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The map label for this gene is pyrD

Identifier: 116623492

GI number: 116623492

Start: 5573110

End: 5574024

Strand: Reverse

Name: pyrD

Synonym: Acid_4402

Alternate gene names: 116623492

Gene position: 5574024-5573110 (Counterclockwise)

Preceding gene: 116623493

Following gene: 116623488

Centisome position: 55.93

GC content: 65.14

Gene sequence:

>915_bases
ATGACGCCGCAACTGGCCACCACCATCTGCGGAATCGCTCTCAAGAATCCGGTGTTGGCCGCCAGCGGCACGTTCGCGTA
CGGTGTGGAATTCGAAAAGCTCGTTGATCTCAACGCGCTCGGGGGCTTCGTGGTCAAGGGCCTGTCGCGCGAGCCGATCG
AAGGCAATCCGCCGCCGCGCGTCTTTGAGAGCGAGGCCGGCATGATCAACTCCGTCGGCCTGCAGAACATTGGTGTGCGT
GCTTTCGTCGCCGAGAAACTTCCGGCGCTCGCCGGCCTGCGCACCGCTGTTTTCGCCAACGTCTTTGGCTACTGCACAGA
GGATTACGTCGAAGTCGTACGCGTCCTCAACGATCATGCGGGGCTCGCCGGATACGAGCTCAACGTATCCTGCCCCAACA
CGGCGCACGGCGGCATCTACTTCTCGAACGATCCCGTGCTGCTGGCCGAGGTCGTCACCGCGGCCAAGCGGGTGGCTACC
CGCCCTCTGATCGTCAAGCTCTCCCCCAACGTGTCCGCCATCGAGCCGCTCGCCCGTGTAGCCGAGGAGAGCGGTGCCGA
TGCCCTCTCGCTGGTGAACACCGTGATCAGCCTGGCCATCGACGCGCGCACCCGCCGGCCGCGCATCGGCGCCGGTTTCG
GAGGACTCTCCGGGCCGGCAATCAAGCCCATCGCGCTCCGCTTCGTCTATCAGGCGGCGCGCGCGGTGCGCATTCCGGTA
ATCGGACTCGGCGGCATCGCGACTGGCGAAGATGCCGCCGAATTCCTGATCGCCGGTGCGAGCGCCGTCGAAGTCGGCAC
CGCCACGTTCTGGGATCCCCGCGCCCCCCTTCGCATCGCCGAAGAACTCGGGAAATTCCTCGAACGCGAAGGCATCCGGA
AGGCTACCGACTTGGTGGGCACGCTGAAGTTTTAG

Upstream 100 bases:

>100_bases
CGGTGCAATCCGTGGACCTGGCCCCGACGCTGGCGCGTGCCACCGGCATGGCCACACCCGAATCCTCGGTGGGCCAGGTG
CTTGGTGAGGCGTTCGCGTA

Downstream 100 bases:

>100_bases
TTTTTCTCGCAGAGACGCAGAGCCGCAGAGAACCGCAAAGAAGAAAAGGTCCGGATCTTTCTTCTTGGCTTTGCGGCTTT
GCGAGAACCGGCTGTTTGGC

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRVFESEAGMINSVGLQNIGVR
AFVAEKLPALAGLRTAVFANVFGYCTEDYVEVVRVLNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVAT
RPLIVKLSPNVSAIEPLARVAEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPIALRFVYQAARAVRIPV
IGLGGIATGEDAAEFLIAGASAVEVGTATFWDPRAPLRIAEELGKFLEREGIRKATDLVGTLKF

Sequences:

>Translated_304_residues
MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRVFESEAGMINSVGLQNIGVR
AFVAEKLPALAGLRTAVFANVFGYCTEDYVEVVRVLNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVAT
RPLIVKLSPNVSAIEPLARVAEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPIALRFVYQAARAVRIPV
IGLGGIATGEDAAEFLIAGASAVEVGTATFWDPRAPLRIAEELGKFLEREGIRKATDLVGTLKF
>Mature_303_residues
TPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRVFESEAGMINSVGLQNIGVRA
FVAEKLPALAGLRTAVFANVFGYCTEDYVEVVRVLNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATR
PLIVKLSPNVSAIEPLARVAEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPIALRFVYQAARAVRIPVI
GLGGIATGEDAAEFLIAGASAVEVGTATFWDPRAPLRIAEELGKFLEREGIRKATDLVGTLKF

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=31.25, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI119943098, Length=179, Percent_Identity=36.3128491620112, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=29.4670846394984, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=179, Percent_Identity=32.4022346368715, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=319, Percent_Identity=31.3479623824451, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281361352, Length=324, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137316, Length=324, Percent_Identity=30.5555555555556, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640763, Length=176, Percent_Identity=33.5227272727273, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18858217, Length=176, Percent_Identity=33.5227272727273, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SOLUE (Q01YA2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825648.1
- ProteinModelPortal:   Q01YA2
- SMR:   Q01YA2
- STRING:   Q01YA2
- GeneID:   4427326
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4402
- NMPDR:   fig|234267.9.peg.4188
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- PhylomeDB:   Q01YA2
- ProtClustDB:   CLSK774280
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 31894; Mature: 31763

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPR
CCCHHHHHHHHHHHCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VFESEAGMINSVGLQNIGVRAFVAEKLPALAGLRTAVFANVFGYCTEDYVEVVRVLNDHA
CCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATRPLIVKLSPNVSAIEPLARV
CCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
AEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPIALRFVYQAARAVRIPV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECEE
IGLGGIATGEDAAEFLIAGASAVEVGTATFWDPRAPLRIAEELGKFLEREGIRKATDLVG
EECCCCCCCHHHHHHHHCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
TLKF
HCCC
>Mature Secondary Structure 
TPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPR
CCHHHHHHHHHHHCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
VFESEAGMINSVGLQNIGVRAFVAEKLPALAGLRTAVFANVFGYCTEDYVEVVRVLNDHA
CCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATRPLIVKLSPNVSAIEPLARV
CCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
AEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPIALRFVYQAARAVRIPV
HHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECEE
IGLGGIATGEDAAEFLIAGASAVEVGTATFWDPRAPLRIAEELGKFLEREGIRKATDLVG
EECCCCCCCHHHHHHHHCCCCHHEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
TLKF
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA