Click here to switch to the map view.

The map label for this gene is pyrF [H]

Identifier: 116623812

GI number: 116623812

Start: 5977460

End: 5978164

Strand: Reverse

Name: pyrF [H]

Synonym: Acid_4724

Alternate gene names: 116623812

Gene position: 5978164-5977460 (Counterclockwise)

Preceding gene: 116623813

Following gene: 116623811

Centisome position: 59.99

GC content: 65.11

Gene sequence:

>705_bases
ATGACGACGAAAGCTATGCACAACCCAATCATTGTCGCGCTGGACGTGGAATCGGCGGCGGAGGCCCGCGAGATGATCGC
GCGCATCGGACCGCGAGTGAACTTCTACAAGGTCGGGCTGGAACTCTATGCCGCATCGGGCATGGAGGTGGTGAAGGAAC
TGCTCGGCCAGGGCAAACAGGTTTTCCTGGATCTGAAGATGTATGACATCCCCGAAACGGTGTCGCGGGCGGTGGCTCAG
GTCGCGAAGACGGGAGTCACGTTCCTCACTGTGCATGCGGTGAGCAGCGTGATGCGGGCGGCGGTAGCGGCGCGCGAAGG
CAGCAAGCTGCGGATACTGGGAGTCACGGTGCTCACGAGCTTCGGGCCGGAAGACATGGACGATTTGGGGTACGACGGAA
CCGTCGGGGAACTGGTGGAGCGCCGCGCCAACAAGGCCGCGGAACTGGGCGTGGATGGAGTGGTGGCGTCGCCGCTGGAG
GCAGCGTCGGTGCGGCGAATTGTGGGTCCGCGGGTGGCGATCGTGACTCCGGGCGTGCGGTCGGCCGGTGTGGATGCGGG
CGATCAGAAGCGGATCGCGACCCCGGCGCAGGCGATGCTCGATGGCGCGGATTACCTGGTGATCGGGCGGCAGATCACGC
GCGCGAAGGATCCAGCGGCAGCGGTGGATCAGGTGCTGATGGAGATCGCCACGGCGCTGGTGTAA

Upstream 100 bases:

>100_bases
GGCTGCTGTACACGCTGCCGGAAGCCGAAGCGGCGAAGCTGAAGGTCGCGTGGCGCGTGGGACGGGTGCTGCCGCGCGGG
GAAAGAGCAATGCGAATCAT

Downstream 100 bases:

>100_bases
GGTTTCTGAAGTAAGAGGATTTTCAAAATTATGTGGAAGCGCGTTGTTTTTGTTTCGTTGCTGGCGGCGGTCTGCTTTGC
GCAGCATAGCGGAATCGACC

Product: orotidine-5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTTKAMHNPIIVALDVESAAEAREMIARIGPRVNFYKVGLELYAASGMEVVKELLGQGKQVFLDLKMYDIPETVSRAVAQ
VAKTGVTFLTVHAVSSVMRAAVAAREGSKLRILGVTVLTSFGPEDMDDLGYDGTVGELVERRANKAAELGVDGVVASPLE
AASVRRIVGPRVAIVTPGVRSAGVDAGDQKRIATPAQAMLDGADYLVIGRQITRAKDPAAAVDQVLMEIATALV

Sequences:

>Translated_234_residues
MTTKAMHNPIIVALDVESAAEAREMIARIGPRVNFYKVGLELYAASGMEVVKELLGQGKQVFLDLKMYDIPETVSRAVAQ
VAKTGVTFLTVHAVSSVMRAAVAAREGSKLRILGVTVLTSFGPEDMDDLGYDGTVGELVERRANKAAELGVDGVVASPLE
AASVRRIVGPRVAIVTPGVRSAGVDAGDQKRIATPAQAMLDGADYLVIGRQITRAKDPAAAVDQVLMEIATALV
>Mature_233_residues
TTKAMHNPIIVALDVESAAEAREMIARIGPRVNFYKVGLELYAASGMEVVKELLGQGKQVFLDLKMYDIPETVSRAVAQV
AKTGVTFLTVHAVSSVMRAAVAAREGSKLRILGVTVLTSFGPEDMDDLGYDGTVGELVERRANKAAELGVDGVVASPLEA
ASVRRIVGPRVAIVTPGVRSAGVDAGDQKRIATPAQAMLDGADYLVIGRQITRAKDPAAAVDQVLMEIATALV

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=219, Percent_Identity=41.5525114155251, Blast_Score=151, Evalue=4e-38,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 24685; Mature: 24554

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKAMHNPIIVALDVESAAEAREMIARIGPRVNFYKVGLELYAASGMEVVKELLGQGKQ
CCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCHHHHHHHHCCCCE
VFLDLKMYDIPETVSRAVAQVAKTGVTFLTVHAVSSVMRAAVAAREGSKLRILGVTVLTS
EEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHC
FGPEDMDDLGYDGTVGELVERRANKAAELGVDGVVASPLEAASVRRIVGPRVAIVTPGVR
CCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCH
SAGVDAGDQKRIATPAQAMLDGADYLVIGRQITRAKDPAAAVDQVLMEIATALV
HCCCCCCCCCCCCCHHHHHHCCCCEEEECHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTKAMHNPIIVALDVESAAEAREMIARIGPRVNFYKVGLELYAASGMEVVKELLGQGKQ
CCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCHHHHHHHHCCCCE
VFLDLKMYDIPETVSRAVAQVAKTGVTFLTVHAVSSVMRAAVAAREGSKLRILGVTVLTS
EEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHC
FGPEDMDDLGYDGTVGELVERRANKAAELGVDGVVASPLEAASVRRIVGPRVAIVTPGVR
CCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCH
SAGVDAGDQKRIATPAQAMLDGADYLVIGRQITRAKDPAAAVDQVLMEIATALV
HCCCCCCCCCCCCCHHHHHHCCCCEEEECHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA