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The map label for this gene is ahcY

Identifier: 116624353

GI number: 116624353

Start: 6610630

End: 6612057

Strand: Direct

Name: ahcY

Synonym: Acid_5273

Alternate gene names: 116624353

Gene position: 6610630-6612057 (Clockwise)

Preceding gene: 116624351

Following gene: 116624354

Centisome position: 66.33

GC content: 61.13

Gene sequence:

>1428_bases
ATGGGCACCGCAACCGAAAAACTCTCCGACGCCACATTTAAAGTGGCCGACCTTTCGCTGGCCGAATGGGGACGCAAGGA
AATCTCCGTCTCCGAATTCGAAATGCCGGGCCTGATGGCGATCCGCCGCAAGTACGCCAAGGAAAAGCCCCTCGCCGGCG
TGCGCATCACCGGGTCGCTCCACATGACCATTCAGACCGCCGTGCTCATTGAGACGCTGGTCGATCTCGGCGCCAGCGTG
CGCTGGGCGAGTTGCAACATCTTCTCCACGCAGGATCACGCCGCGGCCGCGATCGCCAAGGCCGGCGTGCCCGTGTTCGC
CTGGAAGGGCGAGAGCCTCGAAGAATACTGGTGGTGTACCCTGCAGGCCGTGACTCATCCCGGCGGCAAAGGCCCGCAGC
TGGTAGTGGACGATGGCGGCGACGTGACGCTGCTCATCCACAAAGGCTACGAGCTGGAAAATGGCAGCGACTGGGTCAAC
ACTCCCTCGGGAAGCCACGAAGAAAAGGTCATCAAAGACCTGCTCAAACAGGTGCACGCGGAAGATCCCCAGCGCTGGCA
CAAAATGGTCGCGGAGTGGCGCGGCGTCAGTGAAGAGACCACCACCGGAGTTCACCGCCTGTACAAGATGCAGGAGCAGG
GCAAGCTGCTGGTGCCCGCGATCAACGTCAACGATTCCGTCACCAAGAGCAAGTTCGACAACCTGTACGGCTGCCGTGAA
TCGCTGGCCGACGGCATCAAGCGCGCCACCGACGTCATGGTGGCCGGCAAGGTCGCCGTCATCTGCGGCTACGGCGACGT
GGGCAAGGGCTCGGCGCATTCGCTGCGCGGCATGGGCGCGCGCGTGATCGTCACTGAGATCGACCCCATCAACGCCCTGC
AGGCCGCGATGGAAGGCTTCGAAGTCACCACGATCGAAGACACGCTCGGCCGCGGCGATATCTACGTCACCTGCACCGGC
AACTGCGAGATCATCACGCTGGAACACATGCGCCTGATGAAGGACCAGGCCATCGTCTGCAACATCGGCCACTTCGACAA
CGAAATCCAAATGGACCGACTCAATGAGAGCGACGCCAAGCGTCTGCAGATTAAACCGCAGGTGGACATGTACACCTTTC
CCGGCGGCAGCAGCATCTTCATCCTCGCCGAAGGCCGCCTGGTCAACCTGGGCTGCGCCACCGGCCACCCTAGTTTCGTG
ATGAGCAACAGCTTCGCGAACCAGACGCTGGCTCAGCTGGATCTGTGGAAGAATAAGGATACATACAAGGTTGGGGTTTA
CACACTTCCCAAGAAACTGGACGAGGAAGTGGCACGCCTTCACCTGGAGAAAATCGGCGTGAAGCTCACGACGCTGACGC
CCGCGCAGGCCGAATACCTCGGTGTGCCGGTCGAGGGGCCGTACAAGCCCGATCATTATCGGTACTAA

Upstream 100 bases:

>100_bases
TGCCAGCCGCAGCGATTTCAGGATTGACGCCATAGGTCCAAAGGGTCTAATATCAATCTATCAAGATTTATTGATACGAG
GGAATAAAAGAAAATCGATT

Downstream 100 bases:

>100_bases
TAGTCAGGAACTGGAGAAATAACCTTGGCAGACACTCAAAGACATATCTTCACCTCGGAATCGGTGACCGAAGGCCACCC
CGACAAAATTGCCGACCAGA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MGTATEKLSDATFKVADLSLAEWGRKEISVSEFEMPGLMAIRRKYAKEKPLAGVRITGSLHMTIQTAVLIETLVDLGASV
RWASCNIFSTQDHAAAAIAKAGVPVFAWKGESLEEYWWCTLQAVTHPGGKGPQLVVDDGGDVTLLIHKGYELENGSDWVN
TPSGSHEEKVIKDLLKQVHAEDPQRWHKMVAEWRGVSEETTTGVHRLYKMQEQGKLLVPAINVNDSVTKSKFDNLYGCRE
SLADGIKRATDVMVAGKVAVICGYGDVGKGSAHSLRGMGARVIVTEIDPINALQAAMEGFEVTTIEDTLGRGDIYVTCTG
NCEIITLEHMRLMKDQAIVCNIGHFDNEIQMDRLNESDAKRLQIKPQVDMYTFPGGSSIFILAEGRLVNLGCATGHPSFV
MSNSFANQTLAQLDLWKNKDTYKVGVYTLPKKLDEEVARLHLEKIGVKLTTLTPAQAEYLGVPVEGPYKPDHYRY

Sequences:

>Translated_475_residues
MGTATEKLSDATFKVADLSLAEWGRKEISVSEFEMPGLMAIRRKYAKEKPLAGVRITGSLHMTIQTAVLIETLVDLGASV
RWASCNIFSTQDHAAAAIAKAGVPVFAWKGESLEEYWWCTLQAVTHPGGKGPQLVVDDGGDVTLLIHKGYELENGSDWVN
TPSGSHEEKVIKDLLKQVHAEDPQRWHKMVAEWRGVSEETTTGVHRLYKMQEQGKLLVPAINVNDSVTKSKFDNLYGCRE
SLADGIKRATDVMVAGKVAVICGYGDVGKGSAHSLRGMGARVIVTEIDPINALQAAMEGFEVTTIEDTLGRGDIYVTCTG
NCEIITLEHMRLMKDQAIVCNIGHFDNEIQMDRLNESDAKRLQIKPQVDMYTFPGGSSIFILAEGRLVNLGCATGHPSFV
MSNSFANQTLAQLDLWKNKDTYKVGVYTLPKKLDEEVARLHLEKIGVKLTTLTPAQAEYLGVPVEGPYKPDHYRY
>Mature_474_residues
GTATEKLSDATFKVADLSLAEWGRKEISVSEFEMPGLMAIRRKYAKEKPLAGVRITGSLHMTIQTAVLIETLVDLGASVR
WASCNIFSTQDHAAAAIAKAGVPVFAWKGESLEEYWWCTLQAVTHPGGKGPQLVVDDGGDVTLLIHKGYELENGSDWVNT
PSGSHEEKVIKDLLKQVHAEDPQRWHKMVAEWRGVSEETTTGVHRLYKMQEQGKLLVPAINVNDSVTKSKFDNLYGCRES
LADGIKRATDVMVAGKVAVICGYGDVGKGSAHSLRGMGARVIVTEIDPINALQAAMEGFEVTTIEDTLGRGDIYVTCTGN
CEIITLEHMRLMKDQAIVCNIGHFDNEIQMDRLNESDAKRLQIKPQVDMYTFPGGSSIFILAEGRLVNLGCATGHPSFVM
SNSFANQTLAQLDLWKNKDTYKVGVYTLPKKLDEEVARLHLEKIGVKLTTLTPAQAEYLGVPVEGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=463, Percent_Identity=61.5550755939525, Blast_Score=556, Evalue=1e-158,
Organism=Homo sapiens, GI239937451, Length=441, Percent_Identity=61.9047619047619, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=47.8448275862069, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=47.8448275862069, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=47.8448275862069, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=47.8448275862069, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI21361647, Length=472, Percent_Identity=46.3983050847458, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17506425, Length=470, Percent_Identity=61.4893617021277, Blast_Score=569, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=57.8288100208768, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24642172, Length=468, Percent_Identity=61.965811965812, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24656245, Length=454, Percent_Identity=47.3568281938326, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=47.732181425486, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=47.6190476190476, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_SOLUE (Q01VU1)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826509.1
- ProteinModelPortal:   Q01VU1
- SMR:   Q01VU1
- STRING:   Q01VU1
- GeneID:   4426532
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5273
- NMPDR:   fig|234267.9.peg.5004
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   YWWCTDQ
- PhylomeDB:   Q01VU1
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52312; Mature: 52181

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 63-63 BINDING 138-138 BINDING 199-199 BINDING 229-229 BINDING 233-233 BINDING 234-234 BINDING 286-286 BINDING 321-321 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTATEKLSDATFKVADLSLAEWGRKEISVSEFEMPGLMAIRRKYAKEKPLAGVRITGSL
CCCCHHHHCCCEEEEEECCHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEECEE
HMTIQTAVLIETLVDLGASVRWASCNIFSTQDHAAAAIAKAGVPVFAWKGESLEEYWWCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCCHHEEEE
LQAVTHPGGKGPQLVVDDGGDVTLLIHKGYELENGSDWVNTPSGSHEEKVIKDLLKQVHA
EEEEECCCCCCCEEEEECCCCEEEEEECCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
EDPQRWHKMVAEWRGVSEETTTGVHRLYKMQEQGKLLVPAINVNDSVTKSKFDNLYGCRE
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
SLADGIKRATDVMVAGKVAVICGYGDVGKGSAHSLRGMGARVIVTEIDPINALQAAMEGF
HHHHHHHHHHHEEEECCEEEEECCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHCCC
EVTTIEDTLGRGDIYVTCTGNCEIITLEHMRLMKDQAIVCNIGHFDNEIQMDRLNESDAK
EEEEEHHCCCCCCEEEEEECCEEEEEHHHHHHHCCCEEEEECCCCCCEEEHHHCCCCCCC
RLQIKPQVDMYTFPGGSSIFILAEGRLVNLGCATGHPSFVMSNSFANQTLAQLDLWKNKD
EEEECCCEEEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCC
TYKVGVYTLPKKLDEEVARLHLEKIGVKLTTLTPAQAEYLGVPVEGPYKPDHYRY
CEEEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCCHHHEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GTATEKLSDATFKVADLSLAEWGRKEISVSEFEMPGLMAIRRKYAKEKPLAGVRITGSL
CCCHHHHCCCEEEEEECCHHHCCCCCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEECEE
HMTIQTAVLIETLVDLGASVRWASCNIFSTQDHAAAAIAKAGVPVFAWKGESLEEYWWCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCCCHHEEEE
LQAVTHPGGKGPQLVVDDGGDVTLLIHKGYELENGSDWVNTPSGSHEEKVIKDLLKQVHA
EEEEECCCCCCCEEEEECCCCEEEEEECCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
EDPQRWHKMVAEWRGVSEETTTGVHRLYKMQEQGKLLVPAINVNDSVTKSKFDNLYGCRE
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
SLADGIKRATDVMVAGKVAVICGYGDVGKGSAHSLRGMGARVIVTEIDPINALQAAMEGF
HHHHHHHHHHHEEEECCEEEEECCCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHCCC
EVTTIEDTLGRGDIYVTCTGNCEIITLEHMRLMKDQAIVCNIGHFDNEIQMDRLNESDAK
EEEEEHHCCCCCCEEEEEECCEEEEEHHHHHHHCCCEEEEECCCCCCEEEHHHCCCCCCC
RLQIKPQVDMYTFPGGSSIFILAEGRLVNLGCATGHPSFVMSNSFANQTLAQLDLWKNKD
EEEECCCEEEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCC
TYKVGVYTLPKKLDEEVARLHLEKIGVKLTTLTPAQAEYLGVPVEGPYKPDHYRY
CEEEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCCHHHEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA