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The map label for this gene is serA [H]

Identifier: 116624217

GI number: 116624217

Start: 6455225

End: 6456163

Strand: Direct

Name: serA [H]

Synonym: Acid_5133

Alternate gene names: 116624217

Gene position: 6455225-6456163 (Clockwise)

Preceding gene: 116624209

Following gene: 116624221

Centisome position: 64.77

GC content: 66.56

Gene sequence:

>939_bases
ATGACCCGAATTTGCATTCCCGACGACGCACCGGCCGTGCTCGCGCCAAGCCCCGTGTTCCCCGCCTTGCAAGCCCGTGC
CCAGCTCGATTATTACGACACCCTGCCCGGCACCGAGGACTTGCTCATCGAGCGGCTCCGCGAAGCCGAGGTCGCGCTCA
ACATCCGGTCGTCTTCACGTTTCACCGAGCGCGTCTTCGCCGCCTGCCCCAAGCTGCGCATGGTCTCCATCTGGGGCACC
GGCACCGATCACGTCGATCTCGCCGCCGCCGCGCGCCACGGCGTCACAGTCGCGAACACTCCTGGCGTGGCTGCCCGGTC
GATCGCCGAGCACACGCTCGCCTTGTTGTTCGCTGTAGCGCGCCAGATTCCCCACATGGATGCCGCCACCCGCCGCGGCG
CCTGGGAACGCGGTCAATCGATGGAGCTCTACGGAAAGACCTGCGGCGTGATCGGGTATGGCGCCGTCGGCCGCCATTTC
GCCCGCCTCGCAACCGCTATCGGGATGCGCGTGATGCAGTGGACCCTGCACCCCAGCGCCTACCCGGACGTGGAATTCGC
GTCTCTCGAGGACCTCTACCGCGCCAGCGACGTGATCAGCGTTCACCTGCGCCTGTCCCCTGACACTCAGGATTTCATCG
CTGCACCGCAATTCGCTCTGATGAAGTCCGAAGCCATCCTGCTCAACACCGCCCGCGGCGCCATCGTCAGCGAGCCGGCC
CTGCTCGACGCCCTCATCGCCGGCAACCTCGCCGCCGCCGGCCTCGACGTCTTCACAACGGAGCCCCTGCCCCCTAACCA
CCCCTTGACCACGCTCCCCAACGTAGTCCTCACTCCCCACTGCGCGGGCATCACCCCCGAAGCCTTACACGCCGGTCTTC
AGCTAGCCGTGGACAACATCTGGGCTAAGTGCATCAGGCCTCCTGGCCAGTCCACCTGA

Upstream 100 bases:

>100_bases
TATTGGTAACTGGAATCGTAACATTGCCGCTTGCGTACATGGCGCCCCCCTCCCAATAGCATCCAACACTCATGCGACGA
TTGGAAAGCGCCAGGACACC

Downstream 100 bases:

>100_bases
TCAGTTTCGCCACTTGCGTTCCCATCCCCGCCACCAGCCGGCATTCTCCAGTTCGAGCGCATTCCAGCACAGATCGATCA
TCCGACTGTCGCGCCGTACC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTRICIPDDAPAVLAPSPVFPALQARAQLDYYDTLPGTEDLLIERLREAEVALNIRSSSRFTERVFAACPKLRMVSIWGT
GTDHVDLAAAARHGVTVANTPGVAARSIAEHTLALLFAVARQIPHMDAATRRGAWERGQSMELYGKTCGVIGYGAVGRHF
ARLATAIGMRVMQWTLHPSAYPDVEFASLEDLYRASDVISVHLRLSPDTQDFIAAPQFALMKSEAILLNTARGAIVSEPA
LLDALIAGNLAAAGLDVFTTEPLPPNHPLTTLPNVVLTPHCAGITPEALHAGLQLAVDNIWAKCIRPPGQST

Sequences:

>Translated_312_residues
MTRICIPDDAPAVLAPSPVFPALQARAQLDYYDTLPGTEDLLIERLREAEVALNIRSSSRFTERVFAACPKLRMVSIWGT
GTDHVDLAAAARHGVTVANTPGVAARSIAEHTLALLFAVARQIPHMDAATRRGAWERGQSMELYGKTCGVIGYGAVGRHF
ARLATAIGMRVMQWTLHPSAYPDVEFASLEDLYRASDVISVHLRLSPDTQDFIAAPQFALMKSEAILLNTARGAIVSEPA
LLDALIAGNLAAAGLDVFTTEPLPPNHPLTTLPNVVLTPHCAGITPEALHAGLQLAVDNIWAKCIRPPGQST
>Mature_311_residues
TRICIPDDAPAVLAPSPVFPALQARAQLDYYDTLPGTEDLLIERLREAEVALNIRSSSRFTERVFAACPKLRMVSIWGTG
TDHVDLAAAARHGVTVANTPGVAARSIAEHTLALLFAVARQIPHMDAATRRGAWERGQSMELYGKTCGVIGYGAVGRHFA
RLATAIGMRVMQWTLHPSAYPDVEFASLEDLYRASDVISVHLRLSPDTQDFIAAPQFALMKSEAILLNTARGAIVSEPAL
LDALIAGNLAAAGLDVFTTEPLPPNHPLTTLPNVVLTPHCAGITPEALHAGLQLAVDNIWAKCIRPPGQST

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=268, Percent_Identity=39.5522388059701, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI6912396, Length=286, Percent_Identity=32.1678321678322, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=288, Percent_Identity=30.5555555555556, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4557497, Length=288, Percent_Identity=30.5555555555556, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI145580578, Length=236, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557499, Length=236, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580575, Length=236, Percent_Identity=32.2033898305085, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=268, Percent_Identity=37.6865671641791, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=31.2267657992565, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=29.9595141700405, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081824, Length=143, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788660, Length=246, Percent_Identity=28.4552845528455, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=35.408560311284, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=282, Percent_Identity=27.3049645390071, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=295, Percent_Identity=32.8813559322034, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=32.8813559322034, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6324055, Length=260, Percent_Identity=28.0769230769231, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=251, Percent_Identity=27.0916334661355, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=34.0740740740741, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=32.6612903225806, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574286, Length=245, Percent_Identity=30.6122448979592, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=34, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=28.1138790035587, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=28.1138790035587, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=28.1138790035587, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551003, Length=281, Percent_Identity=28.1138790035587, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=28.1138790035587, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=31.4159292035398, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=31.4159292035398, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=31.4159292035398, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=31.4159292035398, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33492; Mature: 33361

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRICIPDDAPAVLAPSPVFPALQARAQLDYYDTLPGTEDLLIERLREAEVALNIRSSSR
CCEEECCCCCCCEECCCCCCHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHEEEECCCHH
FTERVFAACPKLRMVSIWGTGTDHVDLAAAARHGVTVANTPGVAARSIAEHTLALLFAVA
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHH
RQIPHMDAATRRGAWERGQSMELYGKTCGVIGYGAVGRHFARLATAIGMRVMQWTLHPSA
HHCCCCCHHHHCCHHHCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHEEECCCC
YPDVEFASLEDLYRASDVISVHLRLSPDTQDFIAAPQFALMKSEAILLNTARGAIVSEPA
CCCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCHHHHHCCCEEEEECCCCCEECCHH
LLDALIAGNLAAAGLDVFTTEPLPPNHPLTTLPNVVLTPHCAGITPEALHAGLQLAVDNI
HHHHHHHCCHHHCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
WAKCIRPPGQST
HHHHCCCCCCCC
>Mature Secondary Structure 
TRICIPDDAPAVLAPSPVFPALQARAQLDYYDTLPGTEDLLIERLREAEVALNIRSSSR
CEEECCCCCCCEECCCCCCHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHEEEECCCHH
FTERVFAACPKLRMVSIWGTGTDHVDLAAAARHGVTVANTPGVAARSIAEHTLALLFAVA
HHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHH
RQIPHMDAATRRGAWERGQSMELYGKTCGVIGYGAVGRHFARLATAIGMRVMQWTLHPSA
HHCCCCCHHHHCCHHHCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHEEECCCC
YPDVEFASLEDLYRASDVISVHLRLSPDTQDFIAAPQFALMKSEAILLNTARGAIVSEPA
CCCCCHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCHHHHHCCCEEEEECCCCCEECCHH
LLDALIAGNLAAAGLDVFTTEPLPPNHPLTTLPNVVLTPHCAGITPEALHAGLQLAVDNI
HHHHHHHCCHHHCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHH
WAKCIRPPGQST
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]