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The map label for this gene is hpd [H]

Identifier: 116623260

GI number: 116623260

Start: 5283417

End: 5284544

Strand: Direct

Name: hpd [H]

Synonym: Acid_4167

Alternate gene names: 116623260

Gene position: 5283417-5284544 (Clockwise)

Preceding gene: 116623259

Following gene: 116623261

Centisome position: 53.02

GC content: 61.7

Gene sequence:

>1128_bases
ATGCCGCAAATCTTGGAGCAAGCCACGCCGGCTGAGAAGGATTTCCTCCCTCTCAACGGCACCGATTACGTCGAGTTCTA
CGTCGGCAACGCGCGCCAGGCCGCGCACTTCTATCGCACCGCCTTCGGCTTCCGCCTTGCCGCCTATCGCGGCCCCGAAA
CCGGCACCCGCGATCGCGCGAGCTACGTCCTGGTGCAGGACAAGATCCGGATCGTCCTCACCACGCCGCTGCAACCCGAC
GGCGAGATCGCCGAGCATGTTCGTATCCACGGCGATGGCGTGCGCGATATCGCCCTTTGGGTCGATGATGCCGCCGCTGC
GTGGCGCGAAACCACCGCGCGCGGCGCCCGCAGCGTCCGTGAACCCGAAACCGTGCGCGACGATTCCGGCGAAGTCCGCA
TGTCCGCCATCGGCATCTATGGCGATACCATCCACACCTTCGTCGAGCGCCGCGGCTACCAGGGGCCCTTCCTTCCCGGC
TTCGAAGCCGTACCCGGCGAAGACCACCTCGCGCGCCCCGCCGGACTCAAGTACATCGATCACATGGTCGGCAACGTCGG
CTGGGGCGAAATGAATCGCTGGGTGGATTTCTACCGCGATGTCATGGGCTTCCGCATGTTCAAGCACTTCGACGACAACG
ATATTTCCACCGAGTACTCCGCGCTCATGTCGAAGGTCATGTCCAACGGCAACGAGCGCGTCAAGTTCCCCATCAACGAG
CCCGCCCACGCCAAGCGCAAGTCGCAGATCGAAGAGTATCTCGAGTACTATCACGGCCCCGGCGTACAGCACATCGCCAT
GGCGACCGATAACATCATCGAGACCGTCGGCACACTCCGCCGCCAGGGCGTCGATTTCCTGCGCGTCCCTTCCACCTACT
ATGACGACCTGCAATCGCGTGTTGGCAAGATCGATGAGCCCGTCGCCGACCTCAAAGATCTCGGCATCCTGGTGGATCGC
GACGACGAAGGCTACATGTTACAAATCTTCACCCGTCCCGTGGAAGACCGCCCGACTTTGTTCTACGAAGTCATTCAGCG
CAAAGGCAGCCGCAGCTTCGGCAAAGGCAACTTCAAAGCACTCTTCGAAGCCATCGAGCGCGAACAGGAAAGACGCGGAA
ACCTGTAA

Upstream 100 bases:

>100_bases
GTTCGCCCCCTTAAGGCATTCGGCCTCCCCAACTGCCTGCGTATTTCCACCGGCACCGACGACGATAACCGCCTCTGCCT
CGAGGCATGGAGCAAGTGTT

Downstream 100 bases:

>100_bases
GGCAGGCCTCCGGGCCTGTCCACCAAGTTTCTCCAACCTTTACCTGATCGGCCACAAGCAACCCATCCCGCATGCGCTCC
GTCCGTCCCAATATCGGACA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MPQILEQATPAEKDFLPLNGTDYVEFYVGNARQAAHFYRTAFGFRLAAYRGPETGTRDRASYVLVQDKIRIVLTTPLQPD
GEIAEHVRIHGDGVRDIALWVDDAAAAWRETTARGARSVREPETVRDDSGEVRMSAIGIYGDTIHTFVERRGYQGPFLPG
FEAVPGEDHLARPAGLKYIDHMVGNVGWGEMNRWVDFYRDVMGFRMFKHFDDNDISTEYSALMSKVMSNGNERVKFPINE
PAHAKRKSQIEEYLEYYHGPGVQHIAMATDNIIETVGTLRRQGVDFLRVPSTYYDDLQSRVGKIDEPVADLKDLGILVDR
DDEGYMLQIFTRPVEDRPTLFYEVIQRKGSRSFGKGNFKALFEAIEREQERRGNL

Sequences:

>Translated_375_residues
MPQILEQATPAEKDFLPLNGTDYVEFYVGNARQAAHFYRTAFGFRLAAYRGPETGTRDRASYVLVQDKIRIVLTTPLQPD
GEIAEHVRIHGDGVRDIALWVDDAAAAWRETTARGARSVREPETVRDDSGEVRMSAIGIYGDTIHTFVERRGYQGPFLPG
FEAVPGEDHLARPAGLKYIDHMVGNVGWGEMNRWVDFYRDVMGFRMFKHFDDNDISTEYSALMSKVMSNGNERVKFPINE
PAHAKRKSQIEEYLEYYHGPGVQHIAMATDNIIETVGTLRRQGVDFLRVPSTYYDDLQSRVGKIDEPVADLKDLGILVDR
DDEGYMLQIFTRPVEDRPTLFYEVIQRKGSRSFGKGNFKALFEAIEREQERRGNL
>Mature_374_residues
PQILEQATPAEKDFLPLNGTDYVEFYVGNARQAAHFYRTAFGFRLAAYRGPETGTRDRASYVLVQDKIRIVLTTPLQPDG
EIAEHVRIHGDGVRDIALWVDDAAAAWRETTARGARSVREPETVRDDSGEVRMSAIGIYGDTIHTFVERRGYQGPFLPGF
EAVPGEDHLARPAGLKYIDHMVGNVGWGEMNRWVDFYRDVMGFRMFKHFDDNDISTEYSALMSKVMSNGNERVKFPINEP
AHAKRKSQIEEYLEYYHGPGVQHIAMATDNIIETVGTLRRQGVDFLRVPSTYYDDLQSRVGKIDEPVADLKDLGILVDRD
DEGYMLQIFTRPVEDRPTLFYEVIQRKGSRSFGKGNFKALFEAIEREQERRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=376, Percent_Identity=47.0744680851064, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI285002264, Length=342, Percent_Identity=47.3684210526316, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI14249394, Length=296, Percent_Identity=29.7297297297297, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555220, Length=364, Percent_Identity=46.1538461538462, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17550752, Length=369, Percent_Identity=35.230352303523, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24667510, Length=373, Percent_Identity=49.597855227882, Blast_Score=337, Evalue=6e-93,
Organism=Drosophila melanogaster, GI21356105, Length=292, Percent_Identity=52.3972602739726, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 42768; Mature: 42636

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQILEQATPAEKDFLPLNGTDYVEFYVGNARQAAHFYRTAFGFRLAAYRGPETGTRDRA
CCCHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCCHH
SYVLVQDKIRIVLTTPLQPDGEIAEHVRIHGDGVRDIALWVDDAAAAWRETTARGARSVR
EEEEEECCEEEEEECCCCCCCHHHHHEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHCC
EPETVRDDSGEVRMSAIGIYGDTIHTFVERRGYQGPFLPGFEAVPGEDHLARPAGLKYID
CCCHHCCCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
HMVGNVGWGEMNRWVDFYRDVMGFRMFKHFDDNDISTEYSALMSKVMSNGNERVKFPINE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
PAHAKRKSQIEEYLEYYHGPGVQHIAMATDNIIETVGTLRRQGVDFLRVPSTYYDDLQSR
CHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHH
VGKIDEPVADLKDLGILVDRDDEGYMLQIFTRPVEDRPTLFYEVIQRKGSRSFGKGNFKA
HCCCCCHHHHHHHCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHH
LFEAIEREQERRGNL
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
PQILEQATPAEKDFLPLNGTDYVEFYVGNARQAAHFYRTAFGFRLAAYRGPETGTRDRA
CCHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCCCHH
SYVLVQDKIRIVLTTPLQPDGEIAEHVRIHGDGVRDIALWVDDAAAAWRETTARGARSVR
EEEEEECCEEEEEECCCCCCCHHHHHEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHCC
EPETVRDDSGEVRMSAIGIYGDTIHTFVERRGYQGPFLPGFEAVPGEDHLARPAGLKYID
CCCHHCCCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
HMVGNVGWGEMNRWVDFYRDVMGFRMFKHFDDNDISTEYSALMSKVMSNGNERVKFPINE
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
PAHAKRKSQIEEYLEYYHGPGVQHIAMATDNIIETVGTLRRQGVDFLRVPSTYYDDLQSR
CHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHH
VGKIDEPVADLKDLGILVDRDDEGYMLQIFTRPVEDRPTLFYEVIQRKGSRSFGKGNFKA
HCCCCCHHHHHHHCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHH
LFEAIEREQERRGNL
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]