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The map label for this gene is fadA [H]

Identifier: 116624771

GI number: 116624771

Start: 7133714

End: 7134895

Strand: Reverse

Name: fadA [H]

Synonym: Acid_5695

Alternate gene names: 116624771

Gene position: 7134895-7133714 (Counterclockwise)

Preceding gene: 116624772

Following gene: 116624770

Centisome position: 71.59

GC content: 64.72

Gene sequence:

>1182_bases
ATGAGAGACGCGGTGATTGTGAGCGCGGTGAGGACGGCGGTGGGCAAGGCTCCGAAGGGAATGCTGCGCGCTACGCGGCC
CGATGATCTGGCCGCGGTGGCGATTCAGGGGGCGATGGCGCGGGTACCGGGGCTCGAGGCGCGCGAAGTGGAGGATGTGA
TCATCGGCTGCGCGATGCCGGAGGGCGAGCAGGGGATGAACGTGGCGCGGATTGCGGCGCTGCGCGCGGGAATGCCGATT
GAATCGTCGGCGATGACGATTAACCGCTATTGCGCGTCGGGGCTGCAATCGATCGCGCTGGCGGCGGAGCGCATACGGGG
CGCCGGAGCGGAGGCGATTGTCGCGGGCGGCACGGAATCGATGTCGTTCATCCCGTTCGGCGGCAATAAGATTTCGATTA
ACCCGTGGCTGCAGCAGAACTATCCGGATTCGTATCTTTCGATGGGGTTGACGGCGGAGCGGGTGGCGAAGCATTACGGC
ATCACGCGCGAGCAGGCCGACGAATTCGCGCTCGCGAGCCATACCAAGGCGCTGGCGGCGCAGGCGGCAGGCAAGTTCGT
GCAGGAGATTGTGCCGGTGCCGGTGACCTTCTCGGCGCCGGATGCGAAGTCGAAAATCCGCAGGACGGAAATGCAGTTCA
ATATTGATGAAGGGCCGCGTGCCGATACTTCAATGGAGGCGCTCGGGAAGTTGAAGGCGGCCTTTCACGCGAAGGGAACA
GTGACGGCGGGTAACTCGTCGCAGACCAGTGACGGGGCCGCCGCGGCGGTGGTGATGTCGGAGGATCGCGCGCGCGCGCT
GGGGATCGCGCCGCTCGCGCGCTTCGTGGCCTACGCCTACGCGGGCTGCTTGCCGGAAGAGATGGGGATCGGTCCGGTGT
ATGCTATCCCGAAGGCGCTGAAACTGGCGGGGCTGACCCTGGACCAGATCGACCTGATCGAATTGAATGAAGCCTTCGCG
GCGCAATCCCTGGCGGTGATCAAGGCGCTCGGACTCGCGATGGACCGGGTAAATGTGAACGGTGGCGCGATCGCGCTGGG
CCATCCGCTGGGCTGCACGGGGGCTAAGCTTACGGCCAGCCTGCTGCAGGAAATGAAGCGTCGAAAAGCGCGGTACGGCA
TCGTAACGATGTGCGTGGGGGGCGGCATGGGCGCCGCGGGAATCTTCGAGAACCTGAATTAA

Upstream 100 bases:

>100_bases
GCGGATCGCGTACACGTTAAAGAGCGGCCGGCCGTTGCGGAACTGAAATTGGCCGCAGATGAACGCAGATAAACGCGGAT
AAGAAGAAGCAGGAGAACTT

Downstream 100 bases:

>100_bases
TAGAGGAAAAGAAAATGGCAACCACCAACGTGCAGTTTATGGCGAAACGGGTCAAGGGCGGCAGCTTCCTCACCGAGGAA
CGCGACCCGCAAGACGTGTT

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRDAVIVSAVRTAVGKAPKGMLRATRPDDLAAVAIQGAMARVPGLEAREVEDVIIGCAMPEGEQGMNVARIAALRAGMPI
ESSAMTINRYCASGLQSIALAAERIRGAGAEAIVAGGTESMSFIPFGGNKISINPWLQQNYPDSYLSMGLTAERVAKHYG
ITREQADEFALASHTKALAAQAAGKFVQEIVPVPVTFSAPDAKSKIRRTEMQFNIDEGPRADTSMEALGKLKAAFHAKGT
VTAGNSSQTSDGAAAAVVMSEDRARALGIAPLARFVAYAYAGCLPEEMGIGPVYAIPKALKLAGLTLDQIDLIELNEAFA
AQSLAVIKALGLAMDRVNVNGGAIALGHPLGCTGAKLTASLLQEMKRRKARYGIVTMCVGGGMGAAGIFENLN

Sequences:

>Translated_393_residues
MRDAVIVSAVRTAVGKAPKGMLRATRPDDLAAVAIQGAMARVPGLEAREVEDVIIGCAMPEGEQGMNVARIAALRAGMPI
ESSAMTINRYCASGLQSIALAAERIRGAGAEAIVAGGTESMSFIPFGGNKISINPWLQQNYPDSYLSMGLTAERVAKHYG
ITREQADEFALASHTKALAAQAAGKFVQEIVPVPVTFSAPDAKSKIRRTEMQFNIDEGPRADTSMEALGKLKAAFHAKGT
VTAGNSSQTSDGAAAAVVMSEDRARALGIAPLARFVAYAYAGCLPEEMGIGPVYAIPKALKLAGLTLDQIDLIELNEAFA
AQSLAVIKALGLAMDRVNVNGGAIALGHPLGCTGAKLTASLLQEMKRRKARYGIVTMCVGGGMGAAGIFENLN
>Mature_393_residues
MRDAVIVSAVRTAVGKAPKGMLRATRPDDLAAVAIQGAMARVPGLEAREVEDVIIGCAMPEGEQGMNVARIAALRAGMPI
ESSAMTINRYCASGLQSIALAAERIRGAGAEAIVAGGTESMSFIPFGGNKISINPWLQQNYPDSYLSMGLTAERVAKHYG
ITREQADEFALASHTKALAAQAAGKFVQEIVPVPVTFSAPDAKSKIRRTEMQFNIDEGPRADTSMEALGKLKAAFHAKGT
VTAGNSSQTSDGAAAAVVMSEDRARALGIAPLARFVAYAYAGCLPEEMGIGPVYAIPKALKLAGLTLDQIDLIELNEAFA
AQSLAVIKALGLAMDRVNVNGGAIALGHPLGCTGAKLTASLLQEMKRRKARYGIVTMCVGGGMGAAGIFENLN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=44.5012787723785, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=40.9429280397022, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI148539872, Length=395, Percent_Identity=39.4936708860759, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=38.3292383292383, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4504327, Length=442, Percent_Identity=33.0316742081448, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI194353979, Length=242, Percent_Identity=35.1239669421488, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=44.6969696969697, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=46.7980295566502, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=44.1747572815534, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=41.7910447761194, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788683, Length=397, Percent_Identity=33.7531486146096, Blast_Score=191, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=43.1077694235589, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=36.2962962962963, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=33.0845771144279, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=31.5192743764172, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=27.8606965174129, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=39, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=36.2962962962963, Blast_Score=229, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=42.0792079207921, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=42.2110552763819, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24640423, Length=404, Percent_Identity=36.6336633663366, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17137578, Length=390, Percent_Identity=32.3076923076923, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40961; Mature: 40961

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVIVSAVRTAVGKAPKGMLRATRPDDLAAVAIQGAMARVPGLEAREVEDVIIGCAMP
CCCHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHEEEECCC
EGEQGMNVARIAALRAGMPIESSAMTINRYCASGLQSIALAAERIRGAGAEAIVAGGTES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSFIPFGGNKISINPWLQQNYPDSYLSMGLTAERVAKHYGITREQADEFALASHTKALAA
CEEEECCCCEEEECCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAAGKFVQEIVPVPVTFSAPDAKSKIRRTEMQFNIDEGPRADTSMEALGKLKAAFHAKGT
HHHHHHHHHHCCCCEEECCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCCE
VTAGNSSQTSDGAAAAVVMSEDRARALGIAPLARFVAYAYAGCLPEEMGIGPVYAIPKAL
EECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHH
KLAGLTLDQIDLIELNEAFAAQSLAVIKALGLAMDRVNVNGGAIALGHPLGCTGAKLTAS
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHHHH
LLQEMKRRKARYGIVTMCVGGGMGAAGIFENLN
HHHHHHHHHHHCCEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure
MRDAVIVSAVRTAVGKAPKGMLRATRPDDLAAVAIQGAMARVPGLEAREVEDVIIGCAMP
CCCHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHEEEECCC
EGEQGMNVARIAALRAGMPIESSAMTINRYCASGLQSIALAAERIRGAGAEAIVAGGTES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
MSFIPFGGNKISINPWLQQNYPDSYLSMGLTAERVAKHYGITREQADEFALASHTKALAA
CEEEECCCCEEEECCCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAAGKFVQEIVPVPVTFSAPDAKSKIRRTEMQFNIDEGPRADTSMEALGKLKAAFHAKGT
HHHHHHHHHHCCCCEEECCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCCE
VTAGNSSQTSDGAAAAVVMSEDRARALGIAPLARFVAYAYAGCLPEEMGIGPVYAIPKAL
EECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHH
KLAGLTLDQIDLIELNEAFAAQSLAVIKALGLAMDRVNVNGGAIALGHPLGCTGAKLTAS
HHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHHHH
LLQEMKRRKARYGIVTMCVGGGMGAAGIFENLN
HHHHHHHHHHHCCEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]