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The map label for this gene is fucA [C]

Identifier: 116624693

GI number: 116624693

Start: 7042164

End: 7042955

Strand: Direct

Name: fucA [C]

Synonym: Acid_5617

Alternate gene names: 116624693

Gene position: 7042164-7042955 (Clockwise)

Preceding gene: 116624692

Following gene: 116624694

Centisome position: 70.66

GC content: 63.89

Gene sequence:

>792_bases
ATGGCAGAAGCACAGATGACCGAAGCTCCGGGGAGAGCAAAGAACGTTCCGGCGCCGCCGGTGTTCGCGACGCTGGCTGA
AGAACGCCGCCATCGCAAAGAGCGTCTGGCGGGGGCCTTCCGGCTGTTTTCACGATACGGGTTCGATGAAGGAGTCGCCG
GGCACATCACGGCGCGCGATCCCGAGTATGCCGACCACTTCTGGGTCAATCCCTTCGGCGTCCACTTCGGCCAGATCCGC
GTCTCGGACCTGGTGATGGTGGACCATAAGGGTGAAGTCGTCGAGGGCAACTATCCGGTCAACACCGCCGCCTTCGCGAT
CCATTCGCGGGTTCATGCCGCGCGGCCGGAGGCGGTGGCCGCCGCCCATGCGCATTCGATCCACGGCAAGGCATGGGCGT
CGCTCGGCAGGTTGCTCGACCCGATCACGCAGGATGCCTGCGCGTTTTACGAAGACCACGGGCTGTTCGACGATTTCACC
GGCGTGGTCTACGAGACCAGCGAAGGCGACCGCATCGCCAAGGCGCTCGGACGGCATAAGGCCGTCATCCTGCGCAATCA
CGGATTGCTCACGGTGGGCGCGACCGTGGACGCGGCAGCCTGGTGGTTCATCACCATGGAGCACAGCTGCCAGGGGCAAT
TGATGGCCGAAGCGGCCGGCAAGCCCATCAAGATCGCACACGAACACGCCGTGGTGACGCACCGCCAGATCGGCGACGAA
TACGGCGGCTGGTTCCAGTTCCAACCGCTGTGGCAGAAGATCTCGCGCGAAGAGCCCGATTTATTCGAGTAG

Upstream 100 bases:

>100_bases
GTCGTGATCCCCTTTCCCGGCTGACACTTTTTAGATAGCTACATTCGCGCGACGGTCACGCTTCCCTATCCTTCAGGGCA
GGCCGGTATATGATTTACAG

Downstream 100 bases:

>100_bases
CTTCAGTTTCAGTGGCGCGCTTGCAAATCTTTCAGGGACCGCAGTTCGCTGCCTTCCGCGGCCCGGACCGACAGGTAAAA
GTCGCACGCCGCGCATCCCC

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAEAQMTEAPGRAKNVPAPPVFATLAEERRHRKERLAGAFRLFSRYGFDEGVAGHITARDPEYADHFWVNPFGVHFGQIR
VSDLVMVDHKGEVVEGNYPVNTAAFAIHSRVHAARPEAVAAAHAHSIHGKAWASLGRLLDPITQDACAFYEDHGLFDDFT
GVVYETSEGDRIAKALGRHKAVILRNHGLLTVGATVDAAAWWFITMEHSCQGQLMAEAAGKPIKIAHEHAVVTHRQIGDE
YGGWFQFQPLWQKISREEPDLFE

Sequences:

>Translated_263_residues
MAEAQMTEAPGRAKNVPAPPVFATLAEERRHRKERLAGAFRLFSRYGFDEGVAGHITARDPEYADHFWVNPFGVHFGQIR
VSDLVMVDHKGEVVEGNYPVNTAAFAIHSRVHAARPEAVAAAHAHSIHGKAWASLGRLLDPITQDACAFYEDHGLFDDFT
GVVYETSEGDRIAKALGRHKAVILRNHGLLTVGATVDAAAWWFITMEHSCQGQLMAEAAGKPIKIAHEHAVVTHRQIGDE
YGGWFQFQPLWQKISREEPDLFE
>Mature_262_residues
AEAQMTEAPGRAKNVPAPPVFATLAEERRHRKERLAGAFRLFSRYGFDEGVAGHITARDPEYADHFWVNPFGVHFGQIRV
SDLVMVDHKGEVVEGNYPVNTAAFAIHSRVHAARPEAVAAAHAHSIHGKAWASLGRLLDPITQDACAFYEDHGLFDDFTG
VVYETSEGDRIAKALGRHKAVILRNHGLLTVGATVDAAAWWFITMEHSCQGQLMAEAAGKPIKIAHEHAVVTHRQIGDEY
GGWFQFQPLWQKISREEPDLFE

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826321, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI29826323, Length=226, Percent_Identity=31.4159292035398, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI29826325, Length=226, Percent_Identity=31.4159292035398, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI29826319, Length=226, Percent_Identity=31.4159292035398, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI89276787, Length=197, Percent_Identity=29.9492385786802, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI297307160, Length=197, Percent_Identity=29.9492385786802, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI9257190, Length=197, Percent_Identity=29.9492385786802, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI297307158, Length=196, Percent_Identity=30.1020408163265, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI9257192, Length=196, Percent_Identity=30.1020408163265, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI9951927, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI62912453, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI9943848, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1789164, Length=224, Percent_Identity=25, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115533216, Length=197, Percent_Identity=27.9187817258883, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533218, Length=197, Percent_Identity=27.9187817258883, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71989560, Length=198, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989555, Length=194, Percent_Identity=27.8350515463918, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989544, Length=201, Percent_Identity=28.8557213930348, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989541, Length=198, Percent_Identity=28.2828282828283, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989550, Length=201, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281363755, Length=189, Percent_Identity=35.4497354497354, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363751, Length=189, Percent_Identity=35.4497354497354, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655690, Length=189, Percent_Identity=35.4497354497354, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24655685, Length=189, Percent_Identity=35.4497354497354, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281363761, Length=189, Percent_Identity=35.4497354497354, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI281363759, Length=189, Percent_Identity=35.4497354497354, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI281363753, Length=189, Percent_Identity=35.4497354497354, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI281363763, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363757, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136738, Length=186, Percent_Identity=35.4838709677419, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 29210; Mature: 29079

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAQMTEAPGRAKNVPAPPVFATLAEERRHRKERLAGAFRLFSRYGFDEGVAGHITARD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PEYADHFWVNPFGVHFGQIRVSDLVMVDHKGEVVEGNYPVNTAAFAIHSRVHAARPEAVA
CCCCCCCCCCHHHCEECEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHH
AAHAHSIHGKAWASLGRLLDPITQDACAFYEDHGLFDDFTGVVYETSEGDRIAKALGRHK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHCCCC
AVILRNHGLLTVGATVDAAAWWFITMEHSCQGQLMAEAAGKPIKIAHEHAVVTHRQIGDE
EEEEECCCEEEECCCCCCEEEEEEEEECCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHH
YGGWFQFQPLWQKISREEPDLFE
HCCEEEECHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEAQMTEAPGRAKNVPAPPVFATLAEERRHRKERLAGAFRLFSRYGFDEGVAGHITARD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
PEYADHFWVNPFGVHFGQIRVSDLVMVDHKGEVVEGNYPVNTAAFAIHSRVHAARPEAVA
CCCCCCCCCCHHHCEECEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHH
AAHAHSIHGKAWASLGRLLDPITQDACAFYEDHGLFDDFTGVVYETSEGDRIAKALGRHK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHCCCC
AVILRNHGLLTVGATVDAAAWWFITMEHSCQGQLMAEAAGKPIKIAHEHAVVTHRQIGDE
EEEEECCCEEEECCCCCCEEEEEEEEECCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHH
YGGWFQFQPLWQKISREEPDLFE
HCCEEEECHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]