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The map label for this gene is nuoM [H]

Identifier: 116624765

GI number: 116624765

Start: 7125786

End: 7127366

Strand: Direct

Name: nuoM [H]

Synonym: Acid_5689

Alternate gene names: 116624765

Gene position: 7125786-7127366 (Clockwise)

Preceding gene: 116624764

Following gene: 116624766

Centisome position: 71.5

GC content: 60.34

Gene sequence:

>1581_bases
ATGGACCAGCACTTACTGACGATCATATTGTTCACGCCCCTCGCCGGCCTTGCGGTCCTGCTCTTCATTCCGGGAAAGAG
CAAAGACCTGATCCGCGTGTGGGCAAACCTGGTGGCCTTCGCCGGGTTTCTGATTTCGCTCCCGCTGGCCTCGCGCTTTC
AGGCCGGCCGTCCCGGCTACCAGTTTGAAGAGAGCTCGGATTGGATTCCCGCGATCGGCGCGCACTTTCACATCGGCGTA
GACGGCATCAGCATGCTGATGATCATGCTGACCACCGTGATGGGCTTTATCGCCGTGCTGTGCAGCTGGAATGCGATCCA
GGATCGCGTCAAGGAATACTACGCCATGTTCATGCTGCTGCAAGCCGGCATGATTGGCGTCTTCCTCTCGCTCGATTTCT
TCCTGTTCTACGTCTTCTGGGAACTGGTGCTGGTCCCGATGTACTTCATCATCGGCGTCTGGGGCGGTCCGCGAAAGTTG
TACGCAGCAATCAAATTCTTCCTCTACACCCTGGCCGGCAGCGTGCTTATGCTGCTCGGCATCCTGACACTCTACTTCCA
GCACTTCCACCAGTTCGGCTTCTACAGCTTCGAGATCTCCAACCTCATGAAGCTCAACCTTCCCATCGGCACGCAGGAGT
GGGTCTTCTGGGCCTTCTTCATCGGCTTCGCGATCAAGGTCCCAATGTTCCCCTTCCACACCTGGCTGCCTGACGCGCAC
GTGGAAGCGCCCACCGCCGGCTCGGTGATCCTGGCGGCGGTGCTCCTCAAGATGGGGACCTACGGCTTCCTGCGATTCTC
GCTGCCGCTTTTGCCGGAGGCGAGTTCGGACCGCACTATCGTTCAAATTCTGGCCACCCTGTCGTTGATCGGCATCATTT
ACGGCGCGCTGGTCAGCCTGATGCAGGCCGATTGGAAGAAGCTGATCGCGTATTCCTCGGTCAGCCACCTCGGCTTCTGC
ACGCTCGGCATCTTCTCGCTGAACCCGAATGGAATCGCGGGCAGCGTGCTCCAGCAGATCAATCACGGCATCTCCACCGG
CATGCTCTTCATGGTGATCGGCGTGATCTACGAACGCCGCCACACCCGCGAGATCAAGGAGTACGGCGGACTGGCGCACG
TGATGCCGAAGTTCGCCATAATCTTCGCGATCGCGATGCTGAGCTCCGCCGGACTGCCGCTGTTGAACGGCTTCGTGGGC
GAGTTCACGATCATGCAGGGCGCGTTTGAGGCCAGCTGGGTGTGGGCAGCATTCGCGGTCACCGGCGTCATTCTCGGCGC
CGCATACCTTCTGTGGCTCTACCAGCGCACCATGCTCGGCCAGGTCACCAACGGCAAAAACCTGACCATCCCCGATATGT
CCGCGCGCGAAGTCGCGATGTTCGTGCCGTTGATCGCGTGGGCTATCTGGATCGGCATTTACCCGAAACCATACTTTGAT
ATTCTGCGGCAGCCGGTGACGGAAATCGTGCAGCGTGTGCGGCCCGGATATTTTAGCGGCGCCGTGCAAAACGCGGGAGC
GCGGCCCGCTGCCCCACCGGTGGCGCAGGCCCCGGCGGTTGTCGCTGGAGGCGCGCAATGA

Upstream 100 bases:

>100_bases
CCGGTGTGCATCGTGCAGACCGGACGCGTGCAGGCGTACGCCTTCTTCGTGGTGATCGGCGTCCTGATGTTCTTCGGCTA
TTACGTTGTGCGGTAACCCT

Downstream 100 bases:

>100_bases
TCGATTTCAGCCTGTTCTACAATTCCACCGATCACTTCTCGATCATTCCGGCGGTCATGCTGGCGCTCTTCGGCTGCGCC
ATCCTGCTCTTCGATTTCCT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MDQHLLTIILFTPLAGLAVLLFIPGKSKDLIRVWANLVAFAGFLISLPLASRFQAGRPGYQFEESSDWIPAIGAHFHIGV
DGISMLMIMLTTVMGFIAVLCSWNAIQDRVKEYYAMFMLLQAGMIGVFLSLDFFLFYVFWELVLVPMYFIIGVWGGPRKL
YAAIKFFLYTLAGSVLMLLGILTLYFQHFHQFGFYSFEISNLMKLNLPIGTQEWVFWAFFIGFAIKVPMFPFHTWLPDAH
VEAPTAGSVILAAVLLKMGTYGFLRFSLPLLPEASSDRTIVQILATLSLIGIIYGALVSLMQADWKKLIAYSSVSHLGFC
TLGIFSLNPNGIAGSVLQQINHGISTGMLFMVIGVIYERRHTREIKEYGGLAHVMPKFAIIFAIAMLSSAGLPLLNGFVG
EFTIMQGAFEASWVWAAFAVTGVILGAAYLLWLYQRTMLGQVTNGKNLTIPDMSAREVAMFVPLIAWAIWIGIYPKPYFD
ILRQPVTEIVQRVRPGYFSGAVQNAGARPAAPPVAQAPAVVAGGAQ

Sequences:

>Translated_526_residues
MDQHLLTIILFTPLAGLAVLLFIPGKSKDLIRVWANLVAFAGFLISLPLASRFQAGRPGYQFEESSDWIPAIGAHFHIGV
DGISMLMIMLTTVMGFIAVLCSWNAIQDRVKEYYAMFMLLQAGMIGVFLSLDFFLFYVFWELVLVPMYFIIGVWGGPRKL
YAAIKFFLYTLAGSVLMLLGILTLYFQHFHQFGFYSFEISNLMKLNLPIGTQEWVFWAFFIGFAIKVPMFPFHTWLPDAH
VEAPTAGSVILAAVLLKMGTYGFLRFSLPLLPEASSDRTIVQILATLSLIGIIYGALVSLMQADWKKLIAYSSVSHLGFC
TLGIFSLNPNGIAGSVLQQINHGISTGMLFMVIGVIYERRHTREIKEYGGLAHVMPKFAIIFAIAMLSSAGLPLLNGFVG
EFTIMQGAFEASWVWAAFAVTGVILGAAYLLWLYQRTMLGQVTNGKNLTIPDMSAREVAMFVPLIAWAIWIGIYPKPYFD
ILRQPVTEIVQRVRPGYFSGAVQNAGARPAAPPVAQAPAVVAGGAQ
>Mature_526_residues
MDQHLLTIILFTPLAGLAVLLFIPGKSKDLIRVWANLVAFAGFLISLPLASRFQAGRPGYQFEESSDWIPAIGAHFHIGV
DGISMLMIMLTTVMGFIAVLCSWNAIQDRVKEYYAMFMLLQAGMIGVFLSLDFFLFYVFWELVLVPMYFIIGVWGGPRKL
YAAIKFFLYTLAGSVLMLLGILTLYFQHFHQFGFYSFEISNLMKLNLPIGTQEWVFWAFFIGFAIKVPMFPFHTWLPDAH
VEAPTAGSVILAAVLLKMGTYGFLRFSLPLLPEASSDRTIVQILATLSLIGIIYGALVSLMQADWKKLIAYSSVSHLGFC
TLGIFSLNPNGIAGSVLQQINHGISTGMLFMVIGVIYERRHTREIKEYGGLAHVMPKFAIIFAIAMLSSAGLPLLNGFVG
EFTIMQGAFEASWVWAAFAVTGVILGAAYLLWLYQRTMLGQVTNGKNLTIPDMSAREVAMFVPLIAWAIWIGIYPKPYFD
ILRQPVTEIVQRVRPGYFSGAVQNAGARPAAPPVAQAPAVVAGGAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=361, Percent_Identity=33.5180055401662, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI251831117, Length=215, Percent_Identity=30.2325581395349, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1788613, Length=447, Percent_Identity=41.1633109619687, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1788827, Length=306, Percent_Identity=29.7385620915033, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788831, Length=364, Percent_Identity=28.2967032967033, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788829, Length=429, Percent_Identity=26.5734265734266, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI145693160, Length=433, Percent_Identity=27.0207852193995, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788614, Length=482, Percent_Identity=25.9336099585062, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI2367154, Length=235, Percent_Identity=25.531914893617, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 58137; Mature: 58137

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCHHCCHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCHHCCHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]