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The map label for this gene is maeB [H]

Identifier: 116623627

GI number: 116623627

Start: 5738794

End: 5741085

Strand: Reverse

Name: maeB [H]

Synonym: Acid_4539

Alternate gene names: 116623627

Gene position: 5741085-5738794 (Counterclockwise)

Preceding gene: 116623628

Following gene: 116623626

Centisome position: 57.61

GC content: 63.44

Gene sequence:

>2292_bases
ATGAAGATTCGTCCCGAAGACGCTCTGGAGTACCATTCCTCAGCTCCCGCCGGAAAACTGGCGGTAAATCCTACCAAACC
CTGCCGTACGCAGCGCGATCTCAGTCTCGCCTATACGCCGGGCGTCGCTGTACCCTGCCTGGAAATCGAGCGCGATCCCA
GCCTCGCCTACAAATACACCGCCAAGGGCAACCTGGTGGGGGTCGTCTCCAATGGAACCGCGGTCCTCGGACTCGGCAAC
ATCGGCCCGCTCGCCGGCAAGCCGGTGATGGAGGGCAAGGCCGTTTTGTTTAAACGCTTCGCCGATATCGACGTCTTCGA
TATCGAGCTGGACACCGCCAACGCGGACGAGGTCATCCGCACCTGCCAGATTCTGGAGCCTACCTTCGGCGGCATCAACC
TCGAGGACATCAAAGCGCCGGAGTGTTTCTACATCGAAGAGACCCTGCGCAACACCATGAAGATCCCCGTCTTCCACGAC
GACCAGCACGGCACTGCAATCATCAGCGGCGCCGGACTGCTGAATGCCCTGGAGATCGGCGGCAAGAAGATCGAAGATAT
CAAAGTCGTGTTCAACGGCGCGGGCGCGGCGGCCATCAGCTGCGCGGCCCACTATGTGCGTTTGGGCGTGCGCCTGGAAA
ATATCGTGATGTGCGACACCAAGGGCGTGATCTACGAGGGCCGCACCGAGCACATGAACTCCTACAAGGCGCGCTACGCC
AGCAAGACTAAGGCGCGGACTTTGGAAGAAGCGCTGGTCGGCGCCGATGTGTTTTTCGGGCTGAGCAGCGGGGGCGCCGT
CACCCAGGATATGGTGCGCGGCATGGCGCCGAGCCCGGTGATCTTCGCGATGGCCAATCCCGACCCGGAAATCAGCTATG
ACGATGCGATCGCGGCCCGTCCCGATGCGATCGTCGCCACCGGCCGCAGCGACTATCCCAACCAGGTGAACAACGTCCTG
GGCTTCCCGTTCATTTTCCGCGGGGCGCTGGACGTGCGGGCCACCACCATCAACGACGAAATGAAACTGGCGGCGACGCG
GGCATTGGCTGCGCTGGCCAAGGAAGATGTCCCGGACAGCGTGCTGCGGGCCTACTCGATCGACCGCATCGAATTCGGGC
GTGAGTACATCATCCCAAAACCCTTCGATCCCCGCGTCCTGATCTGGGAGGCGTCGGCCGTGGCGCAGGCGGCCATGGAG
ACCGGCGTCGCACAGCAGCCGGTGGACCTGAAGCAATACCGCGAGGAGCTCGAAAAGCGCTTGGGCCGCGCCAACGAGGT
CATGCGCGCCATGATCAACAAAGCGCGCCGCCAGCCCAAGCGGATCGTCTTCACGGAGGGCGAGGAGGGCAAGATCCTGC
GCGCCTGCCAGATTCTGCTGGACGAGCAGATCGCCGAGCCGATCCTGCTGGGCAGCGCGGAAAAGATCAACGCGAAGATC
GAGGAATTGCACCTGCACCTGAACGGCGCCCAGATCGTGGAACCGGCCAAATTCGCACGACTTCACGAGTACACCGAGGA
ATTCTACAGCCTGCGCCAGCGCAAGGGCATCACCCGGACGGAGGCGGAGCAGACGCTGCTGAATCCGACCACGTTCGGCA
GCATGATGCTGCGTCTGAACGATGCCGACGCGCTGATCGGCGGGTTGACCACCCATTACCCGGACACGATCCGTCCGGCT
CTGCAGGTGATCGACATCCGTCCGGAACTGCGGCGCGTGGCCGGGGTCTACGTGCTGATCACGGCCAAGGGAGACATTTA
CTTCCTGGCCGACGCCACGGTAAACATCGAACCGACCGCCGAAGATCTGGCGGAGATCGCGATCATGGCCGCGGAAAAGG
CGCGGCGCTTCAGTGTGGAGCCGCGCGTGGCGATGCTCAGCTTCTCGAATTTCGGGAGCACGCGGCATCCGCTGGCCGAT
AAGGTACGGCGCGCCGTGGACCTGGTGCGACAGCGCGCGCCCGGCCTGATGATCGATGGCGAGATGCAGGCCGACACCGC
GGTGGTGCCGCACATCATCGAGGAGACCTATCCGTTCAGCACCCTCAAGGGCGGGGCGAATGTGCTGGTCTTCCCCAACC
TGGAATCGGGGAACATCGCGTACAAGCTGCTGCAGCGCATCGGGGACTGCGAACTGATCGGACCGCTGCTTACGGGCCTG
AGCCGTCCCGTTCACGTGCTGCAGCGCGGCAGCGAAGTCAACGACATCGTGCACGTCGCGGCGGTGGCCGTGGTGGACGC
GCAGGAAGTCGGCAAACCGTACCGCACCCTCAGCCAGGAGCCGGTAGCGTAG

Upstream 100 bases:

>100_bases
TCCGAACCCACCGATCACGCGAAAGACTAGCCGGCACGAAAATAGCCTACCTGTAGAATAAGACCTCAGGGTATAATTAT
CGCTGAAAGGCCACGCATTC

Downstream 100 bases:

>100_bases
GTACGGCGCGGCCTCTCTACAAGCGGCCGAGCCGCAAAGAGACGCTCCCTGAGGTCGCGGCTCTGACTGAGGGCGGTGCG
AGAAGCCTTCGACGGCTTGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MKIRPEDALEYHSSAPAGKLAVNPTKPCRTQRDLSLAYTPGVAVPCLEIERDPSLAYKYTAKGNLVGVVSNGTAVLGLGN
IGPLAGKPVMEGKAVLFKRFADIDVFDIELDTANADEVIRTCQILEPTFGGINLEDIKAPECFYIEETLRNTMKIPVFHD
DQHGTAIISGAGLLNALEIGGKKIEDIKVVFNGAGAAAISCAAHYVRLGVRLENIVMCDTKGVIYEGRTEHMNSYKARYA
SKTKARTLEEALVGADVFFGLSSGGAVTQDMVRGMAPSPVIFAMANPDPEISYDDAIAARPDAIVATGRSDYPNQVNNVL
GFPFIFRGALDVRATTINDEMKLAATRALAALAKEDVPDSVLRAYSIDRIEFGREYIIPKPFDPRVLIWEASAVAQAAME
TGVAQQPVDLKQYREELEKRLGRANEVMRAMINKARRQPKRIVFTEGEEGKILRACQILLDEQIAEPILLGSAEKINAKI
EELHLHLNGAQIVEPAKFARLHEYTEEFYSLRQRKGITRTEAEQTLLNPTTFGSMMLRLNDADALIGGLTTHYPDTIRPA
LQVIDIRPELRRVAGVYVLITAKGDIYFLADATVNIEPTAEDLAEIAIMAAEKARRFSVEPRVAMLSFSNFGSTRHPLAD
KVRRAVDLVRQRAPGLMIDGEMQADTAVVPHIIEETYPFSTLKGGANVLVFPNLESGNIAYKLLQRIGDCELIGPLLTGL
SRPVHVLQRGSEVNDIVHVAAVAVVDAQEVGKPYRTLSQEPVA

Sequences:

>Translated_763_residues
MKIRPEDALEYHSSAPAGKLAVNPTKPCRTQRDLSLAYTPGVAVPCLEIERDPSLAYKYTAKGNLVGVVSNGTAVLGLGN
IGPLAGKPVMEGKAVLFKRFADIDVFDIELDTANADEVIRTCQILEPTFGGINLEDIKAPECFYIEETLRNTMKIPVFHD
DQHGTAIISGAGLLNALEIGGKKIEDIKVVFNGAGAAAISCAAHYVRLGVRLENIVMCDTKGVIYEGRTEHMNSYKARYA
SKTKARTLEEALVGADVFFGLSSGGAVTQDMVRGMAPSPVIFAMANPDPEISYDDAIAARPDAIVATGRSDYPNQVNNVL
GFPFIFRGALDVRATTINDEMKLAATRALAALAKEDVPDSVLRAYSIDRIEFGREYIIPKPFDPRVLIWEASAVAQAAME
TGVAQQPVDLKQYREELEKRLGRANEVMRAMINKARRQPKRIVFTEGEEGKILRACQILLDEQIAEPILLGSAEKINAKI
EELHLHLNGAQIVEPAKFARLHEYTEEFYSLRQRKGITRTEAEQTLLNPTTFGSMMLRLNDADALIGGLTTHYPDTIRPA
LQVIDIRPELRRVAGVYVLITAKGDIYFLADATVNIEPTAEDLAEIAIMAAEKARRFSVEPRVAMLSFSNFGSTRHPLAD
KVRRAVDLVRQRAPGLMIDGEMQADTAVVPHIIEETYPFSTLKGGANVLVFPNLESGNIAYKLLQRIGDCELIGPLLTGL
SRPVHVLQRGSEVNDIVHVAAVAVVDAQEVGKPYRTLSQEPVA
>Mature_763_residues
MKIRPEDALEYHSSAPAGKLAVNPTKPCRTQRDLSLAYTPGVAVPCLEIERDPSLAYKYTAKGNLVGVVSNGTAVLGLGN
IGPLAGKPVMEGKAVLFKRFADIDVFDIELDTANADEVIRTCQILEPTFGGINLEDIKAPECFYIEETLRNTMKIPVFHD
DQHGTAIISGAGLLNALEIGGKKIEDIKVVFNGAGAAAISCAAHYVRLGVRLENIVMCDTKGVIYEGRTEHMNSYKARYA
SKTKARTLEEALVGADVFFGLSSGGAVTQDMVRGMAPSPVIFAMANPDPEISYDDAIAARPDAIVATGRSDYPNQVNNVL
GFPFIFRGALDVRATTINDEMKLAATRALAALAKEDVPDSVLRAYSIDRIEFGREYIIPKPFDPRVLIWEASAVAQAAME
TGVAQQPVDLKQYREELEKRLGRANEVMRAMINKARRQPKRIVFTEGEEGKILRACQILLDEQIAEPILLGSAEKINAKI
EELHLHLNGAQIVEPAKFARLHEYTEEFYSLRQRKGITRTEAEQTLLNPTTFGSMMLRLNDADALIGGLTTHYPDTIRPA
LQVIDIRPELRRVAGVYVLITAKGDIYFLADATVNIEPTAEDLAEIAIMAAEKARRFSVEPRVAMLSFSNFGSTRHPLAD
KVRRAVDLVRQRAPGLMIDGEMQADTAVVPHIIEETYPFSTLKGGANVLVFPNLESGNIAYKLLQRIGDCELIGPLLTGL
SRPVHVLQRGSEVNDIVHVAAVAVVDAQEVGKPYRTLSQEPVA

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=403, Percent_Identity=26.7990074441687, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI62420880, Length=403, Percent_Identity=26.7990074441687, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI239049447, Length=403, Percent_Identity=26.7990074441687, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4505143, Length=401, Percent_Identity=24.1895261845387, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1788806, Length=751, Percent_Identity=52.8628495339547, Blast_Score=761, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=317, Percent_Identity=36.5930599369085, Blast_Score=211, Evalue=2e-55,
Organism=Escherichia coli, GI1788635, Length=317, Percent_Identity=38.801261829653, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17537199, Length=418, Percent_Identity=25.1196172248804, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=252, Percent_Identity=30.952380952381, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281362674, Length=398, Percent_Identity=27.1356783919598, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356279, Length=398, Percent_Identity=27.1356783919598, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281362672, Length=398, Percent_Identity=27.1356783919598, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646388, Length=354, Percent_Identity=27.683615819209, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646386, Length=354, Percent_Identity=27.683615819209, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI78707242, Length=415, Percent_Identity=25.3012048192771, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707238, Length=415, Percent_Identity=25.3012048192771, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707240, Length=341, Percent_Identity=26.099706744868, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83451; Mature: 83451

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRPEDALEYHSSAPAGKLAVNPTKPCRTQRDLSLAYTPGVAVPCLEIERDPSLAYKYT
CCCCCCHHHHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCEEEEEE
AKGNLVGVVSNGTAVLGLGNIGPLAGKPVMEGKAVLFKRFADIDVFDIELDTANADEVIR
CCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHH
TCQILEPTFGGINLEDIKAPECFYIEETLRNTMKIPVFHDDQHGTAIISGAGLLNALEIG
HHHHHCCCCCCCCHHHCCCCCEEEHHHHHHCCEECEEEECCCCCEEEEECCCHHHHHHHC
GKKIEDIKVVFNGAGAAAISCAAHYVRLGVRLENIVMCDTKGVIYEGRTEHMNSYKARYA
CCEEEEEEEEEECCCHHHHHHHHHHHHHCEEEEEEEEECCCCCEECCCHHHHHHHHHHHH
SKTKARTLEEALVGADVFFGLSSGGAVTQDMVRGMAPSPVIFAMANPDPEISYDDAIAAR
HHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLGFPFIFRGALDVRATTINDEMKLAATRALAALAKEDVPDS
CCEEEECCCCCCCHHHHHHCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHH
VLRAYSIDRIEFGREYIIPKPFDPRVLIWEASAVAQAAMETGVAQQPVDLKQYREELEKR
HHHHHCCCHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LGRANEVMRAMINKARRQPKRIVFTEGEEGKILRACQILLDEQIAEPILLGSAEKINAKI
HCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHCCEE
EELHLHLNGAQIVEPAKFARLHEYTEEFYSLRQRKGITRTEAEQTLLNPTTFGSMMLRLN
EEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEC
DADALIGGLTTHYPDTIRPALQVIDIRPELRRVAGVYVLITAKGDIYFLADATVNIEPTA
CHHHHHHCHHHCCCHHHHHHHHEEECCHHHHHHCCEEEEEEECCCEEEEEEEEEECCCCH
EDLAEIAIMAAEKARRFSVEPRVAMLSFSNFGSTRHPLADKVRRAVDLVRQRAPGLMIDG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
EMQADTAVVPHIIEETYPFSTLKGGANVLVFPNLESGNIAYKLLQRIGDCELIGPLLTGL
CCCCCCHHHHHHHHHCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCC
SRPVHVLQRGSEVNDIVHVAAVAVVDAQEVGKPYRTLSQEPVA
CCHHHHHHCCCHHHHHHHHHHHHEECHHHHCCHHHHCCCCCCC
>Mature Secondary Structure
MKIRPEDALEYHSSAPAGKLAVNPTKPCRTQRDLSLAYTPGVAVPCLEIERDPSLAYKYT
CCCCCCHHHHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCEEEEECCCCCEEEEEE
AKGNLVGVVSNGTAVLGLGNIGPLAGKPVMEGKAVLFKRFADIDVFDIELDTANADEVIR
CCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHH
TCQILEPTFGGINLEDIKAPECFYIEETLRNTMKIPVFHDDQHGTAIISGAGLLNALEIG
HHHHHCCCCCCCCHHHCCCCCEEEHHHHHHCCEECEEEECCCCCEEEEECCCHHHHHHHC
GKKIEDIKVVFNGAGAAAISCAAHYVRLGVRLENIVMCDTKGVIYEGRTEHMNSYKARYA
CCEEEEEEEEEECCCHHHHHHHHHHHHHCEEEEEEEEECCCCCEECCCHHHHHHHHHHHH
SKTKARTLEEALVGADVFFGLSSGGAVTQDMVRGMAPSPVIFAMANPDPEISYDDAIAAR
HHHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLGFPFIFRGALDVRATTINDEMKLAATRALAALAKEDVPDS
CCEEEECCCCCCCHHHHHHCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHH
VLRAYSIDRIEFGREYIIPKPFDPRVLIWEASAVAQAAMETGVAQQPVDLKQYREELEKR
HHHHHCCCHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LGRANEVMRAMINKARRQPKRIVFTEGEEGKILRACQILLDEQIAEPILLGSAEKINAKI
HCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHCCEE
EELHLHLNGAQIVEPAKFARLHEYTEEFYSLRQRKGITRTEAEQTLLNPTTFGSMMLRLN
EEEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEC
DADALIGGLTTHYPDTIRPALQVIDIRPELRRVAGVYVLITAKGDIYFLADATVNIEPTA
CHHHHHHCHHHCCCHHHHHHHHEEECCHHHHHHCCEEEEEEECCCEEEEEEEEEECCCCH
EDLAEIAIMAAEKARRFSVEPRVAMLSFSNFGSTRHPLADKVRRAVDLVRQRAPGLMIDG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECC
EMQADTAVVPHIIEETYPFSTLKGGANVLVFPNLESGNIAYKLLQRIGDCELIGPLLTGL
CCCCCCHHHHHHHHHCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCC
SRPVHVLQRGSEVNDIVHVAAVAVVDAQEVGKPYRTLSQEPVA
CCHHHHHHCCCHHHHHHHHHHHHEECHHHHCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]