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The map label for this gene is yycR [H]

Identifier: 116624014

GI number: 116624014

Start: 6220552

End: 6221766

Strand: Reverse

Name: yycR [H]

Synonym: Acid_4926

Alternate gene names: 116624014

Gene position: 6221766-6220552 (Counterclockwise)

Preceding gene: 116624016

Following gene: 116624011

Centisome position: 62.43

GC content: 60.99

Gene sequence:

>1215_bases
ATGAAAGCAGTGGTTTATAAAGGAAAGAACAAAGTTGCCGTAGAAGAGGTCTCCAATCCCAAAATCGAGGCTCCCGGCGA
CGTGATTGTGAAAATCACAACGGCGGCGATCTGCGGCAGCGACCTGCACATGTATGAGCAGCGCAGTAACGCCGAACCCG
GAACCGTTTTTGGACACGAGAACCAGGGCGTGGTGGAAGAGGTGGGCAACGGAGTCGTCTCCATCAAGCGGGGCGACCGC
GTAGTGCTGCCCTTTAACATAGCCTGCGGTTTCTGTTTCAACTGCGCGCGGGGTTACACCAACGCCTGCCTGACCGCCAA
CCCCGAGGCGCCGACCGCCGGCTACGGCTACGCCGGTATGGGACCATACCGCGGCGGCCAGGCCGAGTTCCTGCGAGTGC
CGTTCGCGGACTTCAATTGCCTCAAACTCCCCGGCCAGCCCGGAGACCAGTTCGAGGACGATTTCGTACTGCTCGCCGAT
ATTTTCCCGACCGGGTGGCATGCCGCGGAACTTGCGAACGTAAAAGGCGGCGATTCGGTCGCCGTCTTCGGCGCCGGTCC
GGTGGGCCTGCTCTCCGCATACAGCGCGTTCATCAAGGGCGCATCGGAGGTGTACGTAGTGGATCGCGCGCCGGACCGGC
TGGCGCGCGCGAAGAGCATCGGAGCCATAGCGGTGGATTTTACCCAGGGCGATCCGGTGGAGCAGATCAAGGAACTCCGC
TCCAAGAACCGCGCGCATTCACAGGCGCTCCGGCCCGGGGAAGAGAAGATGGCGGGGGTCAATTGCGCCATCGACGCGGT
GGGCTACCAGGCCCGCAGCCAGTCTGATCCGGACCGGGAAGACCCCATGCAGACTATCCGGCAGATCACCGACATCGTCA
ACCCGACAGGTTCGGTAGGCTTGATCGGCGTGTACTTCGACGAAGATCCGGGCGGCGTGGACAAGCACGCCAAGAAAGGC
GAATTCCTGTTCCCGCTGGGCAAGCTTTGGAGCAAAGGAATCACGATCGGCCAGGGACAGGCCCCGGTGAAAAAATACAA
CGTGTATCTACGCGACCTGATTATCGCCGGCAAAGCTAAACCCAGCTTCATCGTGAGCCACCGGTTGCCTCTGGCAAGGG
CGGAGGAGGCCTACGCGCATTTCGATCATCGTGGAGTCGGCAGTGGCAAAGACTGGACCAAGGTCCTGTTGAAGCCGGAA
ATGAAGGCAGCCTAG

Upstream 100 bases:

>100_bases
TGCCGTTTCTTGAATGTGCAGGAACTCTTTCCGGAAGCCTACCTGCATGGAATTAGAGGTCAGGTAAAAATGTCTTCATT
CTTATTCTTGCGAGGAAATC

Downstream 100 bases:

>100_bases
GCTGCCTTCACGCGTCACCCCTTCCACGTCCACTCGCGGATTTCGGGCATGTCTTCACCGAACGTCGTGACGTAGTGCTT
GTGTTCGATCAGCTTGTTGC

Product: alcohol dehydrogenase

Products: formate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKAVVYKGKNKVAVEEVSNPKIEAPGDVIVKITTAAICGSDLHMYEQRSNAEPGTVFGHENQGVVEEVGNGVVSIKRGDR
VVLPFNIACGFCFNCARGYTNACLTANPEAPTAGYGYAGMGPYRGGQAEFLRVPFADFNCLKLPGQPGDQFEDDFVLLAD
IFPTGWHAAELANVKGGDSVAVFGAGPVGLLSAYSAFIKGASEVYVVDRAPDRLARAKSIGAIAVDFTQGDPVEQIKELR
SKNRAHSQALRPGEEKMAGVNCAIDAVGYQARSQSDPDREDPMQTIRQITDIVNPTGSVGLIGVYFDEDPGGVDKHAKKG
EFLFPLGKLWSKGITIGQGQAPVKKYNVYLRDLIIAGKAKPSFIVSHRLPLARAEEAYAHFDHRGVGSGKDWTKVLLKPE
MKAA

Sequences:

>Translated_404_residues
MKAVVYKGKNKVAVEEVSNPKIEAPGDVIVKITTAAICGSDLHMYEQRSNAEPGTVFGHENQGVVEEVGNGVVSIKRGDR
VVLPFNIACGFCFNCARGYTNACLTANPEAPTAGYGYAGMGPYRGGQAEFLRVPFADFNCLKLPGQPGDQFEDDFVLLAD
IFPTGWHAAELANVKGGDSVAVFGAGPVGLLSAYSAFIKGASEVYVVDRAPDRLARAKSIGAIAVDFTQGDPVEQIKELR
SKNRAHSQALRPGEEKMAGVNCAIDAVGYQARSQSDPDREDPMQTIRQITDIVNPTGSVGLIGVYFDEDPGGVDKHAKKG
EFLFPLGKLWSKGITIGQGQAPVKKYNVYLRDLIIAGKAKPSFIVSHRLPLARAEEAYAHFDHRGVGSGKDWTKVLLKPE
MKAA
>Mature_404_residues
MKAVVYKGKNKVAVEEVSNPKIEAPGDVIVKITTAAICGSDLHMYEQRSNAEPGTVFGHENQGVVEEVGNGVVSIKRGDR
VVLPFNIACGFCFNCARGYTNACLTANPEAPTAGYGYAGMGPYRGGQAEFLRVPFADFNCLKLPGQPGDQFEDDFVLLAD
IFPTGWHAAELANVKGGDSVAVFGAGPVGLLSAYSAFIKGASEVYVVDRAPDRLARAKSIGAIAVDFTQGDPVEQIKELR
SKNRAHSQALRPGEEKMAGVNCAIDAVGYQARSQSDPDREDPMQTIRQITDIVNPTGSVGLIGVYFDEDPGGVDKHAKKG
EFLFPLGKLWSKGITIGQGQAPVKKYNVYLRDLIIAGKAKPSFIVSHRLPLARAEEAYAHFDHRGVGSGKDWTKVLLKPE
MKAA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=294, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156627571, Length=414, Percent_Identity=25.1207729468599, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI71565154, Length=258, Percent_Identity=31.7829457364341, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI71565152, Length=238, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786825, Length=426, Percent_Identity=36.3849765258216, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082125, Length=254, Percent_Identity=33.4645669291339, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787863, Length=405, Percent_Identity=26.9135802469136, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788073, Length=225, Percent_Identity=34.6666666666667, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790045, Length=227, Percent_Identity=34.3612334801762, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=32.5892857142857, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI226510992, Length=367, Percent_Identity=25.0681198910082, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=388, Percent_Identity=25.7731958762887, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790718, Length=242, Percent_Identity=26.8595041322314, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081918, Length=240, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=242, Percent_Identity=35.5371900826446, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562878, Length=244, Percent_Identity=33.6065573770492, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=243, Percent_Identity=32.9218106995885, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=270, Percent_Identity=30.7407407407407, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=274, Percent_Identity=28.1021897810219, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=224, Percent_Identity=33.9285714285714, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=224, Percent_Identity=33.9285714285714, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=226, Percent_Identity=33.1858407079646, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=231, Percent_Identity=31.1688311688312, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137530, Length=231, Percent_Identity=30.7359307359307, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551930, Length=203, Percent_Identity=28.0788177339901, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221457811, Length=203, Percent_Identity=28.0788177339901, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45550770, Length=203, Percent_Identity=28.0788177339901, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.2.1.46

Molecular weight: Translated: 43358; Mature: 43358

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVYKGKNKVAVEEVSNPKIEAPGDVIVKITTAAICGSDLHMYEQRSNAEPGTVFGHE
CCEEEEECCCEEEEEECCCCCCCCCCCEEEEEEEHHHCCCHHHHHHHHCCCCCCEEECCC
NQGVVEEVGNGVVSIKRGDRVVLPFNIACGFCFNCARGYTNACLTANPEAPTAGYGYAGM
CCCHHHHHCCCEEEEECCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
GPYRGGQAEFLRVPFADFNCLKLPGQPGDQFEDDFVLLADIFPTGWHAAELANVKGGDSV
CCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCEE
AVFGAGPVGLLSAYSAFIKGASEVYVVDRAPDRLARAKSIGAIAVDFTQGDPVEQIKELR
EEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECCCCCHHHHHHHH
SKNRAHSQALRPGEEKMAGVNCAIDAVGYQARSQSDPDREDPMQTIRQITDIVNPTGSVG
HHHHHHHHHCCCCHHHHCCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
LIGVYFDEDPGGVDKHAKKGEFLFPLGKLWSKGITIGQGQAPVKKYNVYLRDLIIAGKAK
EEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCEEECCCCCCHHHHHHEEEHEEEECCCC
PSFIVSHRLPLARAEEAYAHFDHRGVGSGKDWTKVLLKPEMKAA
CCEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCC
>Mature Secondary Structure
MKAVVYKGKNKVAVEEVSNPKIEAPGDVIVKITTAAICGSDLHMYEQRSNAEPGTVFGHE
CCEEEEECCCEEEEEECCCCCCCCCCCEEEEEEEHHHCCCHHHHHHHHCCCCCCEEECCC
NQGVVEEVGNGVVSIKRGDRVVLPFNIACGFCFNCARGYTNACLTANPEAPTAGYGYAGM
CCCHHHHHCCCEEEEECCCEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
GPYRGGQAEFLRVPFADFNCLKLPGQPGDQFEDDFVLLADIFPTGWHAAELANVKGGDSV
CCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCEE
AVFGAGPVGLLSAYSAFIKGASEVYVVDRAPDRLARAKSIGAIAVDFTQGDPVEQIKELR
EEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEECCCCCHHHHHHHH
SKNRAHSQALRPGEEKMAGVNCAIDAVGYQARSQSDPDREDPMQTIRQITDIVNPTGSVG
HHHHHHHHHCCCCHHHHCCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
LIGVYFDEDPGGVDKHAKKGEFLFPLGKLWSKGITIGQGQAPVKKYNVYLRDLIIAGKAK
EEEEEECCCCCCCCCCCCCCCEEEEHHHHHHCCEEECCCCCCHHHHHHEEEHEEEECCCC
PSFIVSHRLPLARAEEAYAHFDHRGVGSGKDWTKVLLKPEMKAA
CCEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formaldehyde; NAD+; H2O

Specific reaction: formaldehyde + NAD+ + H2O = formate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]