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The map label for this gene is nuoL [H]

Identifier: 116624764

GI number: 116624764

Start: 7123847

End: 7125781

Strand: Direct

Name: nuoL [H]

Synonym: Acid_5688

Alternate gene names: 116624764

Gene position: 7123847-7125781 (Clockwise)

Preceding gene: 116624763

Following gene: 116624765

Centisome position: 71.48

GC content: 62.43

Gene sequence:

>1935_bases
ATGATCCTGCTCTCCTTCATCTTCTCAGCGGGCGCGGTCTGGCAGCTTTCGCAGCAGGCCAATCGCGTGCAGCAGGTGAT
CCAGTTCCAGTGGATCGCGGGGTTGCCGTTCCACATGTCGAACGGGCAGATGGCGACCTTCTCCGTGGACTGGGGCTTCC
TGCTCGATCCGCTCAGTTCCGTGATGATTCTCGTTGTAACCGGAATCGGCTTCCTGATTCACGTCTACTCCACCGGGTAC
ATGGCGCACGATAACGGCTACTACCGCTTCTTCGGCTACCTCAATCTCTTCGTCTTCTTCATGCTGATGCTGGTGCTGGC
CAATAACTACGCGCTGCTCTTCGTAGGCTGGGAAGGCGTCGGCTTGTGCAGCTACCTGTTGATCGGATTCTACTTCCACA
AACGGTCTGCGGGCGATGCCGGCAAGAAGGCCTTCATCGTCAACCGCGTGGGCGACGCCGGCTTCATCCTTGGCATGTTC
CTGCTGATGAGCACCCTCGGCACGCTGCGCTTCACGGACGTCAACTCCGCCCTGCGCGCCGGAGCCTTCACGCCGGAAGT
CGCCGGCATCGGCACGCTGACCATCATCACTCTTTGCATGTTCTTCGGCGCGACCGGTAAATCGGCGCAGTTCCCGCTCT
ACGTCTGGCTGCCCGACGCCATGGAAGGTCCCACGCCCGTATCGGCATTGATCCACGCGGCCACCATGGTGACGGCGGGC
GTGTACATGATCGCGCGCTCCTCGGCGTTGTTCGAACTCACGCCGATCACCTCCACCGTGGTCGCCTCCATCGGCGCCTT
CACCGCGATTCTCGCGGCCAGCATCGCGCTGGTGCAGACCGATATCAAGCGCGTGCTCGCGTACTCCACCGTCAGCCAGT
TGGGCTACATGTTCCTGGCGCTCGGCGTCGGCGCGTACTGGGTCGCGGTCTTCCACCTGATGACCCACGCATTCTTTAAG
GCCCTGCTCTTCCTCGGCTCCGGCTCGGTGATCCACGCCATGGGCGGCGAGCAGGATATGCGCCGCATGGGCGCGCTGAA
GGACAAGATCCCCGTCACGTTCCGCACCATGTGGATCGGCAGCGTGGCGATTGCGGGCATCCCCGGCCTCGCCGGCTTCT
TCTCGAAGGACGAGATCCTCTGGCAGGCGTACAGCTCTCCCAAAGGTGCAACGATTCTGTGGGCCGTCGGCCTGACCACG
GCCGCGATGACCGCCTTTTATATGTGGCGGATGATGTACATGACCTTCTACGGTGCCTCGCGCGTGGCTCCCGAAGTCCA
CCCGCATGAATCGCCGGTGTCGATGACGGGTCCGTTGACCGTGCTCGCAATCGGCAGCGTGTTCGCAGGCTGGCTGGGAG
TTCCGAAACTGTGGACGGTGTTCGGCGAGAGTTTCCGCGGGTTCGAGCGCTGGCTGGAGCCGGCCTTCGCGTCCGCGGCC
GTCGAAGCGGCGAAGGAAGGCGAGCATTCGGCCTCCACCGAGTGGACCCTGATGTTCACCTCCATCGCGATCGCCGCCGC
CGGAATCCTGATCGCGCGCTACTTCTACTGTGTGAAGCCCGAGATTCCAGTGCGCATCGGCGAGATGTTCCCGCGCTGCC
ATCGCGTGCTCTCCAACAAGTGGTACCTGGACGAAATTTACGAGTATGTTTTCGTGGATGGCCTTTGCAAACGCGGCGGA
CTGCTGCTGGGCGCGTTCGACCGCAATGTAGTGGATGGCGGCGTCAACGGGGCCGGCTGGTTCACGCGTTTCGCAGCCAC
GATTTCGGCCTGGTGGGACACCTGGGTGATCGATGGCGCCGTGCGCCTCGGCTCCTTCCTGGTGAAGATGCTCTCCTACC
CGGTGTGCATCGTGCAGACCGGACGCGTGCAGGCGTACGCCTTCTTCGTGGTGATCGGCGTCCTGATGTTCTTCGGCTAT
TACGTTGTGCGGTAA

Upstream 100 bases:

>100_bases
CGATCATGACCACGATCACGGGCACTCTCATGATCATGATCACGGCCACGGGCATCATCATTCGCCTCTGAAGTTCCTGG
TGAACCTGATCTGCCCGGGG

Downstream 100 bases:

>100_bases
CCCTATGGACCAGCACTTACTGACGATCATATTGTTCACGCCCCTCGCCGGCCTTGCGGTCCTGCTCTTCATTCCGGGAA
AGAGCAAAGACCTGATCCGC

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MILLSFIFSAGAVWQLSQQANRVQQVIQFQWIAGLPFHMSNGQMATFSVDWGFLLDPLSSVMILVVTGIGFLIHVYSTGY
MAHDNGYYRFFGYLNLFVFFMLMLVLANNYALLFVGWEGVGLCSYLLIGFYFHKRSAGDAGKKAFIVNRVGDAGFILGMF
LLMSTLGTLRFTDVNSALRAGAFTPEVAGIGTLTIITLCMFFGATGKSAQFPLYVWLPDAMEGPTPVSALIHAATMVTAG
VYMIARSSALFELTPITSTVVASIGAFTAILAASIALVQTDIKRVLAYSTVSQLGYMFLALGVGAYWVAVFHLMTHAFFK
ALLFLGSGSVIHAMGGEQDMRRMGALKDKIPVTFRTMWIGSVAIAGIPGLAGFFSKDEILWQAYSSPKGATILWAVGLTT
AAMTAFYMWRMMYMTFYGASRVAPEVHPHESPVSMTGPLTVLAIGSVFAGWLGVPKLWTVFGESFRGFERWLEPAFASAA
VEAAKEGEHSASTEWTLMFTSIAIAAAGILIARYFYCVKPEIPVRIGEMFPRCHRVLSNKWYLDEIYEYVFVDGLCKRGG
LLLGAFDRNVVDGGVNGAGWFTRFAATISAWWDTWVIDGAVRLGSFLVKMLSYPVCIVQTGRVQAYAFFVVIGVLMFFGY
YVVR

Sequences:

>Translated_644_residues
MILLSFIFSAGAVWQLSQQANRVQQVIQFQWIAGLPFHMSNGQMATFSVDWGFLLDPLSSVMILVVTGIGFLIHVYSTGY
MAHDNGYYRFFGYLNLFVFFMLMLVLANNYALLFVGWEGVGLCSYLLIGFYFHKRSAGDAGKKAFIVNRVGDAGFILGMF
LLMSTLGTLRFTDVNSALRAGAFTPEVAGIGTLTIITLCMFFGATGKSAQFPLYVWLPDAMEGPTPVSALIHAATMVTAG
VYMIARSSALFELTPITSTVVASIGAFTAILAASIALVQTDIKRVLAYSTVSQLGYMFLALGVGAYWVAVFHLMTHAFFK
ALLFLGSGSVIHAMGGEQDMRRMGALKDKIPVTFRTMWIGSVAIAGIPGLAGFFSKDEILWQAYSSPKGATILWAVGLTT
AAMTAFYMWRMMYMTFYGASRVAPEVHPHESPVSMTGPLTVLAIGSVFAGWLGVPKLWTVFGESFRGFERWLEPAFASAA
VEAAKEGEHSASTEWTLMFTSIAIAAAGILIARYFYCVKPEIPVRIGEMFPRCHRVLSNKWYLDEIYEYVFVDGLCKRGG
LLLGAFDRNVVDGGVNGAGWFTRFAATISAWWDTWVIDGAVRLGSFLVKMLSYPVCIVQTGRVQAYAFFVVIGVLMFFGY
YVVR
>Mature_644_residues
MILLSFIFSAGAVWQLSQQANRVQQVIQFQWIAGLPFHMSNGQMATFSVDWGFLLDPLSSVMILVVTGIGFLIHVYSTGY
MAHDNGYYRFFGYLNLFVFFMLMLVLANNYALLFVGWEGVGLCSYLLIGFYFHKRSAGDAGKKAFIVNRVGDAGFILGMF
LLMSTLGTLRFTDVNSALRAGAFTPEVAGIGTLTIITLCMFFGATGKSAQFPLYVWLPDAMEGPTPVSALIHAATMVTAG
VYMIARSSALFELTPITSTVVASIGAFTAILAASIALVQTDIKRVLAYSTVSQLGYMFLALGVGAYWVAVFHLMTHAFFK
ALLFLGSGSVIHAMGGEQDMRRMGALKDKIPVTFRTMWIGSVAIAGIPGLAGFFSKDEILWQAYSSPKGATILWAVGLTT
AAMTAFYMWRMMYMTFYGASRVAPEVHPHESPVSMTGPLTVLAIGSVFAGWLGVPKLWTVFGESFRGFERWLEPAFASAA
VEAAKEGEHSASTEWTLMFTSIAIAAAGILIARYFYCVKPEIPVRIGEMFPRCHRVLSNKWYLDEIYEYVFVDGLCKRGG
LLLGAFDRNVVDGGVNGAGWFTRFAATISAWWDTWVIDGAVRLGSFLVKMLSYPVCIVQTGRVQAYAFFVVIGVLMFFGY
YVVR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=436, Percent_Identity=40.1376146788991, Blast_Score=285, Evalue=1e-76,
Organism=Escherichia coli, GI1788614, Length=545, Percent_Identity=45.3211009174312, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788829, Length=339, Percent_Identity=33.9233038348083, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788827, Length=445, Percent_Identity=30.1123595505618, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1788831, Length=342, Percent_Identity=30.7017543859649, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367154, Length=427, Percent_Identity=25.9953161592506, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788613, Length=423, Percent_Identity=26.9503546099291, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI145693160, Length=209, Percent_Identity=32.0574162679426, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 70702; Mature: 70702

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLSFIFSAGAVWQLSQQANRVQQVIQFQWIAGLPFHMSNGQMATFSVDWGFLLDPLSS
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCHHHHHHHHH
VMILVVTGIGFLIHVYSTGYMAHDNGYYRFFGYLNLFVFFMLMLVLANNYALLFVGWEGV
HHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
GLCSYLLIGFYFHKRSAGDAGKKAFIVNRVGDAGFILGMFLLMSTLGTLRFTDVNSALRA
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCEEEECHHHHHHC
GAFTPEVAGIGTLTIITLCMFFGATGKSAQFPLYVWLPDAMEGPTPVSALIHAATMVTAG
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
VYMIARSSALFELTPITSTVVASIGAFTAILAASIALVQTDIKRVLAYSTVSQLGYMFLA
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVGAYWVAVFHLMTHAFFKALLFLGSGSVIHAMGGEQDMRRMGALKDKIPVTFRTMWIG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHCCCEEEEHHHHH
SVAIAGIPGLAGFFSKDEILWQAYSSPKGATILWAVGLTTAAMTAFYMWRMMYMTFYGAS
HHHHHCCCCHHHCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCHH
RVAPEVHPHESPVSMTGPLTVLAIGSVFAGWLGVPKLWTVFGESFRGFERWLEPAFASAA
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAAKEGEHSASTEWTLMFTSIAIAAAGILIARYFYCVKPEIPVRIGEMFPRCHRVLSNK
HHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WYLDEIYEYVFVDGLCKRGGLLLGAFDRNVVDGGVNGAGWFTRFAATISAWWDTWVIDGA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRLGSFLVKMLSYPVCIVQTGRVQAYAFFVVIGVLMFFGYYVVR
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILLSFIFSAGAVWQLSQQANRVQQVIQFQWIAGLPFHMSNGQMATFSVDWGFLLDPLSS
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCHHHHHHHHH
VMILVVTGIGFLIHVYSTGYMAHDNGYYRFFGYLNLFVFFMLMLVLANNYALLFVGWEGV
HHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCH
GLCSYLLIGFYFHKRSAGDAGKKAFIVNRVGDAGFILGMFLLMSTLGTLRFTDVNSALRA
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCEEEECHHHHHHC
GAFTPEVAGIGTLTIITLCMFFGATGKSAQFPLYVWLPDAMEGPTPVSALIHAATMVTAG
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
VYMIARSSALFELTPITSTVVASIGAFTAILAASIALVQTDIKRVLAYSTVSQLGYMFLA
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVGAYWVAVFHLMTHAFFKALLFLGSGSVIHAMGGEQDMRRMGALKDKIPVTFRTMWIG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCHHHCCCEEEEHHHHH
SVAIAGIPGLAGFFSKDEILWQAYSSPKGATILWAVGLTTAAMTAFYMWRMMYMTFYGAS
HHHHHCCCCHHHCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCHH
RVAPEVHPHESPVSMTGPLTVLAIGSVFAGWLGVPKLWTVFGESFRGFERWLEPAFASAA
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAAKEGEHSASTEWTLMFTSIAIAAAGILIARYFYCVKPEIPVRIGEMFPRCHRVLSNK
HHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WYLDEIYEYVFVDGLCKRGGLLLGAFDRNVVDGGVNGAGWFTRFAATISAWWDTWVIDGA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VRLGSFLVKMLSYPVCIVQTGRVQAYAFFVVIGVLMFFGYYVVR
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]