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The map label for this gene is hisN [H]

Identifier: 116624866

GI number: 116624866

Start: 7255103

End: 7255888

Strand: Direct

Name: hisN [H]

Synonym: Acid_5790

Alternate gene names: 116624866

Gene position: 7255103-7255888 (Clockwise)

Preceding gene: 116624865

Following gene: 116624876

Centisome position: 72.8

GC content: 65.01

Gene sequence:

>786_bases
ATGGTCAACCGAACGAACTACGAGCGCGAGCTTGAGTTCGCCCGCCGCCTTGCCTCGGCGGCGGGCGAGAATGCCAGGCG
CATCCGCGCCGGCGGCGTCGCCGCGGAGTCAAAGGCGGATACCTCCCCCGTCACCATCGCCGATCGGGAAAACGAGCGCC
TGGTCCGCGAAGCTATTGAACGCGAGTTCCCCGCAGATGGCATTCTGGGCGAAGAGGGGGCTTCCAAGGCCGGGACCAGC
GGGCGCCGCTGGGTGGTCGATCCCATCGATGGCACGCGGGACTTCATTCGGGGAAACCGGTTTTGGTGCGTCCTCATCGC
TCTCGAAGACGAGGGCGAACCGGTAGTGGGCGTCGCGCATTTCCCCATGCTCGAGGAGACCTATTGGGCAGTCCGCGACG
GCGGGTCGTATCTGAATGGCGAACGCTTGCGCGTGTCCTCCGCGGAATCGATCAGCGCCTGCGTCTTCAGCCCCAATGGG
CTCCACCAGGTCGAAGCCCGCCCGTACTTGCCTCAGGTCGTGGAATTCATGCAGCGCTCATGGGCAGTGCGCTCGTTCGG
CGGCCCGCTTGATGCGTGCCTGCTTGCCGCCGGCAAGGTGGAGATCTGGTTCGAACCCAAGCTCGAGGTTTGGGACCTCG
CCGCCTTGAAGCTAATCATCGAAGAGGCGGGCGGGGATTTCTTCGCGCTCGATGGTTCACGCCGCATCGATCGGGGAACC
GTGATCGCCTGCCCGCCAGGCGTCTCGGTTCCCGTGCTCGAAGTCTTCGGCTTGATACCGGCCTGA

Upstream 100 bases:

>100_bases
TGCGCGAAGGCATGCCGGTGCGTGTGTTATCGCTCGCGGATGCCTCCGAGTGGGTGCCTCCGGCAGTGACCGTCGATAGT
TTGGCCTAACTCTCACCCTC

Downstream 100 bases:

>100_bases
TGGTTTTGTTAGCGTCCGTTCCGAGCCGCGCGCGTCAGCAAGCGGTTGGTAATTTGCATTTACTAGGCAGCGCCTCGCGA
CGTTCCCACGGCAACTTGCA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MVNRTNYERELEFARRLASAAGENARRIRAGGVAAESKADTSPVTIADRENERLVREAIEREFPADGILGEEGASKAGTS
GRRWVVDPIDGTRDFIRGNRFWCVLIALEDEGEPVVGVAHFPMLEETYWAVRDGGSYLNGERLRVSSAESISACVFSPNG
LHQVEARPYLPQVVEFMQRSWAVRSFGGPLDACLLAAGKVEIWFEPKLEVWDLAALKLIIEEAGGDFFALDGSRRIDRGT
VIACPPGVSVPVLEVFGLIPA

Sequences:

>Translated_261_residues
MVNRTNYERELEFARRLASAAGENARRIRAGGVAAESKADTSPVTIADRENERLVREAIEREFPADGILGEEGASKAGTS
GRRWVVDPIDGTRDFIRGNRFWCVLIALEDEGEPVVGVAHFPMLEETYWAVRDGGSYLNGERLRVSSAESISACVFSPNG
LHQVEARPYLPQVVEFMQRSWAVRSFGGPLDACLLAAGKVEIWFEPKLEVWDLAALKLIIEEAGGDFFALDGSRRIDRGT
VIACPPGVSVPVLEVFGLIPA
>Mature_261_residues
MVNRTNYERELEFARRLASAAGENARRIRAGGVAAESKADTSPVTIADRENERLVREAIEREFPADGILGEEGASKAGTS
GRRWVVDPIDGTRDFIRGNRFWCVLIALEDEGEPVVGVAHFPMLEETYWAVRDGGSYLNGERLRVSSAESISACVFSPNG
LHQVEARPYLPQVVEFMQRSWAVRSFGGPLDACLLAAGKVEIWFEPKLEVWDLAALKLIIEEAGGDFFALDGSRRIDRGT
VIACPPGVSVPVLEVFGLIPA

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=245, Percent_Identity=26.9387755102041, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI221625487, Length=249, Percent_Identity=26.5060240963855, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI7657236, Length=229, Percent_Identity=30.1310043668122, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1788882, Length=228, Percent_Identity=32.4561403508772, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790659, Length=211, Percent_Identity=30.3317535545024, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=248, Percent_Identity=28.2258064516129, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=246, Percent_Identity=28.4552845528455, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320493, Length=198, Percent_Identity=30.3030303030303, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664926, Length=237, Percent_Identity=27.8481012658228, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664922, Length=200, Percent_Identity=30, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357329, Length=235, Percent_Identity=30.2127659574468, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357957, Length=241, Percent_Identity=28.6307053941909, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357303, Length=194, Percent_Identity=28.8659793814433, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664918, Length=236, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28618; Mature: 28618

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNRTNYERELEFARRLASAAGENARRIRAGGVAAESKADTSPVTIADRENERLVREAIE
CCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHH
REFPADGILGEEGASKAGTSGRRWVVDPIDGTRDFIRGNRFWCVLIALEDEGEPVVGVAH
HCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEEEEEEECCCCCEEEEEC
FPMLEETYWAVRDGGSYLNGERLRVSSAESISACVFSPNGLHQVEARPYLPQVVEFMQRS
CCCHHHHHEEEECCCCCCCCCEEEECCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHH
WAVRSFGGPLDACLLAAGKVEIWFEPKLEVWDLAALKLIIEEAGGDFFALDGSRRIDRGT
HHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
VIACPPGVSVPVLEVFGLIPA
EEECCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MVNRTNYERELEFARRLASAAGENARRIRAGGVAAESKADTSPVTIADRENERLVREAIE
CCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHH
REFPADGILGEEGASKAGTSGRRWVVDPIDGTRDFIRGNRFWCVLIALEDEGEPVVGVAH
HCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCEEEEEEEEECCCCCEEEEEC
FPMLEETYWAVRDGGSYLNGERLRVSSAESISACVFSPNGLHQVEARPYLPQVVEFMQRS
CCCHHHHHEEEECCCCCCCCCEEEECCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHH
WAVRSFGGPLDACLLAAGKVEIWFEPKLEVWDLAALKLIIEEAGGDFFALDGSRRIDRGT
HHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
VIACPPGVSVPVLEVFGLIPA
EEECCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]