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The map label for this gene is tcp [H]

Identifier: 116622518

GI number: 116622518

Start: 4323363

End: 4324787

Strand: Direct

Name: tcp [H]

Synonym: Acid_3416

Alternate gene names: 116622518

Gene position: 4323363-4324787 (Clockwise)

Preceding gene: 116622517

Following gene: 116622522

Centisome position: 43.38

GC content: 63.44

Gene sequence:

>1425_bases
ATGAATCTCAGTAAAAGGCTGCTGATCAGCTTTGGATCGATGCTTGGGCTGGTGCTGCTATTGAGCGCGGCAGCCCTGCT
GGTGACGCGGGATCTGGGGGGAGAACTCGACCGTGCCGCTAACGTAACGGCTCGCCAGCAATATCTGGCAGGCTTGGTGA
GTGCCGGCGCAGCGGAGCTGGCGAACCTGGAGCGTGGCACCGTGCTGGCTGCGATGCTGGGCGACAAGGCGCGGGCGGAC
GAATACCAGCAACGGTTCCGCAGCCATGCGGAAGGAGTGCAGAAGGCGCTGGCAAATCTCGGTAAGATGGCGGAATCACG
GGAAGAGTCCGCGCGGCTACAAACACTGGGGCAGCAGGCGGCCCTGGTGGCGCAGGCGCATGAGGAGATGCGGCAGGCGA
TGGCCAATCAGCAGATGGATGCCGGCATGGCGATCTTTGCGCAGAAACTCCAGCCCCAGCTGGAGGAAATCGGGCGCCAG
GCGCTGGAACTGGTGGATCGCCAGAATCGCGATCTGGCGGCGGCGTCGGCTGCATCGGCGTCGCGCAGCGCGCGCAGCAG
CTGGGTGACGGTGGCCCTGATGCTGATTGCGCTTGCCGTGGGAGCCGTAGTGTTCTTGACGGTGCGCCATGCGAGCAGCG
CGCTGAAGGACTTGGCATACCGCATGTACCAGAGCGCGGAAAACGTGTCCAGCGCGGCGTCGATGGTTTCGAGCGCCAGC
CACTCGCTGGCGGAGGGTGCAAGCCAGCAGGCGGCGTCGTTAGAGGAGACCTCGGCATCGACCGAAGAGATCGCGTCGAT
CACGCGTAAGAACGCGGATCACGCGCTGCAGGTGGCCGGACTGATGCAGAAATCGGCTGACGGCGCCGGGGCCGTCAATA
CTTCGCTCGATCGAATGGTGGAGCAAATGGGCGAAATCGGCAATTCCAGCAACAAGATCGCGCGCATTATTAAAGTGATC
GACGAGATCGCGTTTCAGACCAACATTCTGGCGCTGAATGCCGCGGTGGAAGCGGCGCGGGCCGGCGAAGCGGGGCTGGG
ATTCGCGGTAGTTGCGGACGAGGTTCGTAATTTGGCGCAGCGGTGCGCGCAGGCTGCGCGTGACACCGCGGGTCTGATTG
AGGATTCGATTGCAACTTCGCGGGACGGCAATGCGCGCCTGGACCAGATGGCGGATTCAGTGCGGGGTATGACGGAAAGC
GCGACGCGAGTGAAGTCGCTGGTGGATGAAGTCAATCTTGGCAGCCAGGAGCAGGCGCGGGGGATGGAGCAGATTTCCCG
GGTTGTGCTGCAGATGGAGCAGGTGACGCAGAAGACGGCGGCGAGCGCGGAGGAAGGTGCGTCGGCGGGAACCGAGCTCA
ACGATCACGCCAACGGGCTGCGCAAGCTGGTCCACGAGATGCGCACGATGGTGGGGATGGAATAA

Upstream 100 bases:

>100_bases
AAATTTGCGCCGTTTACCAGTGAAGGCAAGACGGTCAAGGCGCTGGTTCCCGTCAGTTTGAGCTTTCACATGTAGTCATG
TCAATTGGGAGAAAAGCTAA

Downstream 100 bases:

>100_bases
AGCGGAAGGAAAAAACAAATGCCCGGCCGGGCCGGAGGAGTCTCCGGCCCGCTCCCGGCAGGATTACATTTTGACGCTGT
CAACTTTGATGGTATCGCCG

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Citrate chemoreceptor protein [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNLSKRLLISFGSMLGLVLLLSAAALLVTRDLGGELDRAANVTARQQYLAGLVSAGAAELANLERGTVLAAMLGDKARAD
EYQQRFRSHAEGVQKALANLGKMAESREESARLQTLGQQAALVAQAHEEMRQAMANQQMDAGMAIFAQKLQPQLEEIGRQ
ALELVDRQNRDLAAASAASASRSARSSWVTVALMLIALAVGAVVFLTVRHASSALKDLAYRMYQSAENVSSAASMVSSAS
HSLAEGASQQAASLEETSASTEEIASITRKNADHALQVAGLMQKSADGAGAVNTSLDRMVEQMGEIGNSSNKIARIIKVI
DEIAFQTNILALNAAVEAARAGEAGLGFAVVADEVRNLAQRCAQAARDTAGLIEDSIATSRDGNARLDQMADSVRGMTES
ATRVKSLVDEVNLGSQEQARGMEQISRVVLQMEQVTQKTAASAEEGASAGTELNDHANGLRKLVHEMRTMVGME

Sequences:

>Translated_474_residues
MNLSKRLLISFGSMLGLVLLLSAAALLVTRDLGGELDRAANVTARQQYLAGLVSAGAAELANLERGTVLAAMLGDKARAD
EYQQRFRSHAEGVQKALANLGKMAESREESARLQTLGQQAALVAQAHEEMRQAMANQQMDAGMAIFAQKLQPQLEEIGRQ
ALELVDRQNRDLAAASAASASRSARSSWVTVALMLIALAVGAVVFLTVRHASSALKDLAYRMYQSAENVSSAASMVSSAS
HSLAEGASQQAASLEETSASTEEIASITRKNADHALQVAGLMQKSADGAGAVNTSLDRMVEQMGEIGNSSNKIARIIKVI
DEIAFQTNILALNAAVEAARAGEAGLGFAVVADEVRNLAQRCAQAARDTAGLIEDSIATSRDGNARLDQMADSVRGMTES
ATRVKSLVDEVNLGSQEQARGMEQISRVVLQMEQVTQKTAASAEEGASAGTELNDHANGLRKLVHEMRTMVGME
>Mature_474_residues
MNLSKRLLISFGSMLGLVLLLSAAALLVTRDLGGELDRAANVTARQQYLAGLVSAGAAELANLERGTVLAAMLGDKARAD
EYQQRFRSHAEGVQKALANLGKMAESREESARLQTLGQQAALVAQAHEEMRQAMANQQMDAGMAIFAQKLQPQLEEIGRQ
ALELVDRQNRDLAAASAASASRSARSSWVTVALMLIALAVGAVVFLTVRHASSALKDLAYRMYQSAENVSSAASMVSSAS
HSLAEGASQQAASLEETSASTEEIASITRKNADHALQVAGLMQKSADGAGAVNTSLDRMVEQMGEIGNSSNKIARIIKVI
DEIAFQTNILALNAAVEAARAGEAGLGFAVVADEVRNLAQRCAQAARDTAGLIEDSIATSRDGNARLDQMADSVRGMTES
ATRVKSLVDEVNLGSQEQARGMEQISRVVLQMEQVTQKTAASAEEGASAGTELNDHANGLRKLVHEMRTMVGME

Specific function: Acts as a receptor for citrate and mediates taxis away from phenol. Also mediates an attractant response to metal-citrate complexes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=257, Percent_Identity=42.4124513618677, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788195, Length=235, Percent_Identity=42.5531914893617, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI2367378, Length=232, Percent_Identity=43.9655172413793, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1787690, Length=245, Percent_Identity=39.5918367346939, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789453, Length=227, Percent_Identity=35.2422907488987, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 50149; Mature: 50149

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSKRLLISFGSMLGLVLLLSAAALLVTRDLGGELDRAANVTARQQYLAGLVSAGAAEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLERGTVLAAMLGDKARADEYQQRFRSHAEGVQKALANLGKMAESREESARLQTLGQQA
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVAQAHEEMRQAMANQQMDAGMAIFAQKLQPQLEEIGRQALELVDRQNRDLAAASAASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRSARSSWVTVALMLIALAVGAVVFLTVRHASSALKDLAYRMYQSAENVSSAASMVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSLAEGASQQAASLEETSASTEEIASITRKNADHALQVAGLMQKSADGAGAVNTSLDRMV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EQMGEIGNSSNKIARIIKVIDEIAFQTNILALNAAVEAARAGEAGLGFAVVADEVRNLAQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RCAQAARDTAGLIEDSIATSRDGNARLDQMADSVRGMTESATRVKSLVDEVNLGSQEQAR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHH
GMEQISRVVLQMEQVTQKTAASAEEGASAGTELNDHANGLRKLVHEMRTMVGME
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLSKRLLISFGSMLGLVLLLSAAALLVTRDLGGELDRAANVTARQQYLAGLVSAGAAEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLERGTVLAAMLGDKARADEYQQRFRSHAEGVQKALANLGKMAESREESARLQTLGQQA
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVAQAHEEMRQAMANQQMDAGMAIFAQKLQPQLEEIGRQALELVDRQNRDLAAASAASA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRSARSSWVTVALMLIALAVGAVVFLTVRHASSALKDLAYRMYQSAENVSSAASMVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSLAEGASQQAASLEETSASTEEIASITRKNADHALQVAGLMQKSADGAGAVNTSLDRMV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EQMGEIGNSSNKIARIIKVIDEIAFQTNILALNAAVEAARAGEAGLGFAVVADEVRNLAQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RCAQAARDTAGLIEDSIATSRDGNARLDQMADSVRGMTESATRVKSLVDEVNLGSQEQAR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHH
GMEQISRVVLQMEQVTQKTAASAEEGASAGTELNDHANGLRKLVHEMRTMVGME
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8419927; 11677609 [H]