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The map label for this gene is dctA

Identifier: 116622791

GI number: 116622791

Start: 4686384

End: 4687670

Strand: Reverse

Name: dctA

Synonym: Acid_3691

Alternate gene names: 116622791

Gene position: 4687670-4686384 (Counterclockwise)

Preceding gene: 116622792

Following gene: 116622789

Centisome position: 47.04

GC content: 62.24

Gene sequence:

>1287_bases
GTGACCAAACTCCGGAGCTCGCTGTATTTCTGGGTCCTGGTGGCGATCGCTCTGGGCGTAATCCTCGGGATCGTTGCCCC
CTCCACCGGCGCTGCCATGAAGCCCTTGGGCGATGGCTTCATCAAGCTCATCAAGATGGTGATCGCCCCCATCATCTTCT
GCACCGTCGTGCTCGGCATCGCCGGCACCGGCGACTTGAAAAAGGTGGGACGCACCGGCGGCCTCGCCCTGCTCTACTTC
GAAGTGGTCAGCACCGTCTCCCTCATCCTCGGCCTCCTGATTGTCAACATCGTCCGCCCCGGCGCCGGCATGAATATCGA
CGTGCGCACGCTCGATGCCGCCGCTGTTTCCGCCTACGCCGGCAAAGGCAAGATGCAATCCACGTCGGAGTTCCTGATCA
ACGTCATCCCCAACACCTTCGTGGACGCCTTCGCCAGGGGCGAAATCCTGCAGGTGCTGCTCCTCGCCGTGCTCTTCGGT
ATCGCGCTCCAGCGCCTCGGCGCCCATCGCAATGAGGTCTTTCAATTCATCGAGAAGTTCTCGGAGATCATGTTCGAACT
GGTGCGCATGATCATGAAGGTCGCTCCCATCGGAGCCTTCGGAGCCATGGCCTTCACGATCGGCGCCTATGGCATCGGCT
CCCTCTTTTCGCTCGCCAAGCTGATGGCGACGTTCTATCTCACCTGCCTCTGCTTCATCTTCCTTGTTCTCGGCGCTATC
GCGCGCTACCACGGCTTCAGCATCTGGAGATTCCTCCGCTATATCCGTGAAGAGCTGCTGATCGTGCTCGGCACGTCCTC
CTCCGAAGCCGCCCTCCCGCGCATGATGGCCAAGATGGAGAGCCTCGGCGCCGGACGCTCCACCGTCGGTCTCGTGATTC
CGGCAGGCTATTCCTTCAATCTCGACGGCACGTCCATCTATCTCACCATGGCCGCCGTCTTCGTCGCCCAGGCCACCAAT
TCCGCGATGACCCTCGGCGAACAGTTCACCCTCCTGGCCGTCCTCCTGCTCATGTCCAAAGGCGCCGCCGGCGTCACCGG
CAGCGGTTTCATCGTCCTCGCCGCCACTCTCTCCGCCATCGGCAAAGTGCCTGTCGGCGGCCTCGCCCTGATCCTCGGCA
TCGATCGCTTCATGAGCGAAGCCCGTGCCCTCACCAACGTAATCGGCAACGGCGTCGCCTCCATCGTCGTCGCCAAATGG
ACCGGCGATCTCGACGAAACCATGCTCACCACCCGCCTGAAGTCGGGCCCCCCGACTCCCGCCGAAGAGCCCGCGATAAT
GTCTTAA

Upstream 100 bases:

>100_bases
TGTTCTTGGCGTTACTCTGCGGCTCTGCGTCTCTGCGAGAAACAGAAGCTATCGGCCCAAGACCACACGCCCCGAATCAG
GCTCGTCGTATTCTAATCTT

Downstream 100 bases:

>100_bases
CCTTCTTGTCTTCTCTTATCTGCGTTTATCTGCAGCCCATATTGCTTGTTAGAACGTCAGCCTAAGCGCAAACTCCATCG
TCCGCGGATCCGTCGCGCCC

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTKLRSSLYFWVLVAIALGVILGIVAPSTGAAMKPLGDGFIKLIKMVIAPIIFCTVVLGIAGTGDLKKVGRTGGLALLYF
EVVSTVSLILGLLIVNIVRPGAGMNIDVRTLDAAAVSAYAGKGKMQSTSEFLINVIPNTFVDAFARGEILQVLLLAVLFG
IALQRLGAHRNEVFQFIEKFSEIMFELVRMIMKVAPIGAFGAMAFTIGAYGIGSLFSLAKLMATFYLTCLCFIFLVLGAI
ARYHGFSIWRFLRYIREELLIVLGTSSSEAALPRMMAKMESLGAGRSTVGLVIPAGYSFNLDGTSIYLTMAAVFVAQATN
SAMTLGEQFTLLAVLLLMSKGAAGVTGSGFIVLAATLSAIGKVPVGGLALILGIDRFMSEARALTNVIGNGVASIVVAKW
TGDLDETMLTTRLKSGPPTPAEEPAIMS

Sequences:

>Translated_428_residues
MTKLRSSLYFWVLVAIALGVILGIVAPSTGAAMKPLGDGFIKLIKMVIAPIIFCTVVLGIAGTGDLKKVGRTGGLALLYF
EVVSTVSLILGLLIVNIVRPGAGMNIDVRTLDAAAVSAYAGKGKMQSTSEFLINVIPNTFVDAFARGEILQVLLLAVLFG
IALQRLGAHRNEVFQFIEKFSEIMFELVRMIMKVAPIGAFGAMAFTIGAYGIGSLFSLAKLMATFYLTCLCFIFLVLGAI
ARYHGFSIWRFLRYIREELLIVLGTSSSEAALPRMMAKMESLGAGRSTVGLVIPAGYSFNLDGTSIYLTMAAVFVAQATN
SAMTLGEQFTLLAVLLLMSKGAAGVTGSGFIVLAATLSAIGKVPVGGLALILGIDRFMSEARALTNVIGNGVASIVVAKW
TGDLDETMLTTRLKSGPPTPAEEPAIMS
>Mature_427_residues
TKLRSSLYFWVLVAIALGVILGIVAPSTGAAMKPLGDGFIKLIKMVIAPIIFCTVVLGIAGTGDLKKVGRTGGLALLYFE
VVSTVSLILGLLIVNIVRPGAGMNIDVRTLDAAAVSAYAGKGKMQSTSEFLINVIPNTFVDAFARGEILQVLLLAVLFGI
ALQRLGAHRNEVFQFIEKFSEIMFELVRMIMKVAPIGAFGAMAFTIGAYGIGSLFSLAKLMATFYLTCLCFIFLVLGAIA
RYHGFSIWRFLRYIREELLIVLGTSSSEAALPRMMAKMESLGAGRSTVGLVIPAGYSFNLDGTSIYLTMAAVFVAQATNS
AMTLGEQFTLLAVLLLMSKGAAGVTGSGFIVLAATLSAIGKVPVGGLALILGIDRFMSEARALTNVIGNGVASIVVAKWT
GDLDETMLTTRLKSGPPTPAEEPAIMS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI21314632, Length=441, Percent_Identity=26.3038548752834, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI40254478, Length=428, Percent_Identity=25.4672897196262, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI5032093, Length=419, Percent_Identity=27.9236276849642, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI223468564, Length=294, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI223468566, Length=294, Percent_Identity=30.6122448979592, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4827012, Length=271, Percent_Identity=28.4132841328413, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI169790839, Length=463, Percent_Identity=22.4622030237581, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI66773030, Length=463, Percent_Identity=23.3261339092873, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI194239697, Length=266, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI301601644, Length=197, Percent_Identity=29.9492385786802, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI262359914, Length=396, Percent_Identity=21.4646464646465, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789947, Length=417, Percent_Identity=66.9064748201439, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=39.2857142857143, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1788024, Length=396, Percent_Identity=24.2424242424242, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789473, Length=327, Percent_Identity=23.8532110091743, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=427, Percent_Identity=25.7611241217799, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71983099, Length=429, Percent_Identity=24.4755244755245, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=429, Percent_Identity=24.4755244755245, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=408, Percent_Identity=22.5490196078431, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=456, Percent_Identity=22.8070175438596, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=21.8468468468468, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=426, Percent_Identity=22.0657276995305, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583025, Length=440, Percent_Identity=23.8636363636364, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137668, Length=440, Percent_Identity=23.8636363636364, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583023, Length=440, Percent_Identity=23.8636363636364, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360481, Length=450, Percent_Identity=23.5555555555556, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281360483, Length=450, Percent_Identity=23.5555555555556, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137666, Length=450, Percent_Identity=23.5555555555556, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCTA_SOLUE (Q020J1)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_824947.1
- ProteinModelPortal:   Q020J1
- SMR:   Q020J1
- STRING:   Q020J1
- GeneID:   4428055
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3691
- NMPDR:   fig|234267.9.peg.3508
- eggNOG:   COG1301
- HOGENOM:   HBG739804
- OMA:   ACFYITC
- PhylomeDB:   Q020J1
- HAMAP:   MF_01300
- InterPro:   IPR001991
- InterPro:   IPR018107
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 45246; Mature: 45115

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a2a4e64)-; HASH(0x19e17c48)-; HASH(0x1a5f9630)-; HASH(0x19975ed4)-; HASH(0x4086f8d8)-; HASH(0x1a214878)-; HASH(0x1a6fe208)-; HASH(0x1a88e56c)-; HASH(0x164c10dc)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCH
>Mature Secondary Structure 
TKLRSSLYFWVLVAIALGVILGIVAPSTGAAMKPLGDGFIKLIKMVIAPIIFCTVVLGI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
AGTGDLKKVGRTGGLALLYFEVVSTVSLILGLLIVNIVRPGAGMNIDVRTLDAAAVSAYA
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHH
GKGKMQSTSEFLINVIPNTFVDAFARGEILQVLLLAVLFGIALQRLGAHRNEVFQFIEKF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
SEIMFELVRMIMKVAPIGAFGAMAFTIGAYGIGSLFSLAKLMATFYLTCLCFIFLVLGAI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARYHGFSIWRFLRYIREELLIVLGTSSSEAALPRMMAKMESLGAGRSTVGLVIPAGYSFN
HHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEC
LDGTSIYLTMAAVFVAQATNSAMTLGEQFTLLAVLLLMSKGAAGVTGSGFIVLAATLSAI
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
GKVPVGGLALILGIDRFMSEARALTNVIGNGVASIVVAKWTGDLDETMLTTRLKSGPPTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHHCCCCCCC
AEEPAIMS
CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA