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The map label for this gene is uxuA2 [H]

Identifier: 116624146

GI number: 116624146

Start: 6395182

End: 6396267

Strand: Reverse

Name: uxuA2 [H]

Synonym: Acid_5062

Alternate gene names: 116624146

Gene position: 6396267-6395182 (Counterclockwise)

Preceding gene: 116624147

Following gene: 116624140

Centisome position: 64.18

GC content: 61.23

Gene sequence:

>1086_bases
ATGACCAGATCAGCAATTACCAGATCGGAATTCGGCAAAACGATCCTCGGTGCCATTCTCGCGGCGCGCCAATCGCGCGC
CGCGGTTCATTCCAACGCGCCTGGCATCAAGCTCTGCGCGCAGTCGGGTGCCACCCCGACGGATGAGCAACTGCTCTTCC
TGAAACAAATCGGCGCGGAGTATGTCAGCGTCGGATCTACGCCGGAATTGCGCACCGCCGAGGGCTTCCTCCAAATCAAG
AAGCGCTACGCCGATGCCGGCATTACGGTCTGGAACATCGGCAACACCAGCGTGCACAATATGCCGGAAGTCACGCTCAA
CCTGCCGGGCCGCGACCAGAAGGTCGAGGAATACAAGCAGTACCTGCGCAACCTCGGCAAGGCCGGCATTTACTACACCA
CGTACGCCCACATGGGCAACGGCATCTGGTCGAGCGGCCGCTCCGAAATTCGCGGAGCCTCGGCTCGCGAGTTCGATATG
AACAGCCCCGCCAAGGCGGGCGTGTGGGACGGCAAGACGTGGAAGGAGCCGCTCTCCCACGGCCGTGTCTTCACCAAGGA
AGAGATCTGGGACAACTTCACCTACTTCATCAAGCAGGTGGCGCCGGTGGCGGAGGAAAACAGCGTGCGCATCGGCATTC
ACCCGGACGATCCGCCGGTGCCGGTGCTGGCCGGAGTGCCGCGGTGCATCTTCAGCAATTTCGAGGGCTACAAGCGAGCG
CTCGAGATCGCCAACAGTCCCAACGTCGGCATCTGCCTGTGCTGCGGCACGTGGCTCGAAGGCGGCAAGGCACTCACCGG
CAAGGATCCCGAGGAGATGATCCGCTACTTCGGCGCCAAGAAAATCTGGAAGATCCACTTTCGCAATGTGACCGCGCCCC
TGCCGCACTTCGTCGAGACCTTCATGGACGATGGCTACTACGACATGTACAAGATCATGAAGGCGCTGCGCGACGTCAAC
TACGATGGGATCGTCATCCTGGATCACTCGCCCGGGATGGTCGGCGGCAACTACGCGCAGACGGCCTACGGGTACGGCTA
CATGCGCGCGCTATTGAATCGCGCCAACGCCGAAGCCAAACGCTAA

Upstream 100 bases:

>100_bases
CCTGCGCCCCATGGGCGGTAAGGTCCCTGCGATCTACGGCGAAAGTTACGATTCCGCCGCCGCCCGCAAAGCCGCGCAGT
AGCGACTACACTATTAGCCG

Downstream 100 bases:

>100_bases
GTCGTCAAATTCCCGAGCCACTCCAGCGCCCGCAGACCTGGCATGAAGCAGTATTCGCCTCCGCGCGTGACCACGAATCG
CGGCAGCCCCTGCAATCGCC

Product: D-mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase 2 [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTRSAITRSEFGKTILGAILAARQSRAAVHSNAPGIKLCAQSGATPTDEQLLFLKQIGAEYVSVGSTPELRTAEGFLQIK
KRYADAGITVWNIGNTSVHNMPEVTLNLPGRDQKVEEYKQYLRNLGKAGIYYTTYAHMGNGIWSSGRSEIRGASAREFDM
NSPAKAGVWDGKTWKEPLSHGRVFTKEEIWDNFTYFIKQVAPVAEENSVRIGIHPDDPPVPVLAGVPRCIFSNFEGYKRA
LEIANSPNVGICLCCGTWLEGGKALTGKDPEEMIRYFGAKKIWKIHFRNVTAPLPHFVETFMDDGYYDMYKIMKALRDVN
YDGIVILDHSPGMVGGNYAQTAYGYGYMRALLNRANAEAKR

Sequences:

>Translated_361_residues
MTRSAITRSEFGKTILGAILAARQSRAAVHSNAPGIKLCAQSGATPTDEQLLFLKQIGAEYVSVGSTPELRTAEGFLQIK
KRYADAGITVWNIGNTSVHNMPEVTLNLPGRDQKVEEYKQYLRNLGKAGIYYTTYAHMGNGIWSSGRSEIRGASAREFDM
NSPAKAGVWDGKTWKEPLSHGRVFTKEEIWDNFTYFIKQVAPVAEENSVRIGIHPDDPPVPVLAGVPRCIFSNFEGYKRA
LEIANSPNVGICLCCGTWLEGGKALTGKDPEEMIRYFGAKKIWKIHFRNVTAPLPHFVETFMDDGYYDMYKIMKALRDVN
YDGIVILDHSPGMVGGNYAQTAYGYGYMRALLNRANAEAKR
>Mature_360_residues
TRSAITRSEFGKTILGAILAARQSRAAVHSNAPGIKLCAQSGATPTDEQLLFLKQIGAEYVSVGSTPELRTAEGFLQIKK
RYADAGITVWNIGNTSVHNMPEVTLNLPGRDQKVEEYKQYLRNLGKAGIYYTTYAHMGNGIWSSGRSEIRGASAREFDMN
SPAKAGVWDGKTWKEPLSHGRVFTKEEIWDNFTYFIKQVAPVAEENSVRIGIHPDDPPVPVLAGVPRCIFSNFEGYKRAL
EIANSPNVGICLCCGTWLEGGKALTGKDPEEMIRYFGAKKIWKIHFRNVTAPLPHFVETFMDDGYYDMYKIMKALRDVNY
DGIVILDHSPGMVGGNYAQTAYGYGYMRALLNRANAEAKR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1790778, Length=302, Percent_Identity=27.4834437086093, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004628
- InterPro:   IPR013022 [H]

Pfam domain/function: PF03786 UxuA [H]

EC number: =4.2.1.8 [H]

Molecular weight: Translated: 40122; Mature: 39991

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSAITRSEFGKTILGAILAARQSRAAVHSNAPGIKLCAQSGATPTDEQLLFLKQIGAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCHH
YVSVGSTPELRTAEGFLQIKKRYADAGITVWNIGNTSVHNMPEVTLNLPGRDQKVEEYKQ
HEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHH
YLRNLGKAGIYYTTYAHMGNGIWSSGRSEIRGASAREFDMNSPAKAGVWDGKTWKEPLSH
HHHHHCCCCEEEEEHHHCCCCHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GRVFTKEEIWDNFTYFIKQVAPVAEENSVRIGIHPDDPPVPVLAGVPRCIFSNFEGYKRA
CCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCHHHHHHCHHHHHHH
LEIANSPNVGICLCCGTWLEGGKALTGKDPEEMIRYFGAKKIWKIHFRNVTAPLPHFVET
HHHCCCCCCEEEEEECCHHCCCEECCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
FMDDGYYDMYKIMKALRDVNYDGIVILDHSPGMVGGNYAQTAYGYGYMRALLNRANAEAK
HHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
R
C
>Mature Secondary Structure 
TRSAITRSEFGKTILGAILAARQSRAAVHSNAPGIKLCAQSGATPTDEQLLFLKQIGAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCHH
YVSVGSTPELRTAEGFLQIKKRYADAGITVWNIGNTSVHNMPEVTLNLPGRDQKVEEYKQ
HEECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHH
YLRNLGKAGIYYTTYAHMGNGIWSSGRSEIRGASAREFDMNSPAKAGVWDGKTWKEPLSH
HHHHHCCCCEEEEEHHHCCCCHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GRVFTKEEIWDNFTYFIKQVAPVAEENSVRIGIHPDDPPVPVLAGVPRCIFSNFEGYKRA
CCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCHHHHHHCHHHHHHH
LEIANSPNVGICLCCGTWLEGGKALTGKDPEEMIRYFGAKKIWKIHFRNVTAPLPHFVET
HHHCCCCCCEEEEEECCHHCCCEECCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
FMDDGYYDMYKIMKALRDVNYDGIVILDHSPGMVGGNYAQTAYGYGYMRALLNRANAEAK
HHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA