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The map label for this gene is nhaC [H]

Identifier: 116624869

GI number: 116624869

Start: 7256831

End: 7258333

Strand: Reverse

Name: nhaC [H]

Synonym: Acid_5793

Alternate gene names: 116624869

Gene position: 7258333-7256831 (Counterclockwise)

Preceding gene: 116624870

Following gene: 116624868

Centisome position: 72.83

GC content: 60.61

Gene sequence:

>1503_bases
ATGGCTAACCAACCGACCCCGCCGCGCAGTGTCAAAGAGCCATCCTATACGGATGCGATCATTCCGCTGGTTACCCTCAT
CATTCTAATCGCGGGATCGGTGTATCTCTTCGGGGCGGACGCTGTCGAAGGGCCGATGCAGGTGGCGCTGATTCTCAGCG
TCATGGTCACTTCCTTCATCATTCTCAAGAACGGGCATCCCTGGGAAGCCATCGTTAAATCGTCGCAAGCCGCGCTTTCC
TCGCTGGCCAGCCCGATCTTTATTCTGCTCGCGGTGGGTGCGCTGATCGGCGCGTGGAACATGTCCGGCACAATTCCCAC
GCTGGTGGTCTATGGCATTCAGTTGCTCCGGCCGAGCTACTTCTATGTCGCGACGGCGCTCATCTGCGGCGTGATCTCAC
TGGGAACCGGGAGTTCCTGGACCACCGCCGGGACAATCGGCGTGGGACTGATCGGGATCGCGTCGCTGGTCGGGGTTTCG
CCGGCCATTACCGCGGGAGCCATCATTTCTGGCGCCTATGTAGGCGACAAAATATCATCTCTGTCGGAGACCACGATTCT
CGCCGCCCAGCTCGCGGAGGTTGACATTCACACGCACATCCGCGCGGCGATCTGGACCTCGGGACCAGCTTTCATCATCG
CGCTGCTTGTCTTTGCGATTCTCGGTTTGCTGGAGAGCGGCGTTACCAACGGCGCCAACATCGCGGTTGACCTGGCCGGG
CTGGATCAGCTCTTCTGGATTTCGCCGCTAAATCTGATCCCCCTGGTCGCTCTGCTGATACTCTCGCTTCGCAAAGCGCC
GGCGTCGCTCGCAGTCATGGGCTCGGCGCTGCTGGCCGGGGTAATGGCGGCGATATTGCAGCCGCAAGCCGTCTTGAGCT
TTGTCAACGATCCGGCGCTCCCGGCTCCGCTCGCGCAAATCAAAGGCATTTGGCTGGCGCTCGCGACCGGCTACCGTTCT
TCCTCGGGAATCCCGGAGTTGGACCAACTGCTCTCCCGCGGCGGCATGGCCAGCATGCTGAAAACCCTCTGGATCATCAT
CGGAGCGGTGACCTTCGGCACGTTGCTCGAGGAATTCAACCTGCTATCGAAACTCACGCTTCCCATGCTGAAGCGTGCAA
AGTCTACCGGGAGTTTGATCGCCACCGTGGTTGCCACGGCCTTTGGACTGAATATCGTGGCCGCCGATCAGTACATCGCG
ATCGTGCTTCCCGCCCGCCTGTTCCGTGCGGAGTTCCGGAAGCGCGGCCTGAAACCGCAGAACCTGTCGCGGGCGTGCGC
CGATGCGGGCACGGTGACATCGCCCCTGGTGCCGTGGAACTCGTGCGGCGCATACATGGCGGCAACACTCGGAGTGGCCA
CCATGGCCTATTTGCCGTTCTGTATTTTCAACATTGCCTCTCCGCTGATATCCATGTTGTGGGGGTTCACGGGTTTCAAG
ATCGAGCACATGCAGGCGGGCGAGGTTCCGGCGGAATCCATACCAAGCCGCCAGAAGGTCTGA

Upstream 100 bases:

>100_bases
CCCTGGGCGGAGGATGGAACCTGACGGATGCGGAATGGGTAACACCCAACGTCCCGCCCGCGAACCATCCGCCAGCCAAG
AGACCGTGAGTGAGGATCTT

Downstream 100 bases:

>100_bases
CTCGGAAAGGAGCGTCCAATGGATTTCCTGCAGCCTGTTTACGAACGAGTCGCGGCCCGCCTGGTCGGGCCAATGCACGT
GCGGTTTATCGTGCAGCCGG

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MANQPTPPRSVKEPSYTDAIIPLVTLIILIAGSVYLFGADAVEGPMQVALILSVMVTSFIILKNGHPWEAIVKSSQAALS
SLASPIFILLAVGALIGAWNMSGTIPTLVVYGIQLLRPSYFYVATALICGVISLGTGSSWTTAGTIGVGLIGIASLVGVS
PAITAGAIISGAYVGDKISSLSETTILAAQLAEVDIHTHIRAAIWTSGPAFIIALLVFAILGLLESGVTNGANIAVDLAG
LDQLFWISPLNLIPLVALLILSLRKAPASLAVMGSALLAGVMAAILQPQAVLSFVNDPALPAPLAQIKGIWLALATGYRS
SSGIPELDQLLSRGGMASMLKTLWIIIGAVTFGTLLEEFNLLSKLTLPMLKRAKSTGSLIATVVATAFGLNIVAADQYIA
IVLPARLFRAEFRKRGLKPQNLSRACADAGTVTSPLVPWNSCGAYMAATLGVATMAYLPFCIFNIASPLISMLWGFTGFK
IEHMQAGEVPAESIPSRQKV

Sequences:

>Translated_500_residues
MANQPTPPRSVKEPSYTDAIIPLVTLIILIAGSVYLFGADAVEGPMQVALILSVMVTSFIILKNGHPWEAIVKSSQAALS
SLASPIFILLAVGALIGAWNMSGTIPTLVVYGIQLLRPSYFYVATALICGVISLGTGSSWTTAGTIGVGLIGIASLVGVS
PAITAGAIISGAYVGDKISSLSETTILAAQLAEVDIHTHIRAAIWTSGPAFIIALLVFAILGLLESGVTNGANIAVDLAG
LDQLFWISPLNLIPLVALLILSLRKAPASLAVMGSALLAGVMAAILQPQAVLSFVNDPALPAPLAQIKGIWLALATGYRS
SSGIPELDQLLSRGGMASMLKTLWIIIGAVTFGTLLEEFNLLSKLTLPMLKRAKSTGSLIATVVATAFGLNIVAADQYIA
IVLPARLFRAEFRKRGLKPQNLSRACADAGTVTSPLVPWNSCGAYMAATLGVATMAYLPFCIFNIASPLISMLWGFTGFK
IEHMQAGEVPAESIPSRQKV
>Mature_499_residues
ANQPTPPRSVKEPSYTDAIIPLVTLIILIAGSVYLFGADAVEGPMQVALILSVMVTSFIILKNGHPWEAIVKSSQAALSS
LASPIFILLAVGALIGAWNMSGTIPTLVVYGIQLLRPSYFYVATALICGVISLGTGSSWTTAGTIGVGLIGIASLVGVSP
AITAGAIISGAYVGDKISSLSETTILAAQLAEVDIHTHIRAAIWTSGPAFIIALLVFAILGLLESGVTNGANIAVDLAGL
DQLFWISPLNLIPLVALLILSLRKAPASLAVMGSALLAGVMAAILQPQAVLSFVNDPALPAPLAQIKGIWLALATGYRSS
SGIPELDQLLSRGGMASMLKTLWIIIGAVTFGTLLEEFNLLSKLTLPMLKRAKSTGSLIATVVATAFGLNIVAADQYIAI
VLPARLFRAEFRKRGLKPQNLSRACADAGTVTSPLVPWNSCGAYMAATLGVATMAYLPFCIFNIASPLISMLWGFTGFKI
EHMQAGEVPAESIPSRQKV

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 52170; Mature: 52039

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQPTPPRSVKEPSYTDAIIPLVTLIILIAGSVYLFGADAVEGPMQVALILSVMVTSFI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECHHCCCHHHHHHHHHHHHHHHH
ILKNGHPWEAIVKSSQAALSSLASPIFILLAVGALIGAWNMSGTIPTLVVYGIQLLRPSY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
FYVATALICGVISLGTGSSWTTAGTIGVGLIGIASLVGVSPAITAGAIISGAYVGDKISS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LSETTILAAQLAEVDIHTHIRAAIWTSGPAFIIALLVFAILGLLESGVTNGANIAVDLAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
LDQLFWISPLNLIPLVALLILSLRKAPASLAVMGSALLAGVMAAILQPQAVLSFVNDPAL
CCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
PAPLAQIKGIWLALATGYRSSSGIPELDQLLSRGGMASMLKTLWIIIGAVTFGTLLEEFN
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSKLTLPMLKRAKSTGSLIATVVATAFGLNIVAADQYIAIVLPARLFRAEFRKRGLKPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
NLSRACADAGTVTSPLVPWNSCGAYMAATLGVATMAYLPFCIFNIASPLISMLWGFTGFK
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IEHMQAGEVPAESIPSRQKV
EECCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
ANQPTPPRSVKEPSYTDAIIPLVTLIILIAGSVYLFGADAVEGPMQVALILSVMVTSFI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECHHCCCHHHHHHHHHHHHHHHH
ILKNGHPWEAIVKSSQAALSSLASPIFILLAVGALIGAWNMSGTIPTLVVYGIQLLRPSY
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHH
FYVATALICGVISLGTGSSWTTAGTIGVGLIGIASLVGVSPAITAGAIISGAYVGDKISS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LSETTILAAQLAEVDIHTHIRAAIWTSGPAFIIALLVFAILGLLESGVTNGANIAVDLAG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
LDQLFWISPLNLIPLVALLILSLRKAPASLAVMGSALLAGVMAAILQPQAVLSFVNDPAL
CCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
PAPLAQIKGIWLALATGYRSSSGIPELDQLLSRGGMASMLKTLWIIIGAVTFGTLLEEFN
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSKLTLPMLKRAKSTGSLIATVVATAFGLNIVAADQYIAIVLPARLFRAEFRKRGLKPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
NLSRACADAGTVTSPLVPWNSCGAYMAATLGVATMAYLPFCIFNIASPLISMLWGFTGFK
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IEHMQAGEVPAESIPSRQKV
EECCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]