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The map label for this gene is purC [H]

Identifier: 116624332

GI number: 116624332

Start: 6588510

End: 6589445

Strand: Direct

Name: purC [H]

Synonym: Acid_5250

Alternate gene names: 116624332

Gene position: 6588510-6589445 (Clockwise)

Preceding gene: 116624331

Following gene: 116624333

Centisome position: 66.11

GC content: 60.68

Gene sequence:

>936_bases
TTGAGTTACTCCCCCGATGAAAACGCGAAGGCAAGATTGGCTCTGACAAAAAACCCTGTCATTTTGGAAACCGACCTCGC
GGGCGTCGTGCGTCATGCGCGCGGCAAGGTGCGAGACGTATACAGCGTGGACAACCGGCTGCTCATCGTCGCCACCGATC
GGATCTCGGCGTTCGACTACATTCTGAAAAGCGGCATTCCCGATAAGGGACGCGTGCTGACGCAGCTCTCGCTATTCTGG
TTCGATTTTCTGCGCGACGTAGTGCCGAATCATTTTCTAACCGCGCGTGTGGACGAGTATCCGGCGCCGCTGCCCGAGTT
CCGCGATCAGCTCGAAGGGCGTTCGATGCTGGTCAAGCGCGCGCAGATGATCGACATCGAGTGCGTGGCGCGGGGATACC
TTTCCGGTTCCGGCTGGAAGGAATATCGCGAGCGCGGCACCGTGTGTGGAATCGCGCTGCCCGCGGGGTTGCGCGAAAGC
GACAAGCTGCCCGAGCCCATCTTCACTCCGGCGACCAAGGCGCAGAGCGGCCACGATGAAAACGTCAGCTTCGCGCATGT
GGTCTCACTGATCGGCGAGTCCCTGGCGGCGCGCCTGCGCGATCTCACGCTTGAGATTTACAAACGAGCTTCGCGGTACG
CGGAGACACGCGGCGTCATCATCGCCGACACCAAGTTCGAGTTTGGCTTCGCCGGCGAGGAACTGCTGTTGGGCGACGAA
GTGCTGACGCCGGACTCTTCGCGCTTCTGGCCCGCCGACACCTATAAGCCAGGCGGTGCGCAGTTCAGTTTCGACAAGCA
ATTCGTTCGCGACTACCTGGAATCGATCCAGTGGAACAAGCAGCCGCCGGCTCCCGCCTTGCCTGACGAGGTCGCCGAAA
AGACCAGCGAGAAATATCGCGAAGCCTTCCGCATCCTGACCGGCCACAGCTTATGA

Upstream 100 bases:

>100_bases
CCAGATTAGATCGACAGGCCGGGAGGGCCGGGAGGCCTGTCCCACTGAAACATAACCTTCCGATCTCGTGAATTGACAAC
ACGGTGATAAGGGTTATCAT

Downstream 100 bases:

>100_bases
ACTGGCTGGATATCGTGCTGGCAGTCATCCTGCTGGCCTGCATTGTCGGAGGATTTCGCCGCGGCCTGTCGCGCCAGGTG
ATCGGACTGGTGTCCGGTCT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSYSPDENAKARLALTKNPVILETDLAGVVRHARGKVRDVYSVDNRLLIVATDRISAFDYILKSGIPDKGRVLTQLSLFW
FDFLRDVVPNHFLTARVDEYPAPLPEFRDQLEGRSMLVKRAQMIDIECVARGYLSGSGWKEYRERGTVCGIALPAGLRES
DKLPEPIFTPATKAQSGHDENVSFAHVVSLIGESLAARLRDLTLEIYKRASRYAETRGVIIADTKFEFGFAGEELLLGDE
VLTPDSSRFWPADTYKPGGAQFSFDKQFVRDYLESIQWNKQPPAPALPDEVAEKTSEKYREAFRILTGHSL

Sequences:

>Translated_311_residues
MSYSPDENAKARLALTKNPVILETDLAGVVRHARGKVRDVYSVDNRLLIVATDRISAFDYILKSGIPDKGRVLTQLSLFW
FDFLRDVVPNHFLTARVDEYPAPLPEFRDQLEGRSMLVKRAQMIDIECVARGYLSGSGWKEYRERGTVCGIALPAGLRES
DKLPEPIFTPATKAQSGHDENVSFAHVVSLIGESLAARLRDLTLEIYKRASRYAETRGVIIADTKFEFGFAGEELLLGDE
VLTPDSSRFWPADTYKPGGAQFSFDKQFVRDYLESIQWNKQPPAPALPDEVAEKTSEKYREAFRILTGHSL
>Mature_310_residues
SYSPDENAKARLALTKNPVILETDLAGVVRHARGKVRDVYSVDNRLLIVATDRISAFDYILKSGIPDKGRVLTQLSLFWF
DFLRDVVPNHFLTARVDEYPAPLPEFRDQLEGRSMLVKRAQMIDIECVARGYLSGSGWKEYRERGTVCGIALPAGLRESD
KLPEPIFTPATKAQSGHDENVSFAHVVSLIGESLAARLRDLTLEIYKRASRYAETRGVIIADTKFEFGFAGEELLLGDEV
LTPDSSRFWPADTYKPGGAQFSFDKQFVRDYLESIQWNKQPPAPALPDEVAEKTSEKYREAFRILTGHSL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=225, Percent_Identity=28.4444444444444, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=49, Blast_Score=279, Evalue=5e-76,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 34990; Mature: 34859

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSPDENAKARLALTKNPVILETDLAGVVRHARGKVRDVYSVDNRLLIVATDRISAFDY
CCCCCCCCCCEEEEEECCCEEEECHHHHHHHHHHCHHHHHHCCCCEEEEEECCCHHHHHH
ILKSGIPDKGRVLTQLSLFWFDFLRDVVPNHFLTARVDEYPAPLPEFRDQLEGRSMLVKR
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCHHHHHHHH
AQMIDIECVARGYLSGSGWKEYRERGTVCGIALPAGLRESDKLPEPIFTPATKAQSGHDE
HHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NVSFAHVVSLIGESLAARLRDLTLEIYKRASRYAETRGVIIADTKFEFGFAGEELLLGDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCEEEECCC
VLTPDSSRFWPADTYKPGGAQFSFDKQFVRDYLESIQWNKQPPAPALPDEVAEKTSEKYR
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EAFRILTGHSL
HHHHHHHCCCC
>Mature Secondary Structure 
SYSPDENAKARLALTKNPVILETDLAGVVRHARGKVRDVYSVDNRLLIVATDRISAFDY
CCCCCCCCCEEEEEECCCEEEECHHHHHHHHHHCHHHHHHCCCCEEEEEECCCHHHHHH
ILKSGIPDKGRVLTQLSLFWFDFLRDVVPNHFLTARVDEYPAPLPEFRDQLEGRSMLVKR
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCHHHHHHHH
AQMIDIECVARGYLSGSGWKEYRERGTVCGIALPAGLRESDKLPEPIFTPATKAQSGHDE
HHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NVSFAHVVSLIGESLAARLRDLTLEIYKRASRYAETRGVIIADTKFEFGFAGEELLLGDE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCEEEECCC
VLTPDSSRFWPADTYKPGGAQFSFDKQFVRDYLESIQWNKQPPAPALPDEVAEKTSEKYR
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EAFRILTGHSL
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA