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The map label for this gene is trpS [H]

Identifier: 116624914

GI number: 116624914

Start: 7316613

End: 7317596

Strand: Reverse

Name: trpS [H]

Synonym: Acid_5840

Alternate gene names: 116624914

Gene position: 7317596-7316613 (Counterclockwise)

Preceding gene: 116624916

Following gene: 116624913

Centisome position: 73.43

GC content: 61.59

Gene sequence:

>984_bases
ATGAAAACACGAGTCTTCTCCGGCATGCAGCCTACCGGAAACCTTCACATCGGCAACTATCTGGGCGCCCTCAAGAACTG
GGTCCGCATCCAGCATGACTACGAGTGCATCTTCTGCATCGTAGATCTCCACGCCGTCACAGTCTATCAGGATCCGGTCG
GACTGCGCGCCAAAATCCGCGAAATCGCTGCCCTCTATCTCGCCGCGGGCATCGATCCCAAAGCCTGCGCCATCATGGTG
CAGTCCGCCGTCCCGGCCCACAGCGAGCTCAGCTGGATGCTCACCTGCGTCACCCCGATCGGCTGGCTGGAACGAATGAC
TCAATACAAAATGAAAGCCGCGAAGCAGGAATCAGTCGGGGACGGACTCCTCCAGTATCCCGTACTTATGGCCGCCGACA
TACTCCTTTATCAGGCGGGCATCGTCCCGGTGGGTGACGATCAGTCGCAGCATCTGGAACTCACCCGCGATATTGCGCAG
CGCTTCAACTCTCTCTATGGCGATACCTTCGTCGTGCCGGGCACGAGCCTGCCCACTGTGGGCGCGCGCGTCATGGGCCT
CGATGATCCCACGCAGAAGATGAGCAAGTCCGCCGCCGGCGCCAATCACGCCGTCGCGCTGCTCGATCCCCCCGCCAAGA
TCCGCAAGACCATCATGCGCGCCACTACCGATTCCCAACCCGCGGTCGATGTCGCCACCGCCGGTCCCGGAGTCCTCAAC
CTGCTCTCGATTTACCAGGCCTTCTCCGGCGCTTCCGATGATGACGTGAAATCCACCTTCGACGGCCTCCGCTACGGCGA
TCTCAAGAAGCAGGTTGCCGAAGTCGTGGTCGCGCACCTTGAACCCTTCCAGCAGCGCTACCGTGAGATCACAGCCGACC
CCGCGTACCTCGATGGCATCCTGCGCGAAGGCGCGGAGCGTGTCGCGCCCATTGCCAACAGCACCGTCCGCACCGTGAAG
GAACGCATGGGCCTCTACACCTAA

Upstream 100 bases:

>100_bases
GCGCCCTTCCAGCCGGCCGAGACCATCGCCTCCGTACACCAGCTTTTCCACCGTGACTTCGAAATTGCTTACGATAGGAG
TTACTCCCGTACTCTTTACC

Downstream 100 bases:

>100_bases
CGCCTCATGTTCGCGGCCTACTTCACGCTGCTTTGCCGCAATCGCAATTATCGCCTCCTGTGGGTCGCCCAGATTGTCAG
TGAACTGGGAGATTGGTTCT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKTRVFSGMQPTGNLHIGNYLGALKNWVRIQHDYECIFCIVDLHAVTVYQDPVGLRAKIREIAALYLAAGIDPKACAIMV
QSAVPAHSELSWMLTCVTPIGWLERMTQYKMKAAKQESVGDGLLQYPVLMAADILLYQAGIVPVGDDQSQHLELTRDIAQ
RFNSLYGDTFVVPGTSLPTVGARVMGLDDPTQKMSKSAAGANHAVALLDPPAKIRKTIMRATTDSQPAVDVATAGPGVLN
LLSIYQAFSGASDDDVKSTFDGLRYGDLKKQVAEVVVAHLEPFQQRYREITADPAYLDGILREGAERVAPIANSTVRTVK
ERMGLYT

Sequences:

>Translated_327_residues
MKTRVFSGMQPTGNLHIGNYLGALKNWVRIQHDYECIFCIVDLHAVTVYQDPVGLRAKIREIAALYLAAGIDPKACAIMV
QSAVPAHSELSWMLTCVTPIGWLERMTQYKMKAAKQESVGDGLLQYPVLMAADILLYQAGIVPVGDDQSQHLELTRDIAQ
RFNSLYGDTFVVPGTSLPTVGARVMGLDDPTQKMSKSAAGANHAVALLDPPAKIRKTIMRATTDSQPAVDVATAGPGVLN
LLSIYQAFSGASDDDVKSTFDGLRYGDLKKQVAEVVVAHLEPFQQRYREITADPAYLDGILREGAERVAPIANSTVRTVK
ERMGLYT
>Mature_327_residues
MKTRVFSGMQPTGNLHIGNYLGALKNWVRIQHDYECIFCIVDLHAVTVYQDPVGLRAKIREIAALYLAAGIDPKACAIMV
QSAVPAHSELSWMLTCVTPIGWLERMTQYKMKAAKQESVGDGLLQYPVLMAADILLYQAGIVPVGDDQSQHLELTRDIAQ
RFNSLYGDTFVVPGTSLPTVGARVMGLDDPTQKMSKSAAGANHAVALLDPPAKIRKTIMRATTDSQPAVDVATAGPGVLN
LLSIYQAFSGASDDDVKSTFDGLRYGDLKKQVAEVVVAHLEPFQQRYREITADPAYLDGILREGAERVAPIANSTVRTVK
ERMGLYT

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=327, Percent_Identity=40.9785932721713, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI41352700, Length=178, Percent_Identity=52.247191011236, Blast_Score=191, Evalue=5e-49,
Organism=Escherichia coli, GI1789786, Length=326, Percent_Identity=51.2269938650307, Blast_Score=327, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI71982800, Length=329, Percent_Identity=31.9148936170213, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71982793, Length=329, Percent_Identity=31.9148936170213, Blast_Score=175, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=38.4393063583815, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24666151, Length=334, Percent_Identity=40.4191616766467, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 35666; Mature: 35666

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRVFSGMQPTGNLHIGNYLGALKNWVRIQHDYECIFCIVDLHAVTVYQDPVGLRAKIR
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEEHHEEEEEECCCCHHHHHH
EIAALYLAAGIDPKACAIMVQSAVPAHSELSWMLTCVTPIGWLERMTQYKMKAAKQESVG
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGLLQYPVLMAADILLYQAGIVPVGDDQSQHLELTRDIAQRFNSLYGDTFVVPGTSLPTV
CHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GARVMGLDDPTQKMSKSAAGANHAVALLDPPAKIRKTIMRATTDSQPAVDVATAGPGVLN
CEEEECCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCHHHH
LLSIYQAFSGASDDDVKSTFDGLRYGDLKKQVAEVVVAHLEPFQQRYREITADPAYLDGI
HHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LREGAERVAPIANSTVRTVKERMGLYT
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTRVFSGMQPTGNLHIGNYLGALKNWVRIQHDYECIFCIVDLHAVTVYQDPVGLRAKIR
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEEHHEEEEEECCCCHHHHHH
EIAALYLAAGIDPKACAIMVQSAVPAHSELSWMLTCVTPIGWLERMTQYKMKAAKQESVG
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGLLQYPVLMAADILLYQAGIVPVGDDQSQHLELTRDIAQRFNSLYGDTFVVPGTSLPTV
CHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GARVMGLDDPTQKMSKSAAGANHAVALLDPPAKIRKTIMRATTDSQPAVDVATAGPGVLN
CEEEECCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCHHHH
LLSIYQAFSGASDDDVKSTFDGLRYGDLKKQVAEVVVAHLEPFQQRYREITADPAYLDGI
HHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LREGAERVAPIANSTVRTVKERMGLYT
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500908 [H]