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The map label for this gene is gdhA [H]

Identifier: 116623169

GI number: 116623169

Start: 5176681

End: 5178510

Strand: Direct

Name: gdhA [H]

Synonym: Acid_4075

Alternate gene names: 116623169

Gene position: 5176681-5178510 (Clockwise)

Preceding gene: 116623165

Following gene: 116623177

Centisome position: 51.95

GC content: 65.9

Gene sequence:

>1830_bases
ATGCGCATGCTGATCCTCTGCCTTCTCGCGACTACCGCCTTCGCAGCCGACCCCGGCTGGACTGCCTATGGTCACGATCC
CGGCGGCACGCGCTACTCCCCGCTCAAACAAATCGATCGCACCAACGTCGCCAAACTCCGCCCGGCCTGGACTTACCACA
CCGGCGCCCTCGATTCCGCCGGCGACCTCATCAAAAAGGCTGCCTTCGAAGCCACCCCGATCCTGATCGATGCCACCCTC
TTCCTGACCACTCCGTTCAATGTCGTGGTCGCGCTCGACCCGGTCACCGGCCGCGAAAAATGGAAGTTCGATCCCAAGCT
CGATCGCACTCAGGATTTCTCTGAAGTCACTTCCCGCGGCGTCTCCGCCTGGCATAGCCCCCGCGGCGAACTCCTGATCT
TCGAAGGGACGCTCGATGGCCGCCTCCTCGCCCTCGACGGCAAAACCGGAAAGCTCGCCTGGCAGACCGACCTCACCAAA
GATGTCAATCTCCGCGATCGCGGCAGCTACCAGGTCACCTCCGCCCCTGCCGTGGTCGGCGACCTCGTCATCACCGGATC
CTCGATCGGCGATAACCGCGCCGTCGATGTCGAGCGCGGCATCGTGCGCGCCTTCGAAGTCCGCACCGGCAAACTCCGCT
GGACCTGGGATCCCATCCCGTGGGCCAACAAACAGGATCCGCGCACCGGCGCCGCCAATGCCTGGGGCACACTCTCCGCC
GACCCCGCGAGCGACCTCCTCTTCATCCCCACCGGCAGCGCCAGCCCCGATTACTTCGGCGGCCAGCGTCCCGGCGACAA
TCGCTACGCCAACTCCGTCGTCGCTCTCAAAGCCAGCACGGGCGAACTGCAGTGGAGTTTCCAGGTGGTCCATCACGACC
TCTGGGACTACGACGTCGCCGGGCAGCCATCGTTGATCGACTACGCCGGCAAGCCTGCCGTCGCCGTCACCACCAAGATG
GGATTGCTCTTCGTGCTCGATCGCGTCACCGGCAAGCCGCTCCACACCGTCGAAGAGCGCGCCGTTCCCAAGAGCGATAT
CGCGGGCGAGGCCGCGTCGCCCACCCAGCCGATTCCGACTTGGGCGCCGATGGTGCCGCAGCGCCTCACCGCCGACGATC
TTTGGGGGGTAACGGAAGCCGATCGCACCGCCTGCCGCGATCGCCTGTCGAAGCTCCGCAACGACGGTCCGTACACTCCG
CCCAGCCTACAGGGCAGCTTGGTCTTCCCCGGCAATGTCGGCGGCGTGAACTGGGGAGGCGCCGCCTGGGATCCCGAGCG
CGGCCTGATCTTCAGCGACACCAACCGCCTCGCCGCCATCTTTCGCATCATTCCGCGCGCCGAACTGCGCGCCGCGATGG
ACAAGGTGAATGCCGAGAAGTCCAATCGCTTCTCGGGCGAGTTCGCCCGCCAGACCGGCACTCCCTACGCGATGTATCGG
ACCTGGCTTGCCTCGCCCTCCGGCCTCCCCTGCAACCCTCCGCCATGGGGCGCGCTCGTGGCCTTCGACTTGAAGACCGG
CACGGTGCGTTGGGAGACCCCGATCGGTGAAGTCGCGCCCGGCGTAAAGGGTGGCTCGCCGAATTTGGGCGGTCCCATGG
CCACCGCCGGTGGTCTCGTCTTCACCGCCGCCGGCATGGATACCGCGCTCCGCGCCTTCGACGTCGATAGCGGCAAAGAA
CTTTGGAAAGCAGACCTTCCGGCATCTGCCCAAGCCACCCCGATGACCTTCGAGGCCGGCGGCAAGCAGTACGTTGTGAT
CTGCGCCGGCGGCCACGGCAAACTCGGCACCAAAATGAGCGATTCCGTCGTGGCCTTCCGCCTCCCATAA

Upstream 100 bases:

>100_bases
ACCGTATGTCCCCGGCCGCCGCAACGCTTTCTTTGTGACCCCAACTAATGGGAAACGTGTGCCTCCCCATCCCTTCCCTT
TTTCCTGGCAAACTGTCCTT

Downstream 100 bases:

>100_bases
ATGACGGCGCCCGGGTTTGTACTACTGTGCACTTGCTTGCCCGCAGGCCGCGAAGATTCCAGGAGGCTTGGCTTTGTGGG
GCAGGCGTTTGGCCTGCAGC

Product: quinoprotein glucose dehydrogenase

Products: NA

Alternate protein names: GDH-A; Glucose dehydrogenase A [pyrroloquinoline-quinone]; Quinoprotein glucose DH [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MRMLILCLLATTAFAADPGWTAYGHDPGGTRYSPLKQIDRTNVAKLRPAWTYHTGALDSAGDLIKKAAFEATPILIDATL
FLTTPFNVVVALDPVTGREKWKFDPKLDRTQDFSEVTSRGVSAWHSPRGELLIFEGTLDGRLLALDGKTGKLAWQTDLTK
DVNLRDRGSYQVTSAPAVVGDLVITGSSIGDNRAVDVERGIVRAFEVRTGKLRWTWDPIPWANKQDPRTGAANAWGTLSA
DPASDLLFIPTGSASPDYFGGQRPGDNRYANSVVALKASTGELQWSFQVVHHDLWDYDVAGQPSLIDYAGKPAVAVTTKM
GLLFVLDRVTGKPLHTVEERAVPKSDIAGEAASPTQPIPTWAPMVPQRLTADDLWGVTEADRTACRDRLSKLRNDGPYTP
PSLQGSLVFPGNVGGVNWGGAAWDPERGLIFSDTNRLAAIFRIIPRAELRAAMDKVNAEKSNRFSGEFARQTGTPYAMYR
TWLASPSGLPCNPPPWGALVAFDLKTGTVRWETPIGEVAPGVKGGSPNLGGPMATAGGLVFTAAGMDTALRAFDVDSGKE
LWKADLPASAQATPMTFEAGGKQYVVICAGGHGKLGTKMSDSVVAFRLP

Sequences:

>Translated_609_residues
MRMLILCLLATTAFAADPGWTAYGHDPGGTRYSPLKQIDRTNVAKLRPAWTYHTGALDSAGDLIKKAAFEATPILIDATL
FLTTPFNVVVALDPVTGREKWKFDPKLDRTQDFSEVTSRGVSAWHSPRGELLIFEGTLDGRLLALDGKTGKLAWQTDLTK
DVNLRDRGSYQVTSAPAVVGDLVITGSSIGDNRAVDVERGIVRAFEVRTGKLRWTWDPIPWANKQDPRTGAANAWGTLSA
DPASDLLFIPTGSASPDYFGGQRPGDNRYANSVVALKASTGELQWSFQVVHHDLWDYDVAGQPSLIDYAGKPAVAVTTKM
GLLFVLDRVTGKPLHTVEERAVPKSDIAGEAASPTQPIPTWAPMVPQRLTADDLWGVTEADRTACRDRLSKLRNDGPYTP
PSLQGSLVFPGNVGGVNWGGAAWDPERGLIFSDTNRLAAIFRIIPRAELRAAMDKVNAEKSNRFSGEFARQTGTPYAMYR
TWLASPSGLPCNPPPWGALVAFDLKTGTVRWETPIGEVAPGVKGGSPNLGGPMATAGGLVFTAAGMDTALRAFDVDSGKE
LWKADLPASAQATPMTFEAGGKQYVVICAGGHGKLGTKMSDSVVAFRLP
>Mature_609_residues
MRMLILCLLATTAFAADPGWTAYGHDPGGTRYSPLKQIDRTNVAKLRPAWTYHTGALDSAGDLIKKAAFEATPILIDATL
FLTTPFNVVVALDPVTGREKWKFDPKLDRTQDFSEVTSRGVSAWHSPRGELLIFEGTLDGRLLALDGKTGKLAWQTDLTK
DVNLRDRGSYQVTSAPAVVGDLVITGSSIGDNRAVDVERGIVRAFEVRTGKLRWTWDPIPWANKQDPRTGAANAWGTLSA
DPASDLLFIPTGSASPDYFGGQRPGDNRYANSVVALKASTGELQWSFQVVHHDLWDYDVAGQPSLIDYAGKPAVAVTTKM
GLLFVLDRVTGKPLHTVEERAVPKSDIAGEAASPTQPIPTWAPMVPQRLTADDLWGVTEADRTACRDRLSKLRNDGPYTP
PSLQGSLVFPGNVGGVNWGGAAWDPERGLIFSDTNRLAAIFRIIPRAELRAAMDKVNAEKSNRFSGEFARQTGTPYAMYR
TWLASPSGLPCNPPPWGALVAFDLKTGTVRWETPIGEVAPGVKGGSPNLGGPMATAGGLVFTAAGMDTALRAFDVDSGKE
LWKADLPASAQATPMTFEAGGKQYVVICAGGHGKLGTKMSDSVVAFRLP

Specific function: Catalyzes an exceptionally high rate of oxidation of a wide range of aldose sugars, including D-glucose, galactose, arabinose and xylose, and also the disaccharides lactose, cellobiose and maltose [H]

COG id: COG4993

COG function: function code G; Glucose dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial PQQ dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786316, Length=634, Percent_Identity=39.2744479495268, Blast_Score=425, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017511
- InterPro:   IPR019556
- InterPro:   IPR019551
- InterPro:   IPR018391
- InterPro:   IPR002372
- InterPro:   IPR011047
- InterPro:   IPR001479 [H]

Pfam domain/function: PF01011 PQQ; PF10535 PQQ_C; PF10527 PQQ_N [H]

EC number: =1.1.99.35 [H]

Molecular weight: Translated: 65474; Mature: 65474

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMLILCLLATTAFAADPGWTAYGHDPGGTRYSPLKQIDRTNVAKLRPAWTYHTGALDSA
CHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHCCCCHHHCCCCEEEECCCCCCH
GDLIKKAAFEATPILIDATLFLTTPFNVVVALDPVTGREKWKFDPKLDRTQDFSEVTSRG
HHHHHHHHHCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHC
VSAWHSPRGELLIFEGTLDGRLLALDGKTGKLAWQTDLTKDVNLRDRGSYQVTSAPAVVG
HHHHCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEE
DLVITGSSIGDNRAVDVERGIVRAFEVRTGKLRWTWDPIPWANKQDPRTGAANAWGTLSA
EEEEECCCCCCCCEEEHHHHHEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DPASDLLFIPTGSASPDYFGGQRPGDNRYANSVVALKASTGELQWSFQVVHHDLWDYDVA
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCC
GQPSLIDYAGKPAVAVTTKMGLLFVLDRVTGKPLHTVEERAVPKSDIAGEAASPTQPIPT
CCCCEEECCCCCCEEEEEHHCCEEEEHHHCCCCCHHHHHHCCCCHHCCCCCCCCCCCCCC
WAPMVPQRLTADDLWGVTEADRTACRDRLSKLRNDGPYTPPSLQGSLVFPGNVGGVNWGG
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCC
AAWDPERGLIFSDTNRLAAIFRIIPRAELRAAMDKVNAEKSNRFSGEFARQTGTPYAMYR
CCCCCCCCEEEECCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHH
TWLASPSGLPCNPPPWGALVAFDLKTGTVRWETPIGEVAPGVKGGSPNLGGPMATAGGLV
HHHCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCEE
FTAAGMDTALRAFDVDSGKELWKADLPASAQATPMTFEAGGKQYVVICAGGHGKLGTKMS
EEECCCCHHHEEEECCCCHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCC
DSVVAFRLP
CCEEEEECC
>Mature Secondary Structure
MRMLILCLLATTAFAADPGWTAYGHDPGGTRYSPLKQIDRTNVAKLRPAWTYHTGALDSA
CHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHCCCCHHHCCCCEEEECCCCCCH
GDLIKKAAFEATPILIDATLFLTTPFNVVVALDPVTGREKWKFDPKLDRTQDFSEVTSRG
HHHHHHHHHCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHC
VSAWHSPRGELLIFEGTLDGRLLALDGKTGKLAWQTDLTKDVNLRDRGSYQVTSAPAVVG
HHHHCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEE
DLVITGSSIGDNRAVDVERGIVRAFEVRTGKLRWTWDPIPWANKQDPRTGAANAWGTLSA
EEEEECCCCCCCCEEEHHHHHEEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DPASDLLFIPTGSASPDYFGGQRPGDNRYANSVVALKASTGELQWSFQVVHHDLWDYDVA
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCC
GQPSLIDYAGKPAVAVTTKMGLLFVLDRVTGKPLHTVEERAVPKSDIAGEAASPTQPIPT
CCCCEEECCCCCCEEEEEHHCCEEEEHHHCCCCCHHHHHHCCCCHHCCCCCCCCCCCCCC
WAPMVPQRLTADDLWGVTEADRTACRDRLSKLRNDGPYTPPSLQGSLVFPGNVGGVNWGG
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCC
AAWDPERGLIFSDTNRLAAIFRIIPRAELRAAMDKVNAEKSNRFSGEFARQTGTPYAMYR
CCCCCCCCEEEECCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHH
TWLASPSGLPCNPPPWGALVAFDLKTGTVRWETPIGEVAPGVKGGSPNLGGPMATAGGLV
HHHCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCEE
FTAAGMDTALRAFDVDSGKELWKADLPASAQATPMTFEAGGKQYVVICAGGHGKLGTKMS
EEECCCCHHHEEEECCCCHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCC
DSVVAFRLP
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3399393 [H]