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The map label for this gene is ntrY [H]

Identifier: 116623262

GI number: 116623262

Start: 5286129

End: 5287457

Strand: Direct

Name: ntrY [H]

Synonym: Acid_4169

Alternate gene names: 116623262

Gene position: 5286129-5287457 (Clockwise)

Preceding gene: 116623261

Following gene: 116623265

Centisome position: 53.04

GC content: 67.34

Gene sequence:

>1329_bases
ATGAACGTCACCGAGAAACCAGCGCTGCTCAGCCACGAAGGCCGCGTCGTCCTGCTGGCGATTCTCGCGGGTTTGCCCGG
CTCCGCCGCCGCCCTCATCATGCTGTGGACCGGCGACGCCACCACCAAAGTTCAGTGGACCCTCAGTGTGATCATCCTCG
GCGCCTGGCTCGGCTTCGCCTTCGCCGTCCGCGAACGCGTCGTCTTCCCGCTGCAGACGCTCTCCAACTTGCTCGGCGCC
CTCCGCGAAGGCGACTTTTCCGTGCGGGGCCGCTCGCCGCGGCCCGACGACGCGCTCGGCGAAGTCATGCGCGAAGTCAA
CACCCTGGGCAGTACTCTGCGCGAGCAGCGCCTCGGCGCCATGGAGGCCACCACTCTTCTCCGCACCGTCATGCGCGAGA
TCGCCGTCGCCATTTTCGCCTTCGACGAAAATCAGCGCCTTCGGCTCGTCAACCGCGCCGGCGAACGACTCCTCGCTTCC
ACCGCCGAACGTCTCCTCGGTCAGACCGCCGCCGAACTTCAAATGGATGTCTGCCTCGATGGTCCCCCGGTCACCACGCT
CCAGACCGTCTTCCCGGGCGGCGCGGGACGCTGGGGCGTGCGCCGCACCCGCATCCGAGAGCACGGCCTGCCGCTCGAAC
TCATCGTGATCTCCGATCTCACCCAGGCCCTGAGCGAGCAGGAGCTCCACGCCTGGCAGCGCCTTGTACGCGTGCTCGGC
CACGAGCTCAATAACTCGCTCACTCCCATCAAATCCATCGCCGGCAGCCTGGAAGCCATCGTCATGCGCCCCACGCTCCC
CGACGACTGGCGCGACGATATGCGCCGCGGCCTCAGCGTCATCATGTCACGCTCGGATAGCCTCAGCCGCTTCATCGGCG
CCTACGCCCGCCTCGCCAAATTGCCGCGCCCGCAACTGCAACCGCTCTCTGTGGCCGATTGCGTGGGCCGCGCCGTCAGC
TTCGAAACCCGCCTGCCCGTGCAAATCGAGGCCGGCCCAAATGTCACCATACAGGGCGACCCCGACCAGCTGGAGCAGGT
CCTCATCAACCTCCTCCGCAACGCCGCCGACGCCTCCCTCACCACTCACGGCGCCGTCACCATCGGCTGGCACCACGACA
CCATGATGGAAATCTGGATCAAAGACGACGGCCCCGGCCTCTCGAGCACGGCCAACCTGTTCGTCCCCTTCTTCACCACC
AAACCCGGCGGCAGCGGCATCGGCCTCGTCCTCAGCCGCCAGATCGCCGAAGGCCACGGCGGCGCGCTCTCCCTGGAAAA
TCGCCCCGACGCCCCCGGCTGCGTTGCGCGCCTGCGATTACCAGCCTGA

Upstream 100 bases:

>100_bases
CGCTTCAGCGGCAACGTCAGCCACGCGGCCAACGCGCTCGGCCTGAGCCGCAGCGCTCTTTATCGCCGGCTCCAACGCTA
CGGGCTCTAGGGCCGACCTT

Downstream 100 bases:

>100_bases
GAGCGCTTCTTATCCGCGTTGATCCGTGTTCATCCGTGGCCCTCCCAGTGTGGGTTGGCTACTGTGCGCCTCGGTGCTCA
ACGCGCAGCGCGCGGCTACC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MNVTEKPALLSHEGRVVLLAILAGLPGSAAALIMLWTGDATTKVQWTLSVIILGAWLGFAFAVRERVVFPLQTLSNLLGA
LREGDFSVRGRSPRPDDALGEVMREVNTLGSTLREQRLGAMEATTLLRTVMREIAVAIFAFDENQRLRLVNRAGERLLAS
TAERLLGQTAAELQMDVCLDGPPVTTLQTVFPGGAGRWGVRRTRIREHGLPLELIVISDLTQALSEQELHAWQRLVRVLG
HELNNSLTPIKSIAGSLEAIVMRPTLPDDWRDDMRRGLSVIMSRSDSLSRFIGAYARLAKLPRPQLQPLSVADCVGRAVS
FETRLPVQIEAGPNVTIQGDPDQLEQVLINLLRNAADASLTTHGAVTIGWHHDTMMEIWIKDDGPGLSSTANLFVPFFTT
KPGGSGIGLVLSRQIAEGHGGALSLENRPDAPGCVARLRLPA

Sequences:

>Translated_442_residues
MNVTEKPALLSHEGRVVLLAILAGLPGSAAALIMLWTGDATTKVQWTLSVIILGAWLGFAFAVRERVVFPLQTLSNLLGA
LREGDFSVRGRSPRPDDALGEVMREVNTLGSTLREQRLGAMEATTLLRTVMREIAVAIFAFDENQRLRLVNRAGERLLAS
TAERLLGQTAAELQMDVCLDGPPVTTLQTVFPGGAGRWGVRRTRIREHGLPLELIVISDLTQALSEQELHAWQRLVRVLG
HELNNSLTPIKSIAGSLEAIVMRPTLPDDWRDDMRRGLSVIMSRSDSLSRFIGAYARLAKLPRPQLQPLSVADCVGRAVS
FETRLPVQIEAGPNVTIQGDPDQLEQVLINLLRNAADASLTTHGAVTIGWHHDTMMEIWIKDDGPGLSSTANLFVPFFTT
KPGGSGIGLVLSRQIAEGHGGALSLENRPDAPGCVARLRLPA
>Mature_442_residues
MNVTEKPALLSHEGRVVLLAILAGLPGSAAALIMLWTGDATTKVQWTLSVIILGAWLGFAFAVRERVVFPLQTLSNLLGA
LREGDFSVRGRSPRPDDALGEVMREVNTLGSTLREQRLGAMEATTLLRTVMREIAVAIFAFDENQRLRLVNRAGERLLAS
TAERLLGQTAAELQMDVCLDGPPVTTLQTVFPGGAGRWGVRRTRIREHGLPLELIVISDLTQALSEQELHAWQRLVRVLG
HELNNSLTPIKSIAGSLEAIVMRPTLPDDWRDDMRRGLSVIMSRSDSLSRFIGAYARLAKLPRPQLQPLSVADCVGRAVS
FETRLPVQIEAGPNVTIQGDPDQLEQVLINLLRNAADASLTTHGAVTIGWHHDTMMEIWIKDDGPGLSSTANLFVPFFTT
KPGGSGIGLVLSRQIAEGHGGALSLENRPDAPGCVARLRLPA

Specific function: Member of the two-component regulatory system ntrY/ntrX involved in nitrogen level control. Probably activates ntrX by phosphorylation [H]

COG id: COG5000

COG function: function code T; Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=385, Percent_Identity=27.7922077922078, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790300, Length=343, Percent_Identity=25.9475218658892, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=27.3127753303965, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=29.1497975708502, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR017232 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48038; Mature: 48038

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTEKPALLSHEGRVVLLAILAGLPGSAAALIMLWTGDATTKVQWTLSVIILGAWLGFA
CCCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHH
FAVRERVVFPLQTLSNLLGALREGDFSVRGRSPRPDDALGEVMREVNTLGSTLREQRLGA
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
MEATTLLRTVMREIAVAIFAFDENQRLRLVNRAGERLLASTAERLLGQTAAELQMDVCLD
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEC
GPPVTTLQTVFPGGAGRWGVRRTRIREHGLPLELIVISDLTQALSEQELHAWQRLVRVLG
CCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
HELNNSLTPIKSIAGSLEAIVMRPTLPDDWRDDMRRGLSVIMSRSDSLSRFIGAYARLAK
HHHCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LPRPQLQPLSVADCVGRAVSFETRLPVQIEAGPNVTIQGDPDQLEQVLINLLRNAADASL
CCCCCCCCCCHHHHHHHHHEECCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCE
TTHGAVTIGWHHDTMMEIWIKDDGPGLSSTANLFVPFFTTKPGGSGIGLVLSRQIAEGHG
EECCEEEEEECCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCC
GALSLENRPDAPGCVARLRLPA
CEEEECCCCCCCCHHHEEECCC
>Mature Secondary Structure
MNVTEKPALLSHEGRVVLLAILAGLPGSAAALIMLWTGDATTKVQWTLSVIILGAWLGFA
CCCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHH
FAVRERVVFPLQTLSNLLGALREGDFSVRGRSPRPDDALGEVMREVNTLGSTLREQRLGA
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
MEATTLLRTVMREIAVAIFAFDENQRLRLVNRAGERLLASTAERLLGQTAAELQMDVCLD
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEC
GPPVTTLQTVFPGGAGRWGVRRTRIREHGLPLELIVISDLTQALSEQELHAWQRLVRVLG
CCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
HELNNSLTPIKSIAGSLEAIVMRPTLPDDWRDDMRRGLSVIMSRSDSLSRFIGAYARLAK
HHHCCCCCHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LPRPQLQPLSVADCVGRAVSFETRLPVQIEAGPNVTIQGDPDQLEQVLINLLRNAADASL
CCCCCCCCCCHHHHHHHHHEECCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCE
TTHGAVTIGWHHDTMMEIWIKDDGPGLSSTANLFVPFFTTKPGGSGIGLVLSRQIAEGHG
EECCEEEEEECCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCC
GALSLENRPDAPGCVARLRLPA
CEEEECCCCCCCCHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1661370 [H]