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The map label for this gene is hemY [H]

Identifier: 116624286

GI number: 116624286

Start: 6530697

End: 6532073

Strand: Direct

Name: hemY [H]

Synonym: Acid_5204

Alternate gene names: 116624286

Gene position: 6530697-6532073 (Clockwise)

Preceding gene: 116624285

Following gene: 116624287

Centisome position: 65.53

GC content: 66.3

Gene sequence:

>1377_bases
ATGCCTCGCGTAGTCATCGTCGGTGGAGGCATTTCCGGTCTTTCCGCGGCGTATTATCTGGCGAAGGGCGGAGTCTCCTC
CACCATCATCGAATCGCGGCCGCGCCTGGGCGGCGTGATCCAGACCGAGCGCATCGAAGACTGCACGATCGAAGCTGGAC
CGGACAGTTTTCTCTCGGTGAAACCCGCCGCGCTCGACCTGATCCGCGATCTCGGCCTCGCGGATGACGTGATCGGGTCC
AACGACCATCTGCGCATCACCTACGTCCGTAAAGGGGGCCGCCTCGTGCCGCTGCCGGACGGATTGATGATGATGGTGCC
GACCAAGATCCTGCCGCTGGTGACCACCGGCCTGCTCAGCCCCGCCACCAAAATCCGCATGGGCATGGAGTTGCTGCGCG
CGCCCAAGATGAGGACGGGAGACGAGTCGGTGGCCGATTTCGTGCGTGAGCACTACGGGCAGGAGGCGGTGGATTATCTG
GCCGAACCCCTGCTGAGCGGCATCTATGGCGGCGACCCGCGCGAGCTCAGCGTCACCGCCGTGCTGCCACGCTTCGTCGA
GCTGGCCGCGAAGTATGGCAGCCTGACGCGCGGCGTGCTGGCATCACGCGCGCAAGCCCCGAAGACGCAATCCCCTGCCC
CGCTCTTCCGCACATTGAAAGGCGGACTCGGGCAGATGGTGGATGCGGTAGTGGCGTCGATTCAAGGCAAGGTCGAAATC
CGCAGCGCGCGCGCGCACTCGGTGGAGCGCACCCCCGCGGGATTCCGCCTGCAGCTCGATGGCGAGTGGATGGAGGCGGA
GCACCTGGTGATCGCGTGCGAAGCGCACAGCGGCGCGGAGTTGCTGGCCGGCGTGGACGCGCGATTGTCTGAACTGCTCG
GCATGGTCGCATACAGCTCCTCGATGACGGTGGCGGTAGGCTTCGACGCCAAGGATTTCGCGAACCTGCCGCGAGGCTTC
GGCTTCCTGGTGCCGAAGAAGGAGCGGCGCCGCCTGGTGGCCTGTACGTGGGTCGGCACCAAGTTCTCCCATCGCGTGCC
GGAAGGCAAGATCGTGGCGCGCTGCTTCCTCGGCGGCATGGAAGACGCCGGCGTGCTGGCGGAGAAGGATGAAGCGATCC
AGGCCGCGGTGCTCGACGAACTGCGCGAGATCGCCGGCGTCACCGCTCCCGCCCGGTTCACGCGCATCGCGCGCTGGCCG
CGCTCGATGGCGCAATACACCGTTGGCCACCCCGCGCGCGAAGCGGAACTCGAAGCGCGCATCGCCGAAATTCCCGGCCT
GCACGTCGCCGGCAACGCCTATCAAGGAATCGGCATCCCCGATTGCATCCGCATGGGCAAGGCCGCTGCGGGGAAGATAC
TTGGAGTGGCCCAATGA

Upstream 100 bases:

>100_bases
TCCGCGATTTCGCTGCCGCGCGCGGCATACGGATCAGGCGCCCGGAAAGCCTCAATGGCTCGCCGTTATTCACGCGGGCA
CTGGCCAAGGTAGCCGGCAC

Downstream 100 bases:

>100_bases
AATACGCCGTGGTTTTTGAGAAGGCAGCCAACAACTGGGGAACCTACGTTCCGGATCTTCCCGGGTGCATCACCACTGCT
CCAACGCTGGAGGACGCTCG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MPRVVIVGGGISGLSAAYYLAKGGVSSTIIESRPRLGGVIQTERIEDCTIEAGPDSFLSVKPAALDLIRDLGLADDVIGS
NDHLRITYVRKGGRLVPLPDGLMMMVPTKILPLVTTGLLSPATKIRMGMELLRAPKMRTGDESVADFVREHYGQEAVDYL
AEPLLSGIYGGDPRELSVTAVLPRFVELAAKYGSLTRGVLASRAQAPKTQSPAPLFRTLKGGLGQMVDAVVASIQGKVEI
RSARAHSVERTPAGFRLQLDGEWMEAEHLVIACEAHSGAELLAGVDARLSELLGMVAYSSSMTVAVGFDAKDFANLPRGF
GFLVPKKERRRLVACTWVGTKFSHRVPEGKIVARCFLGGMEDAGVLAEKDEAIQAAVLDELREIAGVTAPARFTRIARWP
RSMAQYTVGHPAREAELEARIAEIPGLHVAGNAYQGIGIPDCIRMGKAAAGKILGVAQ

Sequences:

>Translated_458_residues
MPRVVIVGGGISGLSAAYYLAKGGVSSTIIESRPRLGGVIQTERIEDCTIEAGPDSFLSVKPAALDLIRDLGLADDVIGS
NDHLRITYVRKGGRLVPLPDGLMMMVPTKILPLVTTGLLSPATKIRMGMELLRAPKMRTGDESVADFVREHYGQEAVDYL
AEPLLSGIYGGDPRELSVTAVLPRFVELAAKYGSLTRGVLASRAQAPKTQSPAPLFRTLKGGLGQMVDAVVASIQGKVEI
RSARAHSVERTPAGFRLQLDGEWMEAEHLVIACEAHSGAELLAGVDARLSELLGMVAYSSSMTVAVGFDAKDFANLPRGF
GFLVPKKERRRLVACTWVGTKFSHRVPEGKIVARCFLGGMEDAGVLAEKDEAIQAAVLDELREIAGVTAPARFTRIARWP
RSMAQYTVGHPAREAELEARIAEIPGLHVAGNAYQGIGIPDCIRMGKAAAGKILGVAQ
>Mature_457_residues
PRVVIVGGGISGLSAAYYLAKGGVSSTIIESRPRLGGVIQTERIEDCTIEAGPDSFLSVKPAALDLIRDLGLADDVIGSN
DHLRITYVRKGGRLVPLPDGLMMMVPTKILPLVTTGLLSPATKIRMGMELLRAPKMRTGDESVADFVREHYGQEAVDYLA
EPLLSGIYGGDPRELSVTAVLPRFVELAAKYGSLTRGVLASRAQAPKTQSPAPLFRTLKGGLGQMVDAVVASIQGKVEIR
SARAHSVERTPAGFRLQLDGEWMEAEHLVIACEAHSGAELLAGVDARLSELLGMVAYSSSMTVAVGFDAKDFANLPRGFG
FLVPKKERRRLVACTWVGTKFSHRVPEGKIVARCFLGGMEDAGVLAEKDEAIQAAVLDELREIAGVTAPARFTRIARWPR
SMAQYTVGHPAREAELEARIAEIPGLHVAGNAYQGIGIPDCIRMGKAAAGKILGVAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=499, Percent_Identity=27.4549098196393, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI4506001, Length=499, Percent_Identity=27.4549098196393, Blast_Score=119, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24649745, Length=463, Percent_Identity=27.2138228941685, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 48926; Mature: 48795

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVVIVGGGISGLSAAYYLAKGGVSSTIIESRPRLGGVIQTERIEDCTIEAGPDSFLSV
CCEEEEECCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCEEECCCCCCEEC
KPAALDLIRDLGLADDVIGSNDHLRITYVRKGGRLVPLPDGLMMMVPTKILPLVTTGLLS
CHHHHHHHHHCCCHHHHCCCCCCEEEEEEECCCEEEECCCCCEEHHHHHHHHHHHHHHCC
PATKIRMGMELLRAPKMRTGDESVADFVREHYGQEAVDYLAEPLLSGIYGGDPRELSVTA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEHHH
VLPRFVELAAKYGSLTRGVLASRAQAPKTQSPAPLFRTLKGGLGQMVDAVVASIQGKVEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
RSARAHSVERTPAGFRLQLDGEWMEAEHLVIACEAHSGAELLAGVDARLSELLGMVAYSS
ECHHHCCCCCCCCCEEEEECCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
SMTVAVGFDAKDFANLPRGFGFLVPKKERRRLVACTWVGTKFSHRVPEGKIVARCFLGGM
CEEEEEECCHHHHHCCCCCCEECCCCHHCCEEEEEEEECCCHHCCCCCCCEEHHHHHCCC
EDAGVLAEKDEAIQAAVLDELREIAGVTAPARFTRIARWPRSMAQYTVGHPAREAELEAR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IAEIPGLHVAGNAYQGIGIPDCIRMGKAAAGKILGVAQ
HHHCCCEEEECCCCCCCCCHHHHHHCCHHCCCEEECCC
>Mature Secondary Structure 
PRVVIVGGGISGLSAAYYLAKGGVSSTIIESRPRLGGVIQTERIEDCTIEAGPDSFLSV
CEEEEECCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCEEECCCCCCEEC
KPAALDLIRDLGLADDVIGSNDHLRITYVRKGGRLVPLPDGLMMMVPTKILPLVTTGLLS
CHHHHHHHHHCCCHHHHCCCCCCEEEEEEECCCEEEECCCCCEEHHHHHHHHHHHHHHCC
PATKIRMGMELLRAPKMRTGDESVADFVREHYGQEAVDYLAEPLLSGIYGGDPRELSVTA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEHHH
VLPRFVELAAKYGSLTRGVLASRAQAPKTQSPAPLFRTLKGGLGQMVDAVVASIQGKVEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
RSARAHSVERTPAGFRLQLDGEWMEAEHLVIACEAHSGAELLAGVDARLSELLGMVAYSS
ECHHHCCCCCCCCCEEEEECCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
SMTVAVGFDAKDFANLPRGFGFLVPKKERRRLVACTWVGTKFSHRVPEGKIVARCFLGGM
CEEEEEECCHHHHHCCCCCCEECCCCHHCCEEEEEEEECCCHHCCCCCCCEEHHHHHCCC
EDAGVLAEKDEAIQAAVLDELREIAGVTAPARFTRIARWPRSMAQYTVGHPAREAELEAR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IAEIPGLHVAGNAYQGIGIPDCIRMGKAAAGKILGVAQ
HHHCCCEEEECCCCCCCCCHHHHHHCCHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]