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The map label for this gene is sucC

Identifier: 116622480

GI number: 116622480

Start: 4278829

End: 4279983

Strand: Reverse

Name: sucC

Synonym: Acid_3378

Alternate gene names: 116622480

Gene position: 4279983-4278829 (Counterclockwise)

Preceding gene: 116622483

Following gene: 116622479

Centisome position: 42.95

GC content: 62.16

Gene sequence:

>1155_bases
ATGAAAATTCACGAGTATCAAGCCAAGGCCATTCTGGCCCAATACAAAGTCCCTGTGCCACGAGGGCATGTCGCATACAC
GGAAGCGGACGCGGAAACCGCGGCCAAAACGCTGGGCGGCTCGGTGGTGGTGAAGGCACAGATTCACGCGGGCGGCCGCG
GCAAAGGCGGAGGAGTGAAGGTCGCCAAAGATGCCGCCGAAGCGCTTGAACTGGCGAAGAAGATTCTGGGGATGACCCTG
GTCACTCACCAGACCGGACCGGAAGGGCGGCTGGTGCAGCGCCTGCTGATCGAAGAAACGCTGCCGATCGAACGCGAGTT
GTATCTCGGCATCGTGCTGGACCGGGTGCAGGGCAAGCCGGTCTTCATGGCGTCCTCGGCGGGCGGCATGGACATCGAAG
AAGTCGCGGCCAAAACGCCGGAACTGATCCTCAAGGAGACGCTGGAGTATCCGGGCCTCTCGCCCTACCAGGCGCGCAAG
CTGGCGTTTGGCATCGGTATCCCGGCGGCGAGCGTGAATGCGGCGGCGGCAGCGATGACGGCGCTCTCCAAGGCATACTG
GGCGATGGACGCGTCGCTGGCGGAGATCAACCCCTTCATCCTGACGACCGACGGCAAGGTTTACGCGCTCGACGCGAAGA
TCACCTTCGACGACAACGCGCTGTATCGCCACAAAGAACTGGTGGAGCTGCGCGATTTGAACGAGGAAGATCCGCTGGAG
GTGGAAGCCTCCAAGCACGGCTTGAATTACATCAAGCTGGATGGCACGGTGGGCTGCATGGTGAATGGCGCCGGACTCGC
GATGGCGACCATGGACATCATTAAATTCGCGGGCGGCAGTCCGGCGAACTTCCTGGATGTGGGCGGCGGGGCCAACGCGG
AGCAAGTGAAGAACGCGTTCCGGATTCTGCTTTCGGATCACAGCGTGAAGGCGGTGCTGATCAACATCTTCGGCGGCATT
CTGCGCTGCGACACGCTGGCCACCGGCGTGGTGGCGGCGGCGCGCGACCTGAACATCCAGGTGCCGATCGTGGTGCGCAT
GGAAGGCACCAACGTGGAAGCGGGCCGGCAGATTCTGCTGGAATCGGGATTCAACTTTACGGTGGGCGCGGACATGTGGG
ACGCCGCTCAAAAAGTAGTGAAGCTGGCTGCGTGA

Upstream 100 bases:

>100_bases
GTCGGCAGCAGAAAGATGCTGCTCCTCAACGAGGCGCATCAAGTGTGGAAGAAGCGACATGTAGTATATTGGGTTTTCTG
TAGGCTAACACAGCAACTCC

Downstream 100 bases:

>100_bases
GGAACTAATGAGCGTACTGGTAGACAAGAATACGAAAGTGATTGTTCAGGGCTTCACCGGTAAGGAAGGCACCTTTCACG
CGCAGCAATCGATTGCGTAC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVKVAKDAAEALELAKKILGMTL
VTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKPVFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARK
LAFGIGIPAASVNAAAAAMTALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLE
VEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAFRILLSDHSVKAVLINIFGGI
LRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILLESGFNFTVGADMWDAAQKVVKLAA

Sequences:

>Translated_384_residues
MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVKVAKDAAEALELAKKILGMTL
VTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKPVFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARK
LAFGIGIPAASVNAAAAAMTALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLE
VEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAFRILLSDHSVKAVLINIFGGI
LRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILLESGFNFTVGADMWDAAQKVVKLAA
>Mature_384_residues
MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVKVAKDAAEALELAKKILGMTL
VTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKPVFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARK
LAFGIGIPAASVNAAAAAMTALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLE
VEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAFRILLSDHSVKAVLINIFGGI
LRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILLESGFNFTVGADMWDAAQKVVKLAA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=45.6632653061224, Blast_Score=348, Evalue=5e-96,
Organism=Homo sapiens, GI157779135, Length=383, Percent_Identity=45.9530026109661, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI294862256, Length=362, Percent_Identity=46.4088397790055, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI1786948, Length=382, Percent_Identity=49.4764397905759, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539378, Length=391, Percent_Identity=45.5242966751918, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI17567829, Length=396, Percent_Identity=43.9393939393939, Blast_Score=318, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6321683, Length=394, Percent_Identity=44.9238578680203, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI161078106, Length=392, Percent_Identity=46.1734693877551, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24645208, Length=392, Percent_Identity=46.1734693877551, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI281361397, Length=393, Percent_Identity=46.3104325699746, Blast_Score=340, Evalue=7e-94,
Organism=Drosophila melanogaster, GI281361395, Length=393, Percent_Identity=46.3104325699746, Blast_Score=340, Evalue=7e-94,
Organism=Drosophila melanogaster, GI21356231, Length=391, Percent_Identity=45.7800511508951, Blast_Score=325, Evalue=4e-89,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_SOLUE (Q021N6)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_824636.1
- ProteinModelPortal:   Q021N6
- SMR:   Q021N6
- STRING:   Q021N6
- GeneID:   4428383
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3378
- NMPDR:   fig|234267.9.peg.3204
- eggNOG:   COG0045
- HOGENOM:   HBG315432
- OMA:   MADGAEK
- PhylomeDB:   Q021N6
- ProtClustDB:   PRK00696
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 40765; Mature: 40765

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVK
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCEEEEEEEEECCCCCCCCCEE
VAKDAAEALELAKKILGMTLVTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKP
EHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCE
VFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARKLAFGIGIPAASVNAAAAAMT
EEEECCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHH
ALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLE
HHHHHHHHHCCCHHHCCCEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEE
VEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAF
EEECCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHH
RILLSDHSVKAVLINIFGGILRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHCHHEEE
ESGFNFTVGADMWDAAQKVVKLAA
ECCCCEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVK
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCEEEEEEEEECCCCCCCCCEE
VAKDAAEALELAKKILGMTLVTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKP
EHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCE
VFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARKLAFGIGIPAASVNAAAAAMT
EEEECCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHH
ALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLE
HHHHHHHHHCCCHHHCCCEEEEECCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEE
VEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAF
EEECCCCCEEEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHH
RILLSDHSVKAVLINIFGGILRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHCHHEEE
ESGFNFTVGADMWDAAQKVVKLAA
ECCCCEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA