Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 116623008

GI number: 116623008

Start: 4945795

End: 4946589

Strand: Direct

Name: fkpA [H]

Synonym: Acid_3912

Alternate gene names: 116623008

Gene position: 4945795-4946589 (Clockwise)

Preceding gene: 116623007

Following gene: 116623009

Centisome position: 49.63

GC content: 66.42

Gene sequence:

>795_bases
ATGCGTGGATTGCTTCTTTTGATTCCCGCGGTGATGCTCGCTCAGACAGCGCCGGCCCCGGCGCCCAAAGCCGCCACCAC
CGCCACCGGCCAGACGGCCGCTCCTAAACCCGCGACCGCTACGCCCGGACGCGGCGCCCCCGGACGCGGCGCCACCACCG
CCAGGCCGGCTGCCCCCAAGCCCGCCGCCCCTCCCCCGTTGACTACGGACGACCAGAAGACCATCTACGCGCTCGGCCTT
TCGATCGCCAAATCGCTGTCGCCCTTCGATCTGTCGCCGGCCGAAATCGACATTATCAAGCGCGCCCTCACCGACGCGGC
CGCCAACAAGCCGGAAGTGCAACTGGAAGAATGGGGCCCCAAGATCGACCCGCTCGTGCGTGCTCGCGGCGCCAAAGTCG
CCGAAAGGGAGAAGGCTGCTTCCGCGGCTTACCTGGCCAAATGCGCCACCGAGCCCGGCGCGGTCAAGACTGAATCCGGA
ATGATCTTCAAGGAACTGCGCGCCGGCACCGGCGCATCGCCCAAGGCCACCGATACCGTGAAGGTCAACTACCGCGGCAC
CCTGGTCAACGGCACCGAGTTCGACAGCTCCTACAAGCGCAATGAGCCCGCCTCCTTCCCCCTGAACGGCGTCATCCCCT
GCTGGACGGAAGGCGTGCAGCGCATGAAGGTCGGCGGCAAGGCGCAGCTGGTCTGCCCCTCGAACCTCGCCTATGGCGAT
CAGGGACGTCCGTCGATCCCCGGCGGAGCCACGCTCATCTTCGAAATCGAACTGCTCGATATCGGCGCCAAATAA

Upstream 100 bases:

>100_bases
CCTCAAACCGCATTAACTCCTTTATTATCAATAAATATGCTCTTCAGGACGGGACACGTTTGTCCCGCCTTGGGGATAAA
GAGTGCTAGCCTGGAGGTGT

Downstream 100 bases:

>100_bases
ACTCTGCCATCGCGCCAAATTGTCGCATCAGCACCTCGCAGGGGTGTGACGTTTGGTGATCGCGAATTTTCCGGTGAGGA
TGGCTGTGGCGTCCATGGGC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRGLLLLIPAVMLAQTAPAPAPKAATTATGQTAAPKPATATPGRGAPGRGATTARPAAPKPAAPPPLTTDDQKTIYALGL
SIAKSLSPFDLSPAEIDIIKRALTDAAANKPEVQLEEWGPKIDPLVRARGAKVAEREKAASAAYLAKCATEPGAVKTESG
MIFKELRAGTGASPKATDTVKVNYRGTLVNGTEFDSSYKRNEPASFPLNGVIPCWTEGVQRMKVGGKAQLVCPSNLAYGD
QGRPSIPGGATLIFEIELLDIGAK

Sequences:

>Translated_264_residues
MRGLLLLIPAVMLAQTAPAPAPKAATTATGQTAAPKPATATPGRGAPGRGATTARPAAPKPAAPPPLTTDDQKTIYALGL
SIAKSLSPFDLSPAEIDIIKRALTDAAANKPEVQLEEWGPKIDPLVRARGAKVAEREKAASAAYLAKCATEPGAVKTESG
MIFKELRAGTGASPKATDTVKVNYRGTLVNGTEFDSSYKRNEPASFPLNGVIPCWTEGVQRMKVGGKAQLVCPSNLAYGD
QGRPSIPGGATLIFEIELLDIGAK
>Mature_264_residues
MRGLLLLIPAVMLAQTAPAPAPKAATTATGQTAAPKPATATPGRGAPGRGATTARPAAPKPAAPPPLTTDDQKTIYALGL
SIAKSLSPFDLSPAEIDIIKRALTDAAANKPEVQLEEWGPKIDPLVRARGAKVAEREKAASAAYLAKCATEPGAVKTESG
MIFKELRAGTGASPKATDTVKVNYRGTLVNGTEFDSSYKRNEPASFPLNGVIPCWTEGVQRMKVGGKAQLVCPSNLAYGD
QGRPSIPGGATLIFEIELLDIGAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=99, Percent_Identity=49.4949494949495, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI224809327, Length=99, Percent_Identity=49.4949494949495, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4758384, Length=99, Percent_Identity=49.4949494949495, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI224809331, Length=110, Percent_Identity=46.3636363636364, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=50.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=50.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=50.5747126436782, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=43.4343434343434, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4758380, Length=91, Percent_Identity=45.0549450549451, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI33469985, Length=89, Percent_Identity=40.4494382022472, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI17149836, Length=91, Percent_Identity=46.1538461538462, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503725, Length=91, Percent_Identity=46.1538461538462, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789745, Length=209, Percent_Identity=41.1483253588517, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=39.3203883495146, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17561782, Length=89, Percent_Identity=51.685393258427, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=44.8275862068966, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=43.956043956044, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=50, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=108, Percent_Identity=39.8148148148148, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323482, Length=106, Percent_Identity=36.7924528301887, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=49.0566037735849, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=46.1538461538462, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281363946, Length=92, Percent_Identity=44.5652173913043, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17352457, Length=92, Percent_Identity=44.5652173913043, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27321; Mature: 27321

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLLLLIPAVMLAQTAPAPAPKAATTATGQTAAPKPATATPGRGAPGRGATTARPAAPK
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAAPPPLTTDDQKTIYALGLSIAKSLSPFDLSPAEIDIIKRALTDAAANKPEVQLEEWGP
CCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHCCC
KIDPLVRARGAKVAEREKAASAAYLAKCATEPGAVKTESGMIFKELRAGTGASPKATDTV
CCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCCCCCCCCCCEE
KVNYRGTLVNGTEFDSSYKRNEPASFPLNGVIPCWTEGVQRMKVGGKAQLVCPSNLAYGD
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
QGRPSIPGGATLIFEIELLDIGAK
CCCCCCCCCEEEEEEEEEEECCCC
>Mature Secondary Structure
MRGLLLLIPAVMLAQTAPAPAPKAATTATGQTAAPKPATATPGRGAPGRGATTARPAAPK
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAAPPPLTTDDQKTIYALGLSIAKSLSPFDLSPAEIDIIKRALTDAAANKPEVQLEEWGP
CCCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHCCC
KIDPLVRARGAKVAEREKAASAAYLAKCATEPGAVKTESGMIFKELRAGTGASPKATDTV
CCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHCCCCCCCCCCCEE
KVNYRGTLVNGTEFDSSYKRNEPASFPLNGVIPCWTEGVQRMKVGGKAQLVCPSNLAYGD
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCC
QGRPSIPGGATLIFEIELLDIGAK
CCCCCCCCCEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]