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The map label for this gene is fadE [H]

Identifier: 116624770

GI number: 116624770

Start: 7131900

End: 7133699

Strand: Reverse

Name: fadE [H]

Synonym: Acid_5694

Alternate gene names: 116624770

Gene position: 7133699-7131900 (Counterclockwise)

Preceding gene: 116624771

Following gene: 116624768

Centisome position: 71.58

GC content: 63.83

Gene sequence:

>1800_bases
ATGGCAACCACCAACGTGCAGTTTATGGCGAAACGGGTCAAGGGCGGCAGCTTCCTCACCGAGGAACGCGACCCGCAAGA
CGTGTTCACACCGGAAGACCTGACCGAAGAGCACCGGCAGATCGCGAAGACCGCGGTCGATTTCACGCAGAACGAAGTGA
TGCCGGCGGCGGCCGAAATCGAGGCCAAGAACTTCGCCGTGACCAAGGCGCTGCTGCGCAAGGCCGGCGAGCTTGGGCTG
ATGAGCGTGGACGTGCCGGAGGCGTACGGCGGCCTGGAGATGGACAAGGTGACCTCCGCGCTGATTGCCGAATCGATCAG
CAAGCTGGCCAGTTTCTCGGTGGCATTCAGCGCGCACGTGGGGATCGGGACGCTGCCCATCGTCTGGTACGGCACAGCGG
CGCAAAAGCAGAAGTACCTGCCGAAGCTGGCGACGGGCGAGTGGATCGGCGCCTACGCGCTTTCGGAATCATCGTCGGCC
AGCGATGCGATGAACTGCCGCACGCGCGCGGTGCTCTCGGCCGACGGCACGCACTACGTGCTCAACGGCGAGAAGATGTG
GATCACTAACAGCGGCTTCGCGGACCTGTTCACCGTGTTTGCGAAGGTGGACGGGGAGAAGTTCTCCGCCTTTCTGATCG
AGCGCGGCACGCCCGGCTTCGCAGTGGGTGCGGAGGAGCACAAGCTGGGGATCCGTGGATCTTCCACCTGCCCGCTGATT
CTGGCGGATTGCCAGGTGCCGGTGGAGAACCTGCTGGGCGAGATCGGCAAGGGCCATCACATCGCGTTCAACATTTTGAA
CATCGGGCGCTTCAAGCTGGGAGCGGCCTGCGTCGGCGGCGCGCGCAACGGCTTGCAGGACGCGATCGGGTACGCCAAGG
AGCGCAAAGCCTTCGGGAAATCGATTTCCGAGTTCGGCTTGATTCAGGAGAAGCTGGCGGAATCGGCGGCCGGAATCTAT
GCGGGCGAAGCCATGGTGTACCGCGCGATCGGCATGATCGACGCGGCGCTCGCCGACGTGGACACCAAGGCGGAAGGCGC
GTCGCGCGAGATCCAGAAGCGGATCGAGGAGTACGCGGTAGAGTGCTCCATCCTCAAGGTGTGGGCCTCGGAGATGCTCG
ACATGGTGGTGGACCACGTGGTGCAGATCTACGCGGGTTACGGCTACGTGGAGGAGTATCCGGCGGAGCGCGCGTATCGC
GATTCGCGCATCAACCGGATCTTCGAAGGCACCAATGAGATCAACCGCCTGATCATCACGGGCTGGCTGATGAAGCGCGC
GGTGGCGGGACAATTGCCGCTGATGGGGGCGATCAAGAAACTGATGGACGAGGTCATGTCGGGCCCCACCGCTGCCGAAG
AGCGCGAGGGTCCGCTGAGCGCGGAGCACCACCTGCTCACGAACGTGAAGAAGCTGGCGTTGTTCGCAGCGGGCGCGGCA
TCGCAGAAATACATGATGGGCCTGGGCGACCAGCAGGAAGTGATGGGGGCGCTGGCGGATTGCATTACGGAAGTCTTCGC
GCTGGAATCGGCCATCCTGCGAACGGAAAAGCTGATTGCCGCCAAGGGCGCGGCGGGCGCGAAGCAGGCGATCGCGATGA
CCCGGTACTATGCGGCGAAGGCGGCGCAGACGGTGGAACAATCGGCGCGAAAGGTAATCGCGACGGTCGCCGAGGGCGAC
ATGCTGCGTACGCAGATGGCGATCCTGCGGCGGCTCTCGAAGCACGAACCGGCGGACACGATCGGGTTGGGAAGGCAAAT
CGCCAAGCACGTGCTGGCGGCGGGCAAGTACTCGCTGTAG

Upstream 100 bases:

>100_bases
AGCGTCGAAAAGCGCGGTACGGCATCGTAACGATGTGCGTGGGGGGCGGCATGGGCGCCGCGGGAATCTTCGAGAACCTG
AATTAATAGAGGAAAAGAAA

Downstream 100 bases:

>100_bases
GCCGCAATTAAGAAAGGCGATCGCTCCCTGAGACTGAGGGAGCGTCCGTTGTACGCGCAAACCACGACCTCAATTTGCGG
CTCGCCGCAATGTGGGGCAG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MATTNVQFMAKRVKGGSFLTEERDPQDVFTPEDLTEEHRQIAKTAVDFTQNEVMPAAAEIEAKNFAVTKALLRKAGELGL
MSVDVPEAYGGLEMDKVTSALIAESISKLASFSVAFSAHVGIGTLPIVWYGTAAQKQKYLPKLATGEWIGAYALSESSSA
SDAMNCRTRAVLSADGTHYVLNGEKMWITNSGFADLFTVFAKVDGEKFSAFLIERGTPGFAVGAEEHKLGIRGSSTCPLI
LADCQVPVENLLGEIGKGHHIAFNILNIGRFKLGAACVGGARNGLQDAIGYAKERKAFGKSISEFGLIQEKLAESAAGIY
AGEAMVYRAIGMIDAALADVDTKAEGASREIQKRIEEYAVECSILKVWASEMLDMVVDHVVQIYAGYGYVEEYPAERAYR
DSRINRIFEGTNEINRLIITGWLMKRAVAGQLPLMGAIKKLMDEVMSGPTAAEEREGPLSAEHHLLTNVKKLALFAAGAA
SQKYMMGLGDQQEVMGALADCITEVFALESAILRTEKLIAAKGAAGAKQAIAMTRYYAAKAAQTVEQSARKVIATVAEGD
MLRTQMAILRRLSKHEPADTIGLGRQIAKHVLAAGKYSL

Sequences:

>Translated_599_residues
MATTNVQFMAKRVKGGSFLTEERDPQDVFTPEDLTEEHRQIAKTAVDFTQNEVMPAAAEIEAKNFAVTKALLRKAGELGL
MSVDVPEAYGGLEMDKVTSALIAESISKLASFSVAFSAHVGIGTLPIVWYGTAAQKQKYLPKLATGEWIGAYALSESSSA
SDAMNCRTRAVLSADGTHYVLNGEKMWITNSGFADLFTVFAKVDGEKFSAFLIERGTPGFAVGAEEHKLGIRGSSTCPLI
LADCQVPVENLLGEIGKGHHIAFNILNIGRFKLGAACVGGARNGLQDAIGYAKERKAFGKSISEFGLIQEKLAESAAGIY
AGEAMVYRAIGMIDAALADVDTKAEGASREIQKRIEEYAVECSILKVWASEMLDMVVDHVVQIYAGYGYVEEYPAERAYR
DSRINRIFEGTNEINRLIITGWLMKRAVAGQLPLMGAIKKLMDEVMSGPTAAEEREGPLSAEHHLLTNVKKLALFAAGAA
SQKYMMGLGDQQEVMGALADCITEVFALESAILRTEKLIAAKGAAGAKQAIAMTRYYAAKAAQTVEQSARKVIATVAEGD
MLRTQMAILRRLSKHEPADTIGLGRQIAKHVLAAGKYSL
>Mature_598_residues
ATTNVQFMAKRVKGGSFLTEERDPQDVFTPEDLTEEHRQIAKTAVDFTQNEVMPAAAEIEAKNFAVTKALLRKAGELGLM
SVDVPEAYGGLEMDKVTSALIAESISKLASFSVAFSAHVGIGTLPIVWYGTAAQKQKYLPKLATGEWIGAYALSESSSAS
DAMNCRTRAVLSADGTHYVLNGEKMWITNSGFADLFTVFAKVDGEKFSAFLIERGTPGFAVGAEEHKLGIRGSSTCPLIL
ADCQVPVENLLGEIGKGHHIAFNILNIGRFKLGAACVGGARNGLQDAIGYAKERKAFGKSISEFGLIQEKLAESAAGIYA
GEAMVYRAIGMIDAALADVDTKAEGASREIQKRIEEYAVECSILKVWASEMLDMVVDHVVQIYAGYGYVEEYPAERAYRD
SRINRIFEGTNEINRLIITGWLMKRAVAGQLPLMGAIKKLMDEVMSGPTAAEEREGPLSAEHHLLTNVKKLALFAAGAAS
QKYMMGLGDQQEVMGALADCITEVFALESAILRTEKLIAAKGAAGAKQAIAMTRYYAAKAAQTVEQSARKVIATVAEGDM
LRTQMAILRRLSKHEPADTIGLGRQIAKHVLAAGKYSL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=422, Percent_Identity=40.9952606635071, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI4557233, Length=408, Percent_Identity=37.0098039215686, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI4557235, Length=407, Percent_Identity=38.5749385749386, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI76496475, Length=407, Percent_Identity=38.5749385749386, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=33.756345177665, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=33.587786259542, Blast_Score=215, Evalue=9e-56,
Organism=Homo sapiens, GI226958414, Length=376, Percent_Identity=32.1808510638298, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI187960098, Length=407, Percent_Identity=32.6781326781327, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4557231, Length=407, Percent_Identity=32.6781326781327, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4501857, Length=398, Percent_Identity=31.6582914572864, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=30.3030303030303, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI4503943, Length=412, Percent_Identity=29.8543689320388, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7669494, Length=304, Percent_Identity=33.2236842105263, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI48976061, Length=419, Percent_Identity=26.0143198090692, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI211971008, Length=419, Percent_Identity=26.0143198090692, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI38505218, Length=351, Percent_Identity=24.5014245014245, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI87081958, Length=359, Percent_Identity=28.4122562674095, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786223, Length=354, Percent_Identity=26.8361581920904, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI87082384, Length=279, Percent_Identity=26.5232974910394, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=498, Percent_Identity=36.9477911646586, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71985192, Length=320, Percent_Identity=42.5, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=389, Percent_Identity=34.4473007712082, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=430, Percent_Identity=31.6279069767442, Blast_Score=212, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=389, Percent_Identity=34.7043701799486, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=400, Percent_Identity=31.5, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=31.5, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17570075, Length=401, Percent_Identity=31.9201995012469, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17533517, Length=416, Percent_Identity=30.7692307692308, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=40.1433691756272, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=40.3361344537815, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=293, Percent_Identity=32.7645051194539, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=409, Percent_Identity=28.8508557457213, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=398, Percent_Identity=27.3869346733668, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=398, Percent_Identity=26.3819095477387, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=26.8, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=404, Percent_Identity=23.5148514851485, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562446, Length=303, Percent_Identity=25.7425742574257, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=352, Percent_Identity=24.4318181818182, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=352, Percent_Identity=24.4318181818182, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356377, Length=397, Percent_Identity=38.2871536523929, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI281363737, Length=433, Percent_Identity=36.4896073903002, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24646207, Length=399, Percent_Identity=34.8370927318296, Blast_Score=213, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=33.756345177665, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24666513, Length=397, Percent_Identity=32.2418136020151, Blast_Score=209, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21355753, Length=403, Percent_Identity=32.0099255583127, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19920834, Length=409, Percent_Identity=27.3838630806846, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 64571; Mature: 64440

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTNVQFMAKRVKGGSFLTEERDPQDVFTPEDLTEEHRQIAKTAVDFTQNEVMPAAAEI
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EAKNFAVTKALLRKAGELGLMSVDVPEAYGGLEMDKVTSALIAESISKLASFSVAFSAHV
HHHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEECC
GIGTLPIVWYGTAAQKQKYLPKLATGEWIGAYALSESSSASDAMNCRTRAVLSADGTHYV
CCCCEEEEEECCHHHHHHCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHEEEECCCCEEE
LNGEKMWITNSGFADLFTVFAKVDGEKFSAFLIERGTPGFAVGAEEHKLGIRGSSTCPLI
ECCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCCCCEE
LADCQVPVENLLGEIGKGHHIAFNILNIGRFKLGAACVGGARNGLQDAIGYAKERKAFGK
EECCCCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
SISEFGLIQEKLAESAAGIYAGEAMVYRAIGMIDAALADVDTKAEGASREIQKRIEEYAV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ECSILKVWASEMLDMVVDHVVQIYAGYGYVEEYPAERAYRDSRINRIFEGTNEINRLIIT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHH
GWLMKRAVAGQLPLMGAIKKLMDEVMSGPTAAEEREGPLSAEHHLLTNVKKLALFAAGAA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCC
SQKYMMGLGDQQEVMGALADCITEVFALESAILRTEKLIAAKGAAGAKQAIAMTRYYAAK
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AAQTVEQSARKVIATVAEGDMLRTQMAILRRLSKHEPADTIGLGRQIAKHVLAAGKYSL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ATTNVQFMAKRVKGGSFLTEERDPQDVFTPEDLTEEHRQIAKTAVDFTQNEVMPAAAEI
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EAKNFAVTKALLRKAGELGLMSVDVPEAYGGLEMDKVTSALIAESISKLASFSVAFSAHV
HHHHHHHHHHHHHHCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEECC
GIGTLPIVWYGTAAQKQKYLPKLATGEWIGAYALSESSSASDAMNCRTRAVLSADGTHYV
CCCCEEEEEECCHHHHHHCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHEEEECCCCEEE
LNGEKMWITNSGFADLFTVFAKVDGEKFSAFLIERGTPGFAVGAEEHKLGIRGSSTCPLI
ECCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCCCCEE
LADCQVPVENLLGEIGKGHHIAFNILNIGRFKLGAACVGGARNGLQDAIGYAKERKAFGK
EECCCCCHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
SISEFGLIQEKLAESAAGIYAGEAMVYRAIGMIDAALADVDTKAEGASREIQKRIEEYAV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
ECSILKVWASEMLDMVVDHVVQIYAGYGYVEEYPAERAYRDSRINRIFEGTNEINRLIIT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHH
GWLMKRAVAGQLPLMGAIKKLMDEVMSGPTAAEEREGPLSAEHHLLTNVKKLALFAAGAA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCC
SQKYMMGLGDQQEVMGALADCITEVFALESAILRTEKLIAAKGAAGAKQAIAMTRYYAAK
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AAQTVEQSARKVIATVAEGDMLRTQMAILRRLSKHEPADTIGLGRQIAKHVLAAGKYSL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]