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The map label for this gene is lepB [H]

Identifier: 116623640

GI number: 116623640

Start: 5751338

End: 5752129

Strand: Direct

Name: lepB [H]

Synonym: Acid_4552

Alternate gene names: 116623640

Gene position: 5751338-5752129 (Clockwise)

Preceding gene: 116623637

Following gene: 116623641

Centisome position: 57.71

GC content: 57.7

Gene sequence:

>792_bases
GTGGATCAAGAAAACGTAGTCGTGGCCGACCAGGAGCCACTTGAGGTAGCGGAACCAACATCTCCCGAACCGCAGCGTGG
GTTCATAGCCGAATGGGCCGTTACCATCATCCTCCTGCTCTTTGGCACCACCAACCTGGTTCAGGCCTTCGTGATTCCCA
CCGGCTCCATGGAAGACACTTTGTTGATCGGCGATCACCTGCTGGTGGACAAGCTCGCCTATGGTCCCCCCGGACCCGCC
TCCAGGTTTATTCTTCCCTACTCCGAACCGAAACGCGGCGATATCATCGTCTTTCGCTATCCCATCGATATCCAGCAGAC
CTTCGTCAAGCGCTGCATCGGCGTTCCGGGCGACCACATACGGCTGGTCAATAAACAGCTCATCCTCAACGGGCACGCCG
TGACCGAGCCCTACGTTTACCACAAGAGCGACATGATCGATTCCTACCGGGATAATTTTCCCGGGGAGCCCAACGTCCGG
GTGCCCGATGCCGCCATCGACATGCTCACCAATCATCTGCAGAACGACGAAATCGTGGTGCCGCCGGGCTTCTATTTCGC
CATGGGCGATAACCGGGACTCGTCGCTCGACAGCCGTTATTGGGGTTTTGTGCCGCGCGCCAACATCATCGGCAAACCGC
TCATTATTTACTGGTCGTACGACGCATCCACCGAGGCCCTCTCCAAACCCATGATGTCCGTAGACCACTTGCTCGACCTG
GTCCAGCATTTTCCGACCAAGACGCGCTGGCTCCGTACCTTCCGCCTGATCCGCGGCTATCCGCTCAAATAA

Upstream 100 bases:

>100_bases
CATCTGGCTGCATGACCTGGACTGTGGAAAGTGTACTCAAGCGGGAACCTTAAAAGATACTCAAAACAGGATAACAAGGA
TTTCGCTAGAATGAGGAGTA

Downstream 100 bases:

>100_bases
CATGAACCGACATCATTATGGATTGATCCTCGCCGGTGGGCGCGGAACGCGCTTCTGGCCGCGAAGCCGCAAGCGCACAG
CCAAGCAGGTGCTCAATGTG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MDQENVVVADQEPLEVAEPTSPEPQRGFIAEWAVTIILLLFGTTNLVQAFVIPTGSMEDTLLIGDHLLVDKLAYGPPGPA
SRFILPYSEPKRGDIIVFRYPIDIQQTFVKRCIGVPGDHIRLVNKQLILNGHAVTEPYVYHKSDMIDSYRDNFPGEPNVR
VPDAAIDMLTNHLQNDEIVVPPGFYFAMGDNRDSSLDSRYWGFVPRANIIGKPLIIYWSYDASTEALSKPMMSVDHLLDL
VQHFPTKTRWLRTFRLIRGYPLK

Sequences:

>Translated_263_residues
MDQENVVVADQEPLEVAEPTSPEPQRGFIAEWAVTIILLLFGTTNLVQAFVIPTGSMEDTLLIGDHLLVDKLAYGPPGPA
SRFILPYSEPKRGDIIVFRYPIDIQQTFVKRCIGVPGDHIRLVNKQLILNGHAVTEPYVYHKSDMIDSYRDNFPGEPNVR
VPDAAIDMLTNHLQNDEIVVPPGFYFAMGDNRDSSLDSRYWGFVPRANIIGKPLIIYWSYDASTEALSKPMMSVDHLLDL
VQHFPTKTRWLRTFRLIRGYPLK
>Mature_263_residues
MDQENVVVADQEPLEVAEPTSPEPQRGFIAEWAVTIILLLFGTTNLVQAFVIPTGSMEDTLLIGDHLLVDKLAYGPPGPA
SRFILPYSEPKRGDIIVFRYPIDIQQTFVKRCIGVPGDHIRLVNKQLILNGHAVTEPYVYHKSDMIDSYRDNFPGEPNVR
VPDAAIDMLTNHLQNDEIVVPPGFYFAMGDNRDSSLDSRYWGFVPRANIIGKPLIIYWSYDASTEALSKPMMSVDHLLDL
VQHFPTKTRWLRTFRLIRGYPLK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=235, Percent_Identity=34.8936170212766, Blast_Score=124, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 29823; Mature: 29823

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQENVVVADQEPLEVAEPTSPEPQRGFIAEWAVTIILLLFGTTNLVQAFVIPTGSMEDT
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCE
LLIGDHLLVDKLAYGPPGPASRFILPYSEPKRGDIIVFRYPIDIQQTFVKRCIGVPGDHI
EEECCHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHE
RLVNKQLILNGHAVTEPYVYHKSDMIDSYRDNFPGEPNVRVPDAAIDMLTNHLQNDEIVV
EEECCEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
PPGFYFAMGDNRDSSLDSRYWGFVPRANIIGKPLIIYWSYDASTEALSKPMMSVDHLLDL
CCCEEEEECCCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQHFPTKTRWLRTFRLIRGYPLK
HHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDQENVVVADQEPLEVAEPTSPEPQRGFIAEWAVTIILLLFGTTNLVQAFVIPTGSMEDT
CCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCE
LLIGDHLLVDKLAYGPPGPASRFILPYSEPKRGDIIVFRYPIDIQQTFVKRCIGVPGDHI
EEECCHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHE
RLVNKQLILNGHAVTEPYVYHKSDMIDSYRDNFPGEPNVRVPDAAIDMLTNHLQNDEIVV
EEECCEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
PPGFYFAMGDNRDSSLDSRYWGFVPRANIIGKPLIIYWSYDASTEALSKPMMSVDHLLDL
CCCEEEEECCCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQHFPTKTRWLRTFRLIRGYPLK
HHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]