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The map label for this gene is glmU

Identifier: 116623455

GI number: 116623455

Start: 5528793

End: 5530193

Strand: Direct

Name: glmU

Synonym: Acid_4364

Alternate gene names: 116623455

Gene position: 5528793-5530193 (Clockwise)

Preceding gene: 116623454

Following gene: 116623456

Centisome position: 55.48

GC content: 64.1

Gene sequence:

>1401_bases
ATGGAAGTGATGCCCCAGCCGCTCACGATCGTCATCCTCGCCGCCGGACTCGGCACCCGCATGAAGAGCCGCCACGCAAA
AGTGCTCCACCAGGCAGGCGGCAAGACCCTCCTGCAGCACGTCATCGATACCGCGCTCGAACTTGCGCCCGCGGAGCGAA
TCTTCGTGGTCGTCGGCCACCAGGCGGAAAAAGTTCGACAGTCCGTGACCACGCCGGGAATCGGCTTTATCGAGCAGACC
GAGCAGAAGGGCACGGGTCACGCGGTCCTGATCGGCCGACACGCGCTCGCGGGCCTCGATGGCCACCTGATGGTGCTTTA
CGGCGATTGCCCGCTGCTCCGTACCGAAACCCTGCGCCGCCTGATCGCACAAGCGGCCGAAGGCCCCGCCGCCGGAGTTC
TGCTCAGCGCCATGATGGATGATCCCTATGGCTACGGCCGCGTGATCCGCGACTCCCGCGGCCACGTACTCGACGTCGTG
GAGCAGAAGTCAGGCACGCCCGAGCAGCTCGCCATCAAGGAAGCCAACATGGGCATCTACTGCTTCCGTGCCGGCCTCTT
CTGGGAGCACGTCGGCGAGATCGAGCCCAACAATCCCGCGGGCGAGTATTATCTCACCGACATGCCGGCCATCCTGCATC
GCGCCGGCCACACCGTGGAAGCCATGCGGATCGACGATCCGGCCGAAGCCCTGGGCATCAACGATCGCGCCCAGCTTGCC
GAGGTTGACCGCATCTTCCGCGATCGCAAACGCCGCGCCGTAATGGCTGCCGGCGTCACGCTGATCCAGCCCGAAACGAT
CACGATCGACCCCGCCGCCGAAATCGGACAGGACAGCATCATCGAGTCCTTCGCGCAAATTCTCGGGAAGACGAAGATCG
GCGAGAATTGCCGCGTCGGCTCCTGCTCCATCGTCAGCGATTCCACGCTCGCCGACGAAGTGCACATCGGCGCCTTCACG
ATTGTCACCACATCAGTACTCGAGCATGGCGTCCACGCCGGCCCCTATGCCCGGCTGCGCATGGAGAACCACGTGGAAGC
CGGCGCTCACATCGGCAACTTCGTCGAGTTGAAAAAGACGCGCATGGGCAAGGGCGCCAAGGCCAATCACCTCGCCTATC
TCGGCGATTCGGAGATCGGCGCGCGCGTCAACATCGGGGCCGGCACCATCACCTGCAATTACGATGGCTTCAAGAAGCAC
CGCACGGGCATCGGCGAAGGCGCATTCGTCGGCAGCAACTCGACGCTGGTGGCGCCGATCGATATCGGCGAAGGAGCCTA
CGTCGCGGCCGGCTCCGTGATCACCAATCCGGTTCCTCCAGACGCCTTGGCGCTGGGCCGCGCGCGCCAGGAAATCAAAG
AAGAGTGGGCTAAAAAGCGGCGGAAACTGGCGAAAACCTGA

Upstream 100 bases:

>100_bases
ATCTGGCTGAGCACAGCAACAAAGTCCGCCACGATTCCGCCGCGACCGCTGCCGTCCTGGTCAAACTCGCCCAGGAAGGC
CACCGCCGCAAGCACGCATA

Downstream 100 bases:

>100_bases
ACACCTCCGGCCCTTCAAGTGCATCTATAAGAGTGTGAAGTACCTTTGCGCGCTGATTCTGCTGCCCTTTGCGCCGGCCT
TCGCCCAATTCAAAAGCACC

Product: UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MEVMPQPLTIVILAAGLGTRMKSRHAKVLHQAGGKTLLQHVIDTALELAPAERIFVVVGHQAEKVRQSVTTPGIGFIEQT
EQKGTGHAVLIGRHALAGLDGHLMVLYGDCPLLRTETLRRLIAQAAEGPAAGVLLSAMMDDPYGYGRVIRDSRGHVLDVV
EQKSGTPEQLAIKEANMGIYCFRAGLFWEHVGEIEPNNPAGEYYLTDMPAILHRAGHTVEAMRIDDPAEALGINDRAQLA
EVDRIFRDRKRRAVMAAGVTLIQPETITIDPAAEIGQDSIIESFAQILGKTKIGENCRVGSCSIVSDSTLADEVHIGAFT
IVTTSVLEHGVHAGPYARLRMENHVEAGAHIGNFVELKKTRMGKGAKANHLAYLGDSEIGARVNIGAGTITCNYDGFKKH
RTGIGEGAFVGSNSTLVAPIDIGEGAYVAAGSVITNPVPPDALALGRARQEIKEEWAKKRRKLAKT

Sequences:

>Translated_466_residues
MEVMPQPLTIVILAAGLGTRMKSRHAKVLHQAGGKTLLQHVIDTALELAPAERIFVVVGHQAEKVRQSVTTPGIGFIEQT
EQKGTGHAVLIGRHALAGLDGHLMVLYGDCPLLRTETLRRLIAQAAEGPAAGVLLSAMMDDPYGYGRVIRDSRGHVLDVV
EQKSGTPEQLAIKEANMGIYCFRAGLFWEHVGEIEPNNPAGEYYLTDMPAILHRAGHTVEAMRIDDPAEALGINDRAQLA
EVDRIFRDRKRRAVMAAGVTLIQPETITIDPAAEIGQDSIIESFAQILGKTKIGENCRVGSCSIVSDSTLADEVHIGAFT
IVTTSVLEHGVHAGPYARLRMENHVEAGAHIGNFVELKKTRMGKGAKANHLAYLGDSEIGARVNIGAGTITCNYDGFKKH
RTGIGEGAFVGSNSTLVAPIDIGEGAYVAAGSVITNPVPPDALALGRARQEIKEEWAKKRRKLAKT
>Mature_466_residues
MEVMPQPLTIVILAAGLGTRMKSRHAKVLHQAGGKTLLQHVIDTALELAPAERIFVVVGHQAEKVRQSVTTPGIGFIEQT
EQKGTGHAVLIGRHALAGLDGHLMVLYGDCPLLRTETLRRLIAQAAEGPAAGVLLSAMMDDPYGYGRVIRDSRGHVLDVV
EQKSGTPEQLAIKEANMGIYCFRAGLFWEHVGEIEPNNPAGEYYLTDMPAILHRAGHTVEAMRIDDPAEALGINDRAQLA
EVDRIFRDRKRRAVMAAGVTLIQPETITIDPAAEIGQDSIIESFAQILGKTKIGENCRVGSCSIVSDSTLADEVHIGAFT
IVTTSVLEHGVHAGPYARLRMENHVEAGAHIGNFVELKKTRMGKGAKANHLAYLGDSEIGARVNIGAGTITCNYDGFKKH
RTGIGEGAFVGSNSTLVAPIDIGEGAYVAAGSVITNPVPPDALALGRARQEIKEEWAKKRRKLAKT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=40.3470715835141, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SOLUE (Q01YD9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_825611.1
- ProteinModelPortal:   Q01YD9
- SMR:   Q01YD9
- STRING:   Q01YD9
- GeneID:   4427358
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_4364
- NMPDR:   fig|234267.9.peg.4152
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q01YD9
- ProtClustDB:   CLSK774617
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50074; Mature: 50074

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 370-370 BINDING 79-79 BINDING 146-146 BINDING 161-161 BINDING 176-176 BINDING 394-394 BINDING 412-412 BINDING 430-430 BINDING 447-447

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVMPQPLTIVILAAGLGTRMKSRHAKVLHQAGGKTLLQHVIDTALELAPAERIFVVVGH
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
QAEKVRQSVTTPGIGFIEQTEQKGTGHAVLIGRHALAGLDGHLMVLYGDCPLLRTETLRR
CHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEECHHHCCCCCCEEEEECCCCCHHHHHHHH
LIAQAAEGPAAGVLLSAMMDDPYGYGRVIRDSRGHVLDVVEQKSGTPEQLAIKEANMGIY
HHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEHHHHCCCCCHHEEEEECCCCEE
CFRAGLFWEHVGEIEPNNPAGEYYLTDMPAILHRAGHTVEAMRIDDPAEALGINDRAQLA
EEECCHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEEECCHHHHCCCCCHHHHH
EVDRIFRDRKRRAVMAAGVTLIQPETITIDPAAEIGQDSIIESFAQILGKTKIGENCRVG
HHHHHHHHHHHHHHHHCCEEEECCCEEEECCHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
SCSIVSDSTLADEVHIGAFTIVTTSVLEHGVHAGPYARLRMENHVEAGAHIGNFVELKKT
CEEEECCCCCCCCEECCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCCCHHHHHHHH
RMGKGAKANHLAYLGDSEIGARVNIGAGTITCNYDGFKKHRTGIGEGAFVGSNSTLVAPI
HCCCCCCCCEEEEECCCCCCCEEEECCEEEEECCCCCHHHHCCCCCCEEECCCCEEEEEE
DIGEGAYVAAGSVITNPVPPDALALGRARQEIKEEWAKKRRKLAKT
ECCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEVMPQPLTIVILAAGLGTRMKSRHAKVLHQAGGKTLLQHVIDTALELAPAERIFVVVGH
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
QAEKVRQSVTTPGIGFIEQTEQKGTGHAVLIGRHALAGLDGHLMVLYGDCPLLRTETLRR
CHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEECHHHCCCCCCEEEEECCCCCHHHHHHHH
LIAQAAEGPAAGVLLSAMMDDPYGYGRVIRDSRGHVLDVVEQKSGTPEQLAIKEANMGIY
HHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEHHHHCCCCCHHEEEEECCCCEE
CFRAGLFWEHVGEIEPNNPAGEYYLTDMPAILHRAGHTVEAMRIDDPAEALGINDRAQLA
EEECCHHHHHHCCCCCCCCCCCEEECCCHHHHHHCCCCEEEEEECCHHHHCCCCCHHHHH
EVDRIFRDRKRRAVMAAGVTLIQPETITIDPAAEIGQDSIIESFAQILGKTKIGENCRVG
HHHHHHHHHHHHHHHHCCEEEECCCEEEECCHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
SCSIVSDSTLADEVHIGAFTIVTTSVLEHGVHAGPYARLRMENHVEAGAHIGNFVELKKT
CEEEECCCCCCCCEECCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCCCHHHHHHHH
RMGKGAKANHLAYLGDSEIGARVNIGAGTITCNYDGFKKHRTGIGEGAFVGSNSTLVAPI
HCCCCCCCCEEEEECCCCCCCEEEECCEEEEECCCCCHHHHCCCCCCEEECCCCEEEEEE
DIGEGAYVAAGSVITNPVPPDALALGRARQEIKEEWAKKRRKLAKT
ECCCCCEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA