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The map label for this gene is ygcA [C]

Identifier: 116624915

GI number: 116624915

Start: 7317646

End: 7318815

Strand: Direct

Name: ygcA [C]

Synonym: Acid_5841

Alternate gene names: 116624915

Gene position: 7317646-7318815 (Clockwise)

Preceding gene: 116624910

Following gene: 116624919

Centisome position: 73.43

GC content: 64.44

Gene sequence:

>1170_bases
GTGGAAAAGCTGGTGTACGGAGGCGATGGTCTCGGCCGGCTGGAAGGGCGCGTTGTCTTCGCACCCTTCGTGCTGCCAGG
CGAACGAATTCGGGCACAGGCCGAGAAGGAAAAGCCCGGCATGGTGCGGGCGCGTATGCTGGAAGTGCTCGCGGCCGCCC
CGGATCGCGTAAGCGCGCCGTGTCCGGTATTCGGGCGCTGCGGCGGTTGCCATTACCAGCACGCACCCTATGAGTATCAG
CTCGCCACCAAGCAGGCGATCCTCGCGGAAGAGATGCGGCGGCTAGGCAAGATCGAGCCACCCGAGGAGATCGCGGTGGT
CTCGTCGGAGCCATTCGGCTATCGCAATCGTGTGCAGCTGCACGTGGAGGAATCGCGGATCGGATATCGCGAGGCGCGGT
CGCACAAGCTGTGCGCGGTGGGGCAGTGCCCCGTGGGATCACCGAAGATCGAGGCGGCAATCCGCGCCTTGAACGAGATG
GCGCGGGACAGCCGCTGGCCGCGGTTCATGAAATCGATTGAAGTTTTCAGCGATGAGAACCAGGTGCAGCTCAACGTACT
CGAGACGGAGCGTCCGGTGGCTCGTCGCTTCTTCGATTGGTGCGGCGAGAAGATTCCGGGGATGGTGGAGGGCGCGCTGG
ATTACGAAGGCCGCTTCCGGGTGAGCAGCAATTCGTTCTTCCAGGTGAATCGCTTCCTGATCGACCGGTTGGTGGAGGTC
GCGATCGAAGGGGCGGAGGGCGATACGGCACTGGATTTGTATGCCGGCGTGGGCCTGCTATCGCTGCCGCTGGCGCGGAA
GTTCCGTGAAGTGACGGCGGTGGAATCGGGCGCGGGCGCGGTCCGCGATCTACAATTCAACGCGGAGCGGAATGGACTCG
CGAACGTGCGTGCGCTGCCCAAGACGGCGGAGGAATACCTGCTGGCGTTGGAGGCTGCGCCAGACCTGGTAGTGCTGGAT
CCGCCGCGGACAGGCTTGGGGAAGACCGTGGTGAAGCGGTTGAGCGAATTGCGGCCGCGGCAGGTGACGATCGTGGCCTG
CGATCCGGCGACCCTGGCGCGCGACCTTGCCGGACTGGTGGCGGCAGGCTATCGCGTGGAGAAGATGACGCTGGTGGATT
TGTTCCCGCAGACCTACCATCTGGAGACGGTGGTGCGGCTGACGTTCTAG

Upstream 100 bases:

>100_bases
GATGTGAAGGTTTCCGGTAGGCTGCATGCCGGAGAAGACTCGTGTTTTCATGGTAAAGAGTACGGGAGTAACTCCTATCG
TAAGCAATTTCGAAGTCACG

Downstream 100 bases:

>100_bases
TACGGCGCTACTCCGGGTTGAACCGACAGTGAGCTTCGAAGACAGCTGTCAACGCAGTTTTCTCGATGACACCCGACGCC
ACGGACAACACTAGATCGGC

Product: 23S rRNA (uracil-5-)-methyltransferase RumA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MEKLVYGGDGLGRLEGRVVFAPFVLPGERIRAQAEKEKPGMVRARMLEVLAAAPDRVSAPCPVFGRCGGCHYQHAPYEYQ
LATKQAILAEEMRRLGKIEPPEEIAVVSSEPFGYRNRVQLHVEESRIGYREARSHKLCAVGQCPVGSPKIEAAIRALNEM
ARDSRWPRFMKSIEVFSDENQVQLNVLETERPVARRFFDWCGEKIPGMVEGALDYEGRFRVSSNSFFQVNRFLIDRLVEV
AIEGAEGDTALDLYAGVGLLSLPLARKFREVTAVESGAGAVRDLQFNAERNGLANVRALPKTAEEYLLALEAAPDLVVLD
PPRTGLGKTVVKRLSELRPRQVTIVACDPATLARDLAGLVAAGYRVEKMTLVDLFPQTYHLETVVRLTF

Sequences:

>Translated_389_residues
MEKLVYGGDGLGRLEGRVVFAPFVLPGERIRAQAEKEKPGMVRARMLEVLAAAPDRVSAPCPVFGRCGGCHYQHAPYEYQ
LATKQAILAEEMRRLGKIEPPEEIAVVSSEPFGYRNRVQLHVEESRIGYREARSHKLCAVGQCPVGSPKIEAAIRALNEM
ARDSRWPRFMKSIEVFSDENQVQLNVLETERPVARRFFDWCGEKIPGMVEGALDYEGRFRVSSNSFFQVNRFLIDRLVEV
AIEGAEGDTALDLYAGVGLLSLPLARKFREVTAVESGAGAVRDLQFNAERNGLANVRALPKTAEEYLLALEAAPDLVVLD
PPRTGLGKTVVKRLSELRPRQVTIVACDPATLARDLAGLVAAGYRVEKMTLVDLFPQTYHLETVVRLTF
>Mature_389_residues
MEKLVYGGDGLGRLEGRVVFAPFVLPGERIRAQAEKEKPGMVRARMLEVLAAAPDRVSAPCPVFGRCGGCHYQHAPYEYQ
LATKQAILAEEMRRLGKIEPPEEIAVVSSEPFGYRNRVQLHVEESRIGYREARSHKLCAVGQCPVGSPKIEAAIRALNEM
ARDSRWPRFMKSIEVFSDENQVQLNVLETERPVARRFFDWCGEKIPGMVEGALDYEGRFRVSSNSFFQVNRFLIDRLVEV
AIEGAEGDTALDLYAGVGLLSLPLARKFREVTAVESGAGAVRDLQFNAERNGLANVRALPKTAEEYLLALEAAPDLVVLD
PPRTGLGKTVVKRLSELRPRQVTIVACDPATLARDLAGLVAAGYRVEKMTLVDLFPQTYHLETVVRLTF

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=185, Percent_Identity=35.6756756756757, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI51173878, Length=185, Percent_Identity=35.6756756756757, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789148, Length=408, Percent_Identity=32.3529411764706, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1787083, Length=370, Percent_Identity=25.4054054054054, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790403, Length=208, Percent_Identity=32.2115384615385, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666579, Length=207, Percent_Identity=28.9855072463768, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 43210; Mature: 43210

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLVYGGDGLGRLEGRVVFAPFVLPGERIRAQAEKEKPGMVRARMLEVLAAAPDRVSAP
CCCEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
CPVFGRCGGCHYQHAPYEYQLATKQAILAEEMRRLGKIEPPEEIAVVSSEPFGYRNRVQL
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCEEEE
HVEESRIGYREARSHKLCAVGQCPVGSPKIEAAIRALNEMARDSRWPRFMKSIEVFSDEN
EEEHHHCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
QVQLNVLETERPVARRFFDWCGEKIPGMVEGALDYEGRFRVSSNSFFQVNRFLIDRLVEV
EEEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AIEGAEGDTALDLYAGVGLLSLPLARKFREVTAVESGAGAVRDLQFNAERNGLANVRALP
HCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCC
KTAEEYLLALEAAPDLVVLDPPRTGLGKTVVKRLSELRPRQVTIVACDPATLARDLAGLV
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHH
AAGYRVEKMTLVDLFPQTYHLETVVRLTF
HCCCEEEEEEEEHHCCCCEEEEEEEEECC
>Mature Secondary Structure
MEKLVYGGDGLGRLEGRVVFAPFVLPGERIRAQAEKEKPGMVRARMLEVLAAAPDRVSAP
CCCEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
CPVFGRCGGCHYQHAPYEYQLATKQAILAEEMRRLGKIEPPEEIAVVSSEPFGYRNRVQL
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHEEEEECCCCCCCCEEEE
HVEESRIGYREARSHKLCAVGQCPVGSPKIEAAIRALNEMARDSRWPRFMKSIEVFSDEN
EEEHHHCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
QVQLNVLETERPVARRFFDWCGEKIPGMVEGALDYEGRFRVSSNSFFQVNRFLIDRLVEV
EEEEEEECCCCHHHHHHHHHHCCCCCCHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
AIEGAEGDTALDLYAGVGLLSLPLARKFREVTAVESGAGAVRDLQFNAERNGLANVRALP
HCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHCC
KTAEEYLLALEAAPDLVVLDPPRTGLGKTVVKRLSELRPRQVTIVACDPATLARDLAGLV
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHH
AAGYRVEKMTLVDLFPQTYHLETVVRLTF
HCCCEEEEEEEEHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]