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The map label for this gene is selA [H]

Identifier: 116622776

GI number: 116622776

Start: 4664597

End: 4665943

Strand: Direct

Name: selA [H]

Synonym: Acid_3675

Alternate gene names: 116622776

Gene position: 4664597-4665943 (Clockwise)

Preceding gene: 116622775

Following gene: 116622781

Centisome position: 46.81

GC content: 67.11

Gene sequence:

>1347_bases
GTGAGCGAGGCCCGCCAATTACGCGAAATTCCCGCCGTGAACCAGGTTTTGGAACGGCTTTCGGACGCGCTCGCACGATA
TCCGCGGACTCTGGTGGTGGAAGAAGTCCGGCGCGCACTGCAACAGGTGCGTACCGGGATTGCCGCGGGAAAGCCCGACG
GCCCACCCGTCGAGGCGCGGGTCGTTAGCGCGCTCGCGGCGCTGGAACGGCCTTCCCTGCGCCCCTTGATCAACGCGACC
GGGGTAGTGCTGCATACCAACCTCGGACGCGCTCCCCTCGGCTCGATCCCACAGGTTCCCGGCTACTCCAACCTGGAATA
CGATGTCGCCGCCGGCAGGCGCGGCAAGCGCGACGTGCATACCGCGCAGCTGCTGGAGCGGCTCACCGGCGCCCACGCGA
TCGTGGTCAATAACAACGCGGCCGCGCTGTTTCTGGCGCTCAACGAACTGGCGGCGGGCGCGGAGGCCATCGTCTCGCGC
GGCGAACTGATCGAGATCGGCGACGGCTTCCGCATTCCCGACATCATGAAGCGTTCCGGCGCGGCCCTGCATGAGGTGGG
CACCACCAATCGCACCCACATTGACGATTACCGCGCAGCCATCAATGACCGCACGCGCGTCATCCTGCGCGTCCACCCGA
GCAATTTCCGGATCACGGGATTCACCGCGCGGCCGGAATTGCGCGAACTCGCGGCTTTGGGCCGTGAGCGCGGAATCCCG
GTCTACGAGGATTTGGGCAGTGGCTGCATCGTGGATCTGCGCGCGTTCGGAATCGACGAGCCGCTGGTAGCGGAGAGCCT
CGCAGCGGGCGCCGACCTCGTCTCCTTCAGCGGCGACAAACTCCTCGGCGGTCCACAGGCCGGGATCCTGGCAGGGAAAC
CGGAGATCGTCTCGCGGCTGCGGCGCAATCCGCTATTCCGCGCCTTGCGCGTAGATAAGCTGATTATCCAGGCCCTCGAG
CACACCCTGCGTGCGGTCCTCTTGGAGCGCTGGGAGTGCGTGCCCGCCCTCGGCATGCTGCGCCAATCGGCCGGCGAGAT
CCGTTCACGCGCGACTGCATTCGTAGAAGGCCTCGTGGGAGTGCGGGCAGAACTGATCCCCGGAGAGAGCGTGATCGGCG
GCGGCGCTACACCCGAGCAATCGATTCCGACGTGGCTTATCGCGGTGGAATGCCCCGACGTGGCCGCCGCCGAACGCCGC
CTGCGCGCCGGCGACCCCGCGGTCGTAGCCCGGATTGAAGAAGGCCGCCTGATCCTCGACCTCCGCACCGTGTTCCCGGA
GGAGGAGCCCGCCCTCGCGACGGCGATTCAGGATGCAACGGACTCTCCACGCGAACCGCGACCGTAA

Upstream 100 bases:

>100_bases
CCTGGTCCCGAACCAGGCGCTCTACCAGGCTGAGCCACGCCCCGAACTTTCTAGTTTAGTCTGTTGCACCCCGCCGACAC
AAGCGCGTACCATCAAATTC

Downstream 100 bases:

>100_bases
GGTAAGGGAGCCGATCTACATGCCTTTTACCCTATTGCAATCTGCAAAATCACGCAAACATGAAAAATATCTTCGCGTTG
TTATCAGCAACTTAGCCGAC

Product: L-seryl-tRNA(Sec) selenium transferase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSEARQLREIPAVNQVLERLSDALARYPRTLVVEEVRRALQQVRTGIAAGKPDGPPVEARVVSALAALERPSLRPLINAT
GVVLHTNLGRAPLGSIPQVPGYSNLEYDVAAGRRGKRDVHTAQLLERLTGAHAIVVNNNAAALFLALNELAAGAEAIVSR
GELIEIGDGFRIPDIMKRSGAALHEVGTTNRTHIDDYRAAINDRTRVILRVHPSNFRITGFTARPELRELAALGRERGIP
VYEDLGSGCIVDLRAFGIDEPLVAESLAAGADLVSFSGDKLLGGPQAGILAGKPEIVSRLRRNPLFRALRVDKLIIQALE
HTLRAVLLERWECVPALGMLRQSAGEIRSRATAFVEGLVGVRAELIPGESVIGGGATPEQSIPTWLIAVECPDVAAAERR
LRAGDPAVVARIEEGRLILDLRTVFPEEEPALATAIQDATDSPREPRP

Sequences:

>Translated_448_residues
MSEARQLREIPAVNQVLERLSDALARYPRTLVVEEVRRALQQVRTGIAAGKPDGPPVEARVVSALAALERPSLRPLINAT
GVVLHTNLGRAPLGSIPQVPGYSNLEYDVAAGRRGKRDVHTAQLLERLTGAHAIVVNNNAAALFLALNELAAGAEAIVSR
GELIEIGDGFRIPDIMKRSGAALHEVGTTNRTHIDDYRAAINDRTRVILRVHPSNFRITGFTARPELRELAALGRERGIP
VYEDLGSGCIVDLRAFGIDEPLVAESLAAGADLVSFSGDKLLGGPQAGILAGKPEIVSRLRRNPLFRALRVDKLIIQALE
HTLRAVLLERWECVPALGMLRQSAGEIRSRATAFVEGLVGVRAELIPGESVIGGGATPEQSIPTWLIAVECPDVAAAERR
LRAGDPAVVARIEEGRLILDLRTVFPEEEPALATAIQDATDSPREPRP
>Mature_447_residues
SEARQLREIPAVNQVLERLSDALARYPRTLVVEEVRRALQQVRTGIAAGKPDGPPVEARVVSALAALERPSLRPLINATG
VVLHTNLGRAPLGSIPQVPGYSNLEYDVAAGRRGKRDVHTAQLLERLTGAHAIVVNNNAAALFLALNELAAGAEAIVSRG
ELIEIGDGFRIPDIMKRSGAALHEVGTTNRTHIDDYRAAINDRTRVILRVHPSNFRITGFTARPELRELAALGRERGIPV
YEDLGSGCIVDLRAFGIDEPLVAESLAAGADLVSFSGDKLLGGPQAGILAGKPEIVSRLRRNPLFRALRVDKLIIQALEH
TLRAVLLERWECVPALGMLRQSAGEIRSRATAFVEGLVGVRAELIPGESVIGGGATPEQSIPTWLIAVECPDVAAAERRL
RAGDPAVVARIEEGRLILDLRTVFPEEEPALATAIQDATDSPREPRP

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=453, Percent_Identity=43.7086092715232, Blast_Score=290, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 48246; Mature: 48115

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEARQLREIPAVNQVLERLSDALARYPRTLVVEEVRRALQQVRTGIAAGKPDGPPVEAR
CCHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VVSALAALERPSLRPLINATGVVLHTNLGRAPLGSIPQVPGYSNLEYDVAAGRRGKRDVH
HHHHHHHHCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHH
TAQLLERLTGAHAIVVNNNAAALFLALNELAAGAEAIVSRGELIEIGDGFRIPDIMKRSG
HHHHHHHHCCCEEEEEECCCEEEEEEHHHHHCCHHHHHCCCCEEEECCCCCCHHHHHHCC
AALHEVGTTNRTHIDDYRAAINDRTRVILRVHPSNFRITGFTARPELRELAALGRERGIP
CHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHCCCC
VYEDLGSGCIVDLRAFGIDEPLVAESLAAGADLVSFSGDKLLGGPQAGILAGKPEIVSRL
HHHHCCCCCEEEHHHHCCCCHHHHHHHHCCCHHEECCCCCCCCCCCCCEECCCHHHHHHH
RRNPLFRALRVDKLIIQALEHTLRAVLLERWECVPALGMLRQSAGEIRSRATAFVEGLVG
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRAELIPGESVIGGGATPEQSIPTWLIAVECPDVAAAERRLRAGDPAVVARIEEGRLILD
HHHHCCCCCCEECCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCEEEEE
LRTVFPEEEPALATAIQDATDSPREPRP
EHHHCCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEARQLREIPAVNQVLERLSDALARYPRTLVVEEVRRALQQVRTGIAAGKPDGPPVEAR
CHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VVSALAALERPSLRPLINATGVVLHTNLGRAPLGSIPQVPGYSNLEYDVAAGRRGKRDVH
HHHHHHHHCCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHH
TAQLLERLTGAHAIVVNNNAAALFLALNELAAGAEAIVSRGELIEIGDGFRIPDIMKRSG
HHHHHHHHCCCEEEEEECCCEEEEEEHHHHHCCHHHHHCCCCEEEECCCCCCHHHHHHCC
AALHEVGTTNRTHIDDYRAAINDRTRVILRVHPSNFRITGFTARPELRELAALGRERGIP
CHHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHCCCC
VYEDLGSGCIVDLRAFGIDEPLVAESLAAGADLVSFSGDKLLGGPQAGILAGKPEIVSRL
HHHHCCCCCEEEHHHHCCCCHHHHHHHHCCCHHEECCCCCCCCCCCCCEECCCHHHHHHH
RRNPLFRALRVDKLIIQALEHTLRAVLLERWECVPALGMLRQSAGEIRSRATAFVEGLVG
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRAELIPGESVIGGGATPEQSIPTWLIAVECPDVAAAERRLRAGDPAVVARIEEGRLILD
HHHHCCCCCCEECCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCEEEEE
LRTVFPEEEPALATAIQDATDSPREPRP
EHHHCCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]