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The map label for this gene is rsmA [H]

Identifier: 116624617

GI number: 116624617

Start: 6944963

End: 6945706

Strand: Direct

Name: rsmA [H]

Synonym: Acid_5541

Alternate gene names: 116624617

Gene position: 6944963-6945706 (Clockwise)

Preceding gene: 116624616

Following gene: 116624623

Centisome position: 69.69

GC content: 61.02

Gene sequence:

>744_bases
GTGCCGCAAAAACTCGGGCAGCACTTCCTCTCCAACGGTTCGGTACTCGATCGCATTGCCTTGGCGGTGTGTCCGGAGGG
GGAAGAACTCGTCATCGAAATCGGCCCCGGCAAGGGCGCGCTCACGGAAAAACTTCTCCAACGGTCGGGCCGTGTGATCG
CCATCGAACTTGACCCAGTGCTGGTGGAGTACCTCCGGCAGAAGTTCGAAGGCGAAAGCCGCCTGCAGGTGATTCACGCC
GACGTCCTGCACACCGACCTGGCGCAATGGGGCCCGGTGCCGATCGCCGGCAACCTGCCCTACTACATCACCTCTCCTAT
CCTGGAAAGATCCGTCCGGGCCGGCGCGCCGCGAACTGTCTTCCTGATTCAGAAGGAGGTCGCCCATCGCTTAGTGGCTC
ATCCCGGCCAGCGCGACTATGGCTATCTGACGCTGCAGACCGCCCTCTTCGCCGATACGAAGCTCTTATTCGAGGTCAAG
CCCGGCGCCTTCAAGCCGCCGCCCAAAGTGGATTCTGCGGTGGTGCTGCTGACTCCCCACGGCCGTGATTACGGGATCAC
GGACCGCGATAAGTTCCTCAAATTCCTCAGCCACAGCTTCCGCCAGAAGAGGAAGACGCTGCGCAATAATCTGTTCGCCG
TGTACGGAAAGGATTTGATCGACGCGTGGCCCGAAGCCGGCCTGCGCGCCGAGCAGATCCCCATGGAAAAATTCGTCGAA
ATGTTCCGGCGGATTCCGGCTTAG

Upstream 100 bases:

>100_bases
TTCCCAATTCAAGCCGGCTACCGTGAACGGCCAACCCGTCTGGGGTCTCAAACAAGTGGTCTTCACTCGCGGCCAACGTC
TGCGGAGCTAGCGGCTCAGC

Downstream 100 bases:

>100_bases
TGGGTTGTTTCGGAAGTTCACCCCTGTATCAGGGGAGGACCCTCCCTTACGGTCGGGGCTCCGAACGGAGCCGCGCGCGT
CAGCAAGCGTCTGCTCGATA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MPQKLGQHFLSNGSVLDRIALAVCPEGEELVIEIGPGKGALTEKLLQRSGRVIAIELDPVLVEYLRQKFEGESRLQVIHA
DVLHTDLAQWGPVPIAGNLPYYITSPILERSVRAGAPRTVFLIQKEVAHRLVAHPGQRDYGYLTLQTALFADTKLLFEVK
PGAFKPPPKVDSAVVLLTPHGRDYGITDRDKFLKFLSHSFRQKRKTLRNNLFAVYGKDLIDAWPEAGLRAEQIPMEKFVE
MFRRIPA

Sequences:

>Translated_247_residues
MPQKLGQHFLSNGSVLDRIALAVCPEGEELVIEIGPGKGALTEKLLQRSGRVIAIELDPVLVEYLRQKFEGESRLQVIHA
DVLHTDLAQWGPVPIAGNLPYYITSPILERSVRAGAPRTVFLIQKEVAHRLVAHPGQRDYGYLTLQTALFADTKLLFEVK
PGAFKPPPKVDSAVVLLTPHGRDYGITDRDKFLKFLSHSFRQKRKTLRNNLFAVYGKDLIDAWPEAGLRAEQIPMEKFVE
MFRRIPA
>Mature_246_residues
PQKLGQHFLSNGSVLDRIALAVCPEGEELVIEIGPGKGALTEKLLQRSGRVIAIELDPVLVEYLRQKFEGESRLQVIHAD
VLHTDLAQWGPVPIAGNLPYYITSPILERSVRAGAPRTVFLIQKEVAHRLVAHPGQRDYGYLTLQTALFADTKLLFEVKP
GAFKPPPKVDSAVVLLTPHGRDYGITDRDKFLKFLSHSFRQKRKTLRNNLFAVYGKDLIDAWPEAGLRAEQIPMEKFVEM
FRRIPA

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=180, Percent_Identity=38.8888888888889, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI156415992, Length=202, Percent_Identity=26.7326732673267, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786236, Length=248, Percent_Identity=32.6612903225806, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI25146882, Length=182, Percent_Identity=38.4615384615385, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25141369, Length=259, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324989, Length=178, Percent_Identity=32.0224719101124, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358017, Length=184, Percent_Identity=34.7826086956522, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357273, Length=227, Percent_Identity=28.6343612334802, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 27770; Mature: 27638

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQKLGQHFLSNGSVLDRIALAVCPEGEELVIEIGPGKGALTEKLLQRSGRVIAIELDPV
CCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECHH
LVEYLRQKFEGESRLQVIHADVLHTDLAQWGPVPIAGNLPYYITSPILERSVRAGAPRTV
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEECCCCCEEHHHHHHHHHHCCCCCEE
FLIQKEVAHRLVAHPGQRDYGYLTLQTALFADTKLLFEVKPGAFKPPPKVDSAVVLLTPH
EEEHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEECCC
GRDYGITDRDKFLKFLSHSFRQKRKTLRNNLFAVYGKDLIDAWPEAGLRAEQIPMEKFVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHHCCCCCCCHHCCCHHHHHH
MFRRIPA
HHHHCCC
>Mature Secondary Structure 
PQKLGQHFLSNGSVLDRIALAVCPEGEELVIEIGPGKGALTEKLLQRSGRVIAIELDPV
CHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECHH
LVEYLRQKFEGESRLQVIHADVLHTDLAQWGPVPIAGNLPYYITSPILERSVRAGAPRTV
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCEECCCCCEEHHHHHHHHHHCCCCCEE
FLIQKEVAHRLVAHPGQRDYGYLTLQTALFADTKLLFEVKPGAFKPPPKVDSAVVLLTPH
EEEHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEECCC
GRDYGITDRDKFLKFLSHSFRQKRKTLRNNLFAVYGKDLIDAWPEAGLRAEQIPMEKFVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECHHHHHHCCCCCCCHHCCCHHHHHH
MFRRIPA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA