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The map label for this gene is ald2 [H]

Identifier: 116624388

GI number: 116624388

Start: 6652204

End: 6653316

Strand: Direct

Name: ald2 [H]

Synonym: Acid_5309

Alternate gene names: 116624388

Gene position: 6652204-6653316 (Clockwise)

Preceding gene: 116624387

Following gene: 116624389

Centisome position: 66.75

GC content: 63.25

Gene sequence:

>1113_bases
ATGATTATCGGCGTCCCCAAGGAAATCAAAGATCACGAAACACGTGTAGGGCTCGTGCCTAGCGGCGTTACCGCGCTGCG
CGAGGCGGGCCATGAAGTTCTGGTGGAAACCCATGCGGGCGAAGGCAGTTCGCTGCCCGATAGCGATTATCTGGAGGCGG
GCGCAAAGATTCTTTCGACCGCCGCCGAGGTTTGGCAGCGCGCCGACCTCGTCGTCAAAGTGAAGGAACCGCAGAAAACC
GAGTACGCGTTCTTCCGGCCCAACCTGACGCTGTTCACCTATCTGCACCTGGCTCCGCTGCCCGAGCTGACGGAAAAACT
GCTGGCTACCAAAGTCAACGGCGTGGCCTACGAAACCATCCGCGAGAAGGACGGCTCCCTGCCGCTGTTGACGCCGATGA
GCGAAGTCGCCGGGCGCATGAGCGTGCAGGTGGGAGCGCAATACCTGGAGCGCCCGAGCGGCGGGCGTGGAATCCTGCTG
GGCGGCGTGCCCGGTGTGGCTCCCGGGAATGTGGTCATCCTGGGCGGCGGGATCGTCGGCACCAATGCAGCGAAGATGGC
GATCGGCATGGGCGCGCACGTGACCATCATCGATCGCAGCCTGAACCGGCTGCGCGAGCTCGACGATATCTTCAATGGCT
ACGCCGTCACGCTCGCCTCCAATGCGTGGACCATCAGCGAAAACCTGAAGACGGCCGACTTGGTGGTGGGCGCGGTACTG
ATTCCGGGCGCTTCGGCGCCGCGGTTGGTGCGGCGCGAAATGATCTCGAAGATGAAGCCCGGTTCCGTGGTCGTCGATGT
CGCGATCGATCAGGGCGGCTGCTTCGAGACCTCGCACGCCACCACCCACACCGAACCGATCTATTTCGTCGATGGCGTGC
TTCACTACTGCGTCAGCAATATGCCGGCCGCGGTGCCGCACACCTCCACCTTCGCACTGACTAACGCGACCTTCCCGTAC
CTCCTGGAACTGGCGAATCACGGACTCGAAGGCGCCTGCGAGCGGCATGCCGCGCTTCGCGAAGGCGTCAACACTTACAA
CGGCTACATCACCTATAAAGGCGTGGCCGAATCCCAGGGGCGCCAGTGGCGCGCCCTGGCGAGCGTGGGGTAA

Upstream 100 bases:

>100_bases
GGAGCAAGATACAGCTATATAGGGCGGGGCGCGAATTCTTCGCGGGAATACAAATTCCCACAGCATCGTGGTGTTAACCT
AATCTCGGAGAAGCGGCACA

Downstream 100 bases:

>100_bases
ACGATGCCGGCACTCGAGAATATGGAAACGGCGCCCGCGCCGTTGACCGCCCTCAGCGAGGAAGAGCGATTCTTCCAGAG
CACGGTGCGCAAATTCGCGC

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIIGVPKEIKDHETRVGLVPSGVTALREAGHEVLVETHAGEGSSLPDSDYLEAGAKILSTAAEVWQRADLVVKVKEPQKT
EYAFFRPNLTLFTYLHLAPLPELTEKLLATKVNGVAYETIREKDGSLPLLTPMSEVAGRMSVQVGAQYLERPSGGRGILL
GGVPGVAPGNVVILGGGIVGTNAAKMAIGMGAHVTIIDRSLNRLRELDDIFNGYAVTLASNAWTISENLKTADLVVGAVL
IPGASAPRLVRREMISKMKPGSVVVDVAIDQGGCFETSHATTHTEPIYFVDGVLHYCVSNMPAAVPHTSTFALTNATFPY
LLELANHGLEGACERHAALREGVNTYNGYITYKGVAESQGRQWRALASVG

Sequences:

>Translated_370_residues
MIIGVPKEIKDHETRVGLVPSGVTALREAGHEVLVETHAGEGSSLPDSDYLEAGAKILSTAAEVWQRADLVVKVKEPQKT
EYAFFRPNLTLFTYLHLAPLPELTEKLLATKVNGVAYETIREKDGSLPLLTPMSEVAGRMSVQVGAQYLERPSGGRGILL
GGVPGVAPGNVVILGGGIVGTNAAKMAIGMGAHVTIIDRSLNRLRELDDIFNGYAVTLASNAWTISENLKTADLVVGAVL
IPGASAPRLVRREMISKMKPGSVVVDVAIDQGGCFETSHATTHTEPIYFVDGVLHYCVSNMPAAVPHTSTFALTNATFPY
LLELANHGLEGACERHAALREGVNTYNGYITYKGVAESQGRQWRALASVG
>Mature_370_residues
MIIGVPKEIKDHETRVGLVPSGVTALREAGHEVLVETHAGEGSSLPDSDYLEAGAKILSTAAEVWQRADLVVKVKEPQKT
EYAFFRPNLTLFTYLHLAPLPELTEKLLATKVNGVAYETIREKDGSLPLLTPMSEVAGRMSVQVGAQYLERPSGGRGILL
GGVPGVAPGNVVILGGGIVGTNAAKMAIGMGAHVTIIDRSLNRLRELDDIFNGYAVTLASNAWTISENLKTADLVVGAVL
IPGASAPRLVRREMISKMKPGSVVVDVAIDQGGCFETSHATTHTEPIYFVDGVLHYCVSNMPAAVPHTSTFALTNATFPY
LLELANHGLEGACERHAALREGVNTYNGYITYKGVAESQGRQWRALASVG

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=331, Percent_Identity=33.5347432024169, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI122939153, Length=331, Percent_Identity=33.5347432024169, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1787887, Length=335, Percent_Identity=32.2388059701493, Blast_Score=131, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17550456, Length=344, Percent_Identity=30.2325581395349, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39465; Mature: 39465

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGVPKEIKDHETRVGLVPSGVTALREAGHEVLVETHAGEGSSLPDSDYLEAGAKILST
CEECCCCHHCCCCCEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AAEVWQRADLVVKVKEPQKTEYAFFRPNLTLFTYLHLAPLPELTEKLLATKVNGVAYETI
HHHHHHCCCEEEEECCCCCCCEEEECCCCEEEEHHHHCCCHHHHHHHHHHHCCCEEHHHH
REKDGSLPLLTPMSEVAGRMSVQVGAQYLERPSGGRGILLGGVPGVAPGNVVILGGGIVG
HHCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCEEC
TNAAKMAIGMGAHVTIIDRSLNRLRELDDIFNGYAVTLASNAWTISENLKTADLVVGAVL
CCCHHHEECCCCEEEEEHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCHHHHHEEHEE
IPGASAPRLVRREMISKMKPGSVVVDVAIDQGGCFETSHATTHTEPIYFVDGVLHYCVSN
ECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPAAVPHTSTFALTNATFPYLLELANHGLEGACERHAALREGVNTYNGYITYKGVAESQG
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
RQWRALASVG
CCEEHHCCCC
>Mature Secondary Structure
MIIGVPKEIKDHETRVGLVPSGVTALREAGHEVLVETHAGEGSSLPDSDYLEAGAKILST
CEECCCCHHCCCCCEEEECCCCHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AAEVWQRADLVVKVKEPQKTEYAFFRPNLTLFTYLHLAPLPELTEKLLATKVNGVAYETI
HHHHHHCCCEEEEECCCCCCCEEEECCCCEEEEHHHHCCCHHHHHHHHHHHCCCEEHHHH
REKDGSLPLLTPMSEVAGRMSVQVGAQYLERPSGGRGILLGGVPGVAPGNVVILGGGIVG
HHCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCEEC
TNAAKMAIGMGAHVTIIDRSLNRLRELDDIFNGYAVTLASNAWTISENLKTADLVVGAVL
CCCHHHEECCCCEEEEEHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCHHHHHEEHEE
IPGASAPRLVRREMISKMKPGSVVVDVAIDQGGCFETSHATTHTEPIYFVDGVLHYCVSN
ECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHC
MPAAVPHTSTFALTNATFPYLLELANHGLEGACERHAALREGVNTYNGYITYKGVAESQG
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
RQWRALASVG
CCEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA