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The map label for this gene is mdtA [H]

Identifier: 116624392

GI number: 116624392

Start: 6655898

End: 6657211

Strand: Direct

Name: mdtA [H]

Synonym: Acid_5313

Alternate gene names: 116624392

Gene position: 6655898-6657211 (Clockwise)

Preceding gene: 116624391

Following gene: 116624393

Centisome position: 66.79

GC content: 61.95

Gene sequence:

>1314_bases
ATGCCTAAACTTGTGGCCCGTGGTCCCGGGTCCCCTCGACATTCGATGAAACTGCTTTCGGCTCTGGGTGTGAGCGCCGT
GCTGGCGCTAGCCCTTTGCGGCTGTTCCGGGAGCAGCACAGCCGCGAAGTCCGACGCGCCGGGAGGCGGCGGGAAAGGCG
GCGGTCGTCGCGGCGGCGGCGACGTTCCGGTGACGGTAGCGAAGGCGAAAGAACGCGATGTCCCGGTGGAAATTCAGGTG
ATCGGCAACGTGGAGGCCTATTCCACCATCACCGTGAAGGCACAGGTAGGCGGATTGCTCACCGACGTCTATTTCCACGA
AGGCGATTTCGTAAAGAAGGGCGAGAAGCTTTTCGCAATCGACCGGCGTCCGCTGGAAGCGGCATACAACCAGGCGTTGG
CCAATATCGCGCGCGATCAGGCCTCGCTCGGGCAGGCCCGGGCAAATCTGGCGCGTGATGAGGCGCAGGCGAAATATCAG
GACACGCAGGCCAAGCGCTATGCCGCGCTCAATGAAAGCGGTGTGATTTCCAAGGACCAGGCGGAGCAGCTGCGCGCCAG
CGCGGACGCCATGGCGCAGGCGGTGAACGCCGATAAAGCGGCGATCCAAAGCGCCCAGGCAGCCATCGGCGCCAGCCAGG
CGACAGCGGAGAATGCCAAAGTCCAAATGGGTTTCACGGACATTTACTCGCCCATCAACGGGCGCACCGGCAACCTGACG
GTGAAGACGGGCAACGTGGTCACTGCCAACAACATGGACATGATGACCATCAACCAGGTGGAGCCGATCTACGTCACCTT
CTCGGTACCGGAAGCGCAATTGCCCTCCATCAAGAAGTACAAGGATATGGGGGTTCTGAGCGTGCGTGCGCGTCCGCAGG
ATGCCGAGACCGCTGTCAACGACGAAACCGGCAGCCTCACGTTCATCGATAACACCGTGGACATGACTACCGGAACGATC
AAATTGAAGGGCACCTTCCCCAACTCCAATCACCAGTTGTGGCCCGGACAGTTCGTCCGCGTGACGCTGCGGTTGACCAC
GCAGAAGAACGCGGTGGTGGTGCCGAACGAAGCGGTTCAGACCGGGCAGACCGGATCTTTCGTCTACGTGGTGAAGCCGG
ATATGAAGGTGGAATCGCGGACCGTGACCACGGGTGCCAGGGTGGACCAGGATATGGTCGTGGACGGCCTGGAATTGGGA
GAAACGGTAGTAACCGAAGGGCAATTGCGATTGGCTCCGGGCAGCAAGGTTTCCATCAAGGACGCGAGTGGTGGGGGCAG
AGGCGGCGGAGGCCGCGGCCGGTCGCGGGGCTAG

Upstream 100 bases:

>100_bases
GCTGTAAGAAAGTTCCAAAATCTTGACCCCATTAGGGCCATTGTTCAGAGAAGCGAGTAACATTACGATGAGGTTGGTCG
CCTAACAGGTAGATTCCACT

Downstream 100 bases:

>100_bases
AGGGGGCTCGGCGTGAACTTTTCCGAAACCTTTATCAGGCGTCCCATTGCAACTAGCCTGCTCATGGCGGGCGTGGCGTT
GTTCGGCGTCATCGCATATG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MPKLVARGPGSPRHSMKLLSALGVSAVLALALCGCSGSSTAAKSDAPGGGGKGGGRRGGGDVPVTVAKAKERDVPVEIQV
IGNVEAYSTITVKAQVGGLLTDVYFHEGDFVKKGEKLFAIDRRPLEAAYNQALANIARDQASLGQARANLARDEAQAKYQ
DTQAKRYAALNESGVISKDQAEQLRASADAMAQAVNADKAAIQSAQAAIGASQATAENAKVQMGFTDIYSPINGRTGNLT
VKTGNVVTANNMDMMTINQVEPIYVTFSVPEAQLPSIKKYKDMGVLSVRARPQDAETAVNDETGSLTFIDNTVDMTTGTI
KLKGTFPNSNHQLWPGQFVRVTLRLTTQKNAVVVPNEAVQTGQTGSFVYVVKPDMKVESRTVTTGARVDQDMVVDGLELG
ETVVTEGQLRLAPGSKVSIKDASGGGRGGGGRGRSRG

Sequences:

>Translated_437_residues
MPKLVARGPGSPRHSMKLLSALGVSAVLALALCGCSGSSTAAKSDAPGGGGKGGGRRGGGDVPVTVAKAKERDVPVEIQV
IGNVEAYSTITVKAQVGGLLTDVYFHEGDFVKKGEKLFAIDRRPLEAAYNQALANIARDQASLGQARANLARDEAQAKYQ
DTQAKRYAALNESGVISKDQAEQLRASADAMAQAVNADKAAIQSAQAAIGASQATAENAKVQMGFTDIYSPINGRTGNLT
VKTGNVVTANNMDMMTINQVEPIYVTFSVPEAQLPSIKKYKDMGVLSVRARPQDAETAVNDETGSLTFIDNTVDMTTGTI
KLKGTFPNSNHQLWPGQFVRVTLRLTTQKNAVVVPNEAVQTGQTGSFVYVVKPDMKVESRTVTTGARVDQDMVVDGLELG
ETVVTEGQLRLAPGSKVSIKDASGGGRGGGGRGRSRG
>Mature_436_residues
PKLVARGPGSPRHSMKLLSALGVSAVLALALCGCSGSSTAAKSDAPGGGGKGGGRRGGGDVPVTVAKAKERDVPVEIQVI
GNVEAYSTITVKAQVGGLLTDVYFHEGDFVKKGEKLFAIDRRPLEAAYNQALANIARDQASLGQARANLARDEAQAKYQD
TQAKRYAALNESGVISKDQAEQLRASADAMAQAVNADKAAIQSAQAAIGASQATAENAKVQMGFTDIYSPINGRTGNLTV
KTGNVVTANNMDMMTINQVEPIYVTFSVPEAQLPSIKKYKDMGVLSVRARPQDAETAVNDETGSLTFIDNTVDMTTGTIK
LKGTFPNSNHQLWPGQFVRVTLRLTTQKNAVVVPNEAVQTGQTGSFVYVVKPDMKVESRTVTTGARVDQDMVVDGLELGE
TVVTEGQLRLAPGSKVSIKDASGGGRGGGGRGRSRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=392, Percent_Identity=32.3979591836735, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789665, Length=378, Percent_Identity=30.952380952381, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1786668, Length=404, Percent_Identity=29.4554455445545, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789929, Length=349, Percent_Identity=27.7936962750716, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87081796, Length=330, Percent_Identity=28.1818181818182, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45810; Mature: 45679

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLVARGPGSPRHSMKLLSALGVSAVLALALCGCSGSSTAAKSDAPGGGGKGGGRRGGG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
DVPVTVAKAKERDVPVEIQVIGNVEAYSTITVKAQVGGLLTDVYFHEGDFVKKGEKLFAI
CCCEEEECCCCCCCCEEEEEEECCEEEEEEEEEEECCCEEEEEEECCCCHHHCCCEEEEE
DRRPLEAAYNQALANIARDQASLGQARANLARDEAQAKYQDTQAKRYAALNESGVISKDQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AEQLRASADAMAQAVNADKAAIQSAQAAIGASQATAENAKVQMGFTDIYSPINGRTGNLT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHCCCCCCCCCEEE
VKTGNVVTANNMDMMTINQVEPIYVTFSVPEAQLPSIKKYKDMGVLSVRARPQDAETAVN
EEECCEEEECCCCEEEECCCCEEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCHHCCC
DETGSLTFIDNTVDMTTGTIKLKGTFPNSNHQLWPGQFVRVTLRLTTQKNAVVVPNEAVQ
CCCCCEEEEECCEEEEEEEEEEEEECCCCCCEECCCCEEEEEEEEEECCCEEECCCHHHC
TGQTGSFVYVVKPDMKVESRTVTTGARVDQDMVVDGLELGETVVTEGQLRLAPGSKVSIK
CCCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHCCHHCCCEEEECCEEEECCCCEEEEE
DASGGGRGGGGRGRSRG
ECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKLVARGPGSPRHSMKLLSALGVSAVLALALCGCSGSSTAAKSDAPGGGGKGGGRRGGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
DVPVTVAKAKERDVPVEIQVIGNVEAYSTITVKAQVGGLLTDVYFHEGDFVKKGEKLFAI
CCCEEEECCCCCCCCEEEEEEECCEEEEEEEEEEECCCEEEEEEECCCCHHHCCCEEEEE
DRRPLEAAYNQALANIARDQASLGQARANLARDEAQAKYQDTQAKRYAALNESGVISKDQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
AEQLRASADAMAQAVNADKAAIQSAQAAIGASQATAENAKVQMGFTDIYSPINGRTGNLT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHCCCCCCCCCEEE
VKTGNVVTANNMDMMTINQVEPIYVTFSVPEAQLPSIKKYKDMGVLSVRARPQDAETAVN
EEECCEEEECCCCEEEECCCCEEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCHHCCC
DETGSLTFIDNTVDMTTGTIKLKGTFPNSNHQLWPGQFVRVTLRLTTQKNAVVVPNEAVQ
CCCCCEEEEECCEEEEEEEEEEEEECCCCCCEECCCCEEEEEEEEEECCCEEECCCHHHC
TGQTGSFVYVVKPDMKVESRTVTTGARVDQDMVVDGLELGETVVTEGQLRLAPGSKVSIK
CCCCCCEEEEECCCCCCCCEEEECCCCCCHHHHHCCHHCCCEEEECCEEEECCCCEEEEE
DASGGGRGGGGRGRSRG
ECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA