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The map label for this gene is zraR [H]

Identifier: 116624238

GI number: 116624238

Start: 6480707

End: 6482365

Strand: Direct

Name: zraR [H]

Synonym: Acid_5155

Alternate gene names: 116624238

Gene position: 6480707-6482365 (Clockwise)

Preceding gene: 116624235

Following gene: 116624240

Centisome position: 65.03

GC content: 68.35

Gene sequence:

>1659_bases
ATGGACGCGGAACTCATCGTCGTATGCGGTTTGCAGTCCGGGGCGAGTTTCGCCCTCGGAACCGGCGAGTTCACTATCGG
GCGCGCGCCGGGCGCCGGCCTCCGCCTGGCCGAGAGCGGCGTCGCCGCCGAGCATTGCGCCGTCCGGCCCTGCGGGACGG
GTTACCGCCTCCTCGACCGCCATAGCGGCTCCGGCACCTACGTCAACGGCATGCGCGTCACCGATCATCTGCTCCAGCCC
GAGGACCAGATCGCGATCGGCGACACCATCCTGGTCTATCGCGAAGCCTCCGCGGAGCGCGAACCCGATTCGCGCCATGT
GCTGCTCCAGGCCTGCGCTTTCCTCTTCCTTTTCCGGGCGCTCGCTTCCGCGCGCGACGAGCGCCAGCGCCTCGCCTTCG
AGGAACAACTGGCCGGGCTGATCTCCAGCATGCTCCCATGCACCGGCGCCGCGATTGTCTTGCGGCCCGGCGCGGAGCCG
CCGCCGCTACCGGAAGTGGATCCCGCAAGTCTGGCGATTGTGCCCCTGTGGGCCCACGGCAAACCTGCGGGCACGCTGGC
AGCCTGGTTCCCGCCGGAACAGATCGTGAATCTGAGCCGCCATCAAGAGACGCTGGGTGCGATCGCGACGCTCGCCGCCG
CAGCCCTCGAGACCGAGCGCGACGTCGAACAGCTGCGCGAACAAAACCAGTTGCTGCGCGAACGGCTCGCGGTCTCAGAG
CCGGGTATCGCGGGCGAGAGCATCGCGATCCACAAGCTGCTCGGCCTGGTGGCGCGCGTGGCGCCGCAGGAAGCCTCCGT
GCTGATCCTCGGGGAAAGCGGTGTGGGCAAGGAACTGGTGGCGCACGCCTTGCACCGCCTCAGCCCGCGCGCCGCCCGCC
CCTTCGTCGCCATCAACTGCGCCGCCCTCACGGAGACGCTGCTCGAGAGCGAGTTGTTCGGCCACGAGAAGGGAGCCTTC
ACCGGCGCGGTAGCGCAGAAGAAGGGCAAGCTCGAGATGGCCGAGGGCGGCACCGTATTCCTCGATGAAATCGGCGAGCT
GGCCGCGCCCCTCCAAGCCAAGCTGCTGCGCGTGCTCCAGCAGCGCGAATTCGAGCGCGTCGGCGGCACCCACACCTGGA
AACTCGACGTGCGCCTCGTGGCCGCGACCAATCGCGATCTCGCCGCCGAAGTGCAGCGCGGCGCTTTTCGCGAGGACCTC
TATCATCGATTGAACGTAGTCGCCCTGCGCGTGCCGCCTCTGCGCGAGCGTCCCGGCGACATCCTGCCGCTCGCGCGCTA
CTTCCTGGATCGCGCCATACCGCGCTGCGGCCGCATGATCAAAGGCATCGCGCCCGAAACAGAGGAGTGCCTGTTGGCCT
ATTCGTGGCCCGGCAACGTGCGCGAGTTGGAGAATGCGATCGAGCGCGCCGTGGTGCTCGGCGATACCGACTGGATTCAG
CCCGAGGACCTGCCCGAAACGGTGCTCGAACACGGCGCCGCGCCGCAGCCGCCCGGAGCGCTTTCGAATTCGGTAGCCGA
CACCAAGCGCCAGCTAATCCTCGCCGCCTGGCGCCAATCCGGCGGCGATCACGACCGCGCCGCGGAGCGCTTGAACATCC
ACCCCAATTCCCTACGCCGTCTAATCCGCACCCTCAAACTCCGCGACGCCCTGCAGTGA

Upstream 100 bases:

>100_bases
GCAAGTGCCTGAGAATGCGTGAAGGGAGCCGCCTTTCCGAACCCGGCGGTTCATGCGGGCCGAACCGAAGCGTTCCTGAT
ACACTGGCGTACAAAATCCA

Downstream 100 bases:

>100_bases
CGAGCCGCGACCATGAGGGAGCGCAACGACCGCTGGGGAGCGATCCGTACGTGCAACCACAATTCCAATTTGCGGCTTGC
CGCCTTGTAATACACTGCTC

Product: sigma-54 dependent trancsriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MDAELIVVCGLQSGASFALGTGEFTIGRAPGAGLRLAESGVAAEHCAVRPCGTGYRLLDRHSGSGTYVNGMRVTDHLLQP
EDQIAIGDTILVYREASAEREPDSRHVLLQACAFLFLFRALASARDERQRLAFEEQLAGLISSMLPCTGAAIVLRPGAEP
PPLPEVDPASLAIVPLWAHGKPAGTLAAWFPPEQIVNLSRHQETLGAIATLAAAALETERDVEQLREQNQLLRERLAVSE
PGIAGESIAIHKLLGLVARVAPQEASVLILGESGVGKELVAHALHRLSPRAARPFVAINCAALTETLLESELFGHEKGAF
TGAVAQKKGKLEMAEGGTVFLDEIGELAAPLQAKLLRVLQQREFERVGGTHTWKLDVRLVAATNRDLAAEVQRGAFREDL
YHRLNVVALRVPPLRERPGDILPLARYFLDRAIPRCGRMIKGIAPETEECLLAYSWPGNVRELENAIERAVVLGDTDWIQ
PEDLPETVLEHGAAPQPPGALSNSVADTKRQLILAAWRQSGGDHDRAAERLNIHPNSLRRLIRTLKLRDALQ

Sequences:

>Translated_552_residues
MDAELIVVCGLQSGASFALGTGEFTIGRAPGAGLRLAESGVAAEHCAVRPCGTGYRLLDRHSGSGTYVNGMRVTDHLLQP
EDQIAIGDTILVYREASAEREPDSRHVLLQACAFLFLFRALASARDERQRLAFEEQLAGLISSMLPCTGAAIVLRPGAEP
PPLPEVDPASLAIVPLWAHGKPAGTLAAWFPPEQIVNLSRHQETLGAIATLAAAALETERDVEQLREQNQLLRERLAVSE
PGIAGESIAIHKLLGLVARVAPQEASVLILGESGVGKELVAHALHRLSPRAARPFVAINCAALTETLLESELFGHEKGAF
TGAVAQKKGKLEMAEGGTVFLDEIGELAAPLQAKLLRVLQQREFERVGGTHTWKLDVRLVAATNRDLAAEVQRGAFREDL
YHRLNVVALRVPPLRERPGDILPLARYFLDRAIPRCGRMIKGIAPETEECLLAYSWPGNVRELENAIERAVVLGDTDWIQ
PEDLPETVLEHGAAPQPPGALSNSVADTKRQLILAAWRQSGGDHDRAAERLNIHPNSLRRLIRTLKLRDALQ
>Mature_552_residues
MDAELIVVCGLQSGASFALGTGEFTIGRAPGAGLRLAESGVAAEHCAVRPCGTGYRLLDRHSGSGTYVNGMRVTDHLLQP
EDQIAIGDTILVYREASAEREPDSRHVLLQACAFLFLFRALASARDERQRLAFEEQLAGLISSMLPCTGAAIVLRPGAEP
PPLPEVDPASLAIVPLWAHGKPAGTLAAWFPPEQIVNLSRHQETLGAIATLAAAALETERDVEQLREQNQLLRERLAVSE
PGIAGESIAIHKLLGLVARVAPQEASVLILGESGVGKELVAHALHRLSPRAARPFVAINCAALTETLLESELFGHEKGAF
TGAVAQKKGKLEMAEGGTVFLDEIGELAAPLQAKLLRVLQQREFERVGGTHTWKLDVRLVAATNRDLAAEVQRGAFREDL
YHRLNVVALRVPPLRERPGDILPLARYFLDRAIPRCGRMIKGIAPETEECLLAYSWPGNVRELENAIERAVVLGDTDWIQ
PEDLPETVLEHGAAPQPPGALSNSVADTKRQLILAAWRQSGGDHDRAAERLNIHPNSLRRLIRTLKLRDALQ

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=50.6622516556291, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788550, Length=303, Percent_Identity=49.1749174917492, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87082117, Length=285, Percent_Identity=50.5263157894737, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI1789087, Length=362, Percent_Identity=45.0276243093923, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1790299, Length=354, Percent_Identity=43.2203389830509, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI87082152, Length=342, Percent_Identity=45.6140350877193, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1789233, Length=256, Percent_Identity=48.046875, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788905, Length=249, Percent_Identity=49.3975903614458, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=42.1538461538462, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786524, Length=287, Percent_Identity=42.1602787456446, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1787583, Length=226, Percent_Identity=46.9026548672566, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1789828, Length=282, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=280, Percent_Identity=32.8571428571429, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59882; Mature: 59882

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50006 FHA_DOMAIN ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAELIVVCGLQSGASFALGTGEFTIGRAPGAGLRLAESGVAAEHCAVRPCGTGYRLLDR
CCCCEEEEEECCCCCCEEECCCCEEEECCCCCCCEECCCCCCHHHCCCCCCCCCCHHHCC
HSGSGTYVNGMRVTDHLLQPEDQIAIGDTILVYREASAEREPDSRHVLLQACAFLFLFRA
CCCCCCEEECCHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LASARDERQRLAFEEQLAGLISSMLPCTGAAIVLRPGAEPPPLPEVDPASLAIVPLWAHG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECC
KPAGTLAAWFPPEQIVNLSRHQETLGAIATLAAAALETERDVEQLREQNQLLRERLAVSE
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGIAGESIAIHKLLGLVARVAPQEASVLILGESGVGKELVAHALHRLSPRAARPFVAINC
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEH
AALTETLLESELFGHEKGAFTGAVAQKKGKLEMAEGGTVFLDEIGELAAPLQAKLLRVLQ
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
QREFERVGGTHTWKLDVRLVAATNRDLAAEVQRGAFREDLYHRLNVVALRVPPLRERPGD
HHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCC
ILPLARYFLDRAIPRCGRMIKGIAPETEECLLAYSWPGNVRELENAIERAVVLGDTDWIQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCC
PEDLPETVLEHGAAPQPPGALSNSVADTKRQLILAAWRQSGGDHDRAAERLNIHPNSLRR
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHH
LIRTLKLRDALQ
HHHHHHHHHHCC
>Mature Secondary Structure
MDAELIVVCGLQSGASFALGTGEFTIGRAPGAGLRLAESGVAAEHCAVRPCGTGYRLLDR
CCCCEEEEEECCCCCCEEECCCCEEEECCCCCCCEECCCCCCHHHCCCCCCCCCCHHHCC
HSGSGTYVNGMRVTDHLLQPEDQIAIGDTILVYREASAEREPDSRHVLLQACAFLFLFRA
CCCCCCEEECCHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
LASARDERQRLAFEEQLAGLISSMLPCTGAAIVLRPGAEPPPLPEVDPASLAIVPLWAHG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECC
KPAGTLAAWFPPEQIVNLSRHQETLGAIATLAAAALETERDVEQLREQNQLLRERLAVSE
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGIAGESIAIHKLLGLVARVAPQEASVLILGESGVGKELVAHALHRLSPRAARPFVAINC
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEH
AALTETLLESELFGHEKGAFTGAVAQKKGKLEMAEGGTVFLDEIGELAAPLQAKLLRVLQ
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
QREFERVGGTHTWKLDVRLVAATNRDLAAEVQRGAFREDLYHRLNVVALRVPPLRERPGD
HHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCC
ILPLARYFLDRAIPRCGRMIKGIAPETEECLLAYSWPGNVRELENAIERAVVLGDTDWIQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHEEEECCCCCCC
PEDLPETVLEHGAAPQPPGALSNSVADTKRQLILAAWRQSGGDHDRAAERLNIHPNSLRR
CCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHH
LIRTLKLRDALQ
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]