Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 116623259

GI number: 116623259

Start: 5282339

End: 5283451

Strand: Direct

Name: hisC [H]

Synonym: Acid_4166

Alternate gene names: 116623259

Gene position: 5282339-5283451 (Clockwise)

Preceding gene: 116623258

Following gene: 116623260

Centisome position: 53.01

GC content: 60.92

Gene sequence:

>1113_bases
GTGCCACTCGTCCCTCCCTATATCGAATCCCTCCGCCCTTACGAGGCCGGCCGGACCATCGAAAGCGTCCGCAAGCAGTA
CGGCCTCACCCGCATTGCCAAACTCGCCTCCAACGAGAATCCCCTGGGCGCCTCCCCCAAAGCCATCGAGGCCATGCACC
GTTCGCTGGACAGCCTCAATCTCTACCCCAACGGCGGCCTCGGCCTCCGCGAAGTCCTCGCCGCCGAGTACGACGTCAAG
CTCGACAACGTCATCGCCGGCAGCGGCAGCGAAGGCATAATGAGCAACATCATCCGCGCCTTCCTCTGCGACGACGACGA
AGTCCTCACCACCGACGCAGCCTTCATCGGCTTTCAGGTCCTCGCCAAATCGCGCGGTGTCAAATATCGCACGGTGGCCT
ATCGCGACTGGCATTACGATCTCGAAGCCATGGCCGCGCAAATCAACCAGAACACCAAGATCATCTACCTCGCCAACCCC
AATAACCCCACCGGCACCATCTTCACGCGCCATCAGTTCGACGAGTTCTATAAACACGTCCCCGAGCGGGTCCTGATCAT
CCTCGATGAAGCCTACTTCGAATACGCGAAGGACAATCCGCGCTACCCCGATTCGATGCACTACCGCTACGACAACGTGA
TCACGCTGCGCACGTTCTCGAAGATCTACGGCCTGGCGGGCGCCCGTATCGGCTACGGCTTCGCCCACGAAGAACTGATC
CGCAATCTCCTCAAGGTCAAGCTCCCTTTCGAGCCCTCTACCCCCGCCCAGGCCGCCGGCATCGCCGCCCTCGGCGATAA
GGAATTCCTTCACCGCTCGCTCGAACTCAACGCCCGCGGACTGCGCTACCTCACCGCCGGCCTGCAGGATCTCGGACTTA
CTGTCGCCCCTTCCCAGGCTAACTTCGTCATGACCGTCCTGCCCAGCGAAGAAGACGCCGCACGTATTTTCGAGAACTTA
CTTACGCAGGGAGTCGTAGTTCGCCCCCTTAAGGCATTCGGCCTCCCCAACTGCCTGCGTATTTCCACCGGCACCGACGA
CGATAACCGCCTCTGCCTCGAGGCATGGAGCAAGTGTTATGCCGCAAATCTTGGAGCAAGCCACGCCGGCTGA

Upstream 100 bases:

>100_bases
CCCTCCCCGTTAAGAAAACCTCCTACGACGATGGGATCCAACAAACACTCGCCTGGATGCGCCAGCACCCGTAGGTGGGT
CCAAGTGTAAAATAGAGTCG

Downstream 100 bases:

>100_bases
GAAGGATTTCCTCCCTCTCAACGGCACCGATTACGTCGAGTTCTACGTCGGCAACGCGCGCCAGGCCGCGCACTTCTATC
GCACCGCCTTCGGCTTCCGC

Product: aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MPLVPPYIESLRPYEAGRTIESVRKQYGLTRIAKLASNENPLGASPKAIEAMHRSLDSLNLYPNGGLGLREVLAAEYDVK
LDNVIAGSGSEGIMSNIIRAFLCDDDEVLTTDAAFIGFQVLAKSRGVKYRTVAYRDWHYDLEAMAAQINQNTKIIYLANP
NNPTGTIFTRHQFDEFYKHVPERVLIILDEAYFEYAKDNPRYPDSMHYRYDNVITLRTFSKIYGLAGARIGYGFAHEELI
RNLLKVKLPFEPSTPAQAAGIAALGDKEFLHRSLELNARGLRYLTAGLQDLGLTVAPSQANFVMTVLPSEEDAARIFENL
LTQGVVVRPLKAFGLPNCLRISTGTDDDNRLCLEAWSKCYAANLGASHAG

Sequences:

>Translated_370_residues
MPLVPPYIESLRPYEAGRTIESVRKQYGLTRIAKLASNENPLGASPKAIEAMHRSLDSLNLYPNGGLGLREVLAAEYDVK
LDNVIAGSGSEGIMSNIIRAFLCDDDEVLTTDAAFIGFQVLAKSRGVKYRTVAYRDWHYDLEAMAAQINQNTKIIYLANP
NNPTGTIFTRHQFDEFYKHVPERVLIILDEAYFEYAKDNPRYPDSMHYRYDNVITLRTFSKIYGLAGARIGYGFAHEELI
RNLLKVKLPFEPSTPAQAAGIAALGDKEFLHRSLELNARGLRYLTAGLQDLGLTVAPSQANFVMTVLPSEEDAARIFENL
LTQGVVVRPLKAFGLPNCLRISTGTDDDNRLCLEAWSKCYAANLGASHAG
>Mature_369_residues
PLVPPYIESLRPYEAGRTIESVRKQYGLTRIAKLASNENPLGASPKAIEAMHRSLDSLNLYPNGGLGLREVLAAEYDVKL
DNVIAGSGSEGIMSNIIRAFLCDDDEVLTTDAAFIGFQVLAKSRGVKYRTVAYRDWHYDLEAMAAQINQNTKIIYLANPN
NPTGTIFTRHQFDEFYKHVPERVLIILDEAYFEYAKDNPRYPDSMHYRYDNVITLRTFSKIYGLAGARIGYGFAHEELIR
NLLKVKLPFEPSTPAQAAGIAALGDKEFLHRSLELNARGLRYLTAGLQDLGLTVAPSQANFVMTVLPSEEDAARIFENLL
TQGVVVRPLKAFGLPNCLRISTGTDDDNRLCLEAWSKCYAANLGASHAG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=320, Percent_Identity=28.75, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788722, Length=275, Percent_Identity=27.6363636363636, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788627, Length=165, Percent_Identity=28.4848484848485, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=353, Percent_Identity=23.7960339943343, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=373, Percent_Identity=27.0777479892761, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41111; Mature: 40980

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVPPYIESLRPYEAGRTIESVRKQYGLTRIAKLASNENPLGASPKAIEAMHRSLDSLN
CCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
LYPNGGLGLREVLAAEYDVKLDNVIAGSGSEGIMSNIIRAFLCDDDEVLTTDAAFIGFQV
CCCCCCCCHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
LAKSRGVKYRTVAYRDWHYDLEAMAAQINQNTKIIYLANPNNPTGTIFTRHQFDEFYKHV
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHC
PERVLIILDEAYFEYAKDNPRYPDSMHYRYDNVITLRTFSKIYGLAGARIGYGFAHEELI
CHHEEEEEEHHHHHHHCCCCCCCCCCCEEECCEEEEHHHHHHHHCCCCHHCCCHHHHHHH
RNLLKVKLPFEPSTPAQAAGIAALGDKEFLHRSLELNARGLRYLTAGLQDLGLTVAPSQA
HHHHHEECCCCCCCCHHHCCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEECCCCC
NFVMTVLPSEEDAARIFENLLTQGVVVRPLKAFGLPNCLRISTGTDDDNRLCLEAWSKCY
CEEEEEECCCHHHHHHHHHHHHCCEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
AANLGASHAG
HHCCCCCCCC
>Mature Secondary Structure 
PLVPPYIESLRPYEAGRTIESVRKQYGLTRIAKLASNENPLGASPKAIEAMHRSLDSLN
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
LYPNGGLGLREVLAAEYDVKLDNVIAGSGSEGIMSNIIRAFLCDDDEVLTTDAAFIGFQV
CCCCCCCCHHHHHHHHCCCEECCEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHH
LAKSRGVKYRTVAYRDWHYDLEAMAAQINQNTKIIYLANPNNPTGTIFTRHQFDEFYKHV
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHC
PERVLIILDEAYFEYAKDNPRYPDSMHYRYDNVITLRTFSKIYGLAGARIGYGFAHEELI
CHHEEEEEEHHHHHHHCCCCCCCCCCCEEECCEEEEHHHHHHHHCCCCHHCCCHHHHHHH
RNLLKVKLPFEPSTPAQAAGIAALGDKEFLHRSLELNARGLRYLTAGLQDLGLTVAPSQA
HHHHHEECCCCCCCCHHHCCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEECCCCC
NFVMTVLPSEEDAARIFENLLTQGVVVRPLKAFGLPNCLRISTGTDDDNRLCLEAWSKCY
CEEEEEECCCHHHHHHHHHHHHCCEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHHHH
AANLGASHAG
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA