPLAVVETGDRITLSVAARKLHLHITEEELRRRTALLQPAAPHYSRGYGKLFLDHVTQAHLGCDFDF
LQAE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=577, Percent_Identity=31.369150779896, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI2367371, Length=464, Percent_Identity=33.8362068965517, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788157, Length=530, Percent_Identity=32.4528301886792, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1786464, Length=453, Percent_Identity=33.5540838852097, Blast_Score=172, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=569, Percent_Identity=31.4586994727592, Blast_Score=265, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 61116; Mature: 60985

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDDPTKLRSYSWFNGKEYYNFSRRANIRALGISREAFHGKPVIGICNSFSELNNCNAH
CCCCCCHHHCCCCCCCCCHHCCCCCCCCEEEEECCHHHHCCCCEEEHHHHHHHHHCHHHH
LRQVADAVKRGVWAAGGLPLEFPVISLGEQYMKPTTMLFRNLMAMDVEECIRANPVDGVV
HHHHHHHHHHCCEECCCCCEECCHHHHCHHHCCHHHHHHHHHHHHCHHHHHCCCCCCCEE
LLAGCDKTTPAMLMGAASADIPAMIVTGGPTLSGNYQGTPIGQGTDGRKIFDLYRMGRVS
EEECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCC
SEELQEIEGCMVRSAGHCTVMGTASTMAIVAEALGMSLPGSAAVPAPDSRRLAMAEMSGR
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHCCH
RMVEMVREDLRPSRVLTRQAFENAITVDMAVGGSTNAVVHLLAIAGRTPNKLVLDDFDAI
HHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEECCHHHH
SRRTPFLVNVRPSGKHMMEDFFFAGGVPAVMRELLPLLHRECLTVNGKTVGENVGEAPCY
HCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
NRDVIRTPDQALFAEGGTVVLRGNLCPDGAVLKQTAASAELCEHTGPAYVFESYQAMHDS
CCCCCCCCCHHHEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IDRMDLPIDRDTVLVMKGCGPKGAPGMPEWGHIPMPKVLLERGVSDCVRISDARMSGTSF
HHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCE
GTVVLHVSPESGVGGPLAVVETGDRITLSVAARKLHLHITEEELRRRTALLQPAAPHYSR
EEEEEEECCCCCCCCCEEEEECCCEEEEEEEEEEEEEEECHHHHHHHHHHCCCCCCCCCC
GYGKLFLDHVTQAHLGCDFDFLQAE
CHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
AIDDPTKLRSYSWFNGKEYYNFSRRANIRALGISREAFHGKPVIGICNSFSELNNCNAH
CCCCCHHHCCCCCCCCCHHCCCCCCCCEEEEECCHHHHCCCCEEEHHHHHHHHHCHHHH
LRQVADAVKRGVWAAGGLPLEFPVISLGEQYMKPTTMLFRNLMAMDVEECIRANPVDGVV
HHHHHHHHHHCCEECCCCCEECCHHHHCHHHCCHHHHHHHHHHHHCHHHHHCCCCCCCEE
LLAGCDKTTPAMLMGAASADIPAMIVTGGPTLSGNYQGTPIGQGTDGRKIFDLYRMGRVS
EEECCCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCC
SEELQEIEGCMVRSAGHCTVMGTASTMAIVAEALGMSLPGSAAVPAPDSRRLAMAEMSGR
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHCCH
RMVEMVREDLRPSRVLTRQAFENAITVDMAVGGSTNAVVHLLAIAGRTPNKLVLDDFDAI
HHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEECCHHHH
SRRTPFLVNVRPSGKHMMEDFFFAGGVPAVMRELLPLLHRECLTVNGKTVGENVGEAPCY
HCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCC
NRDVIRTPDQALFAEGGTVVLRGNLCPDGAVLKQTAASAELCEHTGPAYVFESYQAMHDS
CCCCCCCCCHHHEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IDRMDLPIDRDTVLVMKGCGPKGAPGMPEWGHIPMPKVLLERGVSDCVRISDARMSGTSF
HHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCE
GTVVLHVSPESGVGGPLAVVETGDRITLSVAARKLHLHITEEELRRRTALLQPAAPHYSR
EEEEEEECCCCCCCCCEEEEECCCEEEEEEEEEEEEEEECHHHHHHHHHHCCCCCCCCCC
GYGKLFLDHVTQAHLGCDFDFLQAE
CHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA