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The map label for this gene is hisA [H]

Identifier: 116622947

GI number: 116622947

Start: 4884791

End: 4885474

Strand: Reverse

Name: hisA [H]

Synonym: Acid_3849

Alternate gene names: 116622947

Gene position: 4885474-4884791 (Counterclockwise)

Preceding gene: 116622948

Following gene: 116622937

Centisome position: 49.02

GC content: 63.3

Gene sequence:

>684_bases
ATGATCGTCCCCTGCATCGACCTGATGGATGGCAAGGTGGTCCAGCTCATCCAGGGCCGCGAGAAGGCGCTCGAAGGCGA
TAGCCCCGACGAAATGCTGCGCAGGTTCGCCGGCTTCCCCGAGATCCAGGTGATCGATCTCGACGCCGCACTCGGCAAGG
GCTCGAACGACACGCTGGTAAAAATGCTCGCGTCGAAGGCCGTCTGCCGCGTCGGCGGCGGCGTGCGCACTTTGGATCGC
GCCAACACACTTCTCTCGCAGGGCGCGCACCGCGTCATCGTCGGCACCAGCGCGTTCACGAAGGGCGGCATCAACGTCCC
CTTCCTCGAAACGTTAGACCCAGCCACCACCATCGTCGCGCTGGATTCCAAGGGCGGCCGCATCGTCGTCAAAGGCTGGC
AGGAGGCCACGGAGTTCACCGCCGAAGAGGTGCTTCATTCGCTCGAACCGTATTGCTCGGGCTTCCTCTGCACCTACGTG
GATAAGGAAGGCATGATGCAGGGCACGGATCTCGACTGGTTTGCTCGTCTGCGCGCCGCCACCGCCCACGAGATCACCGC
CGCCGGGGGCATCACGACGCTCGAAGACATCAAGGCCCTGCTCGCCATGAACATCCACACCGCCGTCGGCATGGCGATTT
ACACCGGCAGGTTGGATCTCGAAGAGCTGAGAACTCTGCGTTGA

Upstream 100 bases:

>100_bases
ATGCCGCGCTCGCCGCGTCGATATTCCACTACGGAACCTATACCGTGAATCAACTCAAGGAAGCGCTCGATAAGCGCGGC
ATCCCCGTGCGGGTGACGGC

Downstream 100 bases:

>100_bases
AAAAATGCGAGTTACCAACCGCTTGCTGACGCGCGCGGCTCGGAACGGAGCCGCGACCGTAAGGGAGCGGTTGCTAATTT
AGATCGCTTCCAGCTCTTCT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MIVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFAGFPEIQVIDLDAALGKGSNDTLVKMLASKAVCRVGGGVRTLDR
ANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPATTIVALDSKGGRIVVKGWQEATEFTAEEVLHSLEPYCSGFLCTYV
DKEGMMQGTDLDWFARLRAATAHEITAAGGITTLEDIKALLAMNIHTAVGMAIYTGRLDLEELRTLR

Sequences:

>Translated_227_residues
MIVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFAGFPEIQVIDLDAALGKGSNDTLVKMLASKAVCRVGGGVRTLDR
ANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPATTIVALDSKGGRIVVKGWQEATEFTAEEVLHSLEPYCSGFLCTYV
DKEGMMQGTDLDWFARLRAATAHEITAAGGITTLEDIKALLAMNIHTAVGMAIYTGRLDLEELRTLR
>Mature_227_residues
MIVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFAGFPEIQVIDLDAALGKGSNDTLVKMLASKAVCRVGGGVRTLDR
ANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPATTIVALDSKGGRIVVKGWQEATEFTAEEVLHSLEPYCSGFLCTYV
DKEGMMQGTDLDWFARLRAATAHEITAAGGITTLEDIKALLAMNIHTAVGMAIYTGRLDLEELRTLR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 24481; Mature: 24481

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFAGFPEIQVIDLDAALGKGSNDTLV
CCCCCEECCCCHHHHHHHCHHHHCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCCCHHHH
KMLASKAVCRVGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPATTIVA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCHHCCCCCEEEEE
LDSKGGRIVVKGWQEATEFTAEEVLHSLEPYCSGFLCTYVDKEGMMQGTDLDWFARLRAA
EECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
TAHEITAAGGITTLEDIKALLAMNIHTAVGMAIYTGRLDLEELRTLR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHCCC
>Mature Secondary Structure
MIVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFAGFPEIQVIDLDAALGKGSNDTLV
CCCCCEECCCCHHHHHHHCHHHHCCCCCHHHHHHHHCCCCCEEEEEEHHHHCCCCCHHHH
KMLASKAVCRVGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPATTIVA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCHHCCCCCEEEEE
LDSKGGRIVVKGWQEATEFTAEEVLHSLEPYCSGFLCTYVDKEGMMQGTDLDWFARLRAA
EECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
TAHEITAAGGITTLEDIKALLAMNIHTAVGMAIYTGRLDLEELRTLR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]