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The map label for this gene is lepB [H]

Identifier: 116623926

GI number: 116623926

Start: 6110681

End: 6111634

Strand: Reverse

Name: lepB [H]

Synonym: Acid_4838

Alternate gene names: 116623926

Gene position: 6111634-6110681 (Counterclockwise)

Preceding gene: 116623927

Following gene: 116623925

Centisome position: 61.33

GC content: 63.52

Gene sequence:

>954_bases
ATGACGCCCCAATCGCCGCCAATTGCTCTCTATTGCCGGATCTATTCGATTCTGCTCTATGCCTACCCGCGTGACTTCCG
CCGGCAATACGGCGCCGGCATGCGCCAGGTCTTCCGCGACCGCTGCCGCGAGGTGGCGCGCACCGCGAACCGTCTCGCGA
TGGTTGCGTTTGCCCTTCACCTCATCGCGGACTGGCTGACCACCGCCGTCCGCGAGGGTGCCGCCGCCATCTGGTCGGCC
GGACGCAAGCAGTCGCCCCGCAGCGTCGTCACCGAATGGGCCGTCACTATCGCCATCTATCTCTTCGCCACCACCACGCT
GGTACAGGCCTACGTCATCCCCACTGCGTCGATGGAAAGCACGGTTATGGTGGGCGATCACATGCTCGTCGATCGCGTCA
CGTTCAGCGAGCCCGGTAACGCCGCGCGCGGCATTCTGCCCTACCGCGAGCCCGCCCGCGGAGACATGCTCGTTTTTCTC
TATCCCGACGACGTGCGCCAGACCTACATCAAACGCGTCATCGGACTGCCCGGCGACCGCATTCACCTGGAGCATCAGCA
GGTGGTGCGCAACGGCCTGCGCTTGCTCGAGCCCTACACGCAACACATCACTGCCTGGCCGGATCCCTATCGCGACAATT
TCCCCTTGTCCCCCGAAGGCAGCATCTCGCCGCGCGGGCGCGACATGCTGGAACATCACGTCGTCAACGGTGAAGTCGTG
GTGCCGCCCGGCATGATCTTCGTGATGGGCGATAATCGCGAGAATTCGCTCGACAGCCGCTACTGGGGCTTCGTACCGCG
AAATTACGTGGTGGGCAAGCCCTTGCTGGTCTACTGGTCATACGATGCGCCCACCGCCGACCTGCAGGAATGGAACGTGA
ATCACGTTCTCGACGTGGCCCTGCACTTCTTCTCGCGCACACGCTGGGATCGTACCTTCCGGGTGCCCCGATGA

Upstream 100 bases:

>100_bases
ACCGCATGACGCCCCTCGGCAGGCGCGTCGTGCGCGCCGAGGCGCAGCGCCTGGCCGGAGCCGTCCTGGCTGCCAGGTCG
AAGCTGGCCGGAGGAAACAT

Downstream 100 bases:

>100_bases
CGCCTTTGATCCTCGCCCTCTTCGGCTGGCTCGTCCCGGGCGGCTCGTATCTGTTGATGCGCCGCTACGCGCAGTTTGCG
GCCTTCGCAATTCTGGTCAC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTPQSPPIALYCRIYSILLYAYPRDFRRQYGAGMRQVFRDRCREVARTANRLAMVAFALHLIADWLTTAVREGAAAIWSA
GRKQSPRSVVTEWAVTIAIYLFATTTLVQAYVIPTASMESTVMVGDHMLVDRVTFSEPGNAARGILPYREPARGDMLVFL
YPDDVRQTYIKRVIGLPGDRIHLEHQQVVRNGLRLLEPYTQHITAWPDPYRDNFPLSPEGSISPRGRDMLEHHVVNGEVV
VPPGMIFVMGDNRENSLDSRYWGFVPRNYVVGKPLLVYWSYDAPTADLQEWNVNHVLDVALHFFSRTRWDRTFRVPR

Sequences:

>Translated_317_residues
MTPQSPPIALYCRIYSILLYAYPRDFRRQYGAGMRQVFRDRCREVARTANRLAMVAFALHLIADWLTTAVREGAAAIWSA
GRKQSPRSVVTEWAVTIAIYLFATTTLVQAYVIPTASMESTVMVGDHMLVDRVTFSEPGNAARGILPYREPARGDMLVFL
YPDDVRQTYIKRVIGLPGDRIHLEHQQVVRNGLRLLEPYTQHITAWPDPYRDNFPLSPEGSISPRGRDMLEHHVVNGEVV
VPPGMIFVMGDNRENSLDSRYWGFVPRNYVVGKPLLVYWSYDAPTADLQEWNVNHVLDVALHFFSRTRWDRTFRVPR
>Mature_316_residues
TPQSPPIALYCRIYSILLYAYPRDFRRQYGAGMRQVFRDRCREVARTANRLAMVAFALHLIADWLTTAVREGAAAIWSAG
RKQSPRSVVTEWAVTIAIYLFATTTLVQAYVIPTASMESTVMVGDHMLVDRVTFSEPGNAARGILPYREPARGDMLVFLY
PDDVRQTYIKRVIGLPGDRIHLEHQQVVRNGLRLLEPYTQHITAWPDPYRDNFPLSPEGSISPRGRDMLEHHVVNGEVVV
PPGMIFVMGDNRENSLDSRYWGFVPRNYVVGKPLLVYWSYDAPTADLQEWNVNHVLDVALHFFSRTRWDRTFRVPR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36395; Mature: 36264

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQSPPIALYCRIYSILLYAYPRDFRRQYGAGMRQVFRDRCREVARTANRLAMVAFALH
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIADWLTTAVREGAAAIWSAGRKQSPRSVVTEWAVTIAIYLFATTTLVQAYVIPTASMES
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVMVGDHMLVDRVTFSEPGNAARGILPYREPARGDMLVFLYPDDVRQTYIKRVIGLPGDR
EEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCE
IHLEHQQVVRNGLRLLEPYTQHITAWPDPYRDNFPLSPEGSISPRGRDMLEHHVVNGEVV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEE
VPPGMIFVMGDNRENSLDSRYWGFVPRNYVVGKPLLVYWSYDAPTADLQEWNVNHVLDVA
ECCCEEEEEECCCCCCCCCHHCCCCCCCEECCCCEEEEEECCCCCCCHHHCCHHHHHHHH
LHFFSRTRWDRTFRVPR
HHHHHHHCCCCEECCCC
>Mature Secondary Structure 
TPQSPPIALYCRIYSILLYAYPRDFRRQYGAGMRQVFRDRCREVARTANRLAMVAFALH
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIADWLTTAVREGAAAIWSAGRKQSPRSVVTEWAVTIAIYLFATTTLVQAYVIPTASMES
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVMVGDHMLVDRVTFSEPGNAARGILPYREPARGDMLVFLYPDDVRQTYIKRVIGLPGDR
EEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCE
IHLEHQQVVRNGLRLLEPYTQHITAWPDPYRDNFPLSPEGSISPRGRDMLEHHVVNGEVV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEE
VPPGMIFVMGDNRENSLDSRYWGFVPRNYVVGKPLLVYWSYDAPTADLQEWNVNHVLDVA
ECCCEEEEEECCCCCCCCCHHCCCCCCCEECCCCEEEEEECCCCCCCHHHCCHHHHHHHH
LHFFSRTRWDRTFRVPR
HHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]