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The map label for this gene is mtaD1 [H]

Identifier: 116624317

GI number: 116624317

Start: 6569130

End: 6570515

Strand: Direct

Name: mtaD1 [H]

Synonym: Acid_5235

Alternate gene names: 116624317

Gene position: 6569130-6570515 (Clockwise)

Preceding gene: 116624316

Following gene: 116624318

Centisome position: 65.92

GC content: 63.35

Gene sequence:

>1386_bases
ATGTATCGTATCTGTAGCTTTTTCCTCTTCGCGCTGGCACTGGCCGCGCAAGCGCCAAGTCAATCGGCGGACCTGATCTG
GAGTGCGCGCTATGTAATCACGATGGACGCGCAGCGGCGCGTGATCGAGAACGGCGCGATCGCAATCCGGGGCGATCGTA
TCGTGGGCGTGGGCACCAGGGCAGAGATCGATGCGCGCTTCCAGGCGAAGCAGCGGCTCGACCGTCCGGATGCGATCATC
GCGCCGGGGCTGATTAACACTCACACGCACGCGGCGATGAGCCTGTTCCGGGGCATCGCGGACGATTTGACGCTGCAGGA
CTGGCTGACGAAGTACATCTTCCCGGCGGAGGCTAAGAATGTCACGCCGGATTTCGTGCGCTGGGGAACGCGGCTGGGCT
GCCTGGAAATGCTGCTCAGCGGGACCACAACGTACACCGATATGTACTATTTCGAGGACGTAGTGGCGGAGGCGACCAAA
GAGGCGGGAATGCGCGGCGTGCTCGGGGAGACCATCATTGGCTTCCCGGTGTCGGACAACAAGGCGCCGGCGGACGCACT
GGCTTACACCGAGCGATTTTTGAAGCGATTCCAGAACGATCCGCTGATTGTGGCCGCGGTGGCGCCGCACGCGCTGTACA
CGAATTCCGACGAGACGCTAAAGGCGTCGCGCGCGCTGGCCAATAAGTATCAAGCTCCGCTGGTGATCCACCTCTCCGAG
ACGAAGAAGGAGAACGACGACGAGCAGGCGAAGCGGCACACCTCGCCTACCAAGACGCTGGATGACCTGGGCGTGTGGAA
CGGGCGCTCGGTGGCGGCGCACGGAGTGTGGGTGAGCGAGGCGGATATGGCGATTCTGAAGGCGCGCGGCGTGGGCGTGG
CGCATTGCCCCTCGAGCAATATGAAGCTGGCGAGCGGAGTGGCGCCGGTGACGCGGATGCTGGCGCTCGATATAAACGTG
GGGCTCGGACCGGATGGTCCGGCGGGCAGCAACAACGACTTCAATTTGTTCGAAGAGATGGATCTGGCGGCGAAACTGCA
GAAGGTGACCACGATGAATCCGCAGGCGCTGCCGGCGTCGCAGGCGCTCGAGATGGCGACGATCCGCGGGGCGCGGGCGC
TGGGCATGGAGAAGGAGATCGGGTCGCTCGAGGTGGGCAAGCGCGCGGATGTGATCACGGTGCGGATCGACAGCGCGCAT
GGGCAGCCGCTGTACGACGCGGTTTCGCAGATGGTGTACGCGCTCAAAGGCTCCGACGTGCGGGACGTGATGGTGAACGG
CAGGCCGCTGGTGAAGGACGGGAAGAGCCTCACGCTCAATGAGCAGGCGATTTTGCAGAAGGCCGCGGAGTATAGGGCGA
AGGTCAGCGCGTCGCTGAAGAATTGA

Upstream 100 bases:

>100_bases
ATTCTCTGGGAGTTTTGCGGAGATATCGAGCTGGTGCTGGCAAACCTCAGCGGCAAAACCGAAACCTATCATTTGAAAGA
GCTGTTCCCCAAACCCTTCG

Downstream 100 bases:

>100_bases
GGGCGGTCCCACACGGCCGCGGCTGGGTGAACGCGGCGTATCGGGACGCCGGCTGACAGCCGGCGGCAGCCAGGATTGGC
GGGCACCACCAGGCGGCAAG

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase 1 [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MYRICSFFLFALALAAQAPSQSADLIWSARYVITMDAQRRVIENGAIAIRGDRIVGVGTRAEIDARFQAKQRLDRPDAII
APGLINTHTHAAMSLFRGIADDLTLQDWLTKYIFPAEAKNVTPDFVRWGTRLGCLEMLLSGTTTYTDMYYFEDVVAEATK
EAGMRGVLGETIIGFPVSDNKAPADALAYTERFLKRFQNDPLIVAAVAPHALYTNSDETLKASRALANKYQAPLVIHLSE
TKKENDDEQAKRHTSPTKTLDDLGVWNGRSVAAHGVWVSEADMAILKARGVGVAHCPSSNMKLASGVAPVTRMLALDINV
GLGPDGPAGSNNDFNLFEEMDLAAKLQKVTTMNPQALPASQALEMATIRGARALGMEKEIGSLEVGKRADVITVRIDSAH
GQPLYDAVSQMVYALKGSDVRDVMVNGRPLVKDGKSLTLNEQAILQKAAEYRAKVSASLKN

Sequences:

>Translated_461_residues
MYRICSFFLFALALAAQAPSQSADLIWSARYVITMDAQRRVIENGAIAIRGDRIVGVGTRAEIDARFQAKQRLDRPDAII
APGLINTHTHAAMSLFRGIADDLTLQDWLTKYIFPAEAKNVTPDFVRWGTRLGCLEMLLSGTTTYTDMYYFEDVVAEATK
EAGMRGVLGETIIGFPVSDNKAPADALAYTERFLKRFQNDPLIVAAVAPHALYTNSDETLKASRALANKYQAPLVIHLSE
TKKENDDEQAKRHTSPTKTLDDLGVWNGRSVAAHGVWVSEADMAILKARGVGVAHCPSSNMKLASGVAPVTRMLALDINV
GLGPDGPAGSNNDFNLFEEMDLAAKLQKVTTMNPQALPASQALEMATIRGARALGMEKEIGSLEVGKRADVITVRIDSAH
GQPLYDAVSQMVYALKGSDVRDVMVNGRPLVKDGKSLTLNEQAILQKAAEYRAKVSASLKN
>Mature_461_residues
MYRICSFFLFALALAAQAPSQSADLIWSARYVITMDAQRRVIENGAIAIRGDRIVGVGTRAEIDARFQAKQRLDRPDAII
APGLINTHTHAAMSLFRGIADDLTLQDWLTKYIFPAEAKNVTPDFVRWGTRLGCLEMLLSGTTTYTDMYYFEDVVAEATK
EAGMRGVLGETIIGFPVSDNKAPADALAYTERFLKRFQNDPLIVAAVAPHALYTNSDETLKASRALANKYQAPLVIHLSE
TKKENDDEQAKRHTSPTKTLDDLGVWNGRSVAAHGVWVSEADMAILKARGVGVAHCPSSNMKLASGVAPVTRMLALDINV
GLGPDGPAGSNNDFNLFEEMDLAAKLQKVTTMNPQALPASQALEMATIRGARALGMEKEIGSLEVGKRADVITVRIDSAH
GQPLYDAVSQMVYALKGSDVRDVMVNGRPLVKDGKSLTLNEQAILQKAAEYRAKVSASLKN

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=383, Percent_Identity=27.154046997389, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789249, Length=365, Percent_Identity=25.4794520547945, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=425, Percent_Identity=25.1764705882353, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=331, Percent_Identity=27.7945619335347, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643849, Length=383, Percent_Identity=27.9373368146214, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50122; Mature: 50122

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRICSFFLFALALAAQAPSQSADLIWSARYVITMDAQRRVIENGAIAIRGDRIVGVGTR
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCHHHHHHCCCEEEECCEEEECCCC
AEIDARFQAKQRLDRPDAIIAPGLINTHTHAAMSLFRGIADDLTLQDWLTKYIFPAEAKN
CCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
VTPDFVRWGTRLGCLEMLLSGTTTYTDMYYFEDVVAEATKEAGMRGVLGETIIGFPVSDN
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
KAPADALAYTERFLKRFQNDPLIVAAVAPHALYTNSDETLKASRALANKYQAPLVIHLSE
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHCCCCEEEEECC
TKKENDDEQAKRHTSPTKTLDDLGVWNGRSVAAHGVWVSEADMAILKARGVGVAHCPSSN
CCCCCCHHHHHHCCCCCCCHHHCCCCCCCCEEECCEEECCCCCHHHHCCCCCEEECCCCC
MKLASGVAPVTRMLALDINVGLGPDGPAGSNNDFNLFEEMDLAAKLQKVTTMNPQALPAS
CCHHCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHH
QALEMATIRGARALGMEKEIGSLEVGKRADVITVRIDSAHGQPLYDAVSQMVYALKGSDV
HHHHHHHHCCHHHCCCHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
RDVMVNGRPLVKDGKSLTLNEQAILQKAAEYRAKVSASLKN
HEEEECCCEEECCCCCEEECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYRICSFFLFALALAAQAPSQSADLIWSARYVITMDAQRRVIENGAIAIRGDRIVGVGTR
CHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCHHHHHHCCCEEEECCEEEECCCC
AEIDARFQAKQRLDRPDAIIAPGLINTHTHAAMSLFRGIADDLTLQDWLTKYIFPAEAKN
CCHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
VTPDFVRWGTRLGCLEMLLSGTTTYTDMYYFEDVVAEATKEAGMRGVLGETIIGFPVSDN
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
KAPADALAYTERFLKRFQNDPLIVAAVAPHALYTNSDETLKASRALANKYQAPLVIHLSE
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHCCCCEEEEECC
TKKENDDEQAKRHTSPTKTLDDLGVWNGRSVAAHGVWVSEADMAILKARGVGVAHCPSSN
CCCCCCHHHHHHCCCCCCCHHHCCCCCCCCEEECCEEECCCCCHHHHCCCCCEEECCCCC
MKLASGVAPVTRMLALDINVGLGPDGPAGSNNDFNLFEEMDLAAKLQKVTTMNPQALPAS
CCHHCCHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHH
QALEMATIRGARALGMEKEIGSLEVGKRADVITVRIDSAHGQPLYDAVSQMVYALKGSDV
HHHHHHHHCCHHHCCCHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
RDVMVNGRPLVKDGKSLTLNEQAILQKAAEYRAKVSASLKN
HEEEECCCEEECCCCCEEECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA