Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 116623261

GI number: 116623261

Start: 5284748

End: 5286118

Strand: Direct

Name: zraR [H]

Synonym: Acid_4168

Alternate gene names: 116623261

Gene position: 5284748-5286118 (Clockwise)

Preceding gene: 116623260

Following gene: 116623262

Centisome position: 53.03

GC content: 65.35

Gene sequence:

>1371_bases
ATGAAATCTTCCGAAACGCGCACGCCTTGCATCCTGGTTGCCGACGACCAGGCCGACGTACTCGAAGCGCTACGCTTCCT
GATCAAAGGGGAGAACTACCAGGCTGTGGCCGTCAACTCCCCCGCCGCCGTCATCGATGAAGTCGAATCCCGCGACTACG
ACGCCGTCCTGATCGATCTCAACTACACCCGCGATACCACCAGTGGACAGGAGGGCCTCGAGCTCCTCAACCGCATTCAG
CTTCTGGATAGCACCCTCCCCGTCATCGTCATGACCGCCTGGGGCTCAGTCGAACTCGCGGTCGAAGCCATGCGCCGCGG
CGCCCGCGATTTCATCCAGAAGCCTTGGGAGAACGCCCGCCTCACCGCCATCCTCAAGACCCAGATCGAGCTGGGCCGCG
CCCTGCGCCGCGGCCAGCGCCTCGAAGACGAAAACCGCGCCCTCCGCGCCGAGCGCTTCCCCCAGCTGATCGCGCAATCC
GCCGCCATGCGCCCGGTGCTCGACGTGATCTCCCGCGTCGGACCCTCGGATGCCAACGTCTTCATCACCGGCGAGAACGG
CACCGGCAAAGGCCTGGTCGCCCAGACCCTCCACTCCGTCTCCCTGCGCTCCACCCGCCCGCTGGTCACTGTAAACACCG
GCGGACTCGCCGAAGGCGTCTTCGAAAGCGAACTCTTTGGCCACGTCAAAGGCGCCTTCACGGACGCCAAGAGCGATCGC
GTCGGCCGCTTCGAAATGGCGGACGGCGGCACGCTCTTCCTCGATGAAATCGCGAATATTTCCCAAGGCCTCCAGGCCAA
GCTGCTGCGCACTCTCGAGACCGGCGAGTTCGAACGCGTCGGCTCCTCCAAAACCCGCCGCGTCGATGTGCGTGTCTTCT
CCGCGACGAATGCCGACCTCGTCACCGAAGTCGCCGAAGGCAAATTTCGCCAGGACTTACTCTTCCGCCTCAACACCATC
GAAATCCGCCTGCCCCCGCTGCGCGATCGCCGCGAGGATATCTCCATCCTCGCCGCCCACTTCCTCCGCCAGCACTCCGA
CCATTACCGCAAGCCGCTCAACGGCTTCGACGAAGGCGCGATCAAGGCGCTGCTCGCCCACGCCTGGCCCGGCAACGTCC
GCGAACTCGATCACGCCGTGGAGCGCGCCGTCCTCATGGCGCAGGGCGACTCGGTCCGCGCCGTCGATCTCGGCCTGCGC
ACCGGCCGTGAAGGTCCGCCGCGGCTCGAAGAAATGAGCCTCGAAGATGTGGAAGCCCTGCTCATTAAGAAGGCTCTCGC
CCGCTTCAGCGGCAACGTCAGCCACGCGGCCAACGCGCTCGGCCTGAGCCGCAGCGCTCTTTATCGCCGGCTCCAACGCT
ACGGGCTCTAG

Upstream 100 bases:

>100_bases
CGCACGGTGCTAATGTAATAATAACCGCTTACAGAACAGGCACATAGCATATGGCAGGGGAAATGCCACTGCGGTTCGTT
GCGGCACAACTGAGCGACCG

Downstream 100 bases:

>100_bases
GGCCGACCTTATGAACGTCACCGAGAAACCAGCGCTGCTCAGCCACGAAGGCCGCGTCGTCCTGCTGGCGATTCTCGCGG
GTTTGCCCGGCTCCGCCGCC

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKSSETRTPCILVADDQADVLEALRFLIKGENYQAVAVNSPAAVIDEVESRDYDAVLIDLNYTRDTTSGQEGLELLNRIQ
LLDSTLPVIVMTAWGSVELAVEAMRRGARDFIQKPWENARLTAILKTQIELGRALRRGQRLEDENRALRAERFPQLIAQS
AAMRPVLDVISRVGPSDANVFITGENGTGKGLVAQTLHSVSLRSTRPLVTVNTGGLAEGVFESELFGHVKGAFTDAKSDR
VGRFEMADGGTLFLDEIANISQGLQAKLLRTLETGEFERVGSSKTRRVDVRVFSATNADLVTEVAEGKFRQDLLFRLNTI
EIRLPPLRDRREDISILAAHFLRQHSDHYRKPLNGFDEGAIKALLAHAWPGNVRELDHAVERAVLMAQGDSVRAVDLGLR
TGREGPPRLEEMSLEDVEALLIKKALARFSGNVSHAANALGLSRSALYRRLQRYGL

Sequences:

>Translated_456_residues
MKSSETRTPCILVADDQADVLEALRFLIKGENYQAVAVNSPAAVIDEVESRDYDAVLIDLNYTRDTTSGQEGLELLNRIQ
LLDSTLPVIVMTAWGSVELAVEAMRRGARDFIQKPWENARLTAILKTQIELGRALRRGQRLEDENRALRAERFPQLIAQS
AAMRPVLDVISRVGPSDANVFITGENGTGKGLVAQTLHSVSLRSTRPLVTVNTGGLAEGVFESELFGHVKGAFTDAKSDR
VGRFEMADGGTLFLDEIANISQGLQAKLLRTLETGEFERVGSSKTRRVDVRVFSATNADLVTEVAEGKFRQDLLFRLNTI
EIRLPPLRDRREDISILAAHFLRQHSDHYRKPLNGFDEGAIKALLAHAWPGNVRELDHAVERAVLMAQGDSVRAVDLGLR
TGREGPPRLEEMSLEDVEALLIKKALARFSGNVSHAANALGLSRSALYRRLQRYGL
>Mature_456_residues
MKSSETRTPCILVADDQADVLEALRFLIKGENYQAVAVNSPAAVIDEVESRDYDAVLIDLNYTRDTTSGQEGLELLNRIQ
LLDSTLPVIVMTAWGSVELAVEAMRRGARDFIQKPWENARLTAILKTQIELGRALRRGQRLEDENRALRAERFPQLIAQS
AAMRPVLDVISRVGPSDANVFITGENGTGKGLVAQTLHSVSLRSTRPLVTVNTGGLAEGVFESELFGHVKGAFTDAKSDR
VGRFEMADGGTLFLDEIANISQGLQAKLLRTLETGEFERVGSSKTRRVDVRVFSATNADLVTEVAEGKFRQDLLFRLNTI
EIRLPPLRDRREDISILAAHFLRQHSDHYRKPLNGFDEGAIKALLAHAWPGNVRELDHAVERAVLMAQGDSVRAVDLGLR
TGREGPPRLEEMSLEDVEALLIKKALARFSGNVSHAANALGLSRSALYRRLQRYGL

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=41.7040358744395, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1788550, Length=463, Percent_Identity=38.2289416846652, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1790299, Length=478, Percent_Identity=35.5648535564854, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=34.2984409799555, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=41.6422287390029, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1789087, Length=333, Percent_Identity=42.042042042042, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=39.0625, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=44.5141065830721, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87081872, Length=236, Percent_Identity=48.3050847457627, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1786524, Length=320, Percent_Identity=38.125, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1787583, Length=343, Percent_Identity=35.2769679300292, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI87081858, Length=284, Percent_Identity=31.6901408450704, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789828, Length=238, Percent_Identity=36.5546218487395, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50411; Mature: 50411

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSSETRTPCILVADDQADVLEALRFLIKGENYQAVAVNSPAAVIDEVESRDYDAVLIDL
CCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEE
NYTRDTTSGQEGLELLNRIQLLDSTLPVIVMTAWGSVELAVEAMRRGARDFIQKPWENAR
ECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCE
LTAILKTQIELGRALRRGQRLEDENRALRAERFPQLIAQSAAMRPVLDVISRVGPSDANV
EEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FITGENGTGKGLVAQTLHSVSLRSTRPLVTVNTGGLAEGVFESELFGHVKGAFTDAKSDR
EEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
VGRFEMADGGTLFLDEIANISQGLQAKLLRTLETGEFERVGSSKTRRVDVRVFSATNADL
CCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEECCCHHH
VTEVAEGKFRQDLLFRLNTIEIRLPPLRDRREDISILAAHFLRQHSDHYRKPLNGFDEGA
HHHHHCCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKALLAHAWPGNVRELDHAVERAVLMAQGDSVRAVDLGLRTGREGPPRLEEMSLEDVEAL
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCCHHHCCHHHHHHH
LIKKALARFSGNVSHAANALGLSRSALYRRLQRYGL
HHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKSSETRTPCILVADDQADVLEALRFLIKGENYQAVAVNSPAAVIDEVESRDYDAVLIDL
CCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEE
NYTRDTTSGQEGLELLNRIQLLDSTLPVIVMTAWGSVELAVEAMRRGARDFIQKPWENAR
ECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCE
LTAILKTQIELGRALRRGQRLEDENRALRAERFPQLIAQSAAMRPVLDVISRVGPSDANV
EEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FITGENGTGKGLVAQTLHSVSLRSTRPLVTVNTGGLAEGVFESELFGHVKGAFTDAKSDR
EEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
VGRFEMADGGTLFLDEIANISQGLQAKLLRTLETGEFERVGSSKTRRVDVRVFSATNADL
CCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEECCCHHH
VTEVAEGKFRQDLLFRLNTIEIRLPPLRDRREDISILAAHFLRQHSDHYRKPLNGFDEGA
HHHHHCCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKALLAHAWPGNVRELDHAVERAVLMAQGDSVRAVDLGLRTGREGPPRLEEMSLEDVEAL
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCCHHHCCHHHHHHH
LIKKALARFSGNVSHAANALGLSRSALYRRLQRYGL
HHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]