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The map label for this gene is acdA [H]

Identifier: 116624389

GI number: 116624389

Start: 6653320

End: 6654495

Strand: Direct

Name: acdA [H]

Synonym: Acid_5310

Alternate gene names: 116624389

Gene position: 6653320-6654495 (Clockwise)

Preceding gene: 116624388

Following gene: 116624390

Centisome position: 66.76

GC content: 61.31

Gene sequence:

>1176_bases
ATGCCGGCACTCGAGAATATGGAAACGGCGCCCGCGCCGTTGACCGCCCTCAGCGAGGAAGAGCGATTCTTCCAGAGCAC
GGTGCGCAAATTCGCGCGCGAACAGATCCGCCCGTATGTCCGCGAGATGGATGAGGCGGCGGTATTCCGCAAGGACATCA
TTCAGCAGTTCTTCACCATGGGGCTGATGGGGATCGAAATTCCCGAGGAGTTCGGCGGGCAGGGCGGCACGTTTTTCCAG
GCGATTCTCGCCGTGGAAGAACTCTCGGCGGTGGACCCTTCGGCGGGCGTGATCGTGGACGTGCAGAACACCATCTGCAA
CAACGCGCTGCTGCGCTGGGCCACGGCCGAGCAAAAAGCGAAATACCTGCCGCTGCTCGCCGAAAAGATGGTTGCGAGCT
ACGCGCTCTCCGAAGCCGGCTCGGGCTCCGACGCCTTCGCGATGGCGACGCGCGCCGAGGACAAGGGAGATCACTTCCTG
CTCACCGGCCGCAAGCTGTGGATCACCAACGCGGCCGAAGCCGGCTTCTTTCTGCTTTTCGCCAACGCCAATCCCGAGGC
CGGGTACAAAGGCGTGACGGCCTTCCTGATCGAGCGCGATTTCCCGGGCTTCGCGGTCGGCAAGAAGGAAGACAAGATCG
GGCTGCGCGCGTCCTCAACCTGCGAACTGATCCTCGACAACTGCCGGGTGCCGCGCGAGAACGTGATGGGCGAGGTCGGC
AAGGGCTACAAGATCGCGATCGAGACGCTCAACGAGGGGCGGATCGCGATTGGCGCGCAGATGATCGGCCTGGCGCGCGG
CGCACTCGATCACGCGGTAACCTATGCGCGTGAGCGCAAGCAGTTCGGCAAACCCATCGGCGAATTCCAGGGCGTCCAAT
TTGATCTGGCGAAGATGGCGGTGGAAGTCGAAGCGGCGCGTCTTCTGGTGTATAACGCCGCACGTTTGCGGGACGCCGGG
CTTCCCTTCCTCGCAGAGGCGGCCATGGCGAAGTATTATAGTTCCGAGATCGCCGAACGCGTGGCATCCAAATCCATCGA
AGTTCATGGCGGGGTTGGAATTACGAAGGATTACCCCGTGGAGAAGCTGTACCGGGACGCCAAGATCGGGCGGATCTATG
AAGGGACGAGCAATATACAATTGATGACCATTGCCAAGAAACTATTGGGCAAGTAG

Upstream 100 bases:

>100_bases
TCGCGAAGGCGTCAACACTTACAACGGCTACATCACCTATAAAGGCGTGGCCGAATCCCAGGGGCGCCAGTGGCGCGCCC
TGGCGAGCGTGGGGTAAACG

Downstream 100 bases:

>100_bases
GCTCGTCCACCAAAGAAGGGAAACTATGCGTGCTATCGTTCTTTCCACCGCATTCGCGGCGTTGTGCCTGCCGGGCTGTG
TTGCGGGTTGGGCCGCGGAC

Product: butyryl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MPALENMETAPAPLTALSEEERFFQSTVRKFAREQIRPYVREMDEAAVFRKDIIQQFFTMGLMGIEIPEEFGGQGGTFFQ
AILAVEELSAVDPSAGVIVDVQNTICNNALLRWATAEQKAKYLPLLAEKMVASYALSEAGSGSDAFAMATRAEDKGDHFL
LTGRKLWITNAAEAGFFLLFANANPEAGYKGVTAFLIERDFPGFAVGKKEDKIGLRASSTCELILDNCRVPRENVMGEVG
KGYKIAIETLNEGRIAIGAQMIGLARGALDHAVTYARERKQFGKPIGEFQGVQFDLAKMAVEVEAARLLVYNAARLRDAG
LPFLAEAAMAKYYSSEIAERVASKSIEVHGGVGITKDYPVEKLYRDAKIGRIYEGTSNIQLMTIAKKLLGK

Sequences:

>Translated_391_residues
MPALENMETAPAPLTALSEEERFFQSTVRKFAREQIRPYVREMDEAAVFRKDIIQQFFTMGLMGIEIPEEFGGQGGTFFQ
AILAVEELSAVDPSAGVIVDVQNTICNNALLRWATAEQKAKYLPLLAEKMVASYALSEAGSGSDAFAMATRAEDKGDHFL
LTGRKLWITNAAEAGFFLLFANANPEAGYKGVTAFLIERDFPGFAVGKKEDKIGLRASSTCELILDNCRVPRENVMGEVG
KGYKIAIETLNEGRIAIGAQMIGLARGALDHAVTYARERKQFGKPIGEFQGVQFDLAKMAVEVEAARLLVYNAARLRDAG
LPFLAEAAMAKYYSSEIAERVASKSIEVHGGVGITKDYPVEKLYRDAKIGRIYEGTSNIQLMTIAKKLLGK
>Mature_390_residues
PALENMETAPAPLTALSEEERFFQSTVRKFAREQIRPYVREMDEAAVFRKDIIQQFFTMGLMGIEIPEEFGGQGGTFFQA
ILAVEELSAVDPSAGVIVDVQNTICNNALLRWATAEQKAKYLPLLAEKMVASYALSEAGSGSDAFAMATRAEDKGDHFLL
TGRKLWITNAAEAGFFLLFANANPEAGYKGVTAFLIERDFPGFAVGKKEDKIGLRASSTCELILDNCRVPRENVMGEVGK
GYKIAIETLNEGRIAIGAQMIGLARGALDHAVTYARERKQFGKPIGEFQGVQFDLAKMAVEVEAARLLVYNAARLRDAGL
PFLAEAAMAKYYSSEIAERVASKSIEVHGGVGITKDYPVEKLYRDAKIGRIYEGTSNIQLMTIAKKLLGK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=55.4376657824934, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=42.2459893048128, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=38.4210526315789, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=38.4210526315789, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=35.1851851851852, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=35.5882352941176, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI21361497, Length=395, Percent_Identity=37.4683544303797, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=32.7176781002639, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=35.2331606217617, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=35.2331606217617, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=31.1170212765957, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=28.8359788359788, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI7669494, Length=348, Percent_Identity=29.5977011494253, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI211971008, Length=300, Percent_Identity=30.3333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=31.1188811188811, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38505218, Length=384, Percent_Identity=23.9583333333333, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786223, Length=375, Percent_Identity=28.2666666666667, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=29.6296296296296, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87081702, Length=414, Percent_Identity=27.2946859903382, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=24.2647058823529, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=56.3829787234042, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=51.4360313315927, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=52.5597269624573, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=46.2093862815885, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=52.1929824561403, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=39.2105263157895, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=37.9947229551451, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=35.5437665782493, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=38.3597883597884, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=48.5355648535565, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=387, Percent_Identity=34.1085271317829, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71985192, Length=333, Percent_Identity=33.6336336336336, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=47.4576271186441, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=28.9544235924933, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17505929, Length=373, Percent_Identity=27.8820375335121, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.790450928382, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=28.4722222222222, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=275, Percent_Identity=29.8181818181818, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=275, Percent_Identity=29.8181818181818, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540912, Length=347, Percent_Identity=25.0720461095101, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=52.6041666666667, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=44.3271767810026, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=41.4248021108179, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=39.6825396825397, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=34.4736842105263, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=35.0923482849604, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=28.6089238845144, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45550141, Length=323, Percent_Identity=23.8390092879257, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221473076, Length=323, Percent_Identity=23.8390092879257, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 42835; Mature: 42704

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALENMETAPAPLTALSEEERFFQSTVRKFAREQIRPYVREMDEAAVFRKDIIQQFFTM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMGIEIPEEFGGQGGTFFQAILAVEELSAVDPSAGVIVDVQNTICNNALLRWATAEQKA
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
KYLPLLAEKMVASYALSEAGSGSDAFAMATRAEDKGDHFLLTGRKLWITNAAEAGFFLLF
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCEEEEECCCCCCEEEEE
ANANPEAGYKGVTAFLIERDFPGFAVGKKEDKIGLRASSTCELILDNCRVPRENVMGEVG
ECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCC
KGYKIAIETLNEGRIAIGAQMIGLARGALDHAVTYARERKQFGKPIGEFQGVQFDLAKMA
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHH
VEVEAARLLVYNAARLRDAGLPFLAEAAMAKYYSSEIAERVASKSIEVHGGVGITKDYPV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCH
EKLYRDAKIGRIYEGTSNIQLMTIAKKLLGK
HHHHHHHHCCEEEECCCCEEHHHHHHHHHCC
>Mature Secondary Structure 
PALENMETAPAPLTALSEEERFFQSTVRKFAREQIRPYVREMDEAAVFRKDIIQQFFTM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMGIEIPEEFGGQGGTFFQAILAVEELSAVDPSAGVIVDVQNTICNNALLRWATAEQKA
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
KYLPLLAEKMVASYALSEAGSGSDAFAMATRAEDKGDHFLLTGRKLWITNAAEAGFFLLF
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCEEEEECCCCCCEEEEE
ANANPEAGYKGVTAFLIERDFPGFAVGKKEDKIGLRASSTCELILDNCRVPRENVMGEVG
ECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHCC
KGYKIAIETLNEGRIAIGAQMIGLARGALDHAVTYARERKQFGKPIGEFQGVQFDLAKMA
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHH
VEVEAARLLVYNAARLRDAGLPFLAEAAMAKYYSSEIAERVASKSIEVHGGVGITKDYPV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCH
EKLYRDAKIGRIYEGTSNIQLMTIAKKLLGK
HHHHHHHHCCEEEECCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]