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The map label for this gene is pepP [H]

Identifier: 116623810

GI number: 116623810

Start: 5973977

End: 5975380

Strand: Direct

Name: pepP [H]

Synonym: Acid_4722

Alternate gene names: 116623810

Gene position: 5973977-5975380 (Clockwise)

Preceding gene: 116623805

Following gene: 116623814

Centisome position: 59.95

GC content: 64.81

Gene sequence:

>1404_bases
ATGAAGAAGTTTTGGCTATTATTCTCACTGACCGTCGTCGCCTTCGCGCAACCGCCCCTGTTCACCGACTCCCTTCCCAA
AGAGGAGTTCGCCCAGCGCCGTGCCCGCCTCATGGAACAAATCGGCGACGGCATCGCGGTGGTGCAGGGCGCGACCGAAG
ATGCCGCCTACGTGAAGTTCCGCCAGAACAATCACTTCTTCTATCTCACCGGCGTCGAATCCCCGCGCGCCATCCTCCTG
CTCGATGCCCGCACTAAGTCCGCGACCCTATACCTCACGCCGCGCAACGAACGCGCCGAGCGCTCCGAAGGTCCCCTGCT
CGCGCCCGGCGAGGAAGCCGCCGCGCTCACCGGGATCCCCGTGGTCGCCGACCGCGCGCGCTTCGCCGACGACATCAAGA
AGCTCGGCGCCGAGCGCAGCGTGCTCTACACTCCCTACCGCCCCGAATCGCAAGCCGCCGTCACCCCCGACCGCTCCGCC
GTCCACCTCGCCGCCACCGCCGCCGATCCCTGGGATGGACGCCCCTCGCGCGAAACCGTCTTCCGCGAGAAACTCCAGGC
GCAGGCCCCGCGGCTCGAAATCAAGAACATCGACCCGATCCTCGATGCCATGCGCAGCATCAAGAGCCCGCGCGAGCTCG
CCCTCATCCGCGAGGCCACCCGCATCGCCGGCATCGCCATGATCGAGGCCATGCGCGCCGCCAAGCCCGGCATGTACGAG
TACGAAATCGAGGCTATCGGCGATTACGTCTTCAAGAAAAACAACGCGCAATACCCCGCTTACTTCGGCCTGGTCGCCGC
CGGCACCAACTCCTTCTGGCCCCACTATCACGCCGCGCAGGCGCAGCTCAAGCCCGGCGACCTGGTCCTCTTCGATTACG
CGCCGGATTACAAATACTACGCTTCCGACGTCACCCGCGAGTTCCCCGCCAGCGGCAAATTCACCGCGGCCCAGCGCGAT
CTCTACGGCGTCTATGTCGATCTATACCGCGCCCTGATGACGTCCATCCGCCCCAACGTCACCGCCCGCGCCGTCATGCA
GGATGCCGTGAAAAAGATGGATGCCATCATGGCCTCCCACCAGTTCACCAAAGAAACCTACCGCCAGGCCGCCCAGCGCT
TCGTCGAAAGCTATCGCAACAACGTCGGCCGCAGCCTCGGCCACCCCGTGGGCATGGAGGTCCACGACGTGCAGTCCCCT
CAGGAGCTGCTCAAGCCCGGCTACGTCTTCACCATTGAGCCCGCCCTCACGGTGCCCGAAGAGCGCATCTACATCCGCCT
CGAAGACGTCCTGGTGATCACCGAATCCGGTTACGAAAACCTCTCCGCCTTCGTCCCCGAGACCATCGACGAAGTCGAGT
CCGCCATGTCCGGCGCCAAGGTCGCCATCCCCGCAAAACGCTAG

Upstream 100 bases:

>100_bases
GCCAACAGGATGAGTTGTTCGAACTCCCCCAGGTACTCTCCCTTAGCCACTTCTACAAAATAGAGTCAGAGGATTTTCAA
GTCAAGTAAAATTACTACCC

Downstream 100 bases:

>100_bases
CGCGATGTTTTGTGGGGCAGCCAATCCTGGCTGCCGCCGGCTTTCAGCCGGCGCACTAATCAGTCTTTCCTACCACAACG
AGCACTGTTTCTCGTCCACT

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKKFWLLFSLTVVAFAQPPLFTDSLPKEEFAQRRARLMEQIGDGIAVVQGATEDAAYVKFRQNNHFFYLTGVESPRAILL
LDARTKSATLYLTPRNERAERSEGPLLAPGEEAAALTGIPVVADRARFADDIKKLGAERSVLYTPYRPESQAAVTPDRSA
VHLAATAADPWDGRPSRETVFREKLQAQAPRLEIKNIDPILDAMRSIKSPRELALIREATRIAGIAMIEAMRAAKPGMYE
YEIEAIGDYVFKKNNAQYPAYFGLVAAGTNSFWPHYHAAQAQLKPGDLVLFDYAPDYKYYASDVTREFPASGKFTAAQRD
LYGVYVDLYRALMTSIRPNVTARAVMQDAVKKMDAIMASHQFTKETYRQAAQRFVESYRNNVGRSLGHPVGMEVHDVQSP
QELLKPGYVFTIEPALTVPEERIYIRLEDVLVITESGYENLSAFVPETIDEVESAMSGAKVAIPAKR

Sequences:

>Translated_467_residues
MKKFWLLFSLTVVAFAQPPLFTDSLPKEEFAQRRARLMEQIGDGIAVVQGATEDAAYVKFRQNNHFFYLTGVESPRAILL
LDARTKSATLYLTPRNERAERSEGPLLAPGEEAAALTGIPVVADRARFADDIKKLGAERSVLYTPYRPESQAAVTPDRSA
VHLAATAADPWDGRPSRETVFREKLQAQAPRLEIKNIDPILDAMRSIKSPRELALIREATRIAGIAMIEAMRAAKPGMYE
YEIEAIGDYVFKKNNAQYPAYFGLVAAGTNSFWPHYHAAQAQLKPGDLVLFDYAPDYKYYASDVTREFPASGKFTAAQRD
LYGVYVDLYRALMTSIRPNVTARAVMQDAVKKMDAIMASHQFTKETYRQAAQRFVESYRNNVGRSLGHPVGMEVHDVQSP
QELLKPGYVFTIEPALTVPEERIYIRLEDVLVITESGYENLSAFVPETIDEVESAMSGAKVAIPAKR
>Mature_467_residues
MKKFWLLFSLTVVAFAQPPLFTDSLPKEEFAQRRARLMEQIGDGIAVVQGATEDAAYVKFRQNNHFFYLTGVESPRAILL
LDARTKSATLYLTPRNERAERSEGPLLAPGEEAAALTGIPVVADRARFADDIKKLGAERSVLYTPYRPESQAAVTPDRSA
VHLAATAADPWDGRPSRETVFREKLQAQAPRLEIKNIDPILDAMRSIKSPRELALIREATRIAGIAMIEAMRAAKPGMYE
YEIEAIGDYVFKKNNAQYPAYFGLVAAGTNSFWPHYHAAQAQLKPGDLVLFDYAPDYKYYASDVTREFPASGKFTAAQRD
LYGVYVDLYRALMTSIRPNVTARAVMQDAVKKMDAIMASHQFTKETYRQAAQRFVESYRNNVGRSLGHPVGMEVHDVQSP
QELLKPGYVFTIEPALTVPEERIYIRLEDVLVITESGYENLSAFVPETIDEVESAMSGAKVAIPAKR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=510, Percent_Identity=26.4705882352941, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI11559925, Length=481, Percent_Identity=26.1954261954262, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI260593665, Length=362, Percent_Identity=27.9005524861878, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI260593663, Length=513, Percent_Identity=23.7816764132554, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1789275, Length=458, Percent_Identity=31.0043668122271, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1788728, Length=268, Percent_Identity=28.7313432835821, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790282, Length=306, Percent_Identity=24.8366013071895, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=507, Percent_Identity=25.6410256410256, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71989583, Length=285, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320922, Length=459, Percent_Identity=25.4901960784314, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321118, Length=445, Percent_Identity=24.0449438202247, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920384, Length=399, Percent_Identity=31.8295739348371, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21357079, Length=478, Percent_Identity=26.7782426778243, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 52202; Mature: 52202

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFWLLFSLTVVAFAQPPLFTDSLPKEEFAQRRARLMEQIGDGIAVVQGATEDAAYVKF
CCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
RQNNHFFYLTGVESPRAILLLDARTKSATLYLTPRNERAERSEGPLLAPGEEAAALTGIP
EECCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHCCCCC
VVADRARFADDIKKLGAERSVLYTPYRPESQAAVTPDRSAVHLAATAADPWDGRPSRETV
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHH
FREKLQAQAPRLEIKNIDPILDAMRSIKSPRELALIREATRIAGIAMIEAMRAAKPGMYE
HHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
YEIEAIGDYVFKKNNAQYPAYFGLVAAGTNSFWPHYHAAQAQLKPGDLVLFDYAPDYKYY
EEHHHHHHHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHH
ASDVTREFPASGKFTAAQRDLYGVYVDLYRALMTSIRPNVTARAVMQDAVKKMDAIMASH
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QFTKETYRQAAQRFVESYRNNVGRSLGHPVGMEVHDVQSPQELLKPGYVFTIEPALTVPE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHCCCCEEEECCCCCCCC
ERIYIRLEDVLVITESGYENLSAFVPETIDEVESAMSGAKVAIPAKR
CEEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MKKFWLLFSLTVVAFAQPPLFTDSLPKEEFAQRRARLMEQIGDGIAVVQGATEDAAYVKF
CCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
RQNNHFFYLTGVESPRAILLLDARTKSATLYLTPRNERAERSEGPLLAPGEEAAALTGIP
EECCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHCCCCC
VVADRARFADDIKKLGAERSVLYTPYRPESQAAVTPDRSAVHLAATAADPWDGRPSRETV
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHH
FREKLQAQAPRLEIKNIDPILDAMRSIKSPRELALIREATRIAGIAMIEAMRAAKPGMYE
HHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
YEIEAIGDYVFKKNNAQYPAYFGLVAAGTNSFWPHYHAAQAQLKPGDLVLFDYAPDYKYY
EEHHHHHHHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHH
ASDVTREFPASGKFTAAQRDLYGVYVDLYRALMTSIRPNVTARAVMQDAVKKMDAIMASH
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QFTKETYRQAAQRFVESYRNNVGRSLGHPVGMEVHDVQSPQELLKPGYVFTIEPALTVPE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHCCCCEEEECCCCCCCC
ERIYIRLEDVLVITESGYENLSAFVPETIDEVESAMSGAKVAIPAKR
CEEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]