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The map label for this gene is htrA [H]

Identifier: 116623870

GI number: 116623870

Start: 6049078

End: 6050223

Strand: Direct

Name: htrA [H]

Synonym: Acid_4782

Alternate gene names: 116623870

Gene position: 6049078-6050223 (Clockwise)

Preceding gene: 116623869

Following gene: 116623873

Centisome position: 60.7

GC content: 63.09

Gene sequence:

>1146_bases
ATGAGAGTGCTGCGTACCTTCTTTTGGGCTGCCGTTCTGGCCGCTGGTTTCATCTGGGTCACCAGCGTGGCCAACTGGGA
TGTGGGGCGCGCGCTGCGTCCCGTCCGCAATGCCGGGCGTATGTGGAGTGAGCCGACAGCAGCGGCGGGCGCGGGTTTTT
CGACCGACGAGCAGAATAACATCGACGTGTACAAATCGGCGCGCGACGCCACGGTTTTCATCACGTCCACGGTGTTCACG
CGCAGTTTCTTCGGAGTGTATCCGGAGAAGGGCACGGGAACCGGGTTCGTGATCAGTCCGGAAGGCGAGATCCTGACCAA
CAATCACGTAGCCGGCGGCGGCAGCGAGCTGAGCGTGACGCTCTCCGATAAGAAGGTATACAAGGCGCGCGTGCTGGGGA
TCGACACGAGGAACGATCTGGCGCTGATCAAAATCGACGCCGGGCGCAAGCTGCCGGTGGTGCCGCTCGGGGATAGCGAG
CACCTGATGGTGGGGCAGAAGGTGCTCGCGATCGGCAACCCGTTCCAGTTCGAAGGCACGCTGACTACCGGCATCGTGAG
TTCGCTGGGGCGCACCATTCAGACCGAAGGCGAGCGCGAACTGGAGGGCATGATCCAGACCGACGCGGCGATCAATCCGG
GCAACAGCGGCGGACCGCTGCTCGATTCGCACGGCAACGTGATCGGCATCAACACCGCGATCTACGGCGCTCAGGGCAGC
ATCGGTATCGGTTTCGCGATGCCGATCTCACGGGCCAAGGCGATGCTGGAGGAGTACAAGACCCGCGGCAAGATCTCCCG
CCCCACGCTCGGGATCAACACGGTCTATATCGCGGGCGACCTTGCGGAGATGCTGCAACTGCCCTCGTCGGGCGGACTGT
TGATCCAGGAAGTGGAGCGCGGGTCGGCGGCGGCGGTGGCCGGGCTCCGCGGTTATTCCCGGATCGTGATCGTGGGCAAC
TATCGCCTCGGAATCGGCGGCGACCTGATTACGGCGGCGGACGGGCACACGATCGACGATAAGGAAACGCTCAAACGCCT
GATGGACAAAAAGCACGGCGGAGATACGCTGGAACTGACCGTCAATCGCGGCGGCCGCAGCGAAAAGATCAAGGTGAAGT
TGGGCGAGGCCCCGCAGCAGTTCTAA

Upstream 100 bases:

>100_bases
AACGAAAGTTTGCAGATTTCGTCATAGATACATCCGGGGAGAAAGCGGATACCTTACGGCAGACCCGGGCCGTCTACGAC
ACATTACGGAGAATCGAATC

Downstream 100 bases:

>100_bases
CCTGGTATTACACTGCTCTTGTTTGCTCTTTGTGGGGCAGGCATTTTGCCTGCAGCCGCCTTTCAGGCGGCTCCTTCGTT
CATGCTCAGCACCCCGCCGA

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRVLRTFFWAAVLAAGFIWVTSVANWDVGRALRPVRNAGRMWSEPTAAAGAGFSTDEQNNIDVYKSARDATVFITSTVFT
RSFFGVYPEKGTGTGFVISPEGEILTNNHVAGGGSELSVTLSDKKVYKARVLGIDTRNDLALIKIDAGRKLPVVPLGDSE
HLMVGQKVLAIGNPFQFEGTLTTGIVSSLGRTIQTEGERELEGMIQTDAAINPGNSGGPLLDSHGNVIGINTAIYGAQGS
IGIGFAMPISRAKAMLEEYKTRGKISRPTLGINTVYIAGDLAEMLQLPSSGGLLIQEVERGSAAAVAGLRGYSRIVIVGN
YRLGIGGDLITAADGHTIDDKETLKRLMDKKHGGDTLELTVNRGGRSEKIKVKLGEAPQQF

Sequences:

>Translated_381_residues
MRVLRTFFWAAVLAAGFIWVTSVANWDVGRALRPVRNAGRMWSEPTAAAGAGFSTDEQNNIDVYKSARDATVFITSTVFT
RSFFGVYPEKGTGTGFVISPEGEILTNNHVAGGGSELSVTLSDKKVYKARVLGIDTRNDLALIKIDAGRKLPVVPLGDSE
HLMVGQKVLAIGNPFQFEGTLTTGIVSSLGRTIQTEGERELEGMIQTDAAINPGNSGGPLLDSHGNVIGINTAIYGAQGS
IGIGFAMPISRAKAMLEEYKTRGKISRPTLGINTVYIAGDLAEMLQLPSSGGLLIQEVERGSAAAVAGLRGYSRIVIVGN
YRLGIGGDLITAADGHTIDDKETLKRLMDKKHGGDTLELTVNRGGRSEKIKVKLGEAPQQF
>Mature_381_residues
MRVLRTFFWAAVLAAGFIWVTSVANWDVGRALRPVRNAGRMWSEPTAAAGAGFSTDEQNNIDVYKSARDATVFITSTVFT
RSFFGVYPEKGTGTGFVISPEGEILTNNHVAGGGSELSVTLSDKKVYKARVLGIDTRNDLALIKIDAGRKLPVVPLGDSE
HLMVGQKVLAIGNPFQFEGTLTTGIVSSLGRTIQTEGERELEGMIQTDAAINPGNSGGPLLDSHGNVIGINTAIYGAQGS
IGIGFAMPISRAKAMLEEYKTRGKISRPTLGINTVYIAGDLAEMLQLPSSGGLLIQEVERGSAAAVAGLRGYSRIVIVGN
YRLGIGGDLITAADGHTIDDKETLKRLMDKKHGGDTLELTVNRGGRSEKIKVKLGEAPQQF

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=282, Percent_Identity=35.1063829787234, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI22129776, Length=324, Percent_Identity=34.2592592592593, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4506141, Length=173, Percent_Identity=45.0867052023121, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=33.1210191082803, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789629, Length=304, Percent_Identity=36.1842105263158, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1786356, Length=290, Percent_Identity=35.8620689655172, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1789630, Length=291, Percent_Identity=31.6151202749141, Blast_Score=125, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=34.4827586206897, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40550; Mature: 40550

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLRTFFWAAVLAAGFIWVTSVANWDVGRALRPVRNAGRMWSEPTAAAGAGFSTDEQNN
CHHHHHHHHHHHHHHHHHEEHCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCC
IDVYKSARDATVFITSTVFTRSFFGVYPEKGTGTGFVISPEGEILTNNHVAGGGSELSVT
EEEEECCCCEEEEEEEHHHHHHHHCCCCCCCCCCEEEECCCCCEEECCEECCCCCEEEEE
LSDKKVYKARVLGIDTRNDLALIKIDAGRKLPVVPLGDSEHLMVGQKVLAIGNPFQFEGT
ECCCEEEEEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCEEECCEEEEECCCEEECCC
LTTGIVSSLGRTIQTEGERELEGMIQTDAAINPGNSGGPLLDSHGNVIGINTAIYGAQGS
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCC
IGIGFAMPISRAKAMLEEYKTRGKISRPTLGINTVYIAGDLAEMLQLPSSGGLLIQEVER
EEEEEECCHHHHHHHHHHHHHCCCCCCCEECEEEEEEECCHHHHHHCCCCCCEEEEEECC
GSAAAVAGLRGYSRIVIVGNYRLGIGGDLITAADGHTIDDKETLKRLMDKKHGGDTLELT
CCHHEEHHCCCCEEEEEEECEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
VNRGGRSEKIKVKLGEAPQQF
EECCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MRVLRTFFWAAVLAAGFIWVTSVANWDVGRALRPVRNAGRMWSEPTAAAGAGFSTDEQNN
CHHHHHHHHHHHHHHHHHEEHCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCC
IDVYKSARDATVFITSTVFTRSFFGVYPEKGTGTGFVISPEGEILTNNHVAGGGSELSVT
EEEEECCCCEEEEEEEHHHHHHHHCCCCCCCCCCEEEECCCCCEEECCEECCCCCEEEEE
LSDKKVYKARVLGIDTRNDLALIKIDAGRKLPVVPLGDSEHLMVGQKVLAIGNPFQFEGT
ECCCEEEEEEEEEECCCCCEEEEEECCCCCCCEEECCCCCCEEECCEEEEECCCEEECCC
LTTGIVSSLGRTIQTEGERELEGMIQTDAAINPGNSGGPLLDSHGNVIGINTAIYGAQGS
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCC
IGIGFAMPISRAKAMLEEYKTRGKISRPTLGINTVYIAGDLAEMLQLPSSGGLLIQEVER
EEEEEECCHHHHHHHHHHHHHCCCCCCCEECEEEEEEECCHHHHHHCCCCCCEEEEEECC
GSAAAVAGLRGYSRIVIVGNYRLGIGGDLITAADGHTIDDKETLKRLMDKKHGGDTLELT
CCHHEEHHCCCCEEEEEEECEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
VNRGGRSEKIKVKLGEAPQQF
EECCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]