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The map label for this gene is mdh [H]

Identifier: 116623792

GI number: 116623792

Start: 5956554

End: 5957588

Strand: Direct

Name: mdh [H]

Synonym: Acid_4704

Alternate gene names: 116623792

Gene position: 5956554-5957588 (Clockwise)

Preceding gene: 116623788

Following gene: 116623793

Centisome position: 59.77

GC content: 65.12

Gene sequence:

>1035_bases
ATGCCAACCATCTCTGTCCAACATTTGACCCAATTCTGTGAAGCGATTCTTGAAGGCGCGGGAGTTCCGCGCCACAAGGC
GGAGGTCACCACGGGCTGCCTGGTAGCCTCGAATTTGCGTGGCGTCGATTCCCACGGAATTCAGCTGCTGCCGTTTTATA
TCGACCAGCTCTTGGCCGGCGAAATGGACGCGCAGGCCGAGGGCCGCGTGATCTCCGAGAGCGGCAGCTGCCTGCACTTC
GACGGACAGAATGCGCTCGGTCAATGGGTGGCGGAAAACTGCTGCAAGCACGCCGTGCGGATCGCGCGCGAGAACGGAAT
GGCGCTCGTCGTCGCCAGGGAATCGAACCACTTCGGCGCCGCGGCCTGGTGGGCGCAGAAGATGCGCGCCGCCGGACAGA
TCGGCATCGTGATGTGCAACGCGTCGCCGATCGTGCCGCCATGGCAGGGCAGAGAGGGCCGCATGGGCACCAACCCCATC
TGCATGTCGGTGCCCGGCCCCTGGCTCCTCGACATGGCGACCACCACCGTGGCCGCCGGCAAAATCTTCAAGGCCTTCCT
CAACGACCAGCCCGAGATTCCCGCCGGCTGGGCCTTCGATTCCCAAGGCGTGCCGACCACCGATACGCAGGCGGCGTACA
AAGGAATGCTCATGCCACTCGGCGGCTACAAGGGTAGCGGCCTCGCCATGATGGTGGAGATTCTCTGCTCCGTGCTCAGC
GGCGGAGCCATGGCCAACGAAGTCGGCGGTATCCGCTTCCGCGGCAAGCGGGTCCGCGTCAGCCAGATGTACATGGCGAT
CGACGTCGCGCGCTTCATGCCGCTCGAGGTGTTCACGGCCCGCGTGGAGCAACTGGTCGCGCTCATGAAATCCACCAAGA
CCGCGCCCGGTTACACCGAAGTCATGGTGGCCGGCGACCCCGAATGGCGCATGGAGGCCGAGCGCCGCGAGAACGGCATT
CCGATCGCCGGCGGCAATTGGGACCAGCTGGTGAAGGCGGCCGCGAAGGTCCACGTGTCGGCTCCCGCGGTCTGA

Upstream 100 bases:

>100_bases
CTGTTTCCGCGTGTGCCGCGCCAAGGCAGAAAATCAGGAGCCCGAGAGTGCGAAGCATGGTGGGCATTGTATCGCAGGCG
CTGAGTTACCCTGTAGTTTC

Downstream 100 bases:

>100_bases
TCCCGCTACAATGGAATCAGTGCTGGTTTCCATTTCCCCCAAGCTCGATCGTCCGCAGTGGCTGCGTGCGCCCGCACCCG
CAGGCGAGAATTATCGCGAT

Product: malate dehydrogenase (NAD)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPTISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMDAQAEGRVISESGSCLHF
DGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGAAAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPI
CMSVPGPWLLDMATTTVAAGKIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKGMLMPLGGYKGSGLAMMVEILCSVLS
GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTEVMVAGDPEWRMEAERRENGI
PIAGGNWDQLVKAAAKVHVSAPAV

Sequences:

>Translated_344_residues
MPTISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMDAQAEGRVISESGSCLHF
DGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGAAAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPI
CMSVPGPWLLDMATTTVAAGKIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKGMLMPLGGYKGSGLAMMVEILCSVLS
GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTEVMVAGDPEWRMEAERRENGI
PIAGGNWDQLVKAAAKVHVSAPAV
>Mature_343_residues
PTISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAGEMDAQAEGRVISESGSCLHFD
GQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGAAAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPIC
MSVPGPWLLDMATTTVAAGKIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKGMLMPLGGYKGSGLAMMVEILCSVLSG
GAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTEVMVAGDPEWRMEAERRENGIP
IAGGNWDQLVKAAAKVHVSAPAV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=339, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787020, Length=347, Percent_Identity=30.5475504322767, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790000, Length=333, Percent_Identity=25.8258258258258, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17507179, Length=316, Percent_Identity=35.4430379746835, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17536633, Length=348, Percent_Identity=30.7471264367816, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45553211, Length=324, Percent_Identity=33.0246913580247, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24667912, Length=324, Percent_Identity=33.0246913580247, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24667908, Length=324, Percent_Identity=33.0246913580247, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24667904, Length=324, Percent_Identity=33.0246913580247, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24658010, Length=319, Percent_Identity=29.7805642633229, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24648360, Length=318, Percent_Identity=30.188679245283, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 36916; Mature: 36785

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAG
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCCCCCCCCEEHHHHHHHHHHC
EMDAQAEGRVISESGSCLHFDGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGA
CCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
AAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPICMSVPGPWLLDMATTTVAAG
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
KIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKGMLMPLGGYKGSGLAMMVEILCSVLS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHC
GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTE
CCCHHHHCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VMVAGDPEWRMEAERRENGIPIAGGNWDQLVKAAAKVHVSAPAV
EEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCC
>Mature Secondary Structure 
PTISVQHLTQFCEAILEGAGVPRHKAEVTTGCLVASNLRGVDSHGIQLLPFYIDQLLAG
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEECCCCCCCCCCCEEHHHHHHHHHHC
EMDAQAEGRVISESGSCLHFDGQNALGQWVAENCCKHAVRIARENGMALVVARESNHFGA
CCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCH
AAWWAQKMRAAGQIGIVMCNASPIVPPWQGREGRMGTNPICMSVPGPWLLDMATTTVAAG
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
KIFKAFLNDQPEIPAGWAFDSQGVPTTDTQAAYKGMLMPLGGYKGSGLAMMVEILCSVLS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHC
GGAMANEVGGIRFRGKRVRVSQMYMAIDVARFMPLEVFTARVEQLVALMKSTKTAPGYTE
CCCHHHHCCCEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VMVAGDPEWRMEAERRENGIPIAGGNWDQLVKAAAKVHVSAPAV
EEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]